Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast ca... by Guo-Tian Ruan, Li-Chen Zhu, Hai-Lun Xie, He-Yang Zhang, Meng-Meng Song, Li Deng, Han-Ping Shi

“…We established a co-culture model involving mature adipose cells (hADSC and 3T3-L1) and TNBC cells. Cell invasion abilities were assessed using wound healing and Transwell assays. …”
Get full text

A network analysis of facial and vocal emotion recognition deficits in schizophrenia by Wenxuan Zhao, Qi Zhang, Long Gao, Ning Fan, Yajun Yun, Jiaqi Song, Yunhe Ji, Yongqian Wang, Meng Zhang, Fude Yang, Shuping Tan

“…IntroductionFacial and vocal emotion recognition deficits are common in individuals with schizophrenia.MethodsIn this observational, single-center study, 106 patients with schizophrenia (SCZ) and 118 age- and sex-matched healthy controls underwent cognitive and emotional function assessments. …”
Get full text

Silencing long non-coding RNA ROR improves sensitivity of non-small-cell lung cancer to cisplatin resistance by inhibiting PI3K/Akt/mTOR signaling pathway by Hui Shi, Jin Pu, Xiao-Li Zhou, Yun-Ye Ning, Chong Bai

“…Cell proliferation, migration, and invasion abilities decreased in the si-ROR and Wortmannin groups. …”
Get full text

Wearable sensors for measuring spontaneous upper limb use in children with unilateral cerebral palsy and typical development by Elena Beani, Mattia Franchi de ’Cavalieri, Silvia Filogna, Veronica Barzacchi, Matteo Cianchetti, Martina Maselli, Giada Martini, Valentina Menici, Giuseppe Prencipe, Elisa Sicola, Giovanni Cioni, Giuseppina Sgandurra

“…While there are some clinical assessment tools aimed to quantify the Upper Limbs (UpLs) use and the manual abilities, acquiring information regarding the motor abilities outside the clinical environment, such as the UpLs use and their asymmetry during daily life, could provide a more complete evaluation of the child and open a new clinical reasoning. …”
Get full text

Research discussion groups as a component of the development of practical skills of students in the field of training “Construction” by N. I. Taraseeva, O. V. Baulina, N. A. Dezhinova

“…The modern educational process, including theoretical and practical development of the basic educational program, provides that 40% of the basic information the student is receiving during the classes, the remaining 60% — for self-study. Research, practical and creative discussion groups in educational institutions of different levels (school, college, University) are helping talented and interested young people to develop their abilities and find their practical application. …”
Get full text

Item-level measurement properties of the pediatric awareness and sensory motor assessment in children with medical complexity by Brooke Mulrenin, Bryant A. Seamon, Carrie Cormack, Kimberly Lane Kascak, Cynthia Dodds

“…Current assessment tools fail to detect subtle abilities in CMC, hindering development of effective rehabilitation goals and interventions. …”
Get full text

Reflexive Methods of Knowledge in Educational Activities: Phenomenological Hermeneutics by T. N. Korneenko

“…The means of phenomenological hermeneutics described in the article become especially relevant in the conditions of digitalisation and computerisation of pedagogical communication: their use better compensates for the costs of technical methods of training by the means of real teacher-student collaboration through dialogue, knowledge process, experience, interpretation and reflection of the discipline under study.…”
Get full text

Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world by Francesca Terracciani, Antonio De Vincentis, Daphne D’Amato, Laura Cristoferi, Alessio Gerussi, Pietro Invernizzi, Miki Scaravaglio, Ester Vanni, Daniela Campion, Anna Morgando, Vincenzo Valiani, Vincenzo Boccaccio, Filomena Morisco, Lorenzo Surace, Ilaria Cavalli, Guido Delle Monache, Federico Salomone, Donatella Ieluzzi, Debora Angrisani, Raffaella Tortora, Biagio Cuffari, Alessandra Moretti, Gerardo Nardone, Stefano Fagiuoli, Mauro Viganò, Giovanni Vettori, Federica Cerini, Giancarlo Gimignani, Alberto Mattalia, Fabrizio Pizzolante, Nicoletta De Matthaeis, Cristina Rigamonti, Giulia Francesca Manfredi, Valentina Boano, Paola Begini, Ana Lleo, Francesca Colapietro, Riccardo Plebani, Domenico Alvaro, Rosanna Venere, Elisabetta Degasperi, Marta Borghi, Pietro Lampertico, Edoardo Giovanni Giannini, Sara Labanca, Raffaella Viganò, Federico D'Amico, Antonino Castellaneta, Francesco Squeo, Luca Cadamuro, Luigi Capodicasa, Marco Marzioni, Valerio Buzzanca, Guido Poggi, Alessandro Mussetto, Raffaele Cozzolongo, Francesco Losito, Gaetano Bertino, Maurizio Russello, Mariarita Cannavò, Paolo Scivetti, Maurizio Pompili, Annalisa Tortora, Anna Grazia Niro, Rosa Cotugno, Pietro Pozzoni, Alessia Riva, Luchino Chessa, Michela Miglianti, Giuseppe Cuccorese, Valeria Pace Palitti, Ludovico Abenavoli, Natalia Terreni, Teresa Zolfino, Olivia Morelli, Carlo Saitta, Silvia Casella, Adriano Pellicelli, Maurizia Brunetto, Barbara Coco, Andrea Galli, Fabio Marra, Armando Curto, Annarosa Floreani, Nora Cazzagon, Paolo Rollo, Emanuela Bonaiuto, Loredana Simone, Luigi Muratori, Floriano Rosina, Marco Distefano, Elisa Capello, Valentina Bellia, Rodolfo Sacco, Giuliano Alagna, Leonardo Baiocchi, Lory Saveria Crocé, Chiara Ricci, Paolo Poisa, Antonio Izzi, Sara Boninsegna, Vincenza Calvaruso, Marco Carbone, Umberto Vespasiani-Gentilucci, Giulia Di Pasquale, Paolo Gallo, Cossiga Valentina, Falbo Elisabetta, Tatonetti Riccardo, Musumeci Martina, Christou Chrysanthi, Paolo Villa, Eugenia Pesatori, Alessandro Loglio, Alessandro Conforti, Valentina Feletti, Alessandra Garriba, Evelise Frazzetto, Sara Alecci, Annalisa Ardiri, Martina Costanzo, Francesca Romana Ponziani, Francesca Fianchi, Niccolò Bina, Francesca Zani, Barbara Omazzi, Olga Falco, Jessica Piroddu, Anna Rocca, Paola Carnì, Giuseppe Grassi, Francesco Pezzato, Erica D'Ovidio, Matteo Peviani, Alessandro Bellia, Maria Cristina Sapere, Massimiliano Loreno, Masutti Flora, Fusaro Lisa, Riccardo Perbellini, Roberta Soffredini, Concetta Pitrone, Roberto Filomia, Alba Rocco, Pasquale De Crescenzo, Pasquale Piscitelli, Francesca Toffolon, Fabiana Marchetti, Alessandro Inno, Marco Guarracino, Giovan Giuseppe Di Costanzo, Nicola Alessi, Maria Cristina Neglia, Scudu Chiara

“…Impact and Implications: After the conditional approval of OCA for the treatment of PBC, the main confirmatory study failed to demonstrate OCA's ability to reduce liver-related events, leading the EMA to revoke the drug's marketing authorization. …”
Get full text

Gender differences in performance under different evaluation schemes and the leaky pipeline in economics by Fabiana Rocha, Paula Pereda, Maria Dolores Montoya Diaz, Bruna Borges, Gabriel Facundes Monteiro, Luiza Karpavicius, Liz Matsunaga, Clara Brenck

“… The leaky pipeline remains a persistent challenge to achieving gender diversity in the economics career. In this study, we contribute to the existing literature by investigating gender differences in academic performance in economics in Brazil in two distinct stages: undergraduate studies and graduate admission exams. …”
Get full text

BICUSPID AORTIC VALVE (A DEVELOPMENT OF INSIGHT INTO VALVULOPATHIES) by S. L. Dzemeshkevitch, V. A. Ivanov, E. R. Charchian, E. P. Evseev, Yu. V. Frolova, A. N. Lugovoy, S. V. Fedulova, V. V. Khovrin, A. A. Bukaeva, E. V. Zaklyazminskaya

“…Aim. To study different ways of development and combinational abilities of pathological changes common for bicuspid aortic valvulopathy. …”
Get full text

NIR-programmable 3D-printed shape-memory scaffold with dual-thermal responsiveness for precision bone regeneration and bone tumor management by Hui Wang, Jiaxin Zhang, Zuhao Li, Jiaqi Liu, Haoran Chang, Shipu Jia, Zexin Di, He Liu, Jincheng Wang, Delong Gao, Chenyu Wang, Guiwei Li, Xin Zhao

“…Additionally, beta-tricalcium phosphate (β-TCP), with its osteogenic properties, and magnesium (Mg) powder, with its photothermal and bone-promoting abilities, were incorporated to improve the osteogenic potential of the composite and enable the material to respond intelligently to near-infrared (NIR) light. …”
Get full text

Assessment of durum wheat (Triticum durum Desf.) genotypes based on their agro-physiological characteristics and stress tolerance indices by Radhia MEKAOUSSI, Abou-bakr RABTI, Zine El Abidine FELLAHI, Abderrahmane HANNACHI, Amar BENMAHAMMED, Hamenna BOUZERZOUR

“…The present study aimed to investigate the extent of variability and relationships between grain yield and morpho-physiological durum wheat traits. …”
Get full text

Depressive and Anxiety Symptoms, Defense Mechanisms, and Mentalized Affectivity in Individuals with Myocardial Infarction: An Empirical Investigation by Gianluca Cruciani, Gabriele Lo Buglio, Annalisa Tanzilli, Marianna Liotti, Matteo Scalzeri, Gaetano Tanzilli, Federica Galli, Vittorio Lingiardi

“…Defense mechanisms and mentalized affectivity play key roles in affective regulation; however, their roles in individuals with MI remain underexplored. This study examined the relationship between depressive and anxiety symptoms, defensive functioning, and mentalized affectivity in MI patients. …”
Get full text

The effectiveness of integrating making every contact count into an undergraduate medical curriculum by Robyn Fletcher, Alexander Hammant, Rebecca Symes, Andrew Turvey, Andy Ward, Ary Mahdzir, Bharathy Kumaravel

“…The MECC OSCE station was good at discriminating between students' abilities (group discrimination metric 4.36–4.44). …”
Get full text

Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors by Xun Zhou, Eva Berenger, Yong Shi, Vera Shirokova, Elena Kochetkova, Tina Becirovic, Boxi Zhang, Vitaliy O Kaminskyy, Yashar Esmaeilian, Kayoko Hosaka, Cecilia Lindskog, Per Hydbring, Simon Ekman, Yihai Cao, Maria Genander, Marcin Iwanicki, Erik Norberg, Helin Vakifahmetoglu-Norberg

“…Abstract Tumors often recapitulate programs to acquire invasive and dissemination abilities, during which pro-metastatic proteins are distinctively stabilized in cancer cells to drive further progression. …”
Get full text

Trusted Professional Multi-Agency Transitions for Young People Facing Multiple Disadvantage – Learning from Co-Production by a Third Sector Partner in the Plymouth Alliance, UK by Gemma Doyle, Sean Mitchell, Sue Hawley, Katy Krysiak, Felix Gradinger

“…Relational practices were tested to support navigating system challenges, better tailor to young people’s abilities and needs and improve integrated care partnership working and workforce development. …”
Get full text

Integrative approaches to depression in end-stage renal disease: insights into mechanisms, impacts, and pharmacological strategies by Cheng Yuan, Fengpei Chang, Fengpei Chang, Hongfu Zhai, Jiayin Du, Danqin Lu, Haoli Ma, Xiaoyan Wu, Xiaoyan Wu, Ping Gao, Lihua Ni

“…Depression is a frequently overlooked psychiatric symptom in patients with end-stage renal disease (ESRD), seriously affecting their quality of life, risk of death, adherence to treatment, cognitive abilities, and overall health outcomes. The study investigates the prevalence of depression is in ESRD patients, along with the methods for assessment, diagnostic guidelines, underlying factors, consequences, and management strategies. …”
Get full text

Protein characterisation and antioxidant potential of fresh cheese obtained by kombucha inoculum by Maja Bjekić, Mirela Iličić, Vladimir Vukić, Dajana Vukić, Katarina Kanurić, Branimir Pavlić, Zoran Zeković, Ljiljana Popović, Aleksandra Torbica, Jelena Tomić, Jovana Degenek

“…Protein profile, in vitro gastrointestinal digestion and antioxidant potential of two fresh cheese samples obtained by kombucha inoculum and traditional starter culture have been investigated in this study. There is a significant difference in protein profile and bioactive potential between fresh cheese samples. …”
Get full text

Promoting effects of NaCl and KCl stresses on astaxanthin yield in Microcystis flos-aquae by Junjie Ma, Zhehan Yang, Zhuxin Jin, Lexin Huang, Yinggang Wei, Wangbo Chen, Zhaojiang Zuo

“…This study was to uncover the astaxanthin accumulation mechanism of Microcystis flos-aquae stressed by NaCl and KCl and select the optimal condition for astaxanthin production. …”
Get full text

Body composition and performance variables differences in female volleyball players by age-group and playing position by Lucas Samuel Tessutti, Samuel da Silva Aguiar, Gustavo De Conti Teixeira Costa, Filipe Manuel Clemente, Ricardo Franco Lima, Rodrigo Vanerson Passos Neves, Gibson Moreira Praça, Henrique de Oliveira Castro

“…The aim of the present study was to evaluate the age and inter- and intra-position differences in the anthropometric variables and physical performance in young female players of Brazilian women's volleyball. …”
Get full text