De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription by Timothy S. Little, Deirdre A. Cunningham, George K. Christophides, Adam James Reid, Jean Langhorne

“…Their function remains unknown, although studies have suggested a role in virulence of the asexual blood stages. …”
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FaN-REMs: Fair and Normalized Retrieval Evaluation Metrics for Learning Retrieval Systems by Amar Jaiswal, Mohit Kumar, Ajeet Ram Pathak, Kassaye Yitbarek Yigzaw

“…Despite inherent challenges in evaluating evaluation metrics, FaN-REMs demonstrated robust performance across plausible domain values for the FaN relevancy function. …”
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The Phytoplankton Community Exhibited Restored Species Diversity but Fragile Network Stability Under Potential Sustainable Aquaculture Approach of Marine Ranching by Dongqun Wei, Zeping Xie, Jialin Li, Diansheng Ji, Lin Qu, Baoquan Li, Xiao Wei, Song Qin

“…However, few studies have evaluated the ecological impacts through a comparison of in situ survey data across geographical areas. Phytoplankton are vital organisms in marine ecosystems that function as essential indicators of seawater quality and biological diversity, reflecting environmental health and ecological sustainability. …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Results We identified common molecular aging signatures across the nine mouse strains, which included genes associated with photoreceptor function and immune activation. …”
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Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress mice by Hongrui Li, Ping Liu, Tingfang Sun, Yifan Li, Jing Wu, Yu Huang, Jie Yang, Minghao Yuan, Jianping Zhang, Jian Yang, Ma-Li Wong, Julio Licinio, Peng Zheng

“…The microbial composition, function, and fecal metabolites exhibited distinct separations across the different social defeat stress groups. …”
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Protocol for a multisite randomised trial of Hand–Arm Bimanual Intensive Training Including Lower Extremity training for children with bilateral cerebral palsy: HABIT-ILE Australia... by Roslyn N Boyd, Leanne Sakzewski, Mark Chatfield, Yannick Bleyenheuft, Iona Novak, Catherine Elliott, Sarah Reedman, Cathy Morgan, Kerstin Pannek, Jurgen Fripp, Prue Golland, David Rowell, Robert Stuart Ware

“…A within-trial cost–utility analysis will be conducted to synthesise costs and benefits of HABIT-ILE compared with usual care.Methods and analysis 126 children with bilateral cerebral palsy aged 6–16 years will be recruited across three sites in Australia. Children will be stratified by site and Gross Motor Function Classification System and randomised using concealed allocation to either receiving HABIT-ILE immediately or being waitlisted for 26 weeks. …”
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Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes by Yun Shen, Yiming Si, Jingyi Lu, Xiaojing Ma, Lei Zhang, Yifei Mo, Wei Lu, Wei Zhu, Yuqian Bao, Gang Hu, Jian Zhou

“…Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (Ptrend=0.042), respectively. …”
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Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach by Reem Waziry, Olajide A Williams, Henning Tiemeier, Caleb Miles

“…Objective to determine the role of vascular-related biological Stress, DNA methylation-based biological aging and Allostatic Load in the relationship between vascular disorders and major cognitive domains including global cognition, episodic memory and executive function in a representative sample of adults across the age span. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…To our knowledge, we are the first to describe the behavioral contributions of Nprl2's function across multiple cell types. Our findings highlight both critical roles for Nprl2 in learning and behavior and also distinct contributions of select neuronal populations to these NDD-relevant behaviors.…”
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Association of triglyceride-glucose-related indices with adverse clinical outcomes in individuals with normal body mass index by Jiejie Xie, Xiong Pei, Shixuan Zhu, Wei Jiang, Hong Tang, Dongbo Wu, Yan Xie

“…Further analysis revealed linear correlations between TyG, TyG-WC, TyG-BMI, TyG-WHtR and liver function metrics (ALT, AST, GGT, FIB-4, APRI), kidney function metrics (creatinine, eGFR, uric acid), and blood lipids (triglycerides, cholesterol) (P < 0.01). …”
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Trends in diabetes monitoring and control among Aboriginal and Torres Strait Islander Peoples attending general practice in urban and rural locations in Australia: a repeated cross... by David Gonzalez-Chica, Nigel Stocks, Susan Williams, Carla Bernardo, Antoinette Liddell, Natalie Pink, Fernanda Baldim Jardim Nobre

“…We also examined trends over time (2013–2022) and compared urban and rural areas.Design A repeated cross-sectional study using data from a national general practice database (MedicineInsight, 2013–2022).Setting De-identified electronic health records (EHR) of people attending 427 mainstream general practices across Australia.Participants This study included all Aboriginal and/or Torres Strait Islander adults (18+ years) diagnosed with diabetes mellitus who were regular patients (attended at least once a year in three consecutive years) within the MedicineInsight database.Outcome measures Outcomes measured were (i) monitoring of blood glucose, lipids, blood pressure (BP), renal function and Body Mass Index (BMI)/waist circumference (WC) and (ii) achieving recommended targets: glycosylated haemoglobin (HbA1c) ≤7.0%, fasting glucose 4–7 mmol/L, random glucose 5–10 mmol/L, total cholesterol ≤4.0 mmol/L, low-density lipoprotein <2.0 mmol/L, BP ≤130/80 mmHg, estimated glomerular filtration rate >60 mL/min/1.73 m2, urine albumin-creatinine ratio (uACR) <2.5 mg/mmol (men); <3.5 (women), BMI <25 kg/m2, WC <80 cm (men); <94 (women). …”
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The impact of drought on forest spring phenology in northern China by Haowen Hu, Pengcheng Xue, Shaodong Huang, Zong Wang, Nina Xiong, Liang Shi, Boyi Liang, Jia Wang

“…Global warming is altering ecosystem function and productivity, with changes in vegetation phenology playing a crucial role. …”
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The impact of creatine supplementation on the development of kidney disease – literature review by Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa, Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech

“…Elevated serum creatinine levels caused by creatine can mislead eGFR-based renal function tests, warranting cautious interpretation. …”
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Post-TACE ALBI-Score Trajectory in Intermediate and Advanced Hepatocellular Carcinoma: Prognostic Implications and Influencing Factors Analysis by Li J, Feng T, Cui C, Wang H, Su T, Jin L, Zhao X, Xiao W

“…Clinical outcomes and patient characteristics were compared across trajectory groups. A CatBoost-based clinical prediction model was developed to identify factors influencing ALBI-score trajectories, with Shapley Additive Explanations (SHAP) values providing feature importance interpretation.Results: Among 501 patients, three ALBI-score trajectories were identified: improve, stable, and decline. …”
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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

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Evaluating expandable global positioning system collars for white‐tailed deer neonates by Tyler R. Obermoller, Samuel J. Overfors, Shauntel M. Stahlke, Raena A. Kemna, Eric S. Michel, Joseph K. Bump

“…Abstract Recent advances in biotelemetry allow monitoring of large mammals with varying neck sizes across multiple ecological phases (e.g., summer survival, dispersal, winter habitat use). …”
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Early warning and stratification of the elderly cardiopulmonary dysfunction-related diseases: multicentre prospective study protocol by Ping Wang, Min Zhou, Li Fan, Yi Xia, Ziwei Zhang, Zhiping Guo, Zaiyi Liu, Yang Hou, Xiuxiu Zhou, Qianxi Jin, Yu Guan, Chuanchang Li, Yongping Bai, Wei-Hua Liao, Hongyu Lin, Shiyuan Liu

“…To address this gap, this study protocol launched a project to build a clinical imaging technology integration and a multicentre database for early warning and stratification of cardiopulmonary dysfunction in the elderly.Methods and analysis This study employs a cross-sectional design, enrolling over 6000 elderly participants from five regions across China to evaluate cardiopulmonary function and related diseases. …”
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Genomic insights into growth traits in German Black Pied cattle: a dual-purpose breed at risk by P. Korkuć, M. Reißmann, G.A. Brockmann

“…Key positional candidate genes influencing muscle and fat tissue development included RERGL and LMO3 (identified for birth weight), MET and CAPZA2 (identified for BWG0d-18m) which are essential for skeletal muscle development and actin filament regulation, respectively, TLN2 (identified for BW7m), MYO1F and ADAMTS10 (identified for BWG3w-18m) which are critical for actin filament assembly, cytoskeletal function, and skeletal development, respectively. Candidate genes such as CPT2 (identified or BW3w) and VPS13C (identified or BW7m) are involved in lipid metabolism and mitochondrial function. …”
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Urinary GADD45G Protein Excretion Is Associated with IgA Nephropathy Progression by Min-Jeong Lee, Hyunee Yim, Ji Eun Park, Inwhee Park, Heungsoo Kim, Gyu-Tae Shin

“…Univariate Cox regression analysis showed that urinary GADD45G was significantly associated with deterioration of renal function. A Kaplan–Meier test showed a significant difference in event-free survival for deterioration of renal function between the highest urinary GADD45G tertile group and other tertile groups. …”
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Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies? by Manoj Kumar, Manoj Kumar, Linda Yip, Fangyuan Wang, Saci-Elodie Marty, C. Garrison Fathman

“…This approach selectively restores Treg function and immune tolerance without inducing systemic immunosuppression. …”
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