Trends in progress test performance of medical students at a university in Peru. by Franco Romaní-Romaní, César Gutiérrez

“…<h4>Results</h4>We included 1,899 test scores from 669 medical students. The mean score across all tests was 9.19 (standard deviation = 2.34). …”
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Evaluation of initial geostress field of underground powerhouse in the complex alteration area of western Sichuan based on back-propagation neural network method by Hong Zheng, Shiqi Cao, Quan Jiang, Shaojun Li, Dingping Xu, Zhiwei Li

“…Additionally, this classification was used to analyze the distribution function of mechanical parameters in surrounding rocks across different alteration grades. …”
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Technological Resources and Problem-Solving Methods to Foster a Positive Attitude Toward Formative Research in Engineering Students by Ronald Paucar-Curasma, Klinge Orlando Villalba-Condori, Sara Hermelinda Gonzales-Agama, Freddy Toribio Huayta-Meza, David Rondon, Ninna Nyberg Sapallanay-Gomez

“…Formative research, within the context of the pedagogical function of research, employs investigative teaching methods and practices commonly used in universities. …”
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A new approach to estimate the heat thresholds at the county level in China by Qian Yin, Jinfeng Wang, Jiayi Zhou, Zhoupeng Ren

“…Methods Based on the temperature–mortality relationship observed in 36 locations covering all six major climate zones in China, we found that the relative risk (RR) of heat-related mortality and the annual frequency of temperature (AFT) have a power function relationship (adjusted R 2 = 0.74)), and the association is independent to the variation of the temperature across the territory. …”
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Unveiling the multifaceted role of the FLNC gene: implications for cancer diagnosis and prognosis by Peizan Ni, Lilin Li, Yaru Zhu, Kunpeng Du, Pengkhun Nov, Duanyu Wang, Changqian Wang, Qianzi Kou, Ying Li, Yangfeng Zhang, Chongyang Zheng, Wen Fu, Jiqiang Li

“…Results Our findings indicate that abnormal FLNC expression correlates with unfavorable prognosis across multiple cancer types, suggesting its potential as a prognostic biomarker. …”
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Application of artificial intelligence large language models in drug target discovery by Xinyu Liu, Jia Zhang, Xiaoran Wang, Maoda Teng, Guoying Wang, Xiaoming Zhou, Xiaoming Zhou

“…In proteomics, advancements have been made in protein structure analysis, function prediction, and interaction inference. Additionally, the single-cell multi-omics large language model facilitates data integration across different omics technologies. …”
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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as prognostic biomarkers of proteinuria and CKD severity: A cross-sectional study by Fatima Khurshid, Shaikha Amjad, Muhammad Talha, Zainab Nadeem, Mahnoor Sohail, Muhammad Ahmad, Madiha Mumtaz

“…Objectives: Chronic kidney disease (CKD) is characterized by a prolonged decline in kidney function, defined by an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m² for over 3 months. …”
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Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit by Waqas Badar, Sheetal R. Inamdar, Peter Fratzl, Tim Snow, Nicholas J. Terrill, Martin M. Knight, Himadri S. Gupta

“…Abstract By developing a 3D X‐ray modeling and spatially correlative imaging method for fibrous collagenous tissues, this study provides a comprehensive mapping of nanoscale deformation in the collagen fibril network across the intact bone‐cartilage unit (BCU), whose healthy functioning is critical for joint function and preventing degeneration. …”
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Three-Dimensional Evaluation of the Effects of Different Treatment Methods on Pharyngeal Airways in Patients with Skeletal Class III Malocclusion by Mevlude Yuce Polat, İsmail Ceylan

“…<i>Results</i>: The results indicated significant changes in pharyngeal airway volumes across all treatment groups compared to the control group. …”
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Training University Psychology Students to Teach Multiple Skills to Children with Autism Spectrum Disorder by Daniel Carvalho de Matos, Ryan Matos e Silva Moura de Brito, Fabrício Brito Silva, Juliana Ribeiro Rabelo Costa, Leila Bagaiolo, Claudia Romano Pacífico, Pollianna Galvão Soares

“…In addition, across four months after training, all participants maintained high teaching integrity levels while teaching skills to the children related to their individualized curriculum goals. …”
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The acoustic startle response in 22q11 deletion syndrome: from animal models to humans by Sidney Imes, Sidney Imes, David A. Parker, Marissa Chen, Joseph F. Cubells, Joseph F. Cubells, Elaine F. Walker, Erica Duncan, Erica Duncan

“…We then highlight the translational power of the acoustic startle response and how it can be studied in conjunction with more basic cellular investigations related to basic neural function and responsiveness. Because the acoustic startle response is seen across vertebrate species with well characterized circuitry, we argue for using the acoustic startle response as a translational biological probe of underlying neurobiology relevant to 22qDel and by extension, psychosis and psychosis risk.…”
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Membrane-dependent dynamics and dual translocation mechanisms of ABCB4: Insights from molecular dynamics simulations by Veronica Crespi, Ágota Tóth, Angelika Janaszkiewicz, Thomas Falguières, Florent Di Meo

“…Overall, ABCB4 may utilize a cooperative transport mechanism, integrating elements of both models to facilitate efficient phosphatidylcholine motion across the membrane. This study provides new insights into the relationship between membrane environment and ABCB4 function, contributing to our understanding of its role in bile physiology and susceptibility to genetic and xenobiotic influences.…”
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Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer by Fengjie Lin, Hanxuan Yang, Zongwei Huang, Ying Li, Qin Ding, Yunbin Ye, Yunbin Ye, Sufang Qiu

“…ITGAL might exert an important function in the growth and transformation of cancer.MethodsOur study comprehensively analyzed ITGAL expression across various cancers, validated by Immunochemistry (IHC) in the laboratory. …”
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Exploring the relationship between co-abundance of gut microbiota and novel metabolic pathways in different subtypes of irritable bowel syndrome: insights from the American Gut Pro... by Li-li Han, Chun-feng Mei, Hong Xue

“…Through Spearman correlation analysis, the random forest model, SHAP analysis, and the PICRUSt2 prediction function, we constructed and screened the gut microbiota co-abundance groups and their metabolic characteristics of three cohorts of patients with different subtypes among cohorts of patients with three distinct IBS subtypes: predominant constipation (IBS-C), predominant diarrhea (IBS-D), and unclassified (IBS-U), as well as three non-IBS control groups (non-IBS1, non-IBS2, and non-IBS3, respectively).ResultsOur study findings indicate that, in comparison to their respective non-IBS groups, there was a significant difference in the prevalence of 37.5% specific co-abundance groups (CAGs) identified across all three IBS subtypes: IBS-C, IBS-D, and IBS-U. …”
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Identification and Characterization of Flavonoid Biosynthetic Gene Families in <i>Paeonia</i> Species and Their Roles in Stamen Petalization of <i>Paeonia lactiflora</i> by Yanyi Zheng, Yongming Fan, Xiang Ji, Xiaopei Wu

“…Molecular docking identified <i>PlaF3’H07</i> as a key enzyme with strong substrate-binding affinity (ΔG = −4.7 kcal/mol), supporting its catalytic function in quercetin synthesis. The expression pattern of key flavonoid biosynthetic genes was also confirmed across three developmental stages of floral buds by real-time quantitative PCR. …”
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Variants of active assist robotic therapy: feasibility of virtual assistance and proprioceptive training as gauged by their effects on success and motivation during finger movement... by Andria J. Farrens, Dylan Reinsdorf, Luis Garcia-Fernandez, Raymond Diaz Rojas, Vicky Chan, Joel Perry, Eric T. Wolbrecht, David J. Reinkensmeyer

“…Participants used the FINGER robot to train in three sessions across one week, during which an adaptive algorithm titrated success to ~ 80%. …”
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Ecohydrology and paleoenvironment of the Cretaceous (Albian) Cloverly Formation: insights from multi-taxon oxygen isotope analysis of vertebrate phosphates by M. L. Allen, M. B. Suarez, T. L. Adams, C. A. Suarez

“…Using a multi-taxon framework, we estimated warm-season water temperatures from δ18Osurface_water and δ18Οphosphate of lepisosteid (gar) scales, then converted these to air temperatures using a modern climate transfer function. δ18Οphosphate values ranged from 9.5‰ to 23.2‰ (VSMOW) and varied across taxa. …”
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Thermal freeze-out and collective signatures in $$pp$$ collisions with a non-extensive statistical study on energy and pseudorapidity systematics by Haifa I. Alrebdi, Muhammad Ajaz, Murad Badshah, Muhammad Waqas, Norah A. M. Alsaif, Mohammad Ayaz Ahmad, Jihane Ben Slimane

“…Using a modified Tsallis function incorporating an effective transverse flow velocity, we achieve excellent agreement between the model and experimental data, with consistent fit quality across all $$p_T$$ ranges (validated by Data/Fit panels). …”
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Hypocretin: a promising target for the regulation of homeostasis by Yutong Wang, Yutong Wang, Su Fu, Jian Mao, Kun Cui, Hong Jiang, Hong Jiang

“…Yet, human data remain inconsistent, in part due to methodological variability and the limited availability of cerebrospinal fluid sampling to accurately assess central hypocretin function. Therapeutically, the hypocretin system is a promising target across several domains. …”
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A TD3-Based Reinforcement Learning Algorithm With Curriculum Learning for Adaptive Yaw Control in All-Wheel-Drive Electric Vehicles by Reza Jafari, Pouria Sarhadi, Amin Paykani, Shady S. Refaat, Pedram Asef

“…The performance of the proposed algorithm is studied across different maneuvers, demonstrating reduced yaw rate error and sideslip angle, resulting in enhanced dynamic stability.…”
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