Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma by Yu Chen, Yang Chen, Yu Zhou, Yongsheng Li, Ran Ren, Juan Lei

“…Recent research suggests that abnormal lipid metabolism in patients with lung adenocarcinoma may hinder the efficacy of anti-PD-1 monotherapy.Methods Here, we delved into the patterns of lipid metabolism in patients with The Cancer Genome Atlas (TCGA)-lung adenocarcinoma (LUAD) and their correlation with the immune microenvironment’s cellular infiltration characteristics of the tumor. …”
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Adipose-derived stem cells alleviate acute pancreatitis by inhibiting ferroptosis and oxidative damage in canines by Yansong Ge, Mingzhen Chen, Meilin Li, Zheng Wang, Ruxin Ding, Zhiying Wan, Enshuang Xu, Jiasan Zheng

“…Conclusions ADSCs can protect the pancreas of dogs by inhibiting ferroptosis and oxidative stress via paracrine function, indicating immense potential as a therapeutic target for treating AP.…”
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An approach to arousal disorder classification using deformable convolution and adaptive multiscale features in EEG signals by Andia Foroughi, Fardad Farokhi, Fereidoun Nowshiravan Rahatabad, Alireza Kashaninia

“…Our proposed model, a hierarchical multiscale deformable attention module, excels at detecting complex and abnormal patterns in EEG data. We apply this model after segmenting EEG data into 30-second windows and generating spectrogram images. …”
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Adolescent scoliosis in autism spectrum disorder: is it idiopathic or syndromic?? by Ravi Rajendra, Matthew B. Bratton, Claudia Leonardi, R. Carter Clement

“…Our study at a high-volume scoliosis center compares patterns of scoliosis in ASD patients with those of neurotypical patients. …”
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Identification of a metabolic brain network characterizing essential tremor by Solange Volnov, Hamzah Baagil, Oliver Winz, Hans-Juergen Kaiser, Sanne Katherina Meles, Joerg Bernhard Schulz, Kathrin Reetz, Felix Manuel Mottaghy, Florian Holtbernd

“…Our findings suggest ET is characterized by an abnormal brain network associated with disease phenotype.…”
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Combined Transcriptome Analysis Reveals the Mechanism of ‘Shine Muscat’ Pollen Abortion Induced by CPPU and TDZ Treatment by Mengfan Ren, Yixu Wang, Siyi Yi, Jingyi Chen, Wen Zhang, Haoran Li, Ke Du, Jianmin Tao, Huan Zheng

“…CK), 16 DEGs exhibited similar expression patterns. Further tissue-specific expression analysis identified nine genes that were highly expressed in stamens and shared the same expression pattern in sterile lines. …”
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Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series by Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini

“…The older two had seizures that improved with treatment, but their brain activity remained abnormal. The youngest, diagnosed and treated earlier with supplementation, did not develop epilepsy. …”
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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…Additionally, Tan-I restored keratin expression patterns, increasing K1 and decreasing K6 and K17 levels in both mouse skin and HaCaT cells.Conclusion: Tan-I is a promising therapeutic candidate for psoriasis, effectively mitigating inflammation, normalizing keratinocyte differentiation, and inhibiting abnormal keratinocyte apoptosis.Keywords: psoriasis, tanshinone I, immune modulation, keratinocyte, apoptosis…”
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Autoimmune Pulmonary Alveolar Proteinosis: A Rare Diagnosis in Pediatric Age by Inês Pais-Cunha, Augusta Gonçalves, Sara Paulino, José Fontoura Matias, Silva Sónia, Catarina Ferraz, Inês Azevedo

“…Spirometry indicated a mild restrictive pattern (forced vital capacity [FVC] = 77%) and diffusing capacity of the lungs for carbon monoxide (DLCO) showed a moderate decrease at 48.6%. …”
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Posterolateral tibial plateau fracture with anterior cruciate ligament injury has biomechanical characteristics of anterolateral rotatory instability through finite element analysi... by Qinglei Xu, Guoyi Han, Zhijun Zhang, Yandong Ci

“…Simultaneous PLTPF with ACL injury has a common flexion valgus and tibial internal rotation injury mechanism with ALRI and should be treated as a special pattern of ALRI. Clinically, high grade PLTPF associated with ACL injury should be addressed by concomitant PLTPF reduction and ACL reconstruction to fully restore LTP articular congruence and knee stability.…”
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Chromatin modifiers in endometriosis pathogenesis by K. A. Abaeva, R. T. Murtazova, I. A. Vaniev, A. V. Lazarova, A. A. Sozaeva, M. A. Gogichaeva, A. A. Pirozhnikova, K. V. Ignashev, M. S. Dadashov, D. V. Kolesnikova, A. A. Bayramova, V. E. Kucherskaya, L. D. Zulfalieva, A. M. Zaitseva

“…It was revealed that various epigenetic abnormalities may play an important role in the endometriosis pathogenesis. …”
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Nivolumab in combination with radiotherapy for metastatic esophageal neuroendocrine carcinoma after esophagectomy: a case report by Kuniyasu Takagi, Teppei Kamada, Yoshinobu Fuse, Wataru Kai, Junji Takahashi, Keigo Nakashima, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Shinya Okada, Hironori Ohdaira, Yutaka Suzuki

“…Case presentation A man in his 70s presented to our hospital after an abnormality was detected on an upper gastrointestinal series. …”
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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer by Xin Wang, Dawei Zhang, Xiaodi Zhao, Yuanyuan Lu, Yun Zhou, Hua Han, Pei Wang, Wenyao Zhang, Boda Wang, Danxiu Li, Tianyu Cao, Mingfeng Bai

“…Decitabine, a demethylation drug used to treat hematologic neoplasms, disrupted the abnormal methylation pattern of GSDME in tumor cells, enhanced the efficacy of IR700DX-6T-PDT, and elicited a potent antitumor immune response in combination with PD-1 blockade and IR700DX-6T-PDT.Conclusion Our work provides clear a understanding of immunogenic cell death triggered by mitochondria-targeted PDT, offering a new approach for enhancing the efficacy of PD-1 blockade in CRC.…”
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Clinicopathologic Features of IgG4-Related Kidney Disease by Alessia Buglioni, Sarah M. Jenkins, Samih H. Nasr, Pingchuan Zhang, Ian W. Gibson, Mariam P. Alexander, Loren P. Herrera Hernandez, Mary E. Fidler, Naoki Takahashi, Marie C. Hogan, Lynn D. Cornell

“…IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD). …”
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Postoperative Multimodal Analysis in Successful Gas Displacement of a Submacular Hemorrhage by Tatiana Urrea-Victoria, Emiliano Fulda-Graue, Miguel A. Quiroz-Reyes, Felipe Esparza-Correa, Alejandra Nieto-Jordan, Erick A. Quiroz-Gonzalez, Federico Graue-Wiechers

“…The multimodal imaging tests yielded abnormal foveal SD-OCT patterns, with a fibrous sealed tear in the retinal pigment epithelium. …”
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Primary large B-cell lymphoma of the central nervous system misdiagnosed as autoimmune encephalitis: a case report by Aihui Ren, Guanwen Zeng, Riling Chen, Zhixing Cao, Wenyan Zhuo, Yubin Liang, Yubin Liang

“…Physical examination revealed various abnormal signs. Initial cerebrospinal fluid (CSF) analysis was unremarkable, while MRI scans (both plain and contrast-enhanced) showed abnormal signals in the left brainstem, thalamus, and basal ganglia regions, with specific enhancement patterns, and arterial spin labeling (ASL) demonstrated hyperperfusion. …”
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Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma by Peng-Lei Zhai, Peng-Lei Zhai, Meng-Min Chen, Meng-Min Chen, Meng-Min Chen, Qi Wang, Jing-Jun Zhao, Xiao-Mei Tang, Cui-Ni Lu, Jia Liu, Qin-Xin Yang, Ming-Liang Xiang, Qing-Hai Tang, Biao Gu, Shu-Ping Zhang, Si-Ping Tang, Da Fu, Da Fu

“…The LPRS also showed significant correlations with the clinicopathological features and TIME patterns in HNSCC patients. Furthermore, the LPRS effectively predicted responses to immune checkpoint inhibitor therapy and facilitated the screening of potential small-molecule compounds for treating HNSCC patients.ConclusionThis study presents a new classification system for HNSCC patients grounded in LLPS. …”
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Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris by Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou

“…Structural modelling predicted that Tet(X14) shared a high homology with the other 12 variants with RMSD value from 0.003 to 0.055, and Tet(X14) can interact with tetracyclines by a similar pattern as the other Tet(X)s. tet(X14) and two copies of tet(X2) were identified on a genome island with abnormal GC content carried by the chromosome of ES183, and no mobile genetic elements were found surrounding, suggesting that tet(X14) might be heterologously obtained by ES183 via recombination. …”
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Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank by Ambre Bertrand, Xin Zhou, Andrew Lewis, Thomas Monfeuga, Ramneek Gupta, Vicente Grau, Blanca Rodriguez

“…Due to its complexity, HFpEF is a challenging condition to treat, making phenotype-specific disease management a promising approach. …”
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Gradient changes in bioprosthetic valve thrombosis: duration of anticoagulation and strategies to improve detection by Vuyisile T Nkomo, Alexander C Egbe, Heidi M Connolly, Patricia A Pellikka, Sorin V Pislaru, Filip Ionescu, Hartzell V Schaff, Ioana Petrescu, Jwan A Naser, Cristina Pislaru

“…We set forth to (1) evaluate patterns of increase in gradients prior to BPVT diagnosis and (2) characterise time-course of response to anticoagulation.Methods Patients treated with warfarin for BPVT (1999–2019) with clinically significant reduction of mean gradients (≥25%) were identified retrospectively. …”
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