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4521
Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases
Published 2025-05-01“…Recent advancements in sequencing technology have allowed scientists to study the function and expression of different non-coding RNAs (ncRNAs). …”
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4522
The dual nature of neuroinflammation in networked brain
Published 2025-08-01“…We describe how various stimuli—including aging, protein aggregates, and cellular stress—modulate glial function and shift immune activity toward protective or deleterious outcomes. …”
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4523
A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression.
Published 2021-03-01“…This mutation reduced cohesin levels at promoters and enhancers, decreased DNA loops and interactions across short genomic distances, and weakened insulation at CTCF-mediated DNA loops. …”
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4524
Multimodality in the Collicular Pathway: Towards Compensatory Visual Processes
Published 2025-04-01“…The present review outlines the structure and function of the multisensory visual pathways, emphasizing the retinocollicular projections, and their multisensory integration, which depends on synaptic convergence of afferents conveying information from different sensory modalities. …”
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4525
The heat of longevity: sex differences in lifespan and body temperature
Published 2024-11-01“…Dietary restriction (DR) has long been recognized as a powerful intervention for extending lifespan and improving metabolic health across species. In laboratory animals, DR—typically a 30%–40% reduction in caloric intake—delays aging and enhances mitochondrial function, oxidative defense, and anti-inflammatory pathways. …”
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4526
Chasing Down Foreigners at the French-Italian Border (Hautes-Alpes) as a Matter of Social and Racial Policing
Published 2020-10-01“…Mobile police practices include tracking down racialised people across the mountains. These practices expose illegal migrants to dangers inherent in the high-mountain environment and are part of a continuum of police and administrative violence committed against them. …”
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4527
Variable step-size LMS algorithm with hybrid weight coefficients based on the Rayleigh distribution curve
Published 2025-03-01“…Moreover, it exhibits superior convergence speed, tracking performance, and steady-state errors across various signal-to-noise ratios. The proposed algorithm is suitable for electromagnetic interference cancellation in complex environments.…”
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4528
Overflow metabolism originates from growth optimization and cell heterogeneity
Published 2025-06-01“…This counterintuitive phenomenon, known as overflow metabolism or the Warburg effect, is universal across various organisms. Despite extensive research, its origin and function remain unclear. …”
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4529
Enhancing drought tolerance in horticultural plants through plant hormones: a strategic coping mechanism
Published 2025-01-01“…To sum up, this review will predominantly elucidate the role of phytohormones and related mechanisms in drought tolerance across various horticulture crop species.…”
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4530
BoneDat, a database of standardized bone morphology for in silico analyses
Published 2025-06-01“…Abstract In silico analysis is key to understanding bone structure-function relationships in orthopedics and evolutionary biology, but its potential is limited by a lack of standardized, high-quality human bone morphology datasets. …”
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4531
Optimal tuning of bacterial sensing potential
Published 2009-07-01“…Abstract Through production and sensing of small signal molecules, quorum sensing (QS) enables bacteria to detect changes in their density and regulate their functions accordingly. QS systems are tremendously diverse in terms of their specific sensory components, the biochemical and transport properties of signaling molecules, their target functions and the context in which QS‐mediated functions are activated. …”
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4532
A Role for Emotional Granularity in Judging
Published 2018-12-01“…Studies show that individuals who are more emotionally granular have better function across a range of domains, including self regulation and decision making. …”
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4533
Cortical representational geometry of diverse tasks reveals subject-specific and subject-invariant cognitive structures
Published 2025-05-01“…This study quantitatively evaluates these differences by integrating ISC, representational similarity analysis, and vertex-wise encoding models using functional magnetic resonance imaging across 25 cognitive tasks. …”
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4534
Intelligent chlorination in water distribution networks: Integrating genetic algorithm and EPANET fusion
Published 2025-07-01“…To optimize the quality performance index (QPI), the GA is employed with an objective function, i.e., determining the most effective placement of chlorine injection pumps. …”
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4535
Methodological solutions of oral history and their application in research into Czech evangelical communities in Eastern and South-eastern Europe
Published 2022-12-01“…These communities continue to function up to today and the Czech language is still a commonly used form of communication. …”
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4536
Beyond the Hit: The Hidden Costs of Repetitive Head Trauma
Published 2025-02-01“…This review synthesizes research that examines the effects of sports-related head trauma, particularly in football, on cognitive functioning. Post-mortem analyses of players across all positions have revealed neuropathological evidence of CTE, including a distinct reduction in hippocampal volume. …”
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4537
A Performance Analysis of VPN Technologies Used in an IoT Environment
Published 2025-06-01“…Internet of Things (IoT) devices face exponential growth daily across diverse sectors. The need for robust security measures to safeguard sensitive data and ensure privacy is imminent. …”
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4538
Strategies for Enhancing Spin-Shuttling Fidelities in Si/SiGe Quantum Wells with Random-Alloy Disorder
Published 2024-11-01“…At such locations, intervalley tunneling leads to dephasing of the spin wave function, substantially reducing the shuttling fidelity. …”
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4539
Neural networks for parameter estimation in geostatistical models with geometric anisotropies
Published 2025-01-01“…This article presents two neural network approaches for estimating the covariance function of a spatial Gaussian random field defined in a portion of the euclidean plane. …”
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4540
Gears in chemical reaction networks for optimizing energy transduction efficiency
Published 2025-07-01“…We demonstrate this principle in a biological context with a CRN where enzymes function as gear shifters, autonomously adapting the system to achieve near-optimal efficiency across changing environments. …”
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