Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development by Yuan‐Tao Liu, Le‐Le Zhang, Zi‐Ying Jiang, Xian‐Shu Tian, Peng‐Lin Li, Pei‐Huang Wu, Wen‐Ting Du, Bo‐Yu Yuan, Chu Xie, Guo‐Long Bu, Lan‐Yi Zhong, Yan‐Lin Yang, Ting Li, Mu‐Sheng Zeng, Cong Sun

“…However, a comprehensive synthesis of how AI technologies reshape each key modality of drug discovery remains lacking. …”
Get full text

Strong-lensing Analysis of SPT-CL J2325−4111 and SPT-CL J0049−2440, Two Powerful Cosmic Telescopes (RE > 40″) from the SPT Clusters Sample by Guillaume Mahler, Keren Sharon, Matthew Bayliss, Lindsey. E. Bleem, Mark Brodwin, Benjamin Floyd, Raven Gassis, Michael D. Gladders, Gourav Khullar, Juan D. Remolina González, Arnab Sarkar

“…The lens models of SPT-CL J2325−4111 and SPT-CL J0049−2440 were optimized using nine and eight secure multiply imaged systems with a final image-plane rms of 0 $\mathop{.}…”
Get full text

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy by Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu

“…This approach enables nanocarriers to inherit the intrinsic biological properties, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, biodegradability, and naturally optimized biological interfaces. Here, a systematic overview of the BCM‐NHS is provided. …”
Get full text

Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock by Xiang-Yu Liu, Xiang-Yu Liu, Yu-Shou Wu, Yu-Shou Wu, Yi-Rui Qu, Yi-Rui Qu, Hui Zhou, Hui Zhou, Tian Liu, Xiao-Wei Su, Xiao-Wei Su, Fang-Chao Hu, Fang-Chao Hu, Jin-Guang Zheng, Shao-Fang Han, Jia-Ke Chai, Yun-Fei Chi

“…These findings provide a scientific basis for further clinical trials and development of optimized ORS for patients with burns.…”
Get full text

Recommendations on benchmarks for numerical air quality model applications in China – Part 2: Ozone and uncertainty analysis by L. Huang, X. Zhang, C. Emery, Q. Mu, G. Yarwood, H. Zhai, Z. Sun, S. Xue, Y. Wang, J. S. Fu, L. Li

“…The proposed benchmarks for assessing simulated O<span class="inline-formula">₃</span> concentrations, in conjunction with our previous studies on PM<span class="inline-formula">_2.5</span> and other criteria air pollutants, represent a comprehensive and systematic effort to establish a model performance framework for CTM applications in China. …”
Get full text

KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Abstract Background KRAS-G12C inhibitors mark a notable advancement in targeted cancer therapies, yet identifying predictive biomarkers for treatment efficacy and resistance remains essential for optimizing clinical outcomes. …”
Get full text

Construction and Application of Monitoring System for Green Tarpaulin Cover Net in Mega Cities by Yang SUN, Dawei GAO, Haoye JIANG, Wanguang DU

“…This mode can not only optimize the performance of the model, but also promotes seamless integration between the model and actual operations, making monitoring work more efficient and flexible.ResultsThis research constructs a complete working system of “establishment − implementation − verification − monitoring”. …”
Get full text

Real-time morphological and dosimetric adaptation in nasopharyngeal carcinoma radiotherapy: insights from autosegmented fractional fan-beam CT by Xiao-li Yu, Jiang Hu, Yu-xian Yang, Guang-yu Wang, Xin Yang, Wen-chao Diao, Lu Liu, Xiao-bo Jiang, Chen-di Xu, Liu-wen Lin, Le-cheng Jia, Hua Li, Yan-fei Liu, Ying Sun, Guan-qun Zhou

“…Results A systematic review of autosegmentation on FBCT scans demonstrated satisfactory accuracy overall, and missegmentation was manually modified. …”
Get full text

Mesenchymal stem cells derived from hPSC via neural crest attenuate chemotherapy-induced premature ovarian insufficiency by ameliorating apoptosis and oxidative stress in granulosa... by Xinran Li, Jinrong Liao, Youhong Zheng, Wei Cai, Jie Chen, Yu Liang, Yuanmei Chen, Xiaoxuan Li, Jiamao Luo, Jiaxin Xie, Manping Zhou, Lilin Hang, Xiujuan Sun, Xin Yue, Xuefeng Wang, Yifeng Wang, Huiyan Wang

“…Abstract Background Premature ovarian insufficiency (POI) poses a significant threat to female reproductive health and currently lacks effective interventions. …”
Get full text

Analysis of Animal Models of Myasthenia Gravis Based on Its Clinical Characteristics in Chinese and Western Medicine by CHEN Yuhan, CHEN Jinling, LI Xin, OU Yanhua, WANG Si, CHEN Jingyi, WANG Xingyi, YUAN Jiali, DUAN Yuanyuan, YANG Zhongshan, NIU Haitao

“…Evaluation of these models requires integration of behavioral, electrophysiological, and immunological indicators. However, a systematic framework for modelling TCM syndromes is still lacking. …”
Get full text

Strategies for enhancing yield and quality of forage-grain dual-purpose ratoon rice: role of first-season density and nitrogen management by Yuyuan Ouyang, Yuyuan Ouyang, Guangyi Chen, Chuntao Yang, Conghua Zhu, Li Zhang, Wei Li, Hong Yang, Ziyu Li, Yao Zhang, Junqi Yu, Xi Luo, Xuyi Li, Xuyi Li, Tian Li

“…However, integrated strategies to simultaneously improve silage rice and ratoon rice yield and quality across both seasons require further systematic study. A two-year field study (2022–2023) was conducted using two widely cultivated indica hybrid rice cultivars, F You 498 (FY498) and Chuankangyou Simiao (CKYSM), in Southwest China. …”
Get full text

Application progress of integrative Chinese and Western medicine in home-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease (中西医结合肺康复在慢性阻塞性肺疾病居家... by TANG Sanhui (唐三辉), XUE Jingfeng (薛景凤), GONG Fanghua (龚放华)

“…However, current research faces challenges such as a lack of theoretical guidance and limited systematic application. …”
Get full text

CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…The findings are expected to optimize treatment strategies and improve overall patient outcomes.MethodsA total of 141 patients with IS combined with moderate-to-severe OSA admitted to the Affiliated Hospital of Yangzhou University from October 2022 to August 2024 were enrolled. …”
Get full text

Prediction of stable structure and unique charge transfer in Li–Pt intermetallic compounds under pressure by Wenlin Xu, Dengjie Yan, Liguo Zhu, Yifei Wang, Lingxin Kong, Bin Yang, Baoqiang Xu

“…The exploration of new intermetallic compounds is of great significance for basic research and practical application. There is a huge electronegativity difference between Li and Pt, and the metals exhibit interesting and diverse properties; however, the structural behavior of Li–Pt intermetallics with different ratios under high pressure has not been systematically studied. …”
Get full text

Haberleşme Sistemlerinde Turbo Kodlama ve Turbo İlkesinin Bazı Pratik Uygulamaları by Selman KULAÇ, Murat Hüsnü SAZLI

“…SISO algoritmalarının iki ana kategorisi vardır: Sembol (bit) hata olasılığını en küçükleştiren MAP (maximum a posteriori) algoritması ve sözcük (dizi) hata olasılığını en küçükleştiren Yumuşak Çıkış Viterbi Algoritmasıdır (SOVA). 1967’de A. …”
Get full text

Haberleşme Sistemlerinde Turbo Kodlama ve Turbo İlkesinin Bazı Pratik Uygulamaları by Selman KULAÇ, Murat Hüsnü SAZLI

“…SISO algoritmalarının iki ana kategorisi vardır: Sembol (bit) hata olasılığını en küçükleştiren MAP (maximum a posteriori) algoritması ve sözcük (dizi) hata olasılığını en küçükleştiren Yumuşak Çıkış Viterbi Algoritmasıdır (SOVA). 1967’de A. …”
Get full text

Haberleşme Sistemlerinde Turbo Kodlama ve Turbo İlkesinin Bazı Pratik Uygulamaları by Selman KULAÇ, Murat Hüsnü SAZLI

“…SISO algoritmalarının iki ana kategorisi vardır: Sembol (bit) hata olasılığını en küçükleştiren MAP (maximum a posteriori) algoritması ve sözcük (dizi) hata olasılığını en küçükleştiren Yumuşak Çıkış Viterbi Algoritmasıdır (SOVA). 1967’de A. …”
Get full text

Geological characteristics and key technologies for exploration and development of the Yanchuannan coalbed methane field, Ordos Basin by Xipeng HE, Cui XIAO, Yuqiao GAO, Xin LI, Tao GUO, Xiao CAI

“…Through multiple rounds of research and iterative optimization based on a deepened understanding of coal properties, this study developed optimized fracturing with fractures effectively propped characterized by the preflush of high-volume fracturing fluids for longer fractures, variable injection rates of fracturing fluids for fracture height control, and multi-sized proppants for propping multi-scale fractures. …”
Get full text

Expert consensus on early orthodontic treatment of class III malocclusion by Xin Zhou, Si Chen, Chenchen Zhou, Zuolin Jin, Hong He, Yuxing Bai, Weiran Li, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Bin Yan, Jiejun Shi, Jie Guo, Zhihua Li, Wensheng Ma, Yi Liu, Huang Li, Yanqin Lu, Liling Ren, Rui Zou, Linyu Xu, Jiangtian Hu, Xiuping Wu, Shuxia Cui, Lulu Xu, Xudong Wang, Songsong Zhu, Li Hu, Qingming Tang, Jinlin Song, Bing Fang, Lili Chen

“…Therefore, early orthodontic treatment for Class III malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. …”
Get full text

Brazilian Academy of Neurology recommendations for diagnosis, management, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) by Osvaldo J. M. Nascimento, Wilson Marques Jr, Marcus Vinícius Magno Gonçalves, Pedro José Tomaselli, Camila Pupe, Marcondes Cavalcante França Jr, Francisco de Assis Aquino Gondim, Marcos Raimundo Gomes de Freitas, Rodrigo Siqueira Soares Frezatti, Acary Souza Bulle Oliveira, Francisco Tellechea Rotta, Elza Dias Tosta, Rosana Scola, Vanessa Daccach, Carlo Domenico Marrone, Jefferson Becker, Susanie Rigatto, Alberto R. M. Martinez, Hideraldo Cabeça, Pablo Brea Winckler, Mario Emilio Dourado, Diogo Fernandes dos Santos

“…While the incidence rates vary, CIDP remains a challenging condition requiring a standardized and optimized approach to diagnosis and management. …”
Get full text