TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Overall, median overall survival and progression-free survival were 7.6 (95% CI 4.9, 12.0) and 1.4 (95% CI 1.3, 1.8) months, respectively. …”
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From the Banks of the Orkhon to the Banks of the Neva: the History of Mining and Transit of Mongolian Gold to the Russian Empire at the beginning of the 20th century. by Aldar A. Shirapov, Anna M. Plekhanova

“…The strengthening of the ruble exchange rate and its free conversion provided the country with an influx of foreign investment, which contributed to the constant growth of its economy. …”
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The Managers' Perceptions of Telework Implementation Requirements in the Algerian Companies: A Post Covid-19 Assessment by Riad BENGHEBRID

“…Design/Method/Approach: We opted for an essentially qualitative approach field by conducting semi-structured interviews individually with 11 company managers from different sectors of activity in order for the interviewee to feel sufficiently free and to have as much transparency and credibility as possible, and to obtain in-depth information that is difficult to express quantitatively or statistically, with diversity of the sample in terms of (age, professional experience, sector of activity, legal form etc.). …”
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Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis by Stuart Silverman, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, Birol Emir

“…**Methods:** Optum Healthcare Solutions, Inc data (January 2012–March 2017) were used to identify patients over 18 with at least 2 diagnoses of hip and/or knee OA, and at least 90 days’ supply of opioids. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Finally, we explored two public microarray and RNA-seq datasets from patients with non-metastatic or metastatic MSI-H CRC to gain translational insights on the association between sex, BRAF status and immune contextures/ICI efficacy.Results Although no differences were observed between females and males either overall or in the BRAF wild-type cohort, male sex was associated with inferior progression-free survival (PFS) and overall survival (OS) in the BRAF mutated cohort (in multivariable models, HR for PFS: 1.79, 95% CI: 1.13 to 2.83, p=0.014, and for OS: 2.33, 95% CI: 1.36 to 3.98, p=0.002). …”
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The Effects of Soft Tissue Flossing on Hamstring Range of Motion and Lower Extremity Power by Zachary Maust, Debbie Bradney, Sean M Collins, Caroline Wesley, Thomas G Bowman

“…The floss treatment included wrapping the Rogue Wide Voodoo Floss Band™ from the proximal knee to the gluteal fold at a pressure of 140 to 200 mmHg. …”
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Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…Overall survival (OS), progression-free survival (PFS) and toxicities were evaluated. …”
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Response of Soil Respiration to Snowfall in a Kubuqi Salix Plantation Forest of During Freeze-thaw Period by WANG Jixuan, LAN Xiaozhen, PEI Zhiyong, ZHANG Junyao, WANG Xinping, LI Ying, WANG Haichao, SUN Xiaotian, SUN Kai

“…[Methods] Soil respiration rates of salix plantations that were untouched and unlevelled stubble (ww), untouched and levelled stubble (wp), untouched and unlevelled stubble (zw), and levelled and levelled stubble (zp) were measured in the snow-free treatment by using the Li-6800 soil-carbon-water flux measurement chamber in the Salix Forest Germplasm Resource Bank of the Dalate Banner, Ordos, Inner Mongolia, and the atmospheric temperature, soil temperature and humidity were measured simultaneously. …”
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IMPLEMENTASI PENERAPAN PRINSIP KERJASAMA PERDAGANGAN BEBAS DALAM KEBIJAKAN NASIONAL TERKAIT TINDAKAN PENGAMANAN PERDAGANGAN (SAFEGUARD) by Mira Utami, Umar Aris

“…Hasil pembahasan penelitian ini diharapkan dapat digunakan untuk memecahkan masalah terkait perlindungan hukum atas ancaman kerugian akibat tidak maksimalnya  perlindungan negara kepada warga negaranya dari ancaman kerugian serius akibat serbuan produk luar negeri dalam rangka kerjasama ekonomi perdagangan bebas (Free Trade Area) antar negara maupun kumpulan negara, yang saat ini telah diratifikasi, sehingga perdagangan bebas ini tidak merugikan bangsa indonesia dan pengaturan akan safeguard di negara Indonesia sejalan dengan norma norma terkait safeguard yang telah diatur oleh WTO. …”
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Initial versus Subsequent Injury and Illness and Temporal Trends Among Professional Hockey Players by Chelsea Martin, Allison Lieb, John Tokish, Ellen Shanely, Stefan Kluzek, Gary Collins, Garrett Bullock

“…Clinicians should be aware that 'lower body' injuries increased over time; therefore, injuries to the groin/hip/thigh or knee are likely underreported. # Level of Evidence Level 3…”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…The primary endpoint was 5-year overall survival (OS), and the secondary endpoints were 5-year disease-free survival (DFS) and recurrence rates. Results Before PSM, the RAMIE group had a longer operation time (min) than the MIE group (P = 0.019). …”
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Acceptability of and experiences with menstrual hygiene cups among adolescent girls and young women aged 15–24 in two communities in Lusaka, Zambia: an exploratory study nested in... by Melleh Gondwe, Melvin Simuyaba, Mwelwa Phiri, Chisanga Mwansa, Albertus Schaap, Lucheka Sigande, Kwame Shanaube, Sian Floyd, Sarah Fidler, Helen Ayles, Musonda Simwinga, Bernadette Hensen

“…Conclusion Despite concerns, misconceptions and initial challenges, cups were acceptable among AGYW. Free distribution of cups provides an opportunity to address menstrual health challenges among AGYW. …”
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Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the... by Jamshaed Siddiqui, Sally Bowditch

“…**Methods:** A cohort-based Markov model from a Dutch societal perspective, based on seizure frequency and seizure-free days, was developed for patients receiving CBD plus usual care (antiseizure medications, including clobazam) or usual care alone. …”
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Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress by Chao Du, Xinyu Ni, Mengjiao Yan, Qinghan Meng, Junying He

“…Levels of hydrogen peroxide and oxygen free radicals remained relatively stable under osmotic stress. …”
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Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma by Michael Dolph, Gabriel Tremblay, Adrienne M Gilligan, Hoyee Leong

“…**Methods**: Ovid was systematically searched for phase 2-3 randomized clinical trials (RCTs) in MM that assessed progression-free survival (PFS), overall survival (OS) and overall response rates (ORR). …”
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Saussurea gossypiphora extracts reduce inflammation by reversing inflammatory cytokine levels in in-vitro and in-vivo by Kalyani Jatoth, Pawan Kumar Anoor, Ramesh Kande, Sandeepta Burgula

“…Results: The analysis of GC–MS of MESGD revealed the presence of various bio-active components such as Spirohexane-1-Carboxylic acid, ethyl ester; 1-Methyl-1-n-decycloxy-1-silacyclobutane; 1, 2, 4-Trioxolane-2-octanoic acid, 5-octyl, methyl ester; DPPH assay showed inhibition of free radicals by 40 - 95.66 % in the range of 25 – 1000 µg/mL concentrations, comparable with Ascorbic acid. …”
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Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, T. L. Lapina, A. A. Sheptulin, A. S. Trukhmanov, Ye. K. Baranskaya, R. A. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, N. N. Dekhnich, R. S. Kozlov, I. L. Klyaritskaya, N. V. Korochanskaya, S. A. Kurilovich, M. F. Osipenko, V. I. Simanenkov, A. V. Tkachev, I. B. Khlynov, V. V. Tsukanov

“…Breath test with 13С-labeled urea, laboratory test for assessment of anti-H. pylori antibodies in feces, rapid urease test and serological method can be recommended for primary diagnostics of infection. …”
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Comparing the Fiscal Consequences of Controlled and Uncontrolled Osteoarthritis Pain Applying a UK Public Economic Perspective by Rui Martins, Nikos Kotsopoulos, Melodi Kosaner Kließ, Craig Beck, Lucy Abraham, Samuel Large, Patricia Schepman, Mark P. Connolly

“…**Methods:** We used a Markov model to compare labour market participation in people with uncontrolled OA hip or knee pain compared to a cohort with controlled OA pain. …”
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Exploring the antimicrobial and antioxidative potential of Leucas aspera (Willd.) link: Phytochemical screening, molecular docking, and HR-LC/MS profiling against SARS-CoV-2 protei... by Thavasiaanatham Seenivasan Shalini, Ragothaman Prathiviraj, Poomalai Senthilraja

“…Methods: The L. aspera methanolic leaf extract displayed a phenolic content of 100 µg/ml, consisting of 3.02 mg of gallic acid dry weight equivalents and a flavonoid content of 100 µg/ml with 3.35 mg quercetin equivalents per dry weight. The extract's free radical scavenging capabilities were at 150 µg/ml in DPPH, showing an 87 % effectiveness compared to the standard ascorbic acid 49 % inhibition capacity. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Subsequently, in silico analyses such as protein-ligand interaction, physicochemical and pharmacokinetic profiling (ADMET), and molecular dynamics simulation coupled with binding free energy calculations were performed to identify lead compounds with high binding affinity and low toxicity.ResultsFive natural compounds, namely, (+)-pipoxide, Zinc000095485961, Naamidine A, (−)-pipoxide, and 1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside, were identified as potential inhibitors of aldose reductase. …”
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