Optimized exposer region-based modified adaptive histogram equalization method for contrast enhancement in CXR imaging by Shivam Gangwar, Reeta Devi, Nor Ashidi Mat Isa

“…Each region undergoes adaptive contrast enhancement via a novel weighted probability density function (PDF) and power-law transformation to ensure balanced enhancement across different exposure levels. …”
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Does Platelet-rich Plasma Delay Ankle Osteoarthritis Surgery? A Systematic Review by Abhijit Bandyopadhyay

“…Background: Symptomatic ankle osteoarthritis (OA) is a debilitating condition characterized by pain and functional impairment. Platelet-rich plasma (PRP) therapy has emerged as a potential treatment to alleviate symptoms and delay surgical interventions in ankle OA, akin to its established role in knee OA. …”
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Enhancing cost efficiency and promoting sustainable development of rapeseed in China: the role of scale operations and management by Qing Zhang, Feng Ye, Ting Tong, Zhongchao Feng

“…This study takes a comprehensive approach by integrating the Cobb–Douglas production function model with an advanced cost function model to empirically assess the influence of farm operation scale on the cost efficiency of rapeseed cultivation. …”
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Evaluation of SLC6A8 species conservation and the effect of pathogenic variants on creatine transport by Taryn Diep, Gerald S. Lipshutz

“…Of the missense variant analysis, those occurring in C and N termini were tolerated more, while variants in transmembrane domains tended to more likely affect function. While the high degree of amino acid conservation across terrestrial mammals underscores its evolutionary importance, together with the variant analysis, these findings provide a framework for understanding genotype-phenotype correlations in variants of CRT1 and highlight the critical functional constraints.…”
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Natural genetic variation quantitatively regulates heart rate and dimension by Jakob Gierten, Bettina Welz, Tomas Fitzgerald, Thomas Thumberger, Rashi Agarwal, Oliver Hummel, Adrien Leger, Philipp Weber, Kiyoshi Naruse, David Hassel, Norbert Hübner, Ewan Birney, Joachim Wittbrodt

“…Abstract The polygenic contribution to heart development and function along the health-disease continuum remains unresolved. …”
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The Role of (Nuclear) Lipid Droplets in the Pathogenesis of Metabolic Syndrome by Natalia Todosenko, Kristina Yurova, Olga Khaziakhmatova, Maria Vulf, Vladimir Malashchenko, Aleksandra Komar, Ivan Kozlov, Igor Khlusov, Larisa Litvinova

“…The discovery of lipid droplets within the nucleus and the investigation of their functions across various cell types in both health and disease provide a foundation for discussing their role in the development and progression of metabolic syndrome. …”
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AdaSpline-Net for Improved Short-Term Solar Irradiance Forecasting by Ngiap Tiam Koh, Anurag Sharma, Jianfang Xiao, Cheng Siong Chin, Chin Jun Xing, Wai Lok Woo

“…Unlike traditional activation functions, which suffer from issues like the “dying ReLU” problem, the adaptive B-spline function provides smooth, flexible mappings with continuous gradients, allowing it to capture intricate data patterns effectively. …”
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Elucidating the role of KLRD1 in coronary atherosclerosis: harnessing bioinformatics and machine learning to advance understanding by Huan Liang, Xiao Liang, Man Zheng, Shoudong Wang

“…KLRD1 is a gene that encodes a protein involved in the immune system, specifically in the function of natural killer (NK) cells. Methods KLRD1 was identified as a focal point through an integrative analysis of DEGs across multiple datasets (GSE43292 and GSE9820) from the GEO database, aligned with immune-related gene sets from the ImmPort database. …”
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Adaptive gradient scaling: integrating Adam and landscape modification for protein structure prediction by Vitalii Kapitan, Michael Choi

“…Performance was evaluated using Loss function values, predicted Local Distance Difference Test (pLDDT), distance-based Root Mean Square Deviation (dRMSD), and Template Modeling (TM) scores. …”
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Research on Detection and Counting Method of Green Walnut Based on YOLOv8n-RBP by Bangbang Chen, Keke Tan, Kun Li, Baojian Ma, Xiangdong Liu

“…Lastly, to address the weak generalization and slow convergence issues of the CIoU loss function in detection tasks, the PIoUv2 loss function is employed to accelerate bounding box regression and improve detection performance. …”
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Otolith Degeneration with Aging: Insights from Video Ocular Counter-Roll (vOCR) Assessment by Melissa Castillo-Bustamante, Jorge Madrigal, Elizabeth Andalón-Dueñas, Johanna Marcela Vanegas, Ireri Espinoza

“…These results support the clinical value of vOCR as a non-invasive method to assess vestibular function and its changes across the lifespan.…”
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Are physical factors associated with poor prognosis following a whiplash trauma?: a protocol for a systematic review and data synthesis by Deborah Falla, Alessio Gallina, Ahmed Alalawi

“…Studies will be required to assess the prognostic ability of one or more physical factors that directly involve a body function and/or structure and can be measured objectively. …”
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Greenhouse gas emissions of global construction material production by Seth Kane, Josefine A Olsson, Sabbie A Miller

“…Understanding the GHG emissions from building materials production in the context of their function is critical to decarbonizing this important sector. …”
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Impact of GLP-1 receptor agonist-based therapies on cardiovascular and renal outcomes in diabetic and non-diabetic patients with CKD by Aliona Siniukovich, Christoforos K. Travlos, Sarah Freedman, Thomas A. Mavrakanas, Karim Gariani

“…Abstract Background The effect of glucagon-like peptide-1 (GLP-1) receptor agonists-based therapies on cardiovascular and renal outcomes has not been systematically reviewed across baseline kidney function groups. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) with GLP-1 Receptor Agonists (RAs) in patients with and without chronic kidney disease (CKD). …”
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From bench to bedside: translating mesenchymal stem cell therapies through preclinical and clinical evidence by Jai Chand Patel, Meenakshi Shukla, Manish Shukla

“…Unlike traditional cell therapies that rely on engraftment, MSCs primarily function through paracrine signaling—secreting bioactive molecules like vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and exosomes. …”
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Dephasing-assisted transport in a tight-binding chain with a linear potential by Samuel L. Jacob, Laetitia P. Bettmann, Artur M. Lacerda, Krissia Zawadzki, Stephen R. Clark, John Goold, John Goold, Juan José Mendoza-Arenas, Juan José Mendoza-Arenas, Juan José Mendoza-Arenas

“…We also find that the current displays a maximum as a function of the system size, provided that the total potential tilt across the chain remains constant. …”
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The intelligent development and preservation of folk sports culture under artificial intelligence by Zhihui Li, Shamsulariffin Bin Samsudin, Noor Hamzani Farizan, Zulkhairi Azizi Zainal Abidin, Lei Zhang

“…This demonstrates the effectiveness of this loss function in improving image quality. Moreover, the proposed model excels across multiple evaluation metrics when compared to other models. …”
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Insiders, Outsiders, and the Constructed Limits to Social Rights in EU Law by Alezini Loxa

“…By reviewing the justifications put forward behind all the accepted limitations to social rights, the paper argues that the function served by limitations to social rights is uniform across all categories of migrants: that is avoiding the presumed negative effects of migration to national redistributive mechanisms. …”
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On Introduction to q1,q2-Linear Diophantine Fuzzy Sets and Their Applications by Muhammad Bilal Khan, Adrian Marius Deaconu, Javad Tayyebi, Bandar Bin-Mohsin, Loredana Ciurdariu, Miguel Vivas Cortez, Nurnadiah Zamri

“…There is symmetry in the values of both the membership grades function and the nonmembership grades function. Furthermore, when discussing the symmetry between two or more objects, the evolution of a (q1,q2LDFSs via q1 and q2 is more adaptable than the diffused concept of a q-rung orthopair fuzzy sets or a LDFSs. …”
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Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity by Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana, Nanna MacAulay

“…ICP and CSF secretion rate and absorption capacity remain stable with age, and the choroid plexus retains its morphology, structural integrity, gene expression, and high metabolic rate across the tested ages. This work supports the significance of choroid plexus function for brain aging and promotes this tissue as a future target for neurodegenerative diseases associated with impaired waste clearance and cognitive decline.…”
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