All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. by Andrew J Schork, Wesley K Thompson, Phillip Pham, Ali Torkamani, J Cooper Roddey, Patrick F Sullivan, John R Kelsoe, Michael C O'Donovan, Helena Furberg, Tobacco and Genetics Consortium, Bipolar Disorder Psychiatric Genomics Consortium, Schizophrenia Psychiatric Genomics Consortium, Nicholas J Schork, Ole A Andreassen, Anders M Dale

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Frequency-band specific directed connectivity networks reveal functional disruptions and pathogenic patterns in temporal lobe epilepsy: a MEG study by Chen Zhang, Yutong Wu, Wenhan Hu, Guangfei Li, Chunlan Yang, Ting Wu

“…The connectivity patterns across frequency bands in TLE patients were found to be unstable. …”
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Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules. by Xiaolin Xiao, Aida Moreno-Moral, Maxime Rotival, Leonardo Bottolo, Enrico Petretto

“…Yet, genome-scale network analysis across conditions is significantly hampered by the paucity of robust and computationally-efficient methods. …”
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A bespoke water T–maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice by Jeremy Davidson Bailoo, Susan E. Bergeson, Igor Ponomarev, Joshua O. Willms, Brent R. Kisby, Gail A. Cornwall, Clinton C. MacDonald, J. Josh Lawrence, J. Josh Lawrence, Vadivel Ganapathy, Sathish Sivaprakasam, Praneetha Panthagani, Scott Trasti, Justin A. Varholick, Michael Findlater, Amrika Deonarine

“…Given the robust performance observed across spatial acquisition (learning and memory) as well as during reversal learning (executive function), we further reduced (by 43%) the overall distance and time that the animal must swim in order to find the escape platform in a bespoke standalone Water T-Maze (WTM). …”
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Characteristics of Soil Nematode Communities in Pure <i>Populus hopeiensis</i> Forests in the Loess Hilly Region and Their Responses to Precipitation by Yani Hu, Jiahao Shi, Fangfang Qiang, Changhai Liu, Ning Ai

“…To clarify the response mechanisms of soil nematodes as bioindicators of ecosystem health to precipitation variations in loess hilly forests, this study investigated soil nematodes in pure <i>Populus hopeiensis</i> forests across different precipitation gradients in Wuqi County. …”
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Stage-specific transcriptomic analysis reveals insights into the development, reproduction and biological function of allergens in the European house dust mite Dermatophagoides pte... by José Cristian Vidal-Quist, Félix Ortego, Bart N. Lambrecht, Stephane Rombauts, Pedro Hernández-Crespo

“…Abstract Background House dust mites (HDMs) such as Dermatophagoides pteronyssinus are major allergy elicitors worldwide, yet their gene expression across developmental stages remains underexplored. …”
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A comparison of three executive function interventions on direct and far transfer in Chilean school children: a cluster-randomized controlled protocol by Nicholas Napolitano, Cristian A. Rojas-Barahona, Jorge Gaete, Ricardo Araya

“…Abstract Background Executive functions (EF) are cognitive processes that support goal-directed behaviors that are essential for children’s academic success, predicting school performance more strongly than IQ. …”
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Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Association... by Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang

“…Abstract Characterizing the transition or switching behavior between multistable brain states in functional connectivity dynamics (FCD) holds promise for uncovering the underlying neuropathology of Autism Spectrum Disorder (ASD). …”
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Teosinte-derived SynCom and precision biofertilization modulate the maize microbiome, enhancing growth, yield, and soil functionality in a Mexican field by Juan Alfredo Hernández-García, Julio S. Bernal, Sanjay Antony-Babu, Lourdes Villa-Tanaca, César Hernández-Rodríguez, Esaú De-la-Vega-Camarillo, Esaú De-la-Vega-Camarillo, Esaú De-la-Vega-Camarillo

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Assessment of functioning using the WHODAS 2.0 among people with myasthenia gravis-associated disability: a nationwide follow-up study by Jia-Pei Hong, Chih-Hong Lee, Chien Tai Hong, Lung Chan, Chen-Chih Chung, Prangthip Charoenpong, Hou-Chang Chiu, Tsan-Hon Liou

“…At the initial evaluation, younger individuals (< 65 years) generally demonstrated less severe disability across most functional domains, with the exception of social participation. …”
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Modeling Cross-Cultural Competence in Vocational Education Internationalization Using Neutrosophic SuperHyperFunctions and Big Data-Driven Cultural Clusters by Min Huang, Liang Zhang, Fenghua Li

“…This paper introduces a novel approach that models crosscultural competence using Neutrosophic SuperHyperFunctions. These functions allow for the representation of dynamic cultural clusters extracted from big data sources, including digital learning platforms and international student interactions. …”
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Rethreading the needle: A novel molecular index of soil health (MISH) using microbial functional genes to predict soil health management. by Heather L Deel, Daniel K Manter, Jennifer M Moore

“…The bacterial functional profile was characterized using 16S ribosomal RNA gene sequencing paired with PICRUSt2 to predict metagenome functions. …”
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Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. by Ping K Yip, Liang-Fong Wong, Thomas A Sears, Rafael J Yáñez-Muñoz, Stephen B McMahon

“…Improved forelimb function was demonstrated behaviourally and electrophysiologically. …”
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Does Syndesmotic Fixation Technique Impact Complication Rates and Functional Outcomes Measured by PROMIS Scores Following Operative Repair of Ankle Fractures? by Steven Hadley BA, Rachel Bergman MD, John Peabody MD, Sarah Westvold MPH, Ryan Filler MD, Milap Patel DO, Anish Kadakia MD

“…Multiple extremity injuries, open fractures, and pilon variants were excluded. 328 patients with syndesmotic ruptures were sent post-operative questionnaires. 159 patients with minimum one-year follow-up were analyzed for complications. 70 patients who completed PROMIS CATs were analyzed for functional outcomes. Due to rarity of complications and perfect separation in the data, we were unable to use statistical tests to compare complication incidence across techniques. …”
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The Class III Peroxidase Gene Family in <i>Populus simonii</i>: Genome-Wide Identification, Classification, Gene Expression and Functional Analysis by Lu Han, Yishuang Ren, Xinru Bi, Guowei Yao, Jinwang Zhang, Hongtao Yuan, Xiaoyu Xie, Junbo Chen, Yunchang Zhang, Sitong Du, Wanying Chen, Kewei Cai, Xiyang Zhao

“…Chromosomal localization revealed that these <i>PsPOD</i> genes are unevenly distributed across 19 chromosomes, with chromosomes 3 and 7 harboring the highest densities. …”
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THE IMPACT OF THE COVID-19 CRISIS ON THE ECONOMIC BURDEN OF DEPRESSIVE DISORDERS AMONG THE WORKING-AGE POPULATION, CONSIDERING DIFFERENT FUNCTIONAL AREAS IN POLAND by Agnieszka Jakubowska

“…This study aims to assess the economic burden of depressive disorders in this group, taking into account spatial variation across functional areas (urban and rural districts) in Poland. …”
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Aquatic insect functional traits indicate spatiotemporal changes in potential aquatic prey availability to terrestrial consumers after small dam removal by Peter E. Carlson

“…However, there is little understanding how dam removal affects lateral interactions across ecosystem boundaries. The transfer of aquatic resource subsidies into terrestrial food webs via the winged adult stages of aquatic insects is recognized as a key component in the functioning of riverine networks. …”
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<i>Agrobacterium</i>-Mediated Transient Expression Methods to Validate Gene Functions in Strawberry (<i>F.</i> × <i>ananassa</i>) by Yoon Jeong Jang, Hyeondae Han, Seonghee Lee

“…However, variability in tissue-specific responses and inconsistent applicability of <i>Agrobacterium</i>-mediated transient assay across diverse plant species can be challenging. In this study, we provide a method utilizing <i>Agrobacterium</i>-mediated transient expression to examine the function of genes in octoploid strawberry. …”
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The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity. by Kaori Oikawa, Koki Fujisaki, Motoki Shimizu, Takumi Takeda, Keiichiro Nemoto, Hiromasa Saitoh, Akiko Hirabuchi, Yukie Hiraka, Naomi Miyaji, Aleksandra Białas, Thorsten Langner, Ronny Kellner, Tolga O Bozkurt, Stella Cesari, Thomas Kroj, Mark J Banfield, Sophien Kamoun, Ryohei Terauchi

“…However, the functions of host proteins with similarity to NLR integrated domains and the extent to which they are targeted by pathogen effectors remain largely unknown. …”
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Advancing Early Detection of Major Depressive Disorder Using Multisite Functional Magnetic Resonance Imaging Data: Comparative Analysis of AI Models by Masab Mansoor, Kashif Ansari

“…MethodsWe used functional magnetic resonance imaging data from 1200 participants (600 with early-stage MDD and 600 healthy controls) across 3 public datasets. …”
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