Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival by Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni

“…Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ability to block these molecular changes and treat recurrent disease. …”
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p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer by Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello

“…Finally, the loss of p27^Kip1 ability in blocking cell proliferation was in part explained through the different binding efficiency that mutant p27^Kip1 forms exhibited with Cyclin/Cyclin-dependent Kinase complexes (or proteins involved indirectly in that binding) with respect to the WT.…”
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Nano-pumice derived from pumice mine waste as a low-cost electrode catalyst for microbial fuel cell treating edible vegetable oil refinery wastewater for bioenergy generation and r... by Fatemeh Eslami, Kamyar Yaghmaeian, Reza Shokoohi, Roohallah Sajjadipoya, Alireza Rahmani, Hedieh Askarpur, Abbas Norouzian Baghani, Hossein Jafari Mansoorian, Farshid jaberi Ansari

“…MFC-1 achieved removal efficiencies of 66 ± 3 % for COD, 57 ± 6 % for NH4+-N, 48 ± 3 % for TP, 45 ± 3 % for SO42−, 65 ± 3 % for TSS, and 61 ± 1 % for TDS. …”
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Clinical–radiomics model for predicting internal mammary lymph node metastasis in operable breast cancer patients by Wei Wang, Wenyu Zhang, Ting Yu, Ting Yu, QingWei Wu, ChengLin Yang, ChengLin Yang, Jianbin Li

“…DCA substantiated the clinical–radiomics model’s optimal predictive efficiency, enhanced discriminatory ability, and maximum benefit. …”
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Iteratively refined ChatGPT outperforms clinical mentors in generating high-quality interprofessional education clinical scenarios: a comparative study by Tian Qingquan, Ren Feng, Zou Bin, Zhou Jingyu, Liu Ganglei, Zheng Yanwen, Zhang Zequn, Wang Qiyuan, Wang Shalong

“…While AI tools like ChatGPT are increasingly being explored for this purpose, they have yet to demonstrate the ability to generate high-quality IPE scenarios, which remains a significant challenge. …”
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Does prioritization of COVID vaccine distribution to communities with the highest COVID burden reduce health inequity? by Hae-Young Kim, Anna Bershteyn, Rienna Russo, Jessica Mcgillen, Julia Sisti, Charles Ko, Jaimie Shaff, Remle Newton-Dame, R. Scott Braithwaite

“…., the equally preferred number of deaths, considering equity and efficiency) across a range of inequality aversion (Atkinson’s index, ε=0–20). …”
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5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia by Zuowei Yuan, Guoyun Jiang, Ying Yuan, Qian Liang, Yaxin Hou, Wenyao Zhang, Lujia Tang, Kelong Fan, Wenli Feng

“…Pyroptosis, a form of programmed cell death, has emerged as a promising strategy in cancer therapy due to its ability to eliminate tumor cells while stimulating antitumor immunity. …”
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Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain by Mizuki Fukuta, Sayo Fukano, Naoya Maekawa, Shintaro Kobayashi, Shunsuke Okamoto, Minato Hirano, Junko Nio-Kobayashi, Hiroaki Kariwa, Shigeru Kawakami, Satoru Konnai, Kentaro Yoshii

“…The RVG-fused antibodies exhibited a higher transport efficiency to the brain than the non-fused antibodies following peripheral injection in mice. …”
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Potential of Natural Sheep Casings Waste as a Sole Nitrogen Source for the Marine Microalga <i>Scenedesmus rubescens</i> MDP19 Growth and Lipid Production by Sanaa Ouzakar, Nadia Skali Senhaji, Francesca Rigano, Cinzia Cafarella, Francesco Cacciola, Luigi Mondello, Jamal Abrini

“…For this purpose, we evaluated the effects of different NSCW concentrations (0.25–5 g L⁻¹) on the microalga growth, its ability to utilize organic waste components (proteins, amino acids, and carbohydrates) as nutrients, and its efficiency in eliminating nitrogen and phosphorus. …”
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Large language models meet user interfaces: The case of provisioning feedback by Stanislav Pozdniakov, Jonathan Brazil, Solmaz Abdi, Aneesha Bakharia, Shazia Sadiq, Dragan Gašević, Paul Denny, Hassan Khosravi

“…Incorporating Generative Artificial Intelligence (GenAI), especially Large Language Models (LLMs), into educational settings presents valuable opportunities to boost the efficiency of educators and enrich the learning experiences of students. …”
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Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants by Claire Burny, Mia Potočnjak, Mia Potočnjak, Annika Hestermann, Sophie Gartemann, Michael Hollmann, Frank Schifferdecker-Hoch, Nina Markanovic, Simone Di Sanzo, Simone Di Sanzo, Michael Günsel, Victor Solis-Mezarino, Moritz Voelker-Albert, Moritz Voelker-Albert

“…Additionally, epigenetic changes correlate with changes in immune response plasma factors, reflecting their comparable ability to rate therapy effects at the molecular level. …”
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Research on intra-day multi-objective operation control of distribution network system under quantum communication optimization by QIAN Hao, DONG Zhihui, XIANG Jundong, ZHENG Jiewen, TANG Zhipeng, GUO Qiang

“…The introduction of quantum communication enables it to cope with high uncertainty in the scheduling process, ensure secure data transmission, and improve scheduling efficiency. By utilizing the high security, large capacity transmission, and strong anti-interference ability of quantum communication, we can solve the limitations of traditional communication methods in distribution network scheduling. …”
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Evaluation of Antioxidant, Xanthine Oxidase-Inhibitory, and Antibacterial Activity of <i>Syzygium cumini</i> Linn. Seed Extracts by Jitendra Pandey, Nitesh Jaishwal, Mamta Jayswal, Deep Chand Gupta, Bishnu Dhakal, David Budean, Gopal Lamichhane, Hari Prasad Devkota

“…Cold maceration was chosen for its ability to preserve thermolabile compounds and efficiently extract bioactive constituents with minimal energy and equipment requirement, with hexane and methanol employed as extraction solvents. …”
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Quinoa yield modeling revealed that conservative parameters of the AquaCrop model are not conservative: Evidences of planting methods and irrigation managements by Sayyed Mohammad Mirsafi, Ali Reza Sepaskhah, Seyed Hamid Ahmadi

“…The results demonstrated AquaCrop's ability to simulate soil water content with good accuracy as normalized roots mean square error (NRMSE) and Willmott index of agreement (d) values were 12.2 % and 0.71 in the calibration step and 13.1 % and 0.75 in the validation step, respectively. …”
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Enhanced diagnostic capabilities of thromboelastography coupled with standard coagulation indices for predicting perioperative thrombosis in older individuals with hip fractures by Huan Yang, Yusong Yuan, Lei Shi, Yurun Yang, Yidan Zhu, Ying Chen

“…Although traditional laboratory indicators can provide some reference, the diagnostic efficiency is relatively limited This study aimed to investigate the diagnostic accuracies of thromboelastography (TEG) combined with traditional coagulation parameters for early diagnosis of newly occurring lower extremity deep vein thrombosis (DVT) in elderly patients with hip fractures. …”
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A novel Parrot Optimizer for robust and scalable PEMFC parameter optimization by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, Gulothungan G., Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…Abstract The use of proton exchange membrane fuel cells (PEMFCs) in sustainable energy applications depends on their high efficiency levels along with their ability to produce low emissions and operation without noise. …”
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Acute effect of exercise with or without the integration of cooperative activities on inhibitory control in preadolescent school children by Melanie Berger, Markus Gerber, Sebastian Ludyga

“… Introduction Inhibitory control describes the ability to resist distractions and to suppress dominant responses to achieve a specific goal (Miyake & Friedman, 2012). …”
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Environmentally safe sorbent from ash-and-slag waste of heat power engineering by S. A. Bushumov, T. G. Korotkova

“…The modified sorbent has high buoyancy when saturated with oil products and the ability to retain them for a long time.…”
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Modeling of chronic ovary inflammation by N. А. Volkova, M. S. Yuhta, Т. А. Yurchuk, L. V. Stepanuk, E. D. Ivanova, E. V. Pavlovich

“…The aim of research was studying of the ability to use the inactivated vaccine of Staphylococcus aureus strain 209 for modeling of chronic inflammation of the ovaries in laboratory mice. …”
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DORA: Dionaea Observation and Data Collection Analysis for Real-Time Cyberattack Surveillance and Threat Intelligence by Hartinah Hartinah, Andi Syarwani, Ardiansyah Ardiansyah, Irfan Syamsuddin

“…DORA improves threat intelligence workflows, enhancing malware detection accuracy and classifying threats more efficiently. Additionally, it helps identify high-risk attack surfaces, forming the basis for adaptive cybersecurity strategies. …”
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