Forward genetic approach identifies a phylogenetically conserved serine residue critical for the catalytic activity of UBIQUITIN-SPECIFIC PROTEASE 12 in Arabidopsis by Anita Hajdu, Dóra Vivien Nyári, Éva Ádám, Yeon Jeong Kim, David E. Somers, Dániel Silhavy, Ferenc Nagy, László Kozma-Bognár

“…Despite ubp12-3 exhibited a short period phenotype similar to that of a loss-of-function allele, molecular analysis indicated elevated protease activity in ubp12-3. …”
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Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis by Pengcheng Li, Feimu Fan, Bixiang Zhang, Chaoyi Yuan, Huifang Liang

“…Collectively, neutrophils function as central regulators across all stages of tumor evolution, influencing cancer growth, immune evasion, and metastatic progression. …”
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Exercise for Individuals with Lewy Body Dementia: A Systematic Review. by Michael Inskip, Yorgi Mavros, Perminder S Sachdev, Maria A Fiatarone Singh

“…Exercise may improve functional outcomes in Parkinson's disease (PD), and Alzheimer's disease (AD). …”
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RNA guanine content and G-quadruplex structure tune the phase behavior and material properties of biomolecular condensates by Alfredo Vidal Ceballos, Anna Geissmann, Denize C. Favaro, Priyasha Deshpande, Shana Elbaum-Garfinkle

“…Abstract RNA binding proteins (RBPs) are enriched in phase separated biomolecular assemblies across cell types. These RBPs often harbor arginine–glycine rich RGG motifs, which can drive phase separation, and can preferentially interact with RNA G-quadruplex (G4) structures, particularly in the neuron. …”
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A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme. by Tamuno Alfred, Yoav Ben-Shlomo, Rachel Cooper, Rebecca Hardy, Cyrus Cooper, Ian J Deary, Tom R Gaunt, David Gunnell, Sarah E Harris, Meena Kumari, Richard M Martin, Avan Aihie Sayer, John M Starr, Diana Kuh, Ian N M Day, HALCyon study team

“…<h4>Background</h4>Low muscle mass and function have been associated with poorer indicators of physical capability in older people, which are in-turn associated with increased mortality rates. …”
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Causal relationship and shared genetic pathways between diabetic kidney disease and cognitive impairment: a Mendelian randomization study by Ke Yu, Yanqing Chi, Qian Wang, Yongzhe Chen, Ning Han, Ying Li

“…Shared loci and pathways were identified through colocalization and functional enrichment analyses.Results DKD significantly increased cognitive decline risk (inverse-variance weighted (IVW) OR range: 0.55–0.88; all p < .05), with consistent results across sensitivity analyses. …”
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The early transition to cold-induced browning in mouse subcutaneous white adipose tissue (scWAT) involves proteins related to nerve remodeling, cytoskeleton, mitochondria, and immu... by Magdalena Blaszkiewicz, Cory P. Johnson, Jake W. Willows, Miranda L. Gardner, Dylan R. Taplin, Michael A. Freitas, Kristy L. Townsend

“…For example, in response to stimuli such as cold exposure, WAT can develop inducible brown adipocytes (‘browning’) capable of non-shivering thermogenesis, through concurrent changes to mitochondrial content and function. This is aided by increased neurite outgrowth and angiogenesis across the tissue, providing the needed neurovascular supply for uncoupling protein 1 activation. …”
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Co-operative additive effects between HLA alleles in control of HIV-1. by Philippa C Matthews, Jennifer Listgarten, Jonathan M Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, Dewald Steyn, Cloete van Vuuren, Paolo Paioni, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Zenele Mncube, Thumbi Ndung'u, Bruce D Walker, David Heckerman, Philip J R Goulder

“…Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57, appear to function co-operatively to result in greater immune control of HIV than mediated by either single allele alone. …”
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Anti-Inflammation of Natural Components from Medicinal Plants at Low Concentrations in Brain via Inhibiting Neutrophil Infiltration after Stroke by Jiannan Chen, Xiangjian Zhang, Cong Zhang, Wenhui Wang, Rong Chen, Honglei Jiao, Linlin Li, Lan Zhang, Lili Cui

“…However, it is speculated that this classical activity cannot account for the anti-inflammatory function of these natural components in the cerebral parenchyma, where they are detected at very low concentrations due to their poor membrane permeability and slight leakage of BBB. …”
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Bacterial effector screening reveals RNF214 as a virus restriction factor in mammals. by Aaron Embry, David F Schad, Emily A Rex, Neal M Alto, Don B Gammon

“…Phylogenetic analyses reveal that RNF214 is highly conserved across vertebrate species, suggesting a conserved role in host defense. …”
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The Properties of the Monolayers of Sorbitan Lipids as Informative Factors on the Hydrophilic–Lipophilic Balance Value of Their Mixtures, Proposed for Dermatological Applications by Remigiusz Zapolski, Monika Gasztych, Beata Jastrząb-Miśkiewicz, Alina Jankowska-Konsur, Witold Musiał

“…A value of determination coefficient of 0.95 was found for the linear equation representing the slope ratios as a function of HLB, whereas the intercept ratios, as a linear function of HLB, gave a lower value of 0.71. …”
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Evaluation of Autoconversion Representation in E3SMv2 Using an Ensemble of Large‐Eddy Simulations of Low‐Level Warm Clouds by Mikhail Ovchinnikov, Po‐Lun Ma, Colleen M. Kaul, Kyle G. Pressel, Meng Huang, Jacob Shpund, Shuaiqi Tang

“…Abstract In numerical atmospheric models that treat cloud and rain droplet populations as separate condensate categories, precipitation initiation in warm clouds is often represented by an autoconversion rate (Au), which is the rate of formation of new rain droplets through the collisions of cloud droplets. Being a function of the cloud droplet size distribution (DSD), the local Au is commonly parameterized as a function of DSD moments: cloud droplet number nc and mass qc concentrations. …”
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Uniform Quantization for Multi-Antenna Amplify&#x2013;Quantize&#x2013;Forward Relay by Gangsan Jeong, Xianglan Jin

“…Furthermore, we propose a USL method with Monte Carlo (USL-MC), leveraging an approximated loss function to address the heightened complexity observed in multi-antenna systems. …”
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Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis by Yinyi Xiong, Li Li, Xiaorong Zhang

“…In contrast, it is capable of mediating multifaced neurological functions which are more complex than those of Drosophila Dscam. …”
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Application of 3D ELD_MobileNetV2 Incorporating Attention Mechanism and Dilated Convolution in Hepatic Nodules Classification by SUN Haoyun, WANG Lijia

“…Meanwhile, the original activation function was replaced with Leaky ReLU6 activation function to improve the model's robustness. …”
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Pedestrian Trajectory Prediction Based on Dual Social Graph Attention Network by Xinhai Li, Yong Liang, Zhenhao Yang, Jie Li

“…To effectively account for the critical group dynamics, a dedicated group attention function is designed to identify and quantify the collective behaviors within pedestrian crowds. …”
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Genome-Wide Characterization and Expression Profiles of the Superoxide Dismutase Gene Family in Gossypium by Jingbo Zhang, Bo Li, Yang Yang, Wenran Hu, Fangyuan Chen, Lixia Xie, Ling Fan

“…Microarray-based expression analysis revealed that SOD genes have important function in abiotic stress. Moreover, the tissue-specific expression profile reveals the functional divergence of SOD genes in different organs development of cotton. …”
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Compost amendments up to one inch restore dry rangeland soil health by Eva Stricker, Emily Cornell, Zach Withers

“…Societal Impact Statement Rangelands harbor immense diversity and provide ecosystem services across vast swaths of land while supporting rural economies and the food system, but degraded rangelands may require active management to restore diversity and function. …”
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Mathematical Optimization of Wind Turbine Maintenance Using Repair Rate Thresholds by Nataša Kontrec, Stefan Panić, Jelena Vujaković, Dejan Stošović, Sergei Khotnenok

“…Four key lemmas are developed to establish formal proofs for the probability density function (PDF) and cumulative distribution function (CDF) of repair rates, both above and below critical repair rate thresholds. …”
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Optimization of household medical waste recycling logistics routes: Considering contamination risks. by Jihui Hu, Ying Zhang, Yanqiu Liu, Jiaqi Hou, Aobei Zhang

“…To enhance the realism of the simulation, traffic congestion is integrated into the vehicle speed function, reflecting the urban roads' variability. …”
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