Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies by Jianlin Shen, Yue Lai, Yanjiao Wu, Xuan Lin, Cheng Zhang, Huan Liu

“…This review highlights recent progress in elucidating how ubiquitination modulates tumor behavior across signaling pathways. We then focus on the mechanisms by which ubiquitination influences osteosarcoma cell function. …”
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Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. by Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann

“…Employing the novel HCV infection system and using a genetic approach to investigate the function of p7 in the viral replication cycle, we find that this protein is essential for efficient assembly and release of infectious virions across divergent virus strains. …”
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Quantitative subsurface characterization illuminates the origin of the Quaternary Mississippi River Valley alluvial aquifer by Yuqi Song, Frank T.-C. Tsai, Burke J. Minsley, Chenliang Wu, Essam Heggy

“…However, quantitative understanding of its Quaternary origin, architecture, and hydrologic function remains incomplete. Here we develop a three-dimensional hydrostratigraphic model to characterize the deposition of clay and silt, fine-medium sands, and graveliferous sands using lithologic data from 75,000 boreholes compiled across the Lower Mississippi Valley and a geostatistical method—interval kriging. …”
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Prediction of dust storm using artificial neural networks in Kermanshah by Toba Alizadeheh, Majid rezaie banafsh, Gholamreza Goodarzi, Hashem Rostamzadeh

“…Dust is a phenomenon with significant environmental impacts across various aspects of human life, including agriculture, economy, health, and more. …”
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Accurate Wideband RCS Estimation from Limited Field Data Using Infinitesimal Dipole Modeling with Compressive Sensing by Jeong-Wan Lee, Ye Chan Jung, Sung-Jun Yang

“…The proposed method eliminates the need for field sampling at numerous frequency points across the wideband range through Green’s function adjustment. …”
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A Big Data Approach for the Regional-Scale Spatial Pattern Analysis of Amazonian Palm Locations by Matthew J. Drouillard, Anthony R. Cummings

“…<i>Arecaceae</i> (palms) are an important resource for indigenous communities as well as fauna populations across Amazonia. Understanding the spatial patterns and the environmental factors that determine the habitats of palms is of considerable interest to rainforest ecologists. …”
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Defining the methanogenic SECIS element in vivo by targeted mutagenesis by Nils Peiter, Anna Einert, Pauline Just, Frida Jannasch, Marija Najdovska, Michael Rother

“…A recently developed in vivo reporter system was used to study the structure–function relationships of SECIS elements in Methanococcus maripaludis. …”
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Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…Findings Ten SRMAs detailing 22 associations were analyzed, focusing on two NIBS techniques across 12 unique outcomes. Significant improvements were observed in global cognition, language, executive function, and memory. …”
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Analysis of Whole-Genome for <i>Alternaria</i> Species Identification by Ying Yang, Yutong Gan, Wenjie Xu, Yuanhao Huang, Tianyi Xin, Rui Tan, Jingyuan Song

“…The genus <i>Alternaria</i>, functioning as a saprobe, endophyte, and plant pathogen, is widely distributed across various natural and human-impacted environments. …”
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Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortex by Xiaoming Liu, Xiaoming Liu, Yifeng Zhou, Yifeng Zhou, Jiachen Liu, Guangwei Xu, Guangwei Xu

“…Mechanistically, metformin upregulated the protein expression levels of glutamic acid decarboxylase 67 and gephyrin, key components of inhibitory synapses, suggesting that metformin enhances visual processing by strengthening inhibitory signaling and reducing the correlated variability in the V1.DiscussionMetformin treatment effectively ameliorated these deficits through enhanced GABAergic signaling; however, the broader therapeutic mechanisms across sensory systems remain unclear. In this study, we demonstrate that metformin preserves visual function by restoring excitatory-inhibitory balance, suggesting a promising approach for age-related sensory decline.…”
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Performance of routine surveillance diagnostics of external ventricular drain-associated infections in a critical care setting: a retrospective cohort study by Marcus Ståhlberg, Jonas Blixt, Christer Mehle, Viveca Hambäck Hellkvist, Christian G. Giske, Eddie Weitzberg, David W. Nelson

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Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism by Zhiyong Shi, Mingkai Yun, Binbin Nie, Enjun Zhu, Wei Fu, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li

“…Patients with MAEs exhibited decreased cognitive function across various domains, including orientation, registration, and language and praxis (all p < 0.05). …”
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Pupillary manifolds: uncovering the latent geometrical structures behind phasic changes in pupil size by Elvio Blini, Roberto Arrighi, Giovanni Anobile

“…In other words, pupillometry provides an integrated readout of several distinct networks, but it is unclear whether each has a specific fingerprint, stemming from its function or physiological substrate. Here we show that phasic changes in pupil size are inherently low-dimensional, with modes that are highly consistent across behavioral tasks of very different nature, suggesting that these changes occur along pupillary manifolds that are highly constrained by the underlying physiological structures rather than functions. …”
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Comparative Analysis of a Quantum SVM With an Optimized Kernel Versus Classical SVMs by Matheus Cammarosano Hidalgo

“…While focused on the financial sector, the methodology is broadly applicable for reducing churn and boosting revenue across industries. QSVM performance is compared to SVMs with established kernels, including Radial Basis Function (RBF), linear, polynomial, and sigmoid. …”
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Automated marker detection and time series analysis for through-water photogrammetry by M. Russo, L. Martelli, R. Ravanelli, A. Pini

“…In addition to light attenuation as a function of distance travelled by light radiation through the liquid and variation of water optical characteristics across short lenghts, undulation of the free surface and magnitude of refraction (which varies at every point of each acquired image) also come into account. …”
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ECONOMETRIC ANALYSIS OF AGRICULTURAL LAND VALUES IN IMO STATE, NIGERIA (A HEDONIC PRICING APPROACH) by Nnamdi Chukwuemeka EHIRIM, Emeka OSUJI, Uchechi ANYANWU, Melissa OKWARA

“…Double-Log function was selected as the lead equation and was used to interpret the factors influencing land values across the three agricultural zones in the State. …”
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Effects of Balanced Motions and Unbalanced Internal Waves on Steric Height in the Mid‐Latitude Ocean by Xiujie Zhang, Xiaolong Yu, Aurélien L. Ponte, Wenping Gong

“…Using yearlong measurements from a mooring array, we assess the distribution of upper‐ocean steric height across frequencies and spatial scales of O (1–20 km) in the northeast Atlantic. …”
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BERTugues: A Novel BERT Transformer Model Pre-trained for Brazilian Portuguese by Ricardo Mazza Zago, Luciane Agnoletti dos Santos Pedotti

“…Consequently, while these models can function in Portuguese, their performance is suboptimal. …”
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Egocentric and allocentric representations in auditory cortex. by Stephen M Town, W Owen Brimijoin, Jennifer K Bizley

“…A key function of the brain is to provide a stable representation of an object's location in the world. …”
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Decomposed Linear Dynamical Systems (dLDS) models reveal instantaneous, context-dependent dynamic connectivity in C. elegans by Eva Yezerets, Noga Mudrik, Adam S. Charles

“…Abstract Mounting evidence indicates that neural “tuning” can be highly variable within an individual across time and across individuals. Furthermore, modulatory effects can change the relationship between neurons as a function of behavioral or other conditions, meaning that the changes in activity (the derivative) may be as important as the activity itself. …”
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