Conserved function of bat TBK1 in activating innate immunity against RNA viruses: insights into the innate immune response in bats by Qiuju Liu, Qi Shao, Caixia Xu, Chao Liu, Shuhan Li, Jie Wang, Xia Liu, Kehui Zhang, Yaxian Yan, Jianhe Sun, Yuqiang Cheng

“…Here, through bioinformatics analysis, TBK1 was found to exhibit a high sequence conservation across species. Overexpression of bat TBK1 significantly upregulated IFNβ expression, and then inhibited viral replication. …”
Get full text

Evaluating the role of AI-simulated patients compared with peer-to-peer learning models in the enhancement of medical education: is it beyond theoretical functionality? by Pegin Poulose

“…A medical education platform, SIMPAT, which generates timed clinical scenarios of AI-simulated patients with preset clinical backgrounds ranging across a variety of medical specialities, was incorporated in this study. …”
Get full text

Lactococcus petauri LZys1 modulates gut microbiota, diminishes ileal FXR-FGF15 signaling, and regulates hepatic function by Ouyang Li, Yingshun Zhou, Dayoung Kim, Han Xu, Zhijun Bao, Fan Yang

“…Furthermore, we propose that changes in liver status are related to the enterohepatic farnesoid X receptor–fibroblast growth factor axis, which alters bile acid metabolism and disrupts liver function. The above findings suggest that attention should be paid to the effect of probiotics on liver function.…”
Get full text

Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis by Hao Xiong, Haiqing Gao, Jianji Wan, Jieping Xiao, Xiaoqun Luo, Xiuqin Dong, Yueheng Wu, Tao Liu

“…Conclusions This study identified a frameshift mutation in the WRN gene, which was associated with WS. The subsequent functional analysis revealed the inefficiency of the mutated protein. …”
Get full text

Trimester Specific Effect of Pregnancy on Maternal Cognitive Function using Critical Flicker Fusion Frequency: A Cross-sectional Study by J Roshni, S Anu, M Ramji

“…Introduction: Critical Flicker Fusion Frequency (CFFF) measures cognitive function by detecting the threshold at which flickering light appears steady. …”
Get full text

Association of the Systemic Inflammation Response Index with Functional Outcome in Acute Large Vessel Occlusion Stroke Patients Receiving Mechanical Thrombectomy by Wu W, Zhang YP, Qu XG, Zhang ZH

“…Wen Wu,1,2 Yu-Pei Zhang,1,2 Xing-Guang Qu,1,2 Zhao-Hui Zhang1,2 1Departments of Critical Care Medicine, Yichang Central People’s Hospital, Yichang, Hubei, 443003, People’s Republic of China; 2The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443003, People’s Republic of ChinaCorrespondence: Zhao-Hui Zhang, Department of Critical Care Medicine, Yichang Central People’s Hospital, Yichang, Hubei, 443003, People’s Republic of China, Tel/Fax +86 0717 6481546, Email zhaohuizhang0630@163.comPurpose: The systemic inflammation response index (SIRI) has recently emerged as a novel inflammatory and prognostic marker across various diseases. However, there is limited research examining the relationship between SIRI and 90-day functional outcome in patients with acute large vessel occlusion stroke (ALVOS) undergoing mechanical thrombectomy (MT). …”
Get full text

Functional and structural analyses of IMP-27 metallo-β-lactamase: evolution of IMP-type enzymes to overcome Zn(II) deprivation by Yoshiki Kato, Toshio Yamaguchi, Haruka Nakagawa-Kamura, Yoshikazu Ishii, Akiko Shimizu-Ibuka

Get full text

The effects of sleep deprivation on cognitive flexibility: a scoping review of outcomes and biological mechanisms by Xuefeng Sun, Zihan Qu, Xiaotu Zhang, Ye Zhang, Xinye Zhang, Haifeng Zhao, Hongshi Zhang

Get full text

Evaluating Coupling Security and Joint Risks in Northeast China Agricultural Systems Based on Copula Functions and the Rel–Cor–Res Framework by Huanyu Chang, Yong Zhao, Yongqiang Cao, He Ren, Jiaqi Yao, Rong Liu, Wei Li

Get full text

The effects of acupoint catgut embedding therapy on anthropometric parameters and endocrine function in obese women: a systematic review and meta-analysis by Shuangqiu Li, Hongfei Zhou, Muhan Zhou, Liangliang Lou, Li Luo, Shan Ji

“…PurposeThis study aimed to assess the effect of acupoint catgut embedding therapy (ACET) on anthropometric parameters and endocrine function in obese women through a systematic review and meta-analysis.MethodsA comprehensive search was conducted across international and Chinese databases [CNKI, Wanfang, Weipu, Sinomed, PubMed, Embase, Cochrane Library, Web of Science (WOS), and Scopus]. …”
Get full text

The effectiveness of Spencer muscle energy technique on pain, function and range of motion in patients with frozen shoulder: Systematic Reviews and Meta-analyses by Mihret Dejen Takele, Alemu Kassaw Kibret, Gashaw Jember Belay, Moges Baye, Kefale Getie, Kassaw Belay Shiferaw, Getachew Azeze Eriku

“…The outcomes were pain, function, and shoulder range of motion (ROM). Two authors independently did data extraction. …”
Get full text

Respiratory function and respiratory complications in spinal cord injury: protocol for a prospective, multicentre cohort study in high-income countries by David J Berlowitz, Maria T E Hopman, Martin Schubert, Gabi Mueller, Martin W G Brinkhof, Xavier Jordan, Anja M Raab, Karin Postma, David Gobets, Sven Hirschfeld, Burkhart Huber, Margret Hund-Georgiadis, Renate Wildburger

“…This paper details the protocol for a large-scale, multicentre research project that aims to evaluate the ability of parameters of respiratory function to predict and understand variation in inpatient risk of pneumonia in SCI.Methods and analysis RESCOM, a prospective cohort study, began recruitment in October 2016 across 10 SCI rehabilitation centres from Australia, Austria, Germany, the Netherlands and Switzerland. …”
Get full text

Exploring the relationship between temperament traits, psychological symptoms, and functional disability assessed with the WHODAS 2.0 in persons with multiple sclerosis by Carmenrita Infortuna, Maria Buccafusca, Anita Maria Stella Graceffa, Enrica Maiorana, Ray Wang, Siddarth Ganesh, Orion Yedidia, Antonio Bruno, Fiammetta Iannuzzo, Florian P. Thomas, Fortunato Battaglia, Fortunato Battaglia

“…BackgroundThe relationship between psychological comorbidity and functional impairment in multiple sclerosis (MS) remains to be thoroughly investigated. …”
Get full text

Functional Connectivity and MRI Radiomics Biomarkers of Cognitive and Brain Reserve in Post-Stroke Cognitive Impairment Prediction—A Study Protocol by Hanna Maria Dragoș, Adina Stan, Livia Livinț Popa, Roxana Pintican, Diana Feier, Nicu Cătălin Drăghici, Dragoș-Cătălin Jianu, Diana Chira, Ștefan Strilciuc, Dafin F. Mureșanu

“…This article provides the design of a hospital-based study investigating the predictive role of functional connectivity and MRI radiomics in assessing PSCI occurrence one year after AIS. …”
Get full text

Kinetic modeling of 18F-PI-2620 binding in the brain using an image-derived input function with total-body PET by Anjan Bhattarai, Emily Nicole Holy, Yiran Wang, Benjamin A. Spencer, Guobao Wang, Charles DeCarli, Audrey P. Fan

“…Abstract Background Accurate quantification of tau binding from 18F-PI-2620 PET requires kinetic modeling and an input function. We aimed to implement a non-invasive Image-derived input function (IDIF) using the state-of-the-art total-body uEXPLORER PET/CT scanner to quantify tau binding and tracer delivery rate from 18F-PI-2620 in the brain. …”
Get full text

Differential Effects of SGLT-2 Inhibitors on Liver Function and Nocturia in Patients with Type 2 Diabetes: A Randomized Controlled Trial by Kawahara T, Toda M, Kanagawa M, Toyama N, Suzuki G, Kawahara C, Inazu T

“…Glycemic control, body weight, and lipid profiles improved similarly across all groups.Conclusion: SGLT-2is improve liver function as a class effect, but their impact on nocturia frequency differs. …”
Get full text

Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study by Chenyu Fan, Hanfei Li, Hanfei Li, Ke Chen, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li, Meng Li, Meng Li

“…The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. …”
Get full text

Clinical characteristics, risk factors and prognosis of Klebsiella pneumoniae infection in patients with different states of immune function: a retrospective study by Xin Wang, Chonghe Xu, Chao Qin, Juan Liu, Xiaoli Kong, Zhijun Zhu, Chenchen Zhang, Wei Xu, Mei Zhu

Get full text

Effects of blue light during and after exposure on auditory working memory by Kyungshil Kim, Koichi Yokosawa, Ken Okada, Hayate Onishi, Yumiko Tan, Sang-il Lee

“…., blue light) has been shown to enhance cognitive function in humans. While most prior studies have focused on visuospatial working memory, the effects of blue light on auditory working memory, particularly tasks involving the phonological loop, remain underexplored. …”
Get full text

Automated extraction of functional biomarkers of verbal and ambulatory ability from multi-institutional clinical notes using large language models by Levi Kaster, Ethan Hillis, Inez Y. Oh, Bhooma R. Aravamuthan, Virginia C. Lanzotti, Casey R. Vickstrom, Brain Gene Registry Consortium, Christina A. Gurnett, Philip R. O. Payne, Aditi Gupta

“…Conclusions LLMs are effective at extracting functional biomarkers from EHR data and broadly generalizable across variable note-taking practices and institutions. …”
Get full text