Preclinical B cell depletion and safety profile of a brain‐shuttled crystallizable fragment‐silenced CD20 antibody by Vanessa L. Schumacher, Solen Pichereau, Juliana Bessa, Juergen Bachl, Sylvia Herter, Felix C. Weber, Johannes Auer, Anja Kipar, Michael Winter, Martina Stirn, Michael B. Otteneder, Kevin Brady, Anne Eichinger‐Chapelon, Adrian Roth, Nadine Stokar‐Regenscheit, Nicole Clemann, Shanon Seger, Claudia Senn, Juliane Hönig, Cordula Jany, Elisa Di Lenarda, Alain C. Tissot, Christian Klein, H.‐Christian vonBüdingen, Robert Mader, Mohammed Ullah, Niels Janssen, Eduard Urich

“…Endpoints assessed included B cell binding, B cell killing, tolerability, and ability to cross the BBB. Results The Fc‐silenced Brainshuttle construct showed a superior safety profile compared with the Fc‐competent construct while maintaining the ability to cross the BBB and to deplete B cells in head‐to‐head comparisons in human and mouse in vitro and in mouse and cynomolgus macaque in vivo models. …”
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IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment by Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo, Sho-Jen Cheng, Yung-Chieh Chen, Shiu-Wen Huang, Hsing-Jien Kung, Cheng-Yu Chen

“…MRI imaging demonstrated enhanced targeting efficiency in brain tumors, with in vivo studies showing prominent hypointense areas in T2*-weighted MRI scans of tumor-bearing mice injected with CHOL-PEG-SPIO-IL-19, highlighting nanoparticle presence in IL-19-expressing regions. …”
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Effects of Commercial Probiotics on Sperm Traits, Intestinal Morphology, Gut Microflora, and Antioxidant Status in 65-Week-Old Ross 308 Broiler Breeder Roosters by Arash Hadavi, Farogh Kargar, Najeebullah Fayaz, Ali Tayebi pour, Muhammad Namazi zadgan

“…Research indicates that probiotic supplementation can enhance growth performance, feed conversion efficiency, and antioxidant status in broilers (Jadhav et al., 2015; Ogbuewu et al., 2022). …”
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Symbiosis effects of Mycorrhizal and Pseudomonas on morphophysiological traits of mung bean (Vigna radiata (L.) Wilczek) under moisture stressed condition by Mohammad Salehi, Ali Faramarzi, Manochehr Farboodi, Nasser Mohebalipour, Jalil Ajalli

“…In order to increase the efficiency of fungi and bacteria in sowing time, seeds were not sterilized. …”
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Correction of TRMM 3B43 Monthly Precipitation Data Using Quantile Regression Model in the Urmia Lake Basin by Sima Kazempour Choursi, Mahdi Erfanian, Hirad Abghari, Mirhassan Miryaghoobzadeh, khadijeh Javan

“…In all months, the Kling-Gupta efficiency (KGE) values showed a rise when the quantile regression method was used instead of the original TRMM data and the linear regression method. …”
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Janus nanofiber membrane films loading with bioactive calcium silicate for the promotion of burn wound healing by Wang Jin, Li Long, Ma Shanbo, Guo Xiaodi, Zheng Meiling, Miao Shan, Shi Xiaopeng

“…This includes protecting the wound from external liquid contamination and efficiently soaking up excess fluids. The morphology of these membranes was meticulously analyzed using scanning electron microscopy, while their water absorption potential, water contact angle, and crucial mechanical properties were rigorously tested. …”
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Origin assessment of uranium ores using multivariate statistical method based on their rare-earth elemental parameters by Xuepeng Shao, Wenting Bu, Youyi Ni, Hailong Wang, Xuemei Liu, Chuting Yang, Fanhua Hao

“…A database was established, comprising mass spectrometric measurements of rare-earth elemental parameters of twenty-five samples from seven countries. The efficiencies of different multivariate statistical techniques, including cluster analysis (CA), principal component analysis (PCA) and linear discriminant analysis (LDA), were compared. …”
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Enhanced antibacterial potential of exopolysaccharide-stabilized spice oil emulsions against foodborne pathogens by Jahnavi Kumari Singh, Steve Djiazet, Palanisamy Bruntha Devi, Horliane Nzali Ghomdim, G. Bhanuprakash Reddy, Digambar Kavitake, Digambar Kavitake, Prathapkumar Halady Shetty

“…The results of the disk diffusion assay confirmed antibacterial activity of emulsions, exhibiting high antibacterial efficiencies against food pathogens Listeria monocytogenes 1143, Shewanella putrefaciens 8104, and Salmonella enterica 950. …”
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Research review of digital modeling technologies with 3D spatial visualization for pipelines by Xin LIU, Shengwen TU, Yanfang HOU, Dong LIN, Jie SHU, Yu TANG

“…These developments have resulted in more comprehensive functionalities for visualization systems and improved operational and maintenance efficiency. ConclusionGiven the current emphasis on multi-technology integration in digital modeling with 3D spatial visualization for pipelines, developers should select appropriate methods based on specific requirements to ensure the applicability of their systems. …”
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ADVANTAGES ANDDISADVANTAGES OF STUDENTS’ GROUP WORK IN TEACHINGFOREIGN LANGUAGES AT UNIVERSIT by Havryliuk Nataliia

“…The questions concerned the advantages and disadvantages of this training method, the efficiency from group work, the influence on motivation, etc. …”
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Harnessing microorganisms for bioenergy with microbial fuel cells: Powering the future by Ravindra Singh Pandya, Tanveen Kaur, Riya Bhattacharya, Debajyoti Bose, Devansh Saraf

“…Despite these promising prospects, this review acknowledges the challenges of scalability, cost-effectiveness, and optimization, highlighting recent advancements aimed at enhancing efficiency, stability, and economic viability in MFC research. …”
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PhyloScape: interactive and scalable visualization platform for phylogenetic trees by Jiajia Wang, Bo Zhang, Linglu Zheng, Yan Chen, Chunyang Zhang, Guojiao Lin, Zhen Meng, Xuezhi Wang, Yuanchun Zhou

“…Trees published on the website can be efficiently shared and integrated into the users’ own system via a unique address. …”
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Exosomes: their role and therapeutic potential in overcoming drug resistance of gastrointestinal cancers by Jiulian Liu, Shanyu Gao, Xiaoming Liu, Jiaxin Dong, Dingwei Zhen, Tong Liu, Tong Liu

“…Primary challenge to implement this potential is the ability to obtain high-grade exosomes efficiently; however, exosomes lack standard protocols for their processing and characterization. …”
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Detection of false data injection in electric energy metering platforms using gradient lifting decision trees and MLP neural networks by Yakui Zhu, Yangrui Zhang, Chao Zhang, Bingyu Zhang, Hongying Wang, Shaokang Feng

“…Experimental results show that the proposed method can efficiently process a large number of packets per second, the ROC curve performance is excellent, the detection accuracy is more than 99.97%, and the delay is less than 0.04 s. …”
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ECGNet: High-Precision ECG Classification Using Deep Learning and Advanced Activation Functions by Muhammad Abubakar, Ahsan Raza, Arfan Ali Nagra, Anas Bilal, Ahmad Alshammari, Monir Abdullah, Sahraoui Dhelim

“…These matrices reflected their ability to efficiently classify the five different classes. …”
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Designing the organizational schizophrenia phenomenon formation pattern with the TISM phase method by Ali Shariatnejad, Zeinab Safari Ahmadvand, Seyedeh Maryam Mousavi

“…Finally, the organization’s misalignment with changes, along with a lack of coordination between strategies and goals, errors and mistakes in decisions, goal setting and vision, and a decline in productivity and efficiency were among the consequences of the phenomenon of organizational schizophrenia.…”
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Effective delivery of large genes to the retina by dual AAV vectors by Ivana Trapani, Pasqualina Colella, Andrea Sommella, Carolina Iodice, Giulia Cesi, Sonia de Simone, Elena Marrocco, Settimio Rossi, Massimo Giunti, Arpad Palfi, Gwyneth J Farrar, Roman Polishchuk, Alberto Auricchio

“…We found that dual trans‐splicing and hybrid vectors transduce efficiently mouse and pig photoreceptors to levels that, albeit lower than those achieved with a single AAV, resulted in significant improvement of the retinal phenotype of mouse models of STGD and USH1B. …”
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Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease by Ana Volarevic, Carl Randall Harrell, Aleksandar Arsenijevic, Valentin Djonov, Vladislav Volarevic

“…A large number of recently published experimental studies demonstrated that MSC-EVs efficiently alleviated PD-related motor and behavioral deficits in animal models, indicating that MSC-EVs should be considered as potentially new therapeutic agents for the treatment of PD. …”
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Gold Kiwi-Derived Nanovesicles Mitigate Ultraviolet-Induced Photoaging and Enhance Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells by Doyeon Kim, Chanho Lee, Manho Kim, Ju Hyun Park

“…Notably, GK-NVs were efficiently taken up by BM-MSCs without causing cytotoxicity. …”
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Deep learning based local feature classification to automatically identify single molecule fluorescence events by Shuqi Zhou, Yu Miao, Haoren Qiu, Yuan Yao, Wenjuan Wang, Chunlai Chen

“…In this study, we introduce DEBRIS (Deep lEarning Based fRagmentatIon approach for Single-molecule fluorescence event identification), a deep-learning model focusing on classifying local features and capable of automatically identifying steady fluorescence signals and dynamically emerging signals of different patterns. DEBRIS efficiently and accurately identifies both one-color and two-color single-molecule events, including their start and end points. …”
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