Press Forward: Advancing Vaccine Production With High Hydrostatic Pressure Inactivation for Global Health Equity by Miss Martina Brandolini, Dr Alessandra Mistral De Pascali, Mr Giorgio Dirani, Mr Massimiliano Guerra, Ms Silvia Zannoli, Prof Pietro Rocculi, Dr Michele Morbarigazzi, Dr Davide Lelli, Dr Antonio Lavazza, Dr Francesca Battioni, Prof Monica Cricca, Prof Alessandra Scagliarini, Prof Vittorio Sambri

“…Discussion: Preliminary results show HHP efficacy in producing viral inactivates that can efficiently be used as immunogens in murine animal models. …”
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Progress and application of salinomycin-induced cell autophagy in anti-cancer treatment by CHEN Siyuan, HU Ji'an

“…Autophagy is always upregulated in hypoxic and low pH regions of tumors for the metabolic adaptation of cancer cells. The efficiency of hydroxychloroquine, a late-stage autophagy inhibitor by disrupting lysosome acidification under clinical investigation, is strongly impaired in acidic tumor environments due to drug resistance. …”
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Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples by Emily Toscano-Guerra, Roberto Alcántara, Katherine Lozano Untiveros, Robert Gilman, Louis Grandjean, Mirko Zimic, Patricia Sheen

“…The MODS-WQ assay stands out for its ability to quantify pyrazinoic acid (POA) production, as a reliable indicator of PZA resistance. …”
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An Ensemble Learning-Based Predictive Parameterization Approach for Permanent Magnet Synchronous Machines by Sema Nur Ipek, Nur Bekiroglu, Murat Taskiran

“…Permanent Magnet Synchronous Machines (PMSMs) are extensively utilized for their ability to deliver accurate position control, and the equivalent circuit characteristics of these machines are essential in several applications, particularly in formulating the control strategy. …”
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Synergistic effects of foliar applied glycine betaine and proline in enhancing rice yield and stress resilience under salinity conditions by Sobhi F. Lamlom, Aly A. A. El-Banna, Honglei Ren, Bassant A. M. El-Yamany, Ehab A. A. Salama, Gawhara A. El-Sorady, Mohamed M. Kamara, Amal Mohamed AlGarawi, Ashraf Atef Hatamleh, Abdelsalam A. Shehab, Ahmed M. Abdelghany

“…Soil salinity is one of the most challenging environmental factors affecting rice productivity, particularly in regions with high saline soils such as Egypt. The ability of rice to maintain high yield and quality under saline stress is often limited, leading to significant reductions in productivity. …”
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DOES ARTIFICIAL INTELLIGENCE HELP WOMEN IN INTERNATIONAL ARBITRATION? by Magdalena Łągiewska

“…Artificial Intelligence (AI), in particular, is reshaping the field by introducing innovation-driven solutions that enhance efficiency. This article explores AI’s role in international arbitration, focusing on its potential to improve gender diversity in the appointment of arbitrators. …”
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Improving the Nutrient Absorption and Yield of Chickpeas (Cicer arietinum) and Barley (Hordeum vulgare) under Row Inter-cropping with Foliar Application of Plant Growth Regulators... by A Talebi, M. R Owji, F Mohajeri, M. R Baziar

“…Also, row inter-cropping can increase the efficiency of the used resources. Improving the yield of chickpeas and barley in row inter-cropping using foliar spraying of salicylic acid, jasmonic acid and brassinosteroid was the hypothesis proposed in this research. …”
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The Paleochrono-1.1 probabilistic model to derive a common age model for several paleoclimatic sites using absolute and relative dating constraints by F. Parrenin, M. Bouchet, C. Buizert, E. Capron, E. Corrick, R. Drysdale, K. Kawamura, A. Landais, R. Mulvaney, I. Oyabu, S. O. Rasmussen

“…Paleochrono-1.1 outperforms IceChrono in terms of computational efficiency, ease of use and accuracy. We demonstrate the ability of Paleochrono-1.1 in an experiment involving only the MSL speleothem in Hulu Cave (China), and we compare the resulting age model with the Speleothem Isotope Synthesis and Analysis version 2 (SISALv2) age models. …”
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Prediction of the Calorific Value and Moisture Content of <i>Caragana korshinskii</i> Fuel Using Hyperspectral Imaging Technology and Various Stoichiometric Methods by Xuehong De, Haoming Li, Jianchao Zhang, Nanding Li, Huimeng Wan, Yanhua Ma

“…This has seriously hindered the ability of large-scale, rapid detection of fuel particles in industrial production lines. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…BackgroundBone marrow mesenchymal stem cells (BMSCs) hold promise for repairing myocardial injury following acute myocardial infarction (AMI), but their clinical application is hindered by poor migration, homing efficiency, and survival rates. Previously, we demonstrated that ELABELA (ELA), a small peptide, enhances the survival of rat BMSCs under hypoxia-reoxygenation (H/R) conditions by activating ERK1/2. …”
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Prognostic Factors and Nomogram for Klebsiella pneumoniae Infections in Intensive Care Unit by Du C, Zhang H, Zhang Y, Zhang H, Zheng J, Liu C, Lu F, Shen N

“…The nomogram demonstrated good accuracy and predictive efficiency, providing a practical tool for short-term risk assessment and potentially improving clinical outcomes by providing early intervention and personalized patient management.Keywords: Klebsiella pneumoniae, infection, prognosis, mortality, risk factor…”
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Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer by Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X

“…In vitro studies investigated its effects on A549 cell viability, apoptosis, uptake ability, and cell cycle. In vivo studies examined its distribution and/or anti-tumor effects in subcutaneous xenograft tumors in mice. …”
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A tailored phytosomes based nose-to-brain drug delivery strategy: Silver bullet for Alzheimer's disease by Xiao Yue, Haihua Guo, Guanlin Wang, Jieyun Li, Zizhao Zhai, Zeting Wang, Wenhao Wang, Ziyu Zhao, Xiao Xia, Chuangxin Chen, Yingtong Cui, Chuanbin Wu, Zhengwei Huang, Xuejuan Zhang

“…On the other hand, a tailored nose-to-brain drug delivery system was established for the satisfactory nose-to-brain delivery efficiency, avoiding the obstacle of BBB through bypassing it. …”
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Polishing inner wall of crossed deep micropores using magnetic microabrasive jet technology by Zezhi WANG, Jie WANG, Xiaogang MA, Fan LI, Xinya FAN, Yan CHEN

“…Finding suitable processing parameters will further improve the quality and efficiency of workpiece processing.…”
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Daily Runoff Prediction Model Based on Multivariate Variational Mode Decomposition and Correlation Reconstruction by DING Jie, TU Peng-fei, FENG Yu, ZENG Huai-en

“…[Conclusions](1) The MVMD decomposition method can control the number of decomposition layers, ensuring complete signal feature extraction without overfitting while improving processing speed.(2) Pearson correlation coefficient method enhances prediction accuracy through decomposed data classification.(3) The MEA-BP can improve signal-to-noise ratio, adapt to complex environments, enhance learning efficiency and generalization ability, and reduce computational complexity.(4) The GWO-ELM algorithm integrates grey wolf optimizer with extreme learning machine, providing a fast and adaptive solution for time-series prediction with reduced overfitting and improved efficiency.(5) The overall combined model can efficiently and stably process large amount of data while ensuring high accuracy.…”
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Reducing Cd Uptake by Wheat Through Rhizosphere Soil N-C Cycling and Bacterial Community Modulation by Urease-Producing Bacteria and Organo-Fe Hydroxide Coprecipitates by Junqing Zhang, Shuangjiao Tang, Hao Wei, Lunguang Yao, Zhaojin Chen, Hui Han, Mingfei Ji, Jianjun Yang

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Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms by Deborah L. Harrington, Deborah L. Harrington, Qian Shen, Qian Shen, Annemarie Angeles-Quinto, Annemarie Angeles-Quinto, Sharon Nichols, Tao Song, Hayden Hansen, Kate A. Yurgil, Kate A. Yurgil, Roland R. Lee, Roland R. Lee, Dewleen G. Baker, Dewleen G. Baker, Dewleen G. Baker, Ming-Xiong Huang, Ming-Xiong Huang

“…Though larger samples are needed for verification, the preliminary results provide new insights into the associations between regional abnormalities and different facets of emotion regulation and cognition, which in turn may impact an individual’s functional abilities in daily life and responsiveness to psychotherapy.…”
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Evaluating yield and land equivalent ratio in mixcropping of balangu (Lallemantia royleana Benth.) and chickpea (Cicer arietinum L.) affected by weed competition by Ebrahim Eizadi-Darbandi, Arash Maghsoudi, Elnaz Molaei

“…Introduction Intercropping is considered to be important for a lot of reasons like optimizing water and soil resource uses, increasing water use efficiency, increasing pest, diseases and weed control efficiency, decrease pesticide application, increasing total production and land equivalent ratio and sustainability in agroecosystems. …”
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Integrative review of artificial intelligence applications in nursing: education, clinical practice, workload management, and professional perceptions by Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken, Ahmed Ghannam, Fuad H. Abuadas, Joel Somerville, Joel Somerville, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair

“…Nurses noted that these technologies enhanced the precision of assessments without wholly replacing the need for human touch.Workload and workflow managementAI systems that automated routine follow-up tasks and generated predictive workload models freed nurses from repetitive, non-clinical duties and offered data-driven insights to inform staffing decisions. These efficiencies allowed nursing teams to devote more time to direct patient care and were associated with reductions in burnout and improved workplace morale.Nursing perceptionsAcross practice settings, nursing students and practicing nurses broadly welcomed AI’s ability to streamline workflows and support decision-making, recognizing its potential to elevate patient care and professional practice.Ethical implicationsSimultaneously, nurses voiced significant ethical concerns—chiefly around safeguarding patient data privacy, mitigating algorithmic bias, and preserving the compassionate, human-centered essence of nursing in an increasingly automated environment.Framework and recommendationsThe Nursing AI Integration Roadmap (NAIIR) was developed, emphasizing transformational education, advanced clinical integration, ethical governance, robust organizational infrastructure, participatory design, and rigorous economic evaluation. …”
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Evaluation of yield and yield components of green bean and bell pepper under replacement and additive intercropping systems by Alireza Koocheki, Mehdi Nassiri Mahallati, Mohammad Hassan Hatefi Farajian

“…Plants from the family of legumes are among the plants that have a special place in intercropping because of their nitrogen fixation ability. Usefulness of intercropping cultivation of sweet corn and green bean has been reported to be better than monoculture. …”
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