Clinicopathologic Features of IgG4-Related Kidney Disease by Alessia Buglioni, Sarah M. Jenkins, Samih H. Nasr, Pingchuan Zhang, Ian W. Gibson, Mariam P. Alexander, Loren P. Herrera Hernandez, Mary E. Fidler, Naoki Takahashi, Marie C. Hogan, Lynn D. Cornell

“…IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD). …”
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Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfus... by Zan Liu, Zitong Zhao, Zhenghui Xiao, Ming Li, Xiyang Wang, Yan Huang, Yong Li

“…Using a bioinformatics database, we initially identified genes with abnormal expression patterns in II/R injury. Then, we confirmed the association between II/R injury, ferroptosis, and the HMGB1/SREBF2 axis through in vivo and in vitro experiments. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…While prior studies have explored CBF abnormalities in depressed adolescents, the specific patterns of CBF changes following pharmacological interventions, particularly with selective serotonin reuptake inhibitors (SSRIs) such as sertraline, remain insufficiently characterized.ObjectiveTo investigate the alterations in CBF induced by an 8-week sertraline treatment in adolescents with depression, and to assess whether baseline CBF can serve as a potential biomarker for predicting treatment response.MethodsA total of 40 adolescents diagnosed with depression and 31 age- and sex-matched healthy controls were enrolled in the study. …”
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A lung cancer mouse model system based on an inbred C3H strain: Ultrasound imaging, pathological analysis, and proteomic biomarker identification by Ulayatul Kustiati, Wahyu Tri Widayati, Dwi Liliek Kusindarta, Dwi Aris Agung Nugrahaningsih, Dinda Aliffia, Wilda Bunga Tina Sanjaya, Hevi Wihadmadyatami

“…Materials and Methods: Twelve male inbred C3H mice were assigned to non-treated and treatment groups, with the latter receiving 100 mg/kg body weight of benzo(a)pyrene intraperitoneally. …”
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Effect of Aqueous and Ethanolic Extracts of Tribulus terrestris, Phoenix dactylifera and Nasturtium officinale Mixture on Some Reproductive Parameters in Male Mice by Baghdad Science Journal

“…A remarkable increase in sperm concentration and motility with a decreased abnormal morphology was obtained in the experimental groups. …”
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Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients by Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

“…Methods. Among 387 patients treated with ICIs, those who developed drug-induced liver injury were investigated. …”
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ZYGOMYCOSIS IN IMMUNOCOMPROMISED NON-HAEMATOLOGICAL PATIENTS by George Petrikkos, Miranda Drogari-Apiranthitou

“…Suspicion index can be increased through recognition of the differential patterns of clinical presentation. In the <span style="mso-bidi-font-weight: bold;">non</span><strong style="mso-bidi-font-weight: normal;">-</strong> haematological <span style="mso-bidi-font-weight: bold;">immunocompromised </span>patients, zygomycosis can manifest in various clinical forms, depending on the underlying condition: mostly as rhino-orbital or rhino-cerebral in diabetes patients, pulmonary infection in patients with malignancy or solid organ transplantation, disseminated infection in iron overloaded or deferoxamine treated patients, cerebral - with no sinus involvement - in ID users, gastrointestinal in premature infants or malnourishment, and cutaneous after direct inoculation in immunocompetent individuals with trauma or burns.…”
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Reduction of subclinical acute cardiac injury through DIBH radiotherapy: a single-institution real-world clinical cohort analysis by Kun Zhang, Jing Shen, Yongguang Liang, Xiangyin Meng, Bo Yang, Jiabin Ma, Ke Hu, Jie Qiu, Xiaorong Hou, Fuquan Zhang

“…Subclinical acute cardiac injury was characterized by the emergence of elevated myocardial enzymes beyond normal levels and/or EKG alterations in ST-T or T-wave patterns and/or abnormalities detected in ECHO within a 6-month period following radiotherapy. …”
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Rare Encounter Behind the Ear: Unveiling Kimura Disease in the Postaural Region by Divya Nayani, Siddhartha Nyathani, Rahul Kumar Pitale Ashok

“…Its etiology, linked to an abnormal allergic reaction, remains uncertain, featuring a characteristic indolent growth pattern. …”
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Identification of a metabolic brain network characterizing essential tremor by Solange Volnov, Hamzah Baagil, Oliver Winz, Hans-Juergen Kaiser, Sanne Katherina Meles, Joerg Bernhard Schulz, Kathrin Reetz, Felix Manuel Mottaghy, Florian Holtbernd

“…Our findings suggest ET is characterized by an abnormal brain network associated with disease phenotype.…”
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Clinical and imaging features of parenchymal and non-parenchymal neuro-Behçet’s disease: a systematic review of case reports and series by Omar Al-omoush, Majd M. AlBarakat, Deya’a Alasmar, Ali Al-Khalaileh, Ahmad Alzoubi, Husam Tarakhan, Zaid Shakhatreh, Zaid Hatamleh, Mohammed Abu-saleh, Othman Saleh, Abdalrahman Altiti, Wafa’ A. Hazaymeh, Sakhr Alshwayyat, Hamdah Hanifa, Ethar Hazaimeh

“…While previous research highlights MRI abnormalities and cerebrospinal fluid changes, there hasn’t been a systematic effort to identify patterns specific to newly diagnosed patients. …”
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Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series by Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini

“…The older two had seizures that improved with treatment, but their brain activity remained abnormal. The youngest, diagnosed and treated earlier with supplementation, did not develop epilepsy. …”
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Autoimmune Pulmonary Alveolar Proteinosis: A Rare Diagnosis in Pediatric Age by Inês Pais-Cunha, Augusta Gonçalves, Sara Paulino, José Fontoura Matias, Silva Sónia, Catarina Ferraz, Inês Azevedo

“…On examination, he had diminished breath sounds in the lower two thirds of the chest with no other abnormal findings; SpO 2 (oxygen saturation) was 98% on room air. …”
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Posterolateral tibial plateau fracture with anterior cruciate ligament injury has biomechanical characteristics of anterolateral rotatory instability through finite element analysi... by Qinglei Xu, Guoyi Han, Zhijun Zhang, Yandong Ci

“…Simultaneous PLTPF with ACL injury has a common flexion valgus and tibial internal rotation injury mechanism with ALRI and should be treated as a special pattern of ALRI. Clinically, high grade PLTPF associated with ACL injury should be addressed by concomitant PLTPF reduction and ACL reconstruction to fully restore LTP articular congruence and knee stability.…”
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Homozygous Mutation in the FANCD2 Gene Observed in a Saudi Male Infant with Severe Ambiguous Genitalia by Aida Al Jabri, Nusaybah Al Naim, Abeer Al Dossari

“…FA characterizes by multiple congenital abnormalities and malformations including growth retardation, renal agenesis, absence of radial bones and thumbs as well, progressive bone marrow failure, irregular skin pigmentation patterns, and increased susceptibility to cancer. …”
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Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache by Costantini Antonio, Tiberi Massimo, Zarletti Gianpaolo, Pala Maria Immacolata, Trevi Erika

“…Some authors have found in patients affected by this disease abnormality in glucose metabolism. Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine. …”
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Nivolumab in combination with radiotherapy for metastatic esophageal neuroendocrine carcinoma after esophagectomy: a case report by Kuniyasu Takagi, Teppei Kamada, Yoshinobu Fuse, Wataru Kai, Junji Takahashi, Keigo Nakashima, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Shinya Okada, Hironori Ohdaira, Yutaka Suzuki

“…Case presentation A man in his 70s presented to our hospital after an abnormality was detected on an upper gastrointestinal series. …”
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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer by Xin Wang, Dawei Zhang, Xiaodi Zhao, Yuanyuan Lu, Yun Zhou, Hua Han, Pei Wang, Wenyao Zhang, Boda Wang, Danxiu Li, Tianyu Cao, Mingfeng Bai

“…Decitabine, a demethylation drug used to treat hematologic neoplasms, disrupted the abnormal methylation pattern of GSDME in tumor cells, enhanced the efficacy of IR700DX-6T-PDT, and elicited a potent antitumor immune response in combination with PD-1 blockade and IR700DX-6T-PDT.Conclusion Our work provides clear a understanding of immunogenic cell death triggered by mitochondria-targeted PDT, offering a new approach for enhancing the efficacy of PD-1 blockade in CRC.…”
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Autism and α7-nicotinic acetylcholine receptors: new pharmacological and herbal interventions by Nourhan A. Khattab, Aya H. El-Kadem, Nada A. Ashour, Nageh Ahmed El-Mahdy, Nagla A. El-Shitany

“…ASD is characterized by neurological abnormalities that include impaired social interactions, stereotyped patterns of behavior, and cognitive difficulties. …”
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Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris by Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou

“…Structural modelling predicted that Tet(X14) shared a high homology with the other 12 variants with RMSD value from 0.003 to 0.055, and Tet(X14) can interact with tetracyclines by a similar pattern as the other Tet(X)s. tet(X14) and two copies of tet(X2) were identified on a genome island with abnormal GC content carried by the chromosome of ES183, and no mobile genetic elements were found surrounding, suggesting that tet(X14) might be heterologously obtained by ES183 via recombination. …”
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