Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease by Matthias Arnold, Mustafa Buyukozkan, P. Murali Doraiswamy, Kwangsik Nho, Tong Wu, Vilmundur Gudnason, Lenore J. Launer, Rui Wang-Sattler, Jerzy Adamski, The Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Philip L. De Jager, Nilüfer Ertekin-Taner, David A. Bennett, Andrew J. Saykin, Annette Peters, Karsten Suhre, Rima Kaddurah-Daouk, Gabi Kastenmüller, Jan Krumsiek

“…Our data suggests that improving beta-oxidation efficiency can decelerate bioenergetic aging and disease progression. …”
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Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives by Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Karina Mayumi Tani Bezerra de Melo, Lígia Rosa Sales Leal, Benigno Cristofer Flores Espinoza, Maria da Conceição Viana Invenção, Samara Sousa de Pinho, Antonio Carlos de Freitas

“…The conjugation of specific ligands or the modification of parameters such as shape, charge, and size of vectors can enhance the specificity, stability, and efficiency of antigen transport to cellular compartments, thereby facilitating a robust immune response. …”
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Measuring the Carboxypeptidase and γ-Glutamyltranspeptidase Activities of Lager and Ale Yeasts to Assess Their Impact on the Release of Odorant Polyfunctional Thiols Through Fermen... by Coraline Calicis, Romain Christiaens, Natacha Loquet, Margaux Simon, Sonia Collin

“…Measuring transport efficiency and β-lyase activities individually on the three possible intermediates emerges here as more promising for future flavor potential screening.…”
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Toward Enhanced Biomimetic Artificial Visual Systems Based on Organic Heterojunction Optoelectronic Synaptic Transistors by Haonan Wang, Wandi Chen, Wenjuan Su, Zhenyou Zou, Shuchen Weng, Xiongtu Zhou, Chaoxing Wu, Tailiang Guo, Yongai Zhang

“…By utilizing the excellent carrier capture ability of core‐multi‐shell quantum dots (QDs) and the high exciton dissociation efficiency of heterojunction interfaces, the device achieves a recognition capability under different light intensities closely resembling that of the human eye. …”
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Re-understanding and mitigating hydrogen release chemistry toward reversible aqueous zinc metal batteries by Bo Liu, Zhibin Xu, Cong Wei, Zixuan Zhu, Yanyan Fang, Xin Lei, Ya Zhou, Chongyang Tang, Shiyi Ni, Hongge Pan, Gongming Wang

“…Interestingly, a positive correlation between the adsorption strength of additives and the ability to inhibit the interfacial hydrogen release is found. …”
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Can a Simple Static-Equivalent Model Be Used to Predict Major Trends in the Dynamic Structural Response of Monopile Offshore Wind Turbines? by Antonio J. Romero-Monzón, Carlos Romero-Sánchez, Guillermo M. Álamo, Luis A. Padrón

“…Despite the large differences obtained for highly turbulent scenarios, the acceptable accuracy obtained for relevant load scenarios and the conservative nature of the simplified model make it a viable option for preliminary large-scale studies that prioritize efficiency and efficacy over high-precision.…”
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Green synthesis of CuO nanoparticles from Cucurbita maxima leaf extract; a platinum free counter electrode for dye sensitized solar cells by Emma Panzi Mukhokosi, Stephen Tenywa, Nandipha L. Bothab, Shohreh Azizi, Mathapelo Pearl Seopela, Malik Maaza

“…Using a natural dye from of Cucurbita maxima as a photon absorber, a short circuit current density ( Jsc) of 4.2 µA/cm2, open circuit voltage (Voc) of 0.17 V, a maximum power (Pmax) of 0.18 mW/cm2, and a power conversion efficiency (PCE) of 1.8 × 10?4 % under one-sun illumination were obtained. …”
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γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application by Jennifer Huling, Stefan Oschatz, Helge Lange, Katharina Anna Sterenczak, Thomas Stahnke, Jana Markhoff, Oliver Stachs, Steffen Möller, Nasrullah Undre, Anita Peil, Anselm Jünemann, Niels Grabow, Georg Fuellen, Thomas Eickner

“…The crosslinked γ − cyclodextrin retained the ability to form complexes with josamycin, resulting in a 4-fold higher drug loading efficiency when compared to linear dextran hydrogels, and prolonged drug release over 4 days.…”
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Are viral vector-mediated therapies compatible with aberrant glycosylation? by I.J.J. Muffels, R. Budhraja, S. Radenkovic, R. Shah, A. Pandey, E. Morava, T. Kozicz

“…The ability of adeno-associated viruses (AAVs) to transduce host cells relies on interactions with glycan moieties on the cellular surface. …”
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Advances in AAV-mediated gene replacement therapy for pediatric monogenic neurological disorders by Livia Zhou, Yafeng Wang, Yiran Xu, Yaodong Zhang, Changlian Zhu

“…We discuss various strategies to enhance transduction efficiency, target specificity, and safety. Furthermore, we explore challenges such as immune responses, along with innovative approaches to overcome these obstacles. …”
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Advancements and Applications of STR Kits in Forensic DNA Profiling: A Comprehensive Review by Omar A Mahmoud, Mohammed A. Hameed, Shahrazad H. Muhi, Farah B. Abed, Sahar M. Ibrahim, Ibrahim Ramzi Hadi, Dunya A. Mohammed, Ruaa Maan Attallah

“…The continuous advancement of forensic DNA technology, including next-generation sequencing (NGS), aims to enhance STR analysis efficiency and accuracy. This document also discusses various STR kits used in forensic science, their applications, and standard protocols ensuring reliable results. …”
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Exploring the Mechanism of β-Cyclodextrin-Encased Phenolic Acids Functionalized with TPP for Antioxidant Activity and Targeting by Christopher Sbarbaro, Valeria Márquez-Miranda, Matías Leal, Ricardo Pino-Rios, Pedro Olivares, Makarena González, Ignacio Díaz-Franulic, Fernando González-Nilo, Osvaldo Yáñez, Yorley Duarte

“…Our results showed successful encapsulation of TPP conjugates in β-CD with high efficiency. The TPP conjugates maintained antioxidant activity, with slight reductions observed in β-CD complexes. …”
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Enhanced in vivo Stability and Antitumor Efficacy of PEGylated Liposomes of Paclitaxel Palmitate Prodrug by Wu X, Wang X, Zhang H, Chen H, He H, Lu Y, Tai Z, Chen J, Wu W

“…Our in vivo imaging experiments demonstrated that PTX-PA-L labeled with DiR has greater stability in vivo than blank liposomes and that PTX-PA-L can target drugs to the tumor site and efficiently release PTX to exert antitumor effects. …”
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Deep Learning Based 3D Visualization Health Condition Monitoring Method for Anchor Digging Machines by YANG Xueqi, GAO Xinqin, ZHENG Haiyang, YANG Jun

“…The model possessed the structure of dual time-length encoding, which meant that the features of long-time sequences were retained and allowed efficient processing of tightly connected short-time series data. …”
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Canagliflozin: from glycemic control to improvement of cardiovascular and renal prognosis in patients with type 2 diabetes mellitus. Resolution of Advisory Board by M. V. Shestakova, A. S. Ametov, M. B. Antsiferov, T. P. Bardymova, F. V. Valeeva, G. R. Galstyan, T. Yu. Demidova, I. A. Karpova, T. P. Kiseleva, A. Yu. Mayorov, A. M. Mkrtumyan, S. V. Nedogoda, N. А. Petunina, L. A. Ruyatkina, L. A. Suplotova, O. Yu. Sukhareva, V. V. Fadeev, M. S. Shamkhalova

“…For example, one of the most studied SGLT2i, canagliflozin, in addition to its inhibitory activity against SGLT2, can also moderately block SGLT1 in the intestine and kidneys that could give a maximum efficiency in the control glycemia and others cardiometabolic parameters. …”
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Comparison of the Photosynthesis, Hydraulic Properties, and Anatomy of <i>Pteroceltis tatarinowii</i> Leaves Between a Limestone and a Cultivated Forest by Ya Zhang, Yu-Die Wang, Meng-Meng Ma, Ying-Ying Zhang, Dong-Sheng Du, Xian-Can Zhu, Xiao-Hong Li

“…This study reveals a hydraulic trade-off between efficiency and safety for <i>P. tatarinowii leaves</i> growing in distinct habitats. …”
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A strategy for cost-effective large language model use at health system-scale by Eyal Klang, Donald Apakama, Ethan E. Abbott, Akhil Vaid, Joshua Lampert, Ankit Sakhuja, Robert Freeman, Alexander W. Charney, David Reich, Monica Kraft, Girish N. Nadkarni, Benjamin S. Glicksberg

“…These results identify the limits of LLMs for effective utilization and highlight avenues for cost-efficiency at the enterprise scale.…”
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Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study by Quan Vo-An, Thuy Chinh Nguyen, Quang Tung Nguyen, Quoc Trung Vu, Cong Doanh Truong, Thi Len Nguyen, Thi Ngoc Lien Ly, Long Giang Bach, Hoang Thai

“…In addition, the synergistic interaction of lovastatin and ginsenoside Rb1 could be also observed through the modification of relative crystal degree and drug release efficiency.…”
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Effects of silybin on growth performance, antioxidant capacity and immunity in juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) fed with high-lipid... by Mingsheng Xie, Hao Liu, Weibin Huang, Menglong Zhou, Shuang Zhang, Beiping Tan, Shuyan Chi, Yuanzhi Yang, Xiaohui Dong

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Design, development, and testing of a cassava storage root-cutting robot utilizing a Stewart platform and mask R-CNN for precision agriculture by Thanaporn Singhpoo, Seree Wongpichet, Jetsada Posom, Kanda Runapongsa Saikaew, Arthit Phuphaphud, Poramate Banterng, Mahisorn Wongphati, Khwantri Saengprachatanarug

“…This successful integration not only demonstrates the robot's ability to cut cassava stems accurately in various orientations but also significantly improves efficiency by reducing loss and trash. …”
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