Impact of polystyrene microplastics (PS-MPs) on the entire female mouse reproductive cycle: Assessing reproductive toxicity of microplastics through in vitro follicle culture by Jukyeong Jeong, Nhu Thi Quynh Mai, Byoung-San Moon, Jung Kyu Choi

“…Post-superovulation treatment, significant differences were noted in the number of ovulated metaphase II (MII) oocytes, spindle chromosome integrity, mitochondrial patterns, and ROS levels compared to controls. Mating with PS-MPs-exposed females led to fewer offspring. …”
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Autoimmune Pulmonary Alveolar Proteinosis: A Rare Diagnosis in Pediatric Age by Inês Pais-Cunha, Augusta Gonçalves, Sara Paulino, José Fontoura Matias, Silva Sónia, Catarina Ferraz, Inês Azevedo

“…Spirometry indicated a mild restrictive pattern (forced vital capacity [FVC] = 77%) and diffusing capacity of the lungs for carbon monoxide (DLCO) showed a moderate decrease at 48.6%. …”
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Posterolateral tibial plateau fracture with anterior cruciate ligament injury has biomechanical characteristics of anterolateral rotatory instability through finite element analysi... by Qinglei Xu, Guoyi Han, Zhijun Zhang, Yandong Ci

“…Simultaneous PLTPF with ACL injury has a common flexion valgus and tibial internal rotation injury mechanism with ALRI and should be treated as a special pattern of ALRI. Clinically, high grade PLTPF associated with ACL injury should be addressed by concomitant PLTPF reduction and ACL reconstruction to fully restore LTP articular congruence and knee stability.…”
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In Vitro Influenza A Virus-Inactivating Activity of HIDROX^®, Hydroxytyrosol-Rich Aqueous Olive Pulp Extract by Mayar Yasser Zeinelabideen Mohamed, Dulamjav Jamsransuren, Sachiko Matsuda, Koichi Narita, Toshihiro Murata, Haruko Ogawa, Yohei Takeda

“…In HT treatment but not HIDROX treatment, the virucidal activity disappeared, and the induction of abnormal band patterns of a viral protein in WB was cancelled by ROS/RNS scavenger activity. …”
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Emergency Dental Care During the SARS-CoV-2 Pandemic and Its Effect on Medication-Related Osteonecrosis of the Jaw: A Retrospective Study in Hungary by Gabor Kammerhofer, Daniel Vegh, Petra Papocsi, Martin Major, Patrik Fuzes, Mihaly Vaszilko, Marta Ujpal, Kata Sara Haba, Gyorgy Szabo, Zsolt Nemeth

“…The average fasting glucose levels were 5.5 and 5.9 mmol/L in the pre- and post-COVID-19 groups, respectively. Localization patterns shifted, with a higher incidence in the maxilla in the post-COVID-19 group. …”
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Nivolumab in combination with radiotherapy for metastatic esophageal neuroendocrine carcinoma after esophagectomy: a case report by Kuniyasu Takagi, Teppei Kamada, Yoshinobu Fuse, Wataru Kai, Junji Takahashi, Keigo Nakashima, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Shinya Okada, Hironori Ohdaira, Yutaka Suzuki

“…Histopathological examination confirmed a diagnosis of esophageal neuroendocrine carcinoma with features of adenoid cystic-like carcinoma and squamoid pattern (pT2 [MP], INF a, ly1, v1 [EVG], pIM0, pDM0, pRM0, pN1 [1/28], M0; Stage II), which was positive for synaptophysin. …”
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Decoding Cuproptosis-Sphingolipid-Immune Crosstalk in Atopic Dermatitis: A Multi-Omics Network Analysis by Xiaowen Wen, Shulin Jia, Jing Wu, Suitian Wang, Teng Yu, Haoyou Xu

“…Notably, immune infiltration analysis demonstrated abnormal activity in 20 out of 21 immune cell types, particularly Th2 cells and macrophages, which showed strong correlations with CRG expression patterns. …”
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Imaging observation of intervertebral disc degeneration in patients with old thoracolumbar fracture-related kyphotic deformity by Xi-long Cui, Ao Ding, Wen Yin, Wan-mei Yang, Wei Zhang, Hao Wu, Ji-shi Jiang, Yun-lei Zhai, Zi-kai Hua, Hai-yang Yu

“…We hypothesized that patients with OTLFK exhibit distinct patterns of disc degeneration compared to those with chronic low back pain without kyphotic deformity. …”
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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer by Xin Wang, Dawei Zhang, Xiaodi Zhao, Yuanyuan Lu, Yun Zhou, Hua Han, Pei Wang, Wenyao Zhang, Boda Wang, Danxiu Li, Tianyu Cao, Mingfeng Bai

“…Decitabine, a demethylation drug used to treat hematologic neoplasms, disrupted the abnormal methylation pattern of GSDME in tumor cells, enhanced the efficacy of IR700DX-6T-PDT, and elicited a potent antitumor immune response in combination with PD-1 blockade and IR700DX-6T-PDT.Conclusion Our work provides clear a understanding of immunogenic cell death triggered by mitochondria-targeted PDT, offering a new approach for enhancing the efficacy of PD-1 blockade in CRC.…”
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E-cigarettes as a safe alternative to tobacco smoking? A deep dive into vape-associated pneumothorax (VASP) by Saquib Navid Siddiqui, Lwin Paing, Shahnawaz Hashmi, Dinath Perera, Umair Falak

“…Ashraf et al. described potential alveolar damage because of inhaled toxins resulting in bleb formation alongside disruption of visceral mesothelial cells, resulting in a porous elastofibrotic layer that could lead to the development of pneumothorax.1 Also, breathing patterns (Valsalva manoeuvre) while using such devices result in barotrauma to the airways by increasing airway pressure.Surprisingly, 54% of our patients required surgical intervention because thoracostomy failed in resolution. …”
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Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris by Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou

“…Structural modelling predicted that Tet(X14) shared a high homology with the other 12 variants with RMSD value from 0.003 to 0.055, and Tet(X14) can interact with tetracyclines by a similar pattern as the other Tet(X)s. tet(X14) and two copies of tet(X2) were identified on a genome island with abnormal GC content carried by the chromosome of ES183, and no mobile genetic elements were found surrounding, suggesting that tet(X14) might be heterologously obtained by ES183 via recombination. …”
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Restrictive Cardiomyopathies: The Importance of Noninvasive Cardiac Imaging Modalities in Diagnosis and Treatment—A Systematic Review by Aidonis Rammos, Vasileios Meladinis, Georgios Vovas, Dimitrios Patsouras

“…CMR with late gadolinium enhancement (LGE) and novel approaches (myocardial mapping) can direct the diagnosis to specific subtypes of RCM, depending on the pattern of scar formation. When noninvasive studies have failed, endomyocardial biopsy is required. …”
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Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank by Ambre Bertrand, Xin Zhou, Andrew Lewis, Thomas Monfeuga, Ramneek Gupta, Vicente Grau, Blanca Rodriguez

“…Due to its complexity, HFpEF is a challenging condition to treat, making phenotype-specific disease management a promising approach. …”
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Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfus... by Zan Liu, Zitong Zhao, Zhenghui Xiao, Ming Li, Xiyang Wang, Yan Huang, Yong Li

“…Using a bioinformatics database, we initially identified genes with abnormal expression patterns in II/R injury. Then, we confirmed the association between II/R injury, ferroptosis, and the HMGB1/SREBF2 axis through in vivo and in vitro experiments. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…While prior studies have explored CBF abnormalities in depressed adolescents, the specific patterns of CBF changes following pharmacological interventions, particularly with selective serotonin reuptake inhibitors (SSRIs) such as sertraline, remain insufficiently characterized.ObjectiveTo investigate the alterations in CBF induced by an 8-week sertraline treatment in adolescents with depression, and to assess whether baseline CBF can serve as a potential biomarker for predicting treatment response.MethodsA total of 40 adolescents diagnosed with depression and 31 age- and sex-matched healthy controls were enrolled in the study. …”
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A lung cancer mouse model system based on an inbred C3H strain: Ultrasound imaging, pathological analysis, and proteomic biomarker identification by Ulayatul Kustiati, Wahyu Tri Widayati, Dwi Liliek Kusindarta, Dwi Aris Agung Nugrahaningsih, Dinda Aliffia, Wilda Bunga Tina Sanjaya, Hevi Wihadmadyatami

“…Ultrasound imaging revealed tumor formation as hypoechoic areas with irregular patterns on the lung surface. The histological analysis highlighted lymphocyte infiltration, alveolar wall thickening, fibroelastosis, and dysplastic changes in the bronchial epithelium. …”
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ZYGOMYCOSIS IN IMMUNOCOMPROMISED NON-HAEMATOLOGICAL PATIENTS by George Petrikkos, Miranda Drogari-Apiranthitou

“…Suspicion index can be increased through recognition of the differential patterns of clinical presentation. In the <span style="mso-bidi-font-weight: bold;">non</span><strong style="mso-bidi-font-weight: normal;">-</strong> haematological <span style="mso-bidi-font-weight: bold;">immunocompromised </span>patients, zygomycosis can manifest in various clinical forms, depending on the underlying condition: mostly as rhino-orbital or rhino-cerebral in diabetes patients, pulmonary infection in patients with malignancy or solid organ transplantation, disseminated infection in iron overloaded or deferoxamine treated patients, cerebral - with no sinus involvement - in ID users, gastrointestinal in premature infants or malnourishment, and cutaneous after direct inoculation in immunocompetent individuals with trauma or burns.…”
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SUBCLINICAL INTERSTITIAL PULMONARY INJURY IN RHEUMATOID ARTHRITIS by D. V. Bestaev, L. A. Bozhyeva, A. V. Volkov, A. A. Novikov, S. I. Glukhova, E. L. Nasonov

“…The study enrolled 61 inpatients diagnosed with RA (according to the 1987 American College of Rheumatology criteria) who were treated at the V.A. Nasonova Research Institute of Rheumatology; in so doing, high-resolution computed tomography revealed lung changes as a ground glass pattern in 15 patients, reticular striation, traction bronchoectases, and lung tissue changes as honeycomb ones in 25 patients; no lung abnormalities were found in 21 patients. …”
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Reduction of subclinical acute cardiac injury through DIBH radiotherapy: a single-institution real-world clinical cohort analysis by Kun Zhang, Jing Shen, Yongguang Liang, Xiangyin Meng, Bo Yang, Jiabin Ma, Ke Hu, Jie Qiu, Xiaorong Hou, Fuquan Zhang

“…Subclinical acute cardiac injury was characterized by the emergence of elevated myocardial enzymes beyond normal levels and/or EKG alterations in ST-T or T-wave patterns and/or abnormalities detected in ECHO within a 6-month period following radiotherapy. …”
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Clinical and imaging features of parenchymal and non-parenchymal neuro-Behçet’s disease: a systematic review of case reports and series by Omar Al-omoush, Majd M. AlBarakat, Deya’a Alasmar, Ali Al-Khalaileh, Ahmad Alzoubi, Husam Tarakhan, Zaid Shakhatreh, Zaid Hatamleh, Mohammed Abu-saleh, Othman Saleh, Abdalrahman Altiti, Wafa’ A. Hazaymeh, Sakhr Alshwayyat, Hamdah Hanifa, Ethar Hazaimeh

“…While previous research highlights MRI abnormalities and cerebrospinal fluid changes, there hasn’t been a systematic effort to identify patterns specific to newly diagnosed patients. …”
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