Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types by Huiling Mu, Huiling Mu, Yeyi Liu, Yeyi Liu, Yijia Chi, Yijia Chi, Fei Wang, Shuting Meng, Shuting Meng, Yi Zhang, Yi Zhang, Xunting Wang, Xunting Wang, Dongxin Zhao, Dongxin Zhao, Dongxin Zhao

“…To maximize prime editing efficiency, we implemented a series of systematic optimizations, achieving up to 80% editing efficiency across multiple loci and cell lines. …”
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A systematic review and meta-analysis testing the effect of lifestyle modification and medication optimization programs on cholesterol and blood pressure in patients with cardiovascular disease by Semagn Mekonnen Abate, Shivshankar Thanigaimani, Mallika Sinha, David Sun, Jonathan Golledge

“…Sub-analyses examined programs that included both lifestyle modification and drug optimization or type of intervention alone if a minimum of three trials were identified. …”
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The search for an optimal tissue‐engineered urethra model for clinical application based on preclinical trials in male animals: A systematic review and meta‐analysis by Natalia Chepelova, Guzel Sagitova, Daniel Munblit, Aleksandr Suvorov, Andrey Morozov, Anastasia Shpichka, Peter Glybochko, Peter Timashev, Denis Butnaru

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Toward Adaptive and Immune-Inspired Viable Supply Chains: A PRISMA Systematic Review of Mathematical Modeling Trends by Andrés Polo, Daniel Morillo-Torres, John Willmer Escobar

“…This study presents a systematic literature review on the mathematical modeling of resilient and viable supply chains, grounded in the PRISMA methodology and applied to a curated corpus of 235 peer-reviewed scientific articles published between 2011 and 2025. …”
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Opportunities, challenges and future prospects of carbon nanotubes-infused nanocomposite membranes in complex industrial wastewater treatment: A systematic review by S. Letlhabula, O.O. Sadare, S.P. Malinga, K. Moothi

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Effects of real-time EEG neurofeedback training on cognitive, mental, and motor performance in elite athletes: a systematic review and meta-analysis by Skalski Dariusz, Łosińska Kinga, Prończuk Magdalena, Tyrała Florentyna, Trybek Grzegorz, Cięszczyk Paweł, Kuliś Szymon, Maszczyk Adam, Pietraszewski Przemysław

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Particle Swarm Optimization Algorithm for Determining Global Optima of Investment Portfolio Weight Using Mean-Value-at-Risk Model in Banking Sector Stocks by Moh. Alfi Amal, Herlina Napitupulu, Sukono

“…This study aims to develop a computational algorithm based on the metaheuristic particle swarm optimization (PSO) model, which can be used to solve global optimization problems in portfolio investment. …”
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Efficacy of Polydeoxyribonucleic Acid (PDRN) in periodontal regeneration: A systematic review of clinical outcomes by Ranjith Mari, Jaiganesh Ramamurthy, K. Rudhra, Nitya Krishnaswamy

“…While promising, further clinical trials are necessary to determine optimal dosing and long-term effectiveness. This systematic review provides evidence supporting PDRN as a potential adjunctive treatment for periodontitis, with implications for enhancing clinical outcomes in periodontal therapy.…”
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Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs by Olalekan A Uthman, Rachel Court, Jodie Enderby, Chidozie Nduka, Lena Al-Khudairy, Seun Anjorin, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

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Optimal intrapleural therapy with alpha-hemolytic streptococci bio-product (Mannatide) in controlling malignant pleural effusion: a clustered systematic review and meta-analysis by Yan Zhang, Xiao-Tian Zheng, Jiao Xu, Da-Chun Cai, Feng Luo, Jun Huang, Yan-Yan Jin, Teng-Yang Fan, Ji-Hong Feng, Xue Xiao, Zheng Xiao

“…Abstract Background Mannatide is an alpha-hemolytic streptococci bio-product. We conducted a comprehensive clustered systematic review and meta-analysis to reveal the clinical values of Mannatide for controlling malignant pleural effusion (MPE), identify the optimal therapeutic regimens, indications and usage, and assess their clinical effectiveness and safety. …”
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Nutritional Optimization for Brain Health in Contact Sports: A Systematic Review and Meta-Analysis on Long-Chain ω-3 Fatty Acids and Neurofilament Light by Jeffery L Heileson, Michael J Macartney, Nora L Watson, Tina E Sergi, Andrew R Jagim, Ryan Anthony, Gregory E Peoples

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Optimization of electrical stimulation for the treatment of lower limb dysfunction after stroke: A systematic review and Bayesian network meta-analysis of randomized controlled trials. by Yu Fang, Jiang Li, Shanyu Liu, Yan Wang, Jiaming Li, Dongdong Yang, Qiaoling Wang

“…<h4>Methods</h4>We implemented a systematic search of 3915 studies published up to January 2023 from eight databases and two clinical trial registries. …”
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Optimal exercise dose-response improves health-related quality of life in cancer survivors: a systematic review and Bayesian network meta-analysis of RCTs by Zhiyu Xiong, Yuan Yuan, Yong Yang, Bopeng Qiu, Ying Bai, Tao Wang, Junyu Wang, Lin Zhang, Yawen Li

“…Additionally, mind-body exercises, such as tai chi, qigong, or yoga, exhibited optimal effects at a dose of 390 METs-min/week (SMD: 0.672, 95% Crl: 0.259 to 1.087).ConclusionOur study sheds light on the intricate relationship between exercise interventions and health-related quality of life in cancer survivors, as elucidated through a systematic review and Bayesian network meta-analysis. …”
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Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings: a protocol for the systematic review and meta-analysis by Jai K Das, Zulfiqar Ahmed Bhutta, Abigail Smith, Aamer Imdad, Olivia Tsistinas, Emily Tanner-Smith, Melissa François, Fanny F Chen

“…The findings of this review will be published in a peer-reviewed journal and will guide the WHO’s recommendation on the optimal iron content in RUTFs for the treatment of SAM in children aged 6–59 months.…”
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Optimal dose of resistance training to improve handgrip strength in older adults with sarcopenia: a systematic review and Bayesian model-based network meta-analysis by Li Hua-Rui, Huang Shouliang, Yv Zhengze, Jiang Ning, Li Peihua, Zhai Yifei, Peng Fenglin

“…A recommended 19-week program includes 3 sessions per week at 49% 1RM, featuring 15 exercises per set, 6 sets, and 16 repetitions per exercise, totaling up to 1,400 reps weekly.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/recorddashboard.…”
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Redefining electrolyte efficiency: bridging the gap with a systematic samarium–copper co-doping approach for optimized conductivity in advanced semiconductor ionic fuel cell by Muhammad Shahid Sharif, Zuhra Tayyab, Sajid Rauf, Muhammad Ahsan Masood, MAK Yousaf Shah, Muhammad Tayyab, Abdullah N Alodhayb, Bin Zhu

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Depression Detection and Diagnosis Based on Electroencephalogram (EEG) Analysis: A Systematic Review by Kholoud Elnaggar, Mostafa M. El-Gayar, Mohammed Elmogy

“…One of these disorders is depression, a significant factor contributing to the increase in suicide cases worldwide. …”
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Determining optimal strategies for primary prevention of cardiovascular disease: systematic review of cost-effectiveness analyses in the United Kingdom by Hema Mistry, Jodie Enderby, Rachel Court, Lena Al-Khudairy, Chidozie Nduka, GJ Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke, Olalekan Uthman

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Systematic Cognition and Path Optimization of Comprehensive Utilization of Abandoned Mines —— Based on the Theoretical Perspective of Factor Endowment Differences by Jialong WU, Hongju LI, Kai WANG, Shaoqing SU, Yan JIANG, Yun LUO, Yang YU

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Optimal Antithrombotic Therapy after Implantation of a Transcatheter Aortic Valve: Warfarin, Aspirin, or Non-Vitamin K Antagonist Oral Anticoagulants? A Systematic Review and Meta-Analysis by Wenjuan Yang, Xiaoyu Fang, Yu Zhu, Fuqin Tang, Zhao Jian, Tianyu Xu, Xiaoxia Fu

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