Near-Infrared Imaging of Glymphatic Clearance in a Pre-Clinical Model of Repetitive Closed Head Traumatic Brain Injury by Eleftheria Michalaki, Alexis N. Pulliam, Pooja M. Datta Roy, J. Brandon Dixon, Michelle C. LaPlaca

“…Aquaporin-4 (AQP4) expression was reduced 24 h after TBI across all cortical regions examined in the posterior of the brain and in the ventral cortex at all coronal levels, suggesting a complex relationship between AQP4 and glymph function. …”
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Serum multi-trace elements and post-stroke cognitive impairment: a prospective observational cohort study by Ruolin Zhou, Weijie Zhai, Lingjie Meng, Chunxiao Wei, Li Sun

“…Cognitive impairments varied across multi-trace elements. Serum iron affected wider cognition, while magnesium and copper levels were strongly associated with language and executive function. …”
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Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2 by Chennu Manisha, Nagarjuna Palathoti, Jagdish Chand, Akey Krishna Swaroop, Jubie Selvaraj, B.R. Prashantha Kumar, Prisil Naveentha X, Brindha Durairaj, Antony Justin

“…Therefore, compounds that enhance EAAT2 function by reducing oxidative stress and excitotoxicity might be neuroprotective. …”
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Development and validation of a nomogram for predicting low Kt/Vurea in peritoneal dialysis patients by Danfeng Zhang, Tian Zhao, Liting Gao, Huan Zhu, Haowei Jin, Guiling Liu, Deguang Wang

“…Abstract Background This study aimed to develop a nomogram to predict peritoneal dialysis (PD) adequacy in incident PD patients and identify those at high risk for low Kt/Vurea PD function. Methods We retrospectively analyzed 141 incident PD patients from January 2021 to January 2024. …”
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Modifiable factors associated with cognitive health trajectories among Indigenous, Hispanic, Black, and White older adults: an exploratory longitudinal panel analysis of the health... by Cliff Whetung, Ernest Gonzales

“…A college education was a protective factor for initial cognitive function (b0 = 3.09, 95% CI: 2.91, 3.27) and over time (b = 0.24, 95% CI: 0.15, 0.33) across ethnicity. …”
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Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria by Yi Wang, Nahui Liu, Lifan Hu, Jingsong Yang, Mengmeng Han, Tianjiao Zhou, Lei Xing, Hulin Jiang

“…Herein, PARKIN mRNA-loaded nanoparticle (mNP)-engineered mitochondria (mNP-Mito) were designed to replace dysfunctional mitochondria with the delivery of exogenous mitochondria, normalizing the function of complex I for treating LHON. The mNP-Mito facilitated the supplementation of healthy mitochondria containing functional complex I via mitochondrial transfer, along with the elimination of dysfunctional mitochondria with impaired complex I via an enhanced PARKIN-mediated mitophagy process. …”
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Metric Dimension of Nonplanar Networks by Fractional Technique With Application by Arooba Fatima, Muhammad Javaid, Mamo Abebe Ashebo

“…The fractional local metric dimension of <inline-formula> <tex-math notation="LaTeX">$\mathcal {T}$ </tex-math></inline-formula> is the minimum value of <inline-formula> <tex-math notation="LaTeX">$\rho (V(\mathcal {T}))$ </tex-math></inline-formula> across all local resolving functions <inline-formula> <tex-math notation="LaTeX">$\rho $ </tex-math></inline-formula> of <inline-formula> <tex-math notation="LaTeX">$\mathcal {T}$ </tex-math></inline-formula>. …”
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Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial. by Robert S Wallis, Sibuse Ginindza, Trevor Beattie, Nishanee Arjun, Morongwe Likoti, Modulakgotla Sebe, Vinodh A Edward, Mohammed Rassool, Khatija Ahmed, Katherine Fielding, Bintou A Ahidjo, Mboyo D T Vangu, Gavin Churchyard

“…<h4>Background</h4>Current tuberculosis treatments leave most patients with bronchiectasis and fibrosis, permanent conditions that impair lung function and increase all-cause post-TB mortality. …”
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The Aging Brain Cohort (ABC) repository: The University of South Carolina’s multimodal lifespan database for studying the relationship between the brain, cognition, genetics and be... by Roger D. Newman-Norlund, Sarah E. Newman-Norlund, Sara Sayers, Samaneh Nemati, Nicholas Riccardi, Chris Rorden, Julius Fridriksson

“…Data from the ABC@UofSC Repository are easily accessible upon request (abc.sc.edu), and our publicly available statistics and visualization tools provide collaborating researchers with the ability to identify associations between brain structure and function in relation to genetic variation and behavioral measures across the adult life-span with unprecedented ease and rapidity.…”
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Air Pollution and Its Impact on Health and Performance in Football Players by George John, Ekaterina A. Semenova, Dana Amr Mohamed, Tiffany Georges Abi Antoun, Rinat A. Yusupov, Ildus I. Ahmetov

“…These pollutants bypass natural respiratory defenses due to increased pulmonary ventilation during exercise, reaching deeper lung regions and triggering oxidative stress, inflammation, and impaired lung function. Evidence across studies indicates that poor air quality is associated with decreased football performance, including reduced distance covered, fewer high-intensity efforts, elevated physiological strain, and diminished training adaptation. …”
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Exploration of health care utilization, social care utilization and costs for individuals discharged from inpatient geriatric care in Sweden - a registry data study by Carl Willers, Rikard Lindqvist, Stefan Fors, Amelie Lindh Mazya, Gunnar H Nilsson, Anne-Marie Boström, Elisabeth Rydwik

“…The variation of cost is also significant; higher age and lower function were associated with higher health care and social care costs. …”
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Association of physical–mental comorbidity with cognitive decline in middle-aged and older adults in China, India and Indonesia: a multiple country large scale data cross-sectional... by Siqi Zhao, Xing Ye, Yang Zhao, Kanya Anindya, Tiara Marthias, Mercian Daniel, Tianhao Zhao, Li Han

“…Methods: This study utilized three nationally representative survey data from China (China Health and Retirement Longitudinal Study), India (Longitudinal Aging Study in India), and Indonesia (Indonesian Family Life Survey), including a total sample of 73,119 respondentse. Cognitive function was assessed across three domains: time orientation, word recall, and numeracy. …”
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Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes by J. H. Musgrave, J.-C. Han, M.-L. Ward, N. Kang, A. J. Taberner, K. Tran

“…Methods Atrial trabeculae from non-diabetic and type 2 diabetic patients without heart failure were permeabilised and subjected to a series of experiments to measure their cross-bridge function and sensitivity to metabolites. Muscle active stress production and muscle active complex modulus measurements were gathered across different concentrations of ATP and inorganic phosphate (Pi) for the two groups of muscles. …”
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NEU1-Mediated Extracellular Vesicle Glycosylation in Alzheimer’s Disease: Mechanistic Insights into Intercellular Communication and Therapeutic Targeting by Mohd Adnan, Arif Jamal Siddiqui, Fevzi Bardakci, Malvi Surti, Riadh Badraoui, Mitesh Patel

“…Among the regulatory factors influencing EV composition and function, neuraminidase 1 (NEU1), a lysosomal sialidase responsible for desialylating glycoproteins has gained attention for its involvement in EV glycosylation. …”
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Two-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patien... by Rahul Soangra, Marybeth Grant-Beuttler, Harriet Chang, Raymond Y. Wang

“…This study longitudinally assessed the impact of ICV cerliponase alfa ERT on gait, and postural control across a two-year span in two siblings diagnosed with atypical CLN2 disease. …”
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SR-YOLO: Spatial-to-Depth Enhanced Multi-Scale Attention Network for Small Target Detection in UAV Aerial Imagery by Shasha Zhao, He Chen, Di Zhang, Yiyao Tao, Xiangnan Feng, Dengyin Zhang

“…The detection of aerial imagery captured by Unmanned Aerial Vehicles (UAVs) is widely employed across various domains, including engineering construction, traffic regulation, and precision agriculture. …”
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KANDiff: Kolmogorov–Arnold Network and Diffusion Model-Based Network for Hyperspectral and Multispectral Image Fusion by Wei Li, Lu Li, Man Peng, Ran Tao

“…It helps the model understand the complex relationships between the modalities by replacing the fixed activation function in the traditional MLP with a learnable activation function. …”
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Comprehensive Analysis of Oncogenic Somatic Alterations of Mismatch Repair Gene in Breast Cancer Patients by Yin Yan, Yang Wang, Junjie Tang, Xiaoran Liu, Jichuan Wang, Guohong Song, Huiping Li

“…Additionally, somatic MMR alterations were significantly associated with microsatellite instability-high (MSI-H) and MMR-related mutational signatures, indicating that somatic MMR alterations led to impaired function of the MMR system. Biallelic inactivation of MMR genes resulted in a more pronounced loss of MMR function compared to monoallelic inactivation. …”
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Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. by Deepika Dogra, Van Anh Phan, Sinan Zhang, Cezar Gavrilovici, Nadia DiMarzo, Ankita Narang, Kingsley Ibhazehiebo, Deborah M Kurrasch

“…These mutants also exhibited fewer neurons and a concomitant increase in apoptosis across the optic tectum, a region important for sensory processing. …”
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Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility by Amber J. Zimmerman, Antonio Serrano-Rodriguez, Melody Sun, Sandy J. Wilson, David N. Linsenbardt, Jonathan L. Brigman, Jason P. Weick

“…NSG2 is one of the three-member family of Neuron-specific genes (NSG1-3), which have been shown to regulate endolysosomal trafficking of a number of proteins critical for neuronal function, including AMPAR subunits (GluA1-2). Based on these findings and the largely universal expression throughout mammalian brain, we predicted that genetic knockout of NSG2 would result in significant impairments across multiple behavioral modalities including motor, affective, and learning/memory paradigms. …”
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