Oral function and cumulative long-term care costs among older Japanese adults: a prospective 6-year follow-up study of long care receipt data by Masashige Saito, Toshiyuki Ojima, Eisaku Okada, Yasuhiro Miyaguni, Kaori Kojima

“…Objectives This study evaluated the relationship between status of oral function and related long-term care service costs.Design This was a prospective 6-year follow-up study of previous survey data.Setting The data were obtained from the Japan Gerontological Evaluation Study conducted between 2010 and 2011.Participants The participants were functionally independent older adults in 12 municipalities across Japan.Interventions Care service benefit costs were tracked over 6 years using publicly available claims records (n=46 616) to monitor respondents’ cumulative care costs.Primary and secondary outcome measures The primary outcome variable was the cumulative cost of long-term care insurance services during the follow-up period. …”
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Therapeutic efficacy of repetitive transcranial magnetic stimulation on gait and limb balance function in patients with lower limb dysfunction post-cerebral infarction: a systemati... by De-mei Jia, Xuan Li, Bin-cang Zhang, Bing-ran Zhang, Qiu-juan Zhang, Ming-wei Liu, Lin-ming Zhang

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Identification of the SWEET gene family and functional characterization of PsSWEET1a and PsSWEET17b in the regulation of sugar accumulation in ‘Fengtang’ plum (Prunus salicina Lind... by Shan Liu, Xiaoshuang Nie, Hong Chen, Xinjie Shen

“…The PsSWEET genes were unevenly distributed across five chromosomes, and synteny analysis revealed three pairs of fragmented duplication events. …”
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Bicomponent Cutaneous Cell Therapy for Early Burn Care: Manufacturing Homogeneity and Epidermis-Structuring Functions of Clinical Grade FE002-SK2 Allogeneic Dermal Progenitor Fibro... by Xi Chen, Nathalie Hirt-Burri, Corinne Scaletta, Alexis E. Laurent, Lee Ann Applegate

“…<b>Objectives:</b> This study aimed to characterize and functionally compare homogenous progenitor fetal fibroblast (PFF) populations derived from 14-week-old fetal skin with fibroblasts isolated from adult burn patients. …”
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Who Lives Where and Does It Matter? Changes in the Health Profiles of Older People Living in Long Term Care and the Community over Two Decades in a High Income Country. by Fiona E Matthews, Holly Bennett, Raphael Wittenberg, Carol Jagger, Tom Dening, Carol Brayne, Cognitive Function, Ageing Studies (CFAS) collaboration

“…Here change is examined across two decades in England.<h4>Methods and findings</h4>Using the two Cognitive Function and Ageing Studies (CFAS I: 77% response, CFAS II: 56% response), two population based studies of older people carried out in the same areas conducted two decades apart, the study diagnosis of dementia using the Automated Geriatric Examination for Computer Assisted Taxonomy, health and wellbeing were examined, focusing on long term care. …”
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hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke by Zengyu Zhang, Rong Ji, Zhuohang Liu, Zhiwen Jiang, Min Chu, Yong Wang, Jing Zhao

“…By delivering HMGB1, hUMSC-Exos inhibit TREM1-dependent NF-κB/p38 activation, reprogram microglial function, and confer neuroprotection. Validated across in vivo, primary, and BV2 microglial models, and supported by multi-omics analyses, this study establishes hUMSC-Exos as a promising cell-free therapy targeting microglial reprogramming for ischemic stroke recovery. …”
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Effectiveness of Low‐Cost, Virtual Sexual Health Education and Educational Leaflets on Reducing Anxiety and Enhancing Sexual Function Among Infertile Women: A Pilot Randomized Cont... by Mahdiyeh Karimi, Fatemeh Heshmatnia, Sara Azima, Marzieh Akbarzadeh, Subash Thapa

“…Post‐intervention, there were significant differences between the intervention and control groups in mean scores across four dimensions of sexual function: sexual desire, sexual stimulation, orgasm, and sexual satisfaction. …”
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Evaluation of the viability and functionality of human peripheral blood mononuclear cells cryopreserved up to 2 years in animal-protein-free freezing media compared to the FBS-supp... by Frédérique Jantet-Blaudez, Joseline Ruiz, Sylviane Gautheron, Anke Pagnon

“…Media with DMSO concentrations below 7.5% were excluded after M0 due to lower viability. Cell functionality was assessed using various assays including cytokine secretion profiles, T and B FluoroSpot, and intracellular cytokine staining.ResultsPBMCs cryopreserved in CryoStor CS10 and NutriFreez D10 maintained high viability and functionality, comparable to the FBS10 reference medium, across all time points. …”
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Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-li... by Igor V Maev, Aleksey A Samsonov, Liudmila K Palgova, Chavdar S Pavlov, Kirill M Starostin, Elena I Vovk, Elena N Shirokova

“…Objective Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal results of liver function tests. Earlier research showed that polyenylphosphatidylcholine (PPC) has hepatoprotective effects and thus can be used for the treatment of NAFLD and the prevention of its progression. …”
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Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014 by Fan Wang, Fan Wang, Xiangyang Wang, Chaowei Wang, Hao Liu, Zhixiu Xu, Dongli Li, Xiaowen Zhao, Jialu Zhao, Shaomin Li, Jianhua Zhao, Jianhua Zhao, Jianhua Zhao

“…To validate the robustness of our findings, we conducted subgroup analyses, which consistently demonstrated stable results across all evaluated groups.ConclusionThis cross-sectional study revealed a significant negative correlation between HRR and cognitive function.…”
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Mercury capture using functionalized metal-organic framework encapsulated in dual hydrogel layers of β-cyclodextrin and polyethylenimine: Synthesis, characterization, adsorption, t... by Asma O. Obaid, Amnah S. Al Zbedy, Kamelah S. Alrashdi, Meshari M. Aljohani, Sara A. Alqarni, Ameena M. Al-Bonayan, Hana M. Abumelha, Nashwa M. El-Metwaly

“…The main aim of this study is to develop a new functionalized lanthanum-based metal-organic framework adsorbent, which is modified with glutamic acid and then encapsulated with β-Cyclodextrin (β-CD) and Polyethylenimine (PEI). …”
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Genome-wide identification and functional characterization of LBD gene family in four Cymbidium species (Orchidaceae) and potential regulatory role of CsiLBD27 in floral developmen... by Yonglu Wei, Zengyu Lin, Jianpeng Jin, Wei Zhu, Jie Gao, Jie Li, Qi Xie, Chuqiao Lu, Genfa Zhu, Fengxi Yang

“…Abstract Background The Lateral Organ Boundaries Domain (LBD) gene family, encompassing plant-specific LOB domain proteins, plays essential roles in various aspects of plant growth and development, and has continuously diversified its functions across numerous species. However, studies on LBD genes in the Orchidaceae family remain limited. …”
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The benefits of early palliative care on psychological well-being, functional status, and health-related quality of life among cancer patients and their caregivers: a systematic re... by Hartiah Haroen, Sidik Maulana, Hasniatisari Harun, Ristina Mirwanti, Citra Windani Mambang Sari, Hesti Platini, Novita Intan Arovah, Padila Padila, Shakira Amirah, Jerico Franciscus Pardosi

“…Objective The primary aim of this study was to evaluate the pooled effects of EPC on psychological, functional status, and QoL outcomes in both cancer patients and their caregivers. …”
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Disproporations and Development of Regional Insurance Markets and Managing Them by V. G. Khalin, G. V. Chernova, E. L. Prokopjeva

“…The proposed approach to identifying imbalances in the development of RIM and the formation of managerial decisions to reduce them can be used to increase the effectiveness of the functioning of RIM, assessed by the two proposed criteria. …”
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Flow Cytometric Assessment of FcγRIIIa-V158F Polymorphisms and NK Cell Mediated ADCC Revealed Reduced NK Cell Functionality in Colorectal Cancer Patients by Phillip Schiele, Stefan Kolling, Stanislav Rosnev, Charlotte Junkuhn, Anna Luzie Walter, Jobst Christian von Einem, Sebastian Stintzing, Wenzel Schöning, Igor Maximilian Sauer, Dominik Paul Modest, Kathrin Heinrich, Lena Weiss, Volker Heinemann, Lars Bullinger, Marco Frentsch, Il-Kang Na

“…Elevated PD1+ NK cell levels, reduced lysis of PDL1-expressing CRC cells and improved NK cell activation in combination with the PDL1-targeting avelumab indicate that the PD1-PDL1 axis contributes to impaired cetuximab-induced NK cell function. Together, these optimized assays effectively identify NK cell dysfunctions in mCRC patients and offer potential for broader application in evaluating NK cell functionality across cancers and therapeutic settings.…”
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Game Changers: National Referendums and the Politicization of Europe by Swen Hutter

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Application of generalized additive models to explore minerals in sheep milk by Stefano Biffani, Michela Ablondi, Claudio Cipolat-Gotet, Andrea Summer, Elena Mariani, Johanna Ramírez-Díaz, Alessio Negro, Alessandro Lotto, Giorgia Stocco

“…The GAMM included milk yield (MY), parity, and breed as parametric terms, and casein, fat, lactose, pH, SCS, DIM, and sampling day as smooth functions. The objectives were to investigate how these factors could affect minerals in sheep milk and to assess whether their patterns change over time and across different concentrations of major milk components. …”
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Altitude-Driven Variations in Nutritional, Bioactive, and Mineral Profiles of Hawthorn (<i>Crataegus</i> spp.) by Yanyan Liu, Lu Chen, Guohui Shen, Yanting Gu, Yanzhi Guo, Juan Han

“…Known for its remarkable adaptability to various environmental conditions, hawthorn thrives across different altitudes, but these environmental factors, particularly altitude, significantly influence the accumulation of its bioactive substances. …”
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Metagenomic Insight into the Associated Microbiome in Plasmodia of Myxomycetes by Xueyan Peng, Shu Li, Wenjun Dou, Mingxin Li, Andrey A. Gontcharov, Zhanwu Peng, Bao Qi, Qi Wang, Yu Li

“…Functional analysis revealed a highly conserved microbial functional profile across the six plasmodia, suggesting they may serve a specific function for the myxomycetes. …”
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Current status of public health awareness and roles within medical institutions in eastern China by Yuchen Wu, Chuanfeng Zhang, Quan She, Wei Zheng, Kai Lu, Furu Wang, Furu Wang

“…ObjectiveTo examine the current landscape of public health functions and the level of cognition among medical staff across various medical institutions in Jiangsu Province, ultimately aiming to provide a theoretical framework for constructing a hospital public health work model under the integrated medical and defense system.MethodsA mixed-methods approach involving questionnaires and semi-structured interviews was employed to assess the establishment and operational status of public health departments within medical institutions, staffing scenarios, comprehension of public health tasks, and the degree of emphasis placed on them.ResultsOur findings reveal that 70.6% of medical institutions possess standalone public health departments, with a median of 5 full-time public health personnel, predominantly from the nursing profession. …”
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