Dynamic O-GlcNAcylation and phosphorylation attract and expel proteins from RNA polymerase II to regulate mRNA maturation by Aishwarya Gondane, Harri M. Itkonen

“…Unlike previously proposed, we show that, similar to inhibition of CDK12, also targeting CDK9 stimulates transcription of short genes at the cost of long genes. However, our systematic proteomic- and IPA-analysis revealed that these effects are mediated by distinct molecular mechanisms: CDK9 inhibition leads to a failure of recruiting Integrator complex to RNA Pol II, and we then show that depletion of Integrator subunits phenocopy the gene length-dependent effects. …”
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Analysis of Local Community Perception of Physical-Spatial Reconstruction of Hadi Project Implementation in Roshtkhar District by Khadije Sadeghi, Mehrshad ToulabiNejad

“…It can be said that the effects of conducting the plan on the physical development of the villages of the region are not the same and conducting the conducting plan In the meantime, it allows for the development and rehabilitation of a systematic physical environment that is targeted at rural households.…”
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Development of an EOR-produced petroleum wastewater treatment system through integrated polyacrylonitrile membrane and ZrO2/sericin technologies: revelation of interactive mechanis... by Mengna Li, Guohe Huang, Xiujuan Chen, Zeyuan Xu, Jing Huang, Jianan Yin, Renfei Feng, Ning Chen, Stuart Read, Shuguang Wang

“…., fouling modes and interactive force) need further exploration. Herin, a novel ZrO2/sericin polyacrylonitrile (ZrSS) ultrafiltration membrane was developed for PW treatment, and the impacts and mechanisms of contaminants in PW on membrane filtration performance were systematically investigated using synchrotron-based technology and extended Derjaguin–Landau–Verwey–Overbeek (XDLVO) analysis. …”
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Channel length effects on the performance of vOECTs by Jinjie Wen, Baining Tao, Dan Zhao, Yixin Zhou, Yueheng Zhong, Sihui Hou, Liang-Wen Feng, Jianhua Chen, Gang Wang, Wei Huang

“…Emerging vertical organic electrochemical transistors (vOECTs), easily enabling L of less than 100 nm, show extremely high transconductance ( g _m ) and small footprints. However, as a new device structure, systematic studies on the limit and effects of the L on transistor performances remain unexplored. …”
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Engineering design of feedstock powder and relevant thermal–mechanical performance of thermal/environmental barrier coatings by Xinchang Feng, Fangwei Guo, Lirong Luo, Yuzhang Wang, Yun Long, Xiaofeng Zhao, Fei Pan, Lei Guo, Qingfeng Zeng, Jing Feng, Chunlei Wan

“…Here, the structure and properties of feedstock powder prepared by state-of-the-art granulation technologies and their influences on the deposited coatings were systematically investigated, which can provide guidance for configuration optimization of feedstock powder and the manufacturing accuracy of the deposited coating. …”
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Mapping the interactions of critical factors in China’s first-contact healthcare systems using causal loop diagrams by Wenjun He, Yusupujiang Tuersun, Tao Yang, Yuting Wan, Minji Yong, Zizhen Huang, Zhiyong Xiao, Menglin Luo, Yujia Zhang, Yujie Liu, Tao Yang, Yi Qian, Dong Roman Xu

“…Abstract Background Primary healthcare plays a pivotal role in optimizing healthcare resource allocation and ensuring equitable access to services. …”
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Atmosphere regulation: unraveling effective strategies for creating high-performance iron ore/biochar composite nanomaterials in ball milling processes by Hui Zhang, Zi Cheng, Kai Hu, Boxiong Shen, Honghong Lyu, Jingchun Tang

“…All these characteristics significantly enhanced their redox activities. This structural optimization not only increased the active sites of the composites, but also effectively enhanced their activation of persulfate (PS), which was capable of generating a variety of reactive radicals (such as SO4 −·, ·OH, and ·O2 −) for the efficient degradation of phenol, in which ·OH and ·O2 − contributed 50.7% and 25.3% of phenol removal, respectively. …”
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Role, Methodology, and Measurement of Cognitive Load in Computer Science and Information Systems Research by Mira Suryani, Harry Budi Santoso, Martin Schrepp, Rizal Fathoni Aji, Setiawan Hadi, Dana Indra Sensuse, Ryan Randy Suryono, Kautsarina

“…This study investigates trends in CL measurement techniques in CS and IS research from 2017 to 2024, focusing on emerging tools, methods, and their applications. A systematic literature review (SLR) was conducted to provide a comprehensive overview of CL’s role in CS and IS, the methods used to detect it, and how it is analyzed across different tasks and environments. …”
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3D-Printed Organ-Realistic Phantoms to Verify Quantitative SPECT/CT Accuracy for 177Lu-PSMA-617 Treatment Planning by Lydia J. Wilson, Sara Belko, Eric Gingold, Shuying Wan, Rachel Monane, Robert Pugliese, Firas Mourtada

“…Geometric verification showed a slight systematic expansion (<10%) from the representative patient anatomy and leak testing confirmed watertightness of fillable chambers. …”
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The Role of Omega-3 Fatty Acids in Cognitive Health: From Development to Aging and Neurodegenerative Protection by Julia Adamiuk, Karolina Kopeć, Aleksandra Bartoszek, Agnieszka Marut, Marta Biskup, Jagoda Misiuk, Adriana Skuba, Katarzyna Załuska, Agnieszka Świdniak, Sylwia Nykiel

“…Materials and Methods A systematic review of randomized controlled trials, cohort studies, and meta-analyses was conducted. …”
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Effect of Nano-Modified Recycled Wood Fibers on the Micro/Macro Properties of Rapid-Hardening Sulfoaluminate Cement-Based Composites by Chunyu Ma, Liang Wang, Yujiao Li, Qiuyi Li, Gongbing Yue, Yuanxin Guo, Meinan Wang, Xiaolong Zhou

“…In this study, high-performance sulfoaluminate cement (SAC)-RWF composites prepared by modifying RWFs with nano-silica (NS) and a silane coupling agent (KH560) were developed and their effects on mechanical properties, shrinkage behavior, hydration characteristics, and microstructure of SAC-RWF composites were systematically investigated. …”
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Efficient Regulation of Oxygen Vacancies in β-MnO₂ Nanostructures for High-Loading Zinc-Ion Batteries by Jian-Chun Wu, Yaoyu Yin, Haitao Zhou, Xicheng Shen, Hongquan Gao, Xiaowei Li, Zhiyong Liu, Yihong Deng, Yanxin Qiao

“…Further, a hybrid electrode combining oxygen-deficient β-MnO₂-x-3 (air-calcined) and structurally stable β-Mn₅O₈-y-3 (Ar-calcined) achieves a retained capacity of 3.9 mAh cm⁻² with stable cycling performance, achieving an optimal equilibrium between high capacity and long-term operational durability. …”
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The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery by Iwao Sugitani, Naomi Kiyota, Yasuhiro Ito, Naoyoshi Onoda, Tomo Hiromasa, Kiyomi Horiuchi, Seigo Kinuya, Tetsuo Kondo, Sueyoshi Moritani, Kiminori Sugino, Hisato Hara

“…Thirty-two clinical questions were established in these areas. Following a comprehensive search of the literature and systematic review to evaluate the overall evidence, we aimed to present optimal recommendations by considering the balance of benefits and harms from the patient’s perspective. …”
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An explainable machine learning model in predicting vaginal birth after cesarean section by Ming Yang, Dajian Long, Yunxiu Li, Xiaozhu Liu, Zhi Bai, Zhongjun Li

“…However, no valid tools can exactly predict who can have a vaginal birth among eligible candidates with one prior cesarean section. …”
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Concurrent Chemoradiotherapy Increases the Levels of Soluble Immune Checkpoint Proteins in Patients with Locally Advanced Cervical Cancer by Chao Liu, Xiaohui Li, Aijie Li, Wenxue Zou, Rui Huang, Xiaoyu Hu, Jinming Yu, Xiaoling Zhang, Jinbo Yue

“…Concurrent chemoradiotherapy (CCRT) has been widely applied to locally advanced cervical cancer (LACC) patients, inducing the massive release of antigen and systematic immunomodulatory effects. However, its effect on the soluble immune checkpoint proteins (sICPs) remains unclear, which might play a key role in the immune response. …”
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Machine Learning in the Management of Patients Undergoing Catheter Ablation for Atrial Fibrillation: Scoping Review by Aijing Luo, Wei Chen, Hongtao Zhu, Wenzhao Xie, Xi Chen, Zhenjiang Liu, Zirui Xin

“…Machine learning (ML) shows promising potential in optimizing the management and clinical outcomes of patients undergoing atrial fibrillation CA (AFCA). …”
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SIU-ICUD: Screening and Early Detection of Prostate Cancer by Ola Bratt, Mohamed Jalloh, Anwar R. Padhani, Paul F. Pinsky, Hein Van Poppel, Weranja Ranasinghe, Kamran Zargar-Shoshtari, Kai Zhang, Anssi Auvinen

“…<b>Methods:</b> This is a narrative review of modern diagnostic methods, ongoing trials, national policies and knowledge gaps related to screening and early detection of prostate cancer. …”
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Summary of Best Evidence for Integrated Airway Management in ICU Tracheostomy Patients by Guo J, Li Y, Xie D, Zhang M, Fu S

“…These were further divided into 15 sub-themes, covering equipment management, environmental optimization, infection prevention, postoperative care, airway humidification, suctioning, tracheostomy tube management, skin care, rehabilitation exercises, complication prevention, and daily assessments.Conclusion: This research systematically compiles the optimal evidence regarding the care and management of tracheostomy patients, offering a comprehensive foundation for evidence-based clinical practice. …”
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Study on the Deformation Characteristics of the Surrounding Rock and Concrete Support Parameter Design for Deep Tunnel Groups by Zhiyun Deng, Jianqi Yin, Peng Lin, Haodong Huang, Yong Xia, Li Shi, Zhongmin Tang, Haijun Ouyang

“…The influences of surrounding rock strength, reinforcement ratio, and secondary lining thickness on the bearing capacity of the secondary lining were systematically evaluated. The following findings were obtained: (1) The tunnel group effect was found to be negligible when the spacing (<i>D</i>) was ≥65 m and the burial depth was 1600 m. (2) Both <i>P</i>_0.3 and <i>P</i>_max of the secondary lining increased linearly with reinforcement ratio and thickness. (3) For surrounding rock of grade III (IV), 95% <i>u</i>_lim and 90% <i>u</i>_lim were found to be optimal support timings, with secondary lining forces remaining well below the cracking stress during construction. (4) For surrounding rock of grade V in tunnels with a burial depth of 200 m, 90% <i>u</i>_lim is recommended as the initial support timing. …”
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Factors associated with non-adherence to clinic visits among patients with severe mental illness enrolled in the SMILE study in Uganda by Richard Stephen Mpango, Wilber Ssembajjwe, Godfrey Zari Rukundo, Philip Amanyire, Carol Birungi, Allan Kalungi, Rwamahe Rutakumwa, Jonah Ibanda, Christine Tusiime, Kenneth D. Gadow, Vikram Patel, Moffat Nyirenda, Eugene Kinyanda

“…A total of 1,201 participants with confirmed diagnoses of SMI were systematically sampled from over 3,000 outpatients. …”
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