Dual-Drug Delivery Systems Using Hydrogel–Nanoparticle Composites: Recent Advances and Key Applications by Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Su Jeong Kang, Myeong Kyun Yoo, So Yeon Park, Sunghyun Bong, Chan-Su Park, Chun-Woong Park, Jin-Seok Kim, Sang-Bae Han, Hye Jin Lee, Dae Hwan Shin

“…Dual-drug delivery systems using hydrogel–nanoparticle composites have emerged as a versatile platform for achieving controlled, targeted, and efficient delivery of two distinct therapeutic agents. …”
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Treatment Response to Oncolytic Virus in Patient-Derived Breast Cancer and Hypopharyngeal Cancer Organoids: Evaluation via a Microfluidics Organ-on-a-Chip System by Yu Sun, Jiaqi Liu, Li Zhu, Fang Huang, Yanbo Dong, Shuang Liu, Siyi Chen, Wei Ji, Jingjing Lu, Liangfa Liu, Shanhu Li

“…The evaluation system combining OOC systems and PDOs was efficient and reliable, providing personalized OV treatment recommendations for patients and offering industrialized and standardized research ideas for the development of OVs.…”
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Computational nanobody design through deep generative modeling and epitope landscape profiling by Liyun Huo, Tian Tian, Yanqin Xu, Qin Qin, Xinyi Jiang, Qiang Huang

“…Overall, our results demonstrate that computational design and structure-based profiling offer an efficient strategy for early-stage therapeutic nanobody discovery.…”
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Metal Ruthenium Complexes Treat Spinal Cord Injury By Alleviating Oxidative Stress Through Interaction With Antioxidant 1 Copper Chaperone Protein by Juanjuan Li, Cheng Peng, Caiqiang Huang, Li Wan, Ke Wang, Ping Wu, Tianjun Chen, Guodong Sun, Rui Guo, Hongsheng Lin, Zhisheng Ji

“…Thus, this treatment strategy using ruthenium metal complexes can be a new therapeutic approach for the efficient treatment of SCI.…”
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Targeted Screening of <i>Lactiplantibacillus plantarum</i> Strains Isolated from Tomatoes and Its Application in Tomato Fermented Juice by Nuersiman Tuerhong, Liang Wang, Jie Cui, Dilireba Shataer, Huizhen Yan, Xiaoxiao Dong, Ziqi Gao, Minwei Zhang, Yanan Qin, Jing Lu

“…Furthermore, 13 strains used as fermentation starters in tomato juice significantly enhanced antioxidant activity and reduced pH and total soluble solids, indicating efficient sugar utilization and lactic acid production. …”
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ARTEMIS: An independently validated prognostic prediction model of breast cancer incorporating epigenetic biomarkers with main effects and gene-gene interactions by Maojie Xue, Ziang Xu, Xiang Wang, Jiajin Chen, Xinxin Kong, Shenxuan Zhou, Jiamin Wu, Yuhao Zhang, Yi Li, David C. Christiani, Feng Chen, Yang Zhao, Ruyang Zhang

“…Conclusion: ARTEMIS is an efficient and practical tool for breast cancer prognostic prediction.…”
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Application of construction and demolition waste (gypsum and mortar) for the removal of metal ions, Pb2+, Cu2+, and Ni2+ by Jefferson Luiz Alves Marinho, Francisco Assis Bezerra da Cunha, Raimundo Nonato Pereira Teixeira, Henrique Douglas Melo Coutinho, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Lucia Raquel de Lima, Cícera Datiane de Morais Oliveira Tintino, Hyan Thompson Oliveira Lopes, Paulo Ives Pereira de Alcântara

“…Therefore, the results obtained demonstrated that construction and demolition waste by-products rich in gypsum and cementitious mortar are efficient in removing toxic metals, representing promising alternatives for wastewater decontamination.…”
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Hyperspectral estimation of chlorophyll content in grapevine based on feature selection and GA-BP by YaFeng Li, XinGang Xu, WenBiao Wu, Yaohui Zhu, LuTao Gao, XiangTai Jiang, Yang Meng, GuiJun Yang, HanYu Xue

“…It was shown that SNV-based processed hyperspectral data combined with GA-BP has great potential for efficient chlorophyll monitoring in grapevine. This method provides a new framework theory for constructing a hyperspectral analytical model of grapevine key growth indicators.…”
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STF: A spherical transformer for versatile cortical surfaces applications by Jiale Cheng, Fenqiang Zhao, Zhengwang Wu, Xinrui Yuan, Li Wang, John H Gilmore, Weili Lin, Xin Zhang, Gang Li

“…Overlapping regions between neighboring patches naturally enable efficient cross-patch information sharing. To handle longitudinal cortical surface data, we introduce the spatiotemporal self-attention mechanism, which jointly captures spatial context and temporal developmental patterns within a single layer. …”
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Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier by Kaili Liang, Li Yang, Jiawei Kang, Bo Liu, Ding Zhang, Liyan Wang, Wei Wang, Qing Wang

“…This system holds substantial potential as an efficient platform for delivering neuroprotective drugs and advancing PD therapy.…”
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Online evaluation method for MMC submodule capacitor aging based on CapAgingNet by Xinlan Deng, Youhan Deng, Liang Qin, Weiwei Yao, Min He, Kaipei Liu

“…Subsequently, the CapAgingNet model is introduced, incorporating key technical modules to enhance performance: the Deep Stem module, which extracts larger receptive fields through multiple convolution layers and mitigates the impact of data sparsity in capacitor aging on feature extraction; the efficient channel attention (ECA) module, utilizing one-dimensional convolution for dynamic weighting to adjust the importance of each channel, thereby enhancing the ability of the model to process high-dimensional features in capacitor aging data; and the multiscale feature fusion (MSF) module, which integrates capacitor aging information across different scales by combining fine-grained and coarse-grained features, thus improving the capacity of the model to capture high-frequency variation characteristics. …”
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Pre-inoculation of ago2 and DCL2/4-deficient Nicotiana benthamiana plants with the Pepino mosaic virus EU mild isolate confers complete protection against superinfection with the a... by Theodore Spanos, Amira Ghodbane, Aya Rezazga, Márta Ludman, Károly Fátyol, Toufic Elbeaino, Ioannis Livieratos

“…Collectively, our results cannot entirely exclude the complete redundancy of two essential components of RNA silencing, but clearly suggest the activation of an efficient and durable superinfection protection mechanism, which is distinct to it.…”
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Risk assessment of an Aedes flavivirus and its effect on pathogenic flavivirus replication in mosquitoes by Yumei Fu, Wan Zhao, Shaohui Wu, Jinqian Li, Qing Liu, Feng Jiang, Hong Lu, Le Kang, Qianfeng Xia, Feng Cui

“…Abstract Background Mosquitoes are efficient vectors of medically significant flaviviruses and serve as hosts for insect-specific flaviviruses (ISFs). …”
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Attention-based multi-scale convolution and conformer for EEG-based depression detection by Ze Yan, Ze Yan, Ze Yan, Yumei Wan, Xin Pu, Xiaolin Han, Mingming Zhao, Haiyan Wu, Wentao Li, Xueying He, Yunshao Zheng

“…This model showcases strong potential in advancing depression detection in neuroscience, providing an efficient and scalable solution for clinical and practical applications. …”
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Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range by Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu

“…Furthermore, enErCas12a achieves efficient gene editing in both bacterial and mammalian cells at various sites with non‐canonical PAMs, including GC‐rich PAMs such as GCCC, CGCC, and GGCC, which are inaccessible to previous Cas12a variants. …”
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Meloxicam mitigated methylglyoxal-induced glycative stress in rats by Talha Fayyaz, Ghulam Abbas, Hammad Ahmed, Najeeb Khatian, Shumaila Usman, Uzair Nisar, Noor Ain, Yamna Khurshid, Syed Ali

“…Drug repurposing is an efficient and cost-effective way of developing drugs. …”
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Anthocyanins and flavonoids derived from Clitoria ternatea L. flower inhibit bladder cancer growth via suppressing fatty acid synthesis mediated by SREBP1 pathway by Liu Chenkai, Liu Jue, Liu Gao, Song Yusong, Yang Xiuyu, Gao Honglei, Xiang Cheng, Sang Jie, Xu Tianrui, Sang Jun

“…ternatea flowers (DDH) are prepared via macroporous resin-based extraction coupled with an efficient and reliable two-dimensional UPLC-DAD-MS/MS method. …”
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A High-Sensitivity, Bluetooth-Enabled PCB Biosensor for HER2 and CA15-3 Protein Detection in Saliva: A Rapid, Non-Invasive Approach to Breast Cancer Screening by Hsiao-Hsuan Wan, Chao-Ching Chiang, Fan Ren, Cheng-Tse Tsai, Yu-Siang Chou, Chun-Wei Chiu, Yu-Te Liao, Dan Neal, Coy D. Heldermon, Mateus G. Rocha, Josephine F. Esquivel-Upshaw

“…Breast cancer is a leading cause of cancer-related mortality worldwide, requiring efficient diagnostic tools for early detection and monitoring. …”
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Discerning Genes to Deliver Varieties: Enhancing Vegetative- and Reproductive-Stage Flooding Tolerance in Rice by Sanchika Snehi, Kt Ravi Kiran, Sanket Rathi, Sameer Upadhyay, Suneetha Kota, Satish Kumar Sanwal, Bm Lokeshkumar, Arun Balasubramaniam, Nitish Ranjan Prakash, Pawan Kumar Singh

“…However, stagnant flooding (partial submergence of vegetative parts) during the reproductive phase inflicts severe damage on the rice crop, leading to reduced yields, heightened susceptibility to pests and diseases, lodging, and inferior grain quality. The ability to tolerate stagnant flooding can be ascribed to several adaptive traits: accelerated aerenchyma formation, efficient underwater photosynthesis, reduced radial oxygen loss in submerged tissues, reinforced culms, enhanced reactive oxygen species scavenging within cells, dehydration tolerance post-flooding, and resistance to pests and diseases. …”
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Feedback-Based Validation Learning by Chafik Boulealam, Hajar Filali, Jamal Riffi, Adnane Mohamed Mahraz, Hamid Tairi

“…These results demonstrate that FBVL enhances classification accuracy and model generalization, particularly in scenarios involving small or imbalanced datasets, offering practical benefits for designing more efficient and robust neural network architectures.…”
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