Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age by Sahil A. Mapkar, Sarah A. Bliss, Edgar E. Perez Carbajal, Sean H. Murray, Zhiru Li, Anna K. Wilson, Vikrant Piprode, You Jin Lee, Thorsten Kirsch, Katerina S. Petroff, Fengyuan Liu, Michael N. Wosczyna

“…However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significance. We developed a machine learning-based approach that uses nuclear morphometrics to identify senescent cells at single-cell resolution. …”
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Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier by Tiantian Wang, Qi Wu, Lihong Wang, Tao Lan, Zhenyu Yun, Lin Zhao, Xi Wu

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Adaptability in the Building Process: A Multifaceted Perspective Across the Life Cycle of a Building by Efthymia Ratsou Staehr, Tor Kristian Stevik, Leif Daniel Houck

“…The findings emphasise the necessity of incorporating adaptability considerations early in the process, ensuring that buildings can respond to evolving spatial, functional, and environmental demands over time. While existing research acknowledges the importance of adaptability, gaps remain in its practical application across the full building life cycle. …”
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Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families by Ran Liu, Xinyan Jiang, Ruijuan Dong, Yuting Zhang, Cong Gai, Peng Wei

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PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms by Anna Hadarovich, Hari Raj Singh, Soumyadeep Ghosh, Maxim Scheremetjew, Nadia Rostam, Anthony A. Hyman, Agnes Toth-Petroczy

“…While increasing disorder content is associated with organismal complexity, our analysis of 26 species reveals no correlation between predicted condensate proteome content and disorder content across organisms. Overall, we present a machine learning classifier to interrogate condensate components at whole-proteome levels across the tree of life.…”
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Universal fibroblasts across tissues can differentiate into niche cells for hematopoietic stem cells by Kei Higaki, Shota Aiba, Takashi Shimoyama, Yoshiki Omatsu, Takashi Nagasawa

“…A meta-analysis of single-cell RNA sequencing datasets across tissues hypothesized that universal fibroblasts present in all organs give rise to distinct tissue-specific fibroblast subsets designated as specialized fibroblasts, including CAR/LepR+ cells. …”
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Plant tolerance to drought stress: Complexity and mechanism across physiological, molecular and biochemical scales by Asfa Batool, Dong-Xia Yue, Yun-Li Xiao, Shi-Sheng Li, Hai-Xia Duan, Zeeshan Haq, Khalil Ahmed, Ling Zhao, Li Zhu, Y.C. Xiong

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The proteomic landscape of Toxoplasma gondii extracellular vesicles across diverse host cell types by Teresa Cruz-Bustos, Anna Sophia Feix, Karin Hummel, Sarah Schlosser, Ebrahim Razzazi-Fazeli, Anja Joachim

“…Functional enrichment analyses revealed roles for TgEVs in targeting host protein synthesis and stress response pathways, with implications for immune evasion and infection spread.DiscussionThese findings provide insight into the potential role of EVs in host-pathogen interactions and help us understand the adaptive strategies used by T. gondii to survive and spread.…”
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Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum by Srinivas Koutarapu, Junyue Ge, Maciej Dulewicz, Meera Srikrishna, Alicja Szadziewska, Jack Wood, Kaj Blennow, Henrik Zetterberg, Wojciech Michno, Natalie S. Ryan, Tammaryn Lashley, Jeffrey N. Savas, Michael Schöll, Jörg Hanrieder

“…The correlative chemical imaging paradigm presented here allowed to link structural and biochemical characteristics of Aβ plaque polymorphism across various AD etiologies.…”
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Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction by Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Aditya Jhaveri, Ying Cao, Johannes Falter, Janek Frantzén, Fredrika Koskimäki, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Sulo Kolehmainen, Kenneth Nazir, Miro Jänkälä, Jukka Puolitaival, Melissa Rahi, Jaakko Rinne, Anni I. Nieminen, Eero Castrén, Janne Koskimäki

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Sequential Deactivation Across the Hippocampus‐Thalamus‐mPFC Pathway During Loss of Consciousness by Xiaoai Chen, Samuel R. Cramer, Dennis C.Y. Chan, Xu Han, Nanyin Zhang

“…Additionally, fMRI signals exhibit a cascade of deactivation across a pathway including the hippocampus, thalamus, and medial prefrontal cortex (mPFC) surrounding the moment of LOC, followed by a broader increase in brain activity across the cortex during sustained unconsciousness. …”
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Forecasting habitat suitability across large carnivore ranges with climate and land use change by Evie M. Jones, Nyeema C. Harris

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ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. by Thea P Paasch, Morten T Jarlstad Olesen, Juan L García-Rodríguez, Adrienne M Assmus, Robert A Fenton, Jørgen Kjems, Henrik Hager, Lasse S Kristensen

“…In conclusion, our data show that ciRS-7 is mainly expressed in the TME and is regulated through DNA methylation and histone acetylation across all major types of adenocarcinomas.…”
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The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy by Qin Wang, Xin Chen, Xiao‐Ou Zhang

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Busy Bees: Variation in Insect Flower-Visiting Rates across Multiple Plant Species by Margaret J. Couvillon, Chandra M. Walter, Eluned M. Blows, Tomer J. Czaczkes, Karin L. Alton, Francis L. W. Ratnieks

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Multifeature Fusion for Enhanced Content-Based Image Retrieval Across Diverse Data Types by Punit Soni, Mandeep Singh, Purushottam Sharma, Tajinder Kumar, Xiaochun Cheng, Rajender Kumar, Mrinal Paliwal

“…Key characteristic descriptors, along with SIFT, SURF, HOG, texture, and multicharacteristic combinations, were extracted for retrieval functions. The results display that the usage of the Hausdrauff distance as a similarity degree outperforms Euclidean distance, accomplishing retrieval accuracies of 80.02% for HOG, 77.9% for SIFT, 79. 8% for SURF, 77.2% for texture, and 84.2% for multicharacteristic combinations, surpassing Euclidean distance results via 1.7%–3.6% across capabilities. …”
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Differential neural representations of syntactic and semantic information across languages in Chinese-English bilinguals by Zeqi Hou, Hehui Li, Lin Gao, Jian Ou, Min Xu

“…While prior research has established foundational insights into the neural mechanisms in bilingual processing, the extent to which the first (L1) and second language (L2) systems overlap or diverge across different linguistic components remains unclear. …”
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Kolmogorov–Arnold Networks for Interpretable Crop Yield Prediction Across the U.S. Corn Belt by Mustafa Serkan Isik, Ozan Ozturk, Mehmet Furkan Celik

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Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques by Ludwig A. P. Metzler, Robinson W. Goy, Jeanette M. Metzger, Marina E. Emborg, Marina E. Emborg, Amita Kapoor

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Evolution history dominantly regulates fine root lifespan in tree species across the world by Xingzhao Huang, Zhouying Lu, Fangbing Li, Yang Deng, Fangfang Wan, Quancheng Wang, Fousseni Folega, Jinsong Wang, Zijian Guo

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