Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axi... by Xiang Peng, Xiang Peng, Wei Shi, Wei Shi, Haitao Yu, Haitao Yu, Zhenwei Feng, Zhenwei Feng, Zongjie Wei, Weiyang He, Xin Gou, Yongpeng Xie, Yongpeng Xie

“…Additionally, to explore the molecular mechanisms, qRT-PCR, dual-luciferase reporter assays, and other techniques were employed to investigate the role of miR-202-5p in HucMSC-sEVs, with a focus on its ability to regulate the PI3K/AKT pathway through the targeting of GOLIM4. …”
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SET OF ORGANIZATIONALLY-DIDACTIC CONDITIONS OF THE MODEL OF STUDENTS’ AUTONOMY DEVELOPMENT SYSTEM IMPLEMENTATION by Roman A. Popov

“…During their professional trainings, students consciously or unconsciously capture their satisfaction or dissatisfaction with themselves and their behavior, self-confidence, or self-doubt due to which their comprehensive Self-concept is formed – self-confidence (or selfdoubt), ability (inability) to overcome an unpredicted situation. …”
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Carcinogenic health risks and water quality assessment of groundwater around lead–zinc mining areas of Ebonyi state Nigeria: a data-driven machine learning approach by Obinna Chigoziem Akakuru, Moses Oghenenyoreme Eyankware, Godwin O. Aigbadon, Ayatu Ojonugwa Usman, Alexander Iheanyi Opara, Kizito Ojochenemi Musa, Micheal Akaninyene Okon, Okechukwu Pius Aghamelu, Gabriel Ehriga Odesa, Ifeyinwa Juliana Ofoh, Annabel U. Obinna-Akakuru

“…Machine learning was preferred over traditional methods for its ability to capture complex, non-linear relationships in the data, allowing for more accurate predictions of contamination levels and health risks, which is crucial for targeted monitoring and efficient groundwater management in mining-impacted areas. …”
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GENERATION OF CD34+ DERIVED HUMAN MACROPHAGE EXPRESSING CHIMERIC ANTIGEN RECEPTORS FOR CANCER TREATMENT by Ian-Costa, Livia-Furquin, Viviane-Jennifer, Théo-Gremen, Samuel-Campanelli, Rafael-Almeida, Vanderson-Rocha, Rodrigo-Nalio

“…From this perspective, macrophages become promising cells for CAR insertion (CARMac) due to their ability to infiltrate the dense tumor matrix, promote phagocytose and antigen presentation and to secrete pro-inflammatory cytokines. …”
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Properties and sensory acceptability of creatine-fortified foods using ultra-micronized creatine monohydrate – the KREAFOOD Project by Julián Quintero-Quiroz, Sebastian Botero-Ramirez, Simon Jaramillo-Caro, Natalia Zuluaga, Diego A. Bonilla

“…The superior cohesiveness observed in the KreaFood pancake product was attributed to its ability to integrate efficiently into the solid matrix during cooking. …”
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Sistema Electrónico Inteligente para el Control de la Interconexión entre Equipamiento de Generación Distribuida y la Red Eléctrica by Rafael Real-Calvo, Antonio Moreno-Munoz, Victor Pallares-Lopez, Miguel J. Gonzalez-Redondo, Isabel M. Moreno-Garcia, Emilio J. Palacios-Garcia

“…Abstract: The changes that are taking place in the electricity sector are causing an evolution of grid towards a more intelligent and efficient model known as Smart Grid. In this context equipment that connect to electric system require an intelligent control of the connection interface. …”
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Comprehensive rehabilitation of patients with early rheumatoid arthritis: results of 6-month program by Evgenia Vladislavovna Orlova, D E Karateev, A V Kochetkov

“…Objective: to evaluate the efficiency of a comprehensive rehabilitation program (CRP) in patients with early rheumatoid arthritis (RA) for 6 months. …”
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Improving the representation of major Indian crops in the Community Land Model version 5.0 (CLM5) using site-scale crop data by K. N. Reddy, S. Baidya Roy, S. S. Rabin, D. L. Lombardozzi, D. L. Lombardozzi, G. V. Varma, R. Biswas, D. C. Naik

“…The model can also help provide estimates of crop productivity and net carbon capture abilities of agroecosystems in future climate.</p>…”
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A novel index combining meteorological, hydrological, and ecological anomalies used for ecological drought assessment at a grassland-type basin scale by Yixuan Wang, Tingxi Liu, Limin Duan, Shaojie Chu, Jin Sun, Xin Tong, Lina Hao, Yongzhi Bao, Yu Gong

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Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathw... by Zhengchuan Zhang, Jiaqi Shen, Ruogu Xu, Yang Yang, Xiaolin Yu, Dongsheng Yu, Feilong Deng

“…COL1A1 and MMP1 were enriched in Ti-sEVs with enhanced uptake efficiency of fibroblasts and bone marrow-derived MSCs for scarless soft tissue and bone repair abilities via TGF-beta1/SMAD pathway in vitro. …”
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Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells by Jennifer J. Waldo, Julian A.N.M. Halmai, Ankita Singh, Casiana E. Gonzalez, Yi-An Chen, Shaylyn A. Carthen, Jan A. Nolta, Kyle D. Fink

“…A screen of several dCas9 variants with expanded PAM recognition was fused to KRAB and DNMT3A/L to assess the ability to downregulate total HTT. Surprisingly, only SpdCas9 could significantly downregulate HTT, while expanded PAM recognition variants dxCas9 and dCas9-VQR were less efficient or unable to reduce HTT expression. …”
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Deep Learning Based 3D Visualization Health Condition Monitoring Method for Anchor Digging Machines by YANG Xueqi, GAO Xinqin, ZHENG Haiyang, YANG Jun

“…The model possessed the structure of dual time-length encoding, which meant that the features of long-time sequences were retained and allowed efficient processing of tightly connected short-time series data. …”
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Characterization of H9N2 avian influenza virus isolated from chickens and waterfowl in parts of Southern China from 2018 to April 2024 by Wanting Zhou, Jun He, Fangfang Qiao, Mengyao Wang, Qinghang Zeng, Yang Liu, Yue Zhao, Liji Zhang, Ting Li, Shouwen Du, Minhua Sun, Ming Liao

“…In addition, the selected viruses efficiently replicated and transmitted in chickens at a high dose induction. …”
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Surface display of Lys0859, a Streptococcus suis prophage lysin, on Bacillus subtilis spores and its antibacterial activity against Streptococcus suis by Linkang Wang, Linkang Wang, Linkang Wang, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Mengyuan Zhu, Mengyuan Zhu, Mengyuan Zhu, Haiyan Wang, Haiyan Wang, Haiyan Wang, Haiyan Wang, Xinxin Li, Xinxin Li, Xinxin Li, Xinxin Li, Dayue Hu, Dayue Hu, Dayue Hu, Dayue Hu, Xiangmin Li, Xiangmin Li, Xiangmin Li, Xiangmin Li, Ping Qian, Ping Qian, Ping Qian, Ping Qian

“…Phage lysin is regarded as a promising substitute for antibiotics due to its ability to quickly and efficiently kill bacteria without easily developing resistance. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…"[28] This duty extends through a respectful attitude toward the patient and respectful action toward the patient.[29] On average, patients with SMI take 14.6 minutes to complete a PAD, which is well within the 30-minute time limit imposed by insurance reimbursement schedules.[30] However, as other researchers have indicated, this time of completion does not take into account the time required to inform and discuss the implications of future treatment decisions adequately.[31] Given that those living with SMI are often affected by cognitive deficits, the ability of a provider to relay complex health and legal information promptly may be further hamstrung.[32] By offloading the burden of providing efficient and practical education to patients with various levels of cognitive impairment, peer-support specialists could provide the necessary space and time to obtain informed consent and protect patient autonomy.  …”
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Patient and surgeon perspectives of a large-scale system for automated, real-time monitoring and feedback of shared decision-making integrated into surgical practice: a qualitative... by Leila Rooshenas, Jane M Blazeby, Andrew Smith, Angus G K McNair, Andrew Judge, Michael R Whitehouse, Christie Cabral, Jessica Preshaw, Barnaby Reeves, Shelley Potter, Kerry N L Avery, Philip Braude, Adam Williams, Ben Gibbison, Hilary L Bekker, Rhiannon C Macefield, Christin Hoffmann, Val Snelgrove, Della Hopkins, Shireen Hickey, Archana Lingampalli, Paul Cresswell, Timothy Beckitt, Timothy Whittlestone, Jon Aning

“…There was general support for real-time monitoring and feedback because of its perceived ability to efficiently address deficiencies in surgical patients’ SDM experience at scale, and its perceived benefits to patients, surgeons and the wider organisation. …”
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Project quality, regulation quality by Elena Mussinelli

“…Moreover, its ability to govern the ways, times and cultural and technical contents of the project production process to carry out high quality creations is worthy of consideration. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…Therefore, some researchers raised the issue that if alternative solutions for mass tourism are considered, tourism has the ability to develop local communities. The basic condition of this goal was the inclusion of the local community in all stages of tourism decision-making. …”
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Mitigation of coal spontaneous combustion and enhanced coalbed methane recovery using liquid CO₂: Mechanisms, field applications, and implications for mines by Xiaojiao Cheng, Jinsuo Song, Hu Wen, Shixing Fan, Mingyang Liu, Wansheng Mi, Zhijin Yu, Yin Liu, Rijun Li

“…Achieving the collaborative governance of the two disasters and enhancing the ability to prevent and mitigate mine disasters are technical challenges faced by high-gas/outburst mines. …”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. …”
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