Antioxidant Substance Basis and Mechanism of Flavonoids from Apios americana Medic. by Memitimin METSAWUR, Tong LI, Yadi NI, Tianjie YUAN, Daijie WANG, Jin'ao DUAN, Ping XIAO

“…The results revealed that AMF exhibited potent DPPH and OH free radical scavenging abilities, with half-maximal inhibitory concentration (IC50) values of 74.64 μg/mL and 22.54 μg/mL, respectively. …”
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Nonacademic predictors of China medical licensing examination by Jie Sun, Yingying Xie, Ningnannan Zhang, Jingliang Cheng, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Hui Zhang, Shijun Qiu, Xiaojun Xu, Yongqiang Yu, Tong Han, Zuojun Geng, Weihua Liao, Bo Gao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Mengge Liu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Xi-Nian Zuo, Quan Zhang, Feng Chen, Jiance Li, Zhihan Yan, Wen Shen, Yanwei Miao, Junfang Xian, Longjiang Zhang, Kai Xu, Zhaoxiang Ye, Jing Zhang, Guangbin Cui, Chunshui Yu, for the CHIMGEN Consortium

“…Abstract Background National Medical Licensing Examination (NMLE) is the entrance exam for medical practice in China, and its general medical knowledge test (GMKT) evaluates abilities of medical students to comprehensively apply medical knowledge to clinical practice. …”
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Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway by Xuecheng Yu, Xin Wang, Fan Xu, Xinyi Zhang, Muyi Wang, Ruikai Zhou, Zhengyi Sun, Xiaohui Pan, Lin Feng, Wanchao Zhang, Yong Sun, Wenting Zhang, Dong Zhou, Yuqing Jiang

“…In vivo experiments, mouse xenograft model was carried out to assess the tumorigenicity of miR-615-3p. Results This study demonstrated a significant upregulation of miR-615-3p in OS. …”
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Morphosyntactic production and processing skills in relation to age effects and lexical-phonological levels among children with cochlear implants and typically hearing peers: a foc... by Sophie Fagniart, Sophie Fagniart, Brigitte Charlier, Brigitte Charlier, Véronique Delvaux, Véronique Delvaux, Véronique Delvaux, Bernard Georges Harmegnies, Bernard Georges Harmegnies, Bernard Georges Harmegnies, Anne Huberlant, Myriam Piccaluga, Myriam Piccaluga, Kathy Huet, Kathy Huet

“…The perceptual limitations of the CI, which can lead to phonological difficulties, may be responsible for this increased vulnerability in grammatical abilities. In this context, the present study focuses on the morphophonemic processing of items distinguished by nasal and oral vowels in the French language – the feature of vowel nasality being known as challenging for the CI population. …”
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Fe2O3 nanoparticles disrupt microstructure and reduce the viscoelasticity of simulated asthma airway mucus for potential airway mucus clearance applications by Jiayuan Zhong, Lei Shi, Zhiwei Liu, Kai Ni, Lei Liu, Yan Pan, Jingjing Li, Xiaowei Yu, Linhong Deng, Mingzhi Luo

“…Fe2O3 nanoparticles have been developed as carriers to transport drugs through airway mucus (AM); however, their impacts on the rheological properties of AM, especially in disease states, are unknown. In this study, we investigated the abilities of Fe2O3 nanoparticles dispersed in various media to alter the microstructure and rheological behaviors of simulated asthmatic AM. …”
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Newborn mitochondrial DNA copy number is associated with changes to DNA methylation that persist into childhood and are associated with cognitive development by Allison Kupsco, Jonathan A. Heiss, Marco Sanchez-Guerra, Guadalupe Estrada-Gutierrez, Corina Lesseur, Carmen Hernández, Tessa R. Bloomquist, Gaylord Abigail, Jia Guo, Shuang Wang, Julie B. Herbstman, Allan C. Just, Martha M. Téllez-Rojo, Robert O. Wright, Andrea A. Baccarelli

“…At the 48-month visit, we measured DNAm in peripheral blood leukocytes (N = 177) and assessed the McCarthy Scales of Children’s Abilities (N = 290). We performed an epigenome-wide association study (EWAS) with cord mtDNA-CN in mitochondrially relevant genes (23,261 CpG sites) and across the genome (745,691 sites). …”
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A domain-based framework for cognitive profile identification in Parkinson’s disease across diverse samples by Elvira Andújar-Castillo, Carla Carrillo-Molina, Fernando Alonso, Fernando Alonso, Clara Villanueva-Iza, Clara Villanueva-Iza, Gustavo Fernández-Pajarín, Gustavo Fernández-Pajarín, Angel Sesar, Angel Sesar, Isabel Jiménez-Martín, Isabel Jiménez-Martín, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Maria Jesús Lama, Pablo Mir, Pablo Mir, Pablo Mir, Elena Perez-Hernandez, Cristina Nombela Otero

“…Five cognitive domains were constructed, addressing attention/working memory, executive functions, memory, visuospatial abilities, and language, using composite z-scores derived from standardized neuropsychological tests.ResultsLatent Cluster Analysis identified three distinct cognitive profiles: (1) a fronto-striatal profile characterized by mild deficits in executive and attention functions and intact visuospatial abilities, (2) a posterior cortical profile marked by severe memory and visuospatial impairments but strong language performance, and (3) a preserved profile displaying mild deficits across multiple domains. …”
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Construct Validity and Internal Consistency of the Italian Version of the PedsQL^TM 4.0 Generic Core Scale and PedsQL^TM 3.0 Cerebral Palsy Module by Ilaria Pedrinelli, Sofia Biagi, Domenico Marco Romeo, Elisa Musto, Valeria Fagiani, Martina Lanza, Erika Guastafierro, Alice Colombo, Andrea Giordano, Cristina Montomoli, Cristiana Rezzani, Tiziana Casalino, Eugenio Mercuri, Daria Riva, Matilde Leonardi, Giovanni Baranello, Emanuela Pagliano

“…Conclusions: The present study confirms the internal consistency and construct validity of the Italian version of both PedsQL^TM modules. …”
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Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps by Ye Liu, Yonghao Liu, Zhifei Ye, Xinxin Wang, Junyi Li, Peter L. Mei, Li Duan, Ben Wang, Chun Xu, Wei Xiong, Yan He, Qingsong Ye

“…Results DPSC-CM demonstrated superior efficacy in cell preservation. Studies in a mouse model of cranial defects showed that the cranial flaps preserved with DPSC-CM in combination with deep cryopreservation (-196 °C) showed significantly better bone healing after cranioplasty than the other groups, and their neoangiogenic and anti-inflammatory abilities were also significantly better than those of the other groups. …”
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Impacts of loading thymoquinone to gold or silver nanoparticles on the efficacy of anti-tumor treatments in breast cancer with or without chemotherapeutic cisplatin by Soha Gomaa, Mohamed Nassef, Ahlam Abu-Shafey, Mona Elwan, Asmaa Adwey

“…Our results further revealed that the combined synergistic approach of TQ’s anti-tumor properties, along with the efficient penetration abilities of AuNPs or AgNPs, led to a significant inhibition of the growth of tumor cells in EAC tumor-bearing mice. …”
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Características de los talleres extraescolares de los establecimientos educacionales de la Araucanía, Chile (Characteristics of extracurricular activities of educational establish... by Noemi Salvador Soler, Andrés Uribe Delgado, Carlos Roberto Arriagada Hernández

“…Extracurricular activities benefit the integral development of students by stimulating the development of various abilities, capacities and / or talents. In addition, they represent an opportunity to counteract the levels of sedentary lifestyle that young people present at the school level. …”
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Estimulación temprana como programa neurológico en las capacidades y destrezas en niños en etapa infantil by Ruth Narciza Zambrano Pintado, Hugo Luis Moncayo Cueva, Soraya Nathaly López Arcos, Diego Mauricio Bonilla Jurado

“…The research paradigm is positivist with a quantitative approach, a non-experimental type with a documentary and empirical source. Considering the study space is field and longitudinal, and the level is explanatory. …”
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El fútbol como herramienta para el trabajo de los valores y actitudes en la ESO según las Competencias Básicas (Football as a tool for the job of the values and attitudes in the ES... by David Rodríguez Ruiz

“…Palabra clave: Valores, Actitudes, Futbol, Competencias Básicas, Educación. Abstract: In this study we present a practical experience conducted in the I.E.S. …”
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Conceptual frameworks, competencies, contents and teaching methods in planetary health education for health students and professionals: a global systematic scoping review by Carme Carrion, Camilla Alay Llamas, Eka Dian Safitri, Carola Domènech-Panicello, George S. Downward, Ardi Findyartini, Nadia Greviana, Indah Kartika Murni, Sie Meng Lee, Mireia Llimós, Ariadna Moreno, Shannon Leigh O’Brien, Isabel Ruiz-Mallén, Diantha Soemantri, Indah Suci Widyahening, Respati Wulansari Ranakusuma, Dewi Yunia Fitriani, Cristina O’Callaghan-Gordo

“…Methods Following PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines, we included studies targeting undergraduate and postgraduate students, focusing on skills, knowledge, and abilities related to planetary health, published in English or Spanish. …”
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Angiotensin II Attenuates the Bioactivities of Human Endothelial Progenitor Cells via Downregulation of β2-Adrenergic Receptor by Seon Jin Lee, Da Yeon Kim, Jisoo Yun, Sung Hyun Choi, Seok Yun Jung, Songhwa Kang, Ji Hye Park, Yeon Ju Kim, Jong Seong Ha, Seung Taek Ji, Woong Bi Jang, Dong Hyung Lee, Dongjun Lee, Sang-Mo Kwon

“…EPC functional assay clearly demonstrated that the treatment with ADRB2 agonists significantly increased EPC bioactivities including cell proliferation, migration, and tube formation abilities. However, EPC bioactivities were decreased dramatically when treated with Ang II. …”
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Visit-to-visit ultrafiltration volume variability predicts all-cause mortality in patients receiving hemodialysis by Quanchao Zhang, Ning Wang, Ling Nie, Caibao Lu, Hongwei Chen, Wenchang He, Moqi Li, Yiqin Wang, Jinghong Zhao, Jiachuan Xiong

“…Receiver operating characteristic curves were used to evaluate the predictive abilities of UVSD and UVCV for short-term and long-term survival rates.Results A total of 283 HD patients were included. …”
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NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice by Cher-Chia Chang, Yea-Hwey Wang, Jiin-Cherng Yen, Chia-Ching Liaw, Keng-Chang Tsai, Wen-Chi Wei, Wen-Fei Chiou, Chun-Tang Chiou, Kuo-Tong Liou, Yuh-Chiang Shen, Yi-Chang Su

“…To explore whether NRICM101 could combat COVID-19 brain fog, we tested NRICM101 on hACE2 transgenic mice administered the S1 protein of SARS-CoV-2, aiming to mitigate S1-induced cognitive issues by measuring animal behaviors, immunohistochemistry (IHC) staining, and next-generation sequencing (NGS) analysis. The study revealed that S1 protein-administered mice displayed marked signs of brain fog, characterized by reduced learning, memory, and nesting abilities. …”
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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

“…Conclusions This study effectively integrates the CBT-I knowledge graph with the large language model through the RAG architecture, which improves the professionalism of the eCBT-I intelligent dialogue system. …”
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Calcium pyruvate supplementation ameliorates fat accumulation and hepatic health by enhancing lipid utilization and inhibiting gluconeogenesis in Nile tilapia fed high-fat diets by Leping Liu, Wenya Gao, Qiangwei Li, Yalong Xu, Mingxu Xie, Chenglong Wu, Yan Liu

“…Consequently, 0.4 %-1.2 % CP supplementation in HFDs alleviates fat accumulation and increases anti-oxidant and immune abilities by enhancing lipid utilization and inhibiting gluconeogenesis. …”
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Identification of Tumor-Suppressive <i>miR-30a-3p</i> Controlled Genes: <i>ANLN</i> as a Therapeutic Target in Breast Cancer by Reiko Mitsueda, Ayako Nagata, Hiroko Toda, Yuya Tomioka, Ryutaro Yasudome, Mayuko Kato, Yoshiaki Shinden, Akihiro Nakajo, Naohiko Seki

“…., their proliferation, migration, and invasion abilities. These data indicated that <i>miR-30a-3p</i> acted as a tumor-suppressive miRNA in BC cells. …”
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