ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells. by Xiaohui He, Yadong Sun, Hanhui Ma

“…The organization of the human genome in space and time is critical for transcriptional regulation and cell fate determination. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Temporal Analysis of Changes in Anthropogenic Emissions and Urban Heat Islands during COVID-19 Restrictions in Gauteng Province, South Africa by Lerato Shikwambana, Mahlatse Kganyago, Paidamwoyo Mhangara

“…Therefore, the lockdown restrictions provided an experimental scenario in which pollutants could be drastically reduced, thus accentuated the human impact on microclimates.…”
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A daily rhythm of cell proliferation in a songbird brain by Vladimira Hodova, Valentina Maresova, Rebecca Radic, Lubica Kubikova

“…Neurogenesis in laboratory rodents peaks at night, and the rodents are nocturnal, contrary to humans that are active during the day. Here, we studied whether proliferation and apoptosis exhibit a daily rhythm in the brain of the diurnal songbird zebra finch (Taeniopygia guttata) and whether the cell proliferation peaks during the dark phase of the day, as in rodents. …”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Importantly, the induced antibodies effectively inhibited the binding of RBD to human angiotensin-converting enzyme 2 (hACE2) and neutralized SARS-CoV-2 pseudoviruses. …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Typhimurium, ST) is a food-borne pathogen that can be transmitted from animals to humans and causes symptoms such as diarrhea, fever, and vomiting. …”
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Balloon occlusion of the aorta during cardiac arrest -a death blow to the intestines? by Bjørn Hoftun Farbu, Jostein Brede

“…What are the consequences? Main text Human data on REBOA in non-traumatic cardiac arrest is limited. …”
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MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…EMT is involved in multiple physiological and pathological processes in the human body. The occurrence of EMT involves many signal transduction pathways and complex molecular mechanisms related to calnexin, growth factors, transcription factors, and the microenvironment. …”
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Fine Particulate Matter Deposition in 3D Out-of-Plane Bifurcation Lung Airway by Chun-Chih Chuang, Justus Kavita Mutuku, Chih-Che Chueh, Anurita Selvarajoo, Wei-Hsin Chen

“…While the in-plane airway structures of human lungs are usually used in numerical models, a 3D out-of-plane layout that can geometrically represent triple bifurcations airways of the so-called Weibel model is developed in the present study with the presence of fine particles inside. …”
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Assessment of forest soil contamination by heavy metals in the Polish National Park near Warsaw by Aneta Łukaszek-Chmielewska, Joanna Rakowska, Marzena Rachwał, Olga Stawarz

“…Abstract The forest ecosystems are essential for human well-being development and reduction of the risk of natural disasters. …”
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Preschoolers' prosocial behavior in groups—Testing effects of dominance, popularity, and friendship by Anne Katerkamp, Lisa Horn

“…Prosocial, other-benefitting behavior is a fundamental aspect of human social behavior. In the microsystem of their natural social groups, preschool children have to decide not only whether, but also whom to share with and help on a daily basis. …”
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Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria by A.B. Ojekale, O. Lawal, M.O. Lasisi, C.A. Bamgbose, F.A. Dosu

“…A total of 31 bioactive compounds were positively identified in the three bitter drinks analyzed, Out of which are: Yoyo (5-Hydroxymethylfurfural (6.8%), Coumaran (1.7%), Octamethyl cyclotetrasiloxane ( 4.5%), Squalene(3.2%) - 2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one(1.7%),3,3-Dimethyl-2butanol(1.1%),2-Hydroxy-2- cyclopenten-1-one (0.7%)). …”
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Molecular investigation on active compounds in papaya leaves (Carica papaya Linn) as anti-malaria using network pharmacology, molecular docking, clustering-based analysis and molec... by Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti, Yenni Yusuf, Hartono, Abdur Rahman Arif

“…A total of 23 proteins linked to the active compounds and malaria-related targets in human proteins were identified using network analysis. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Herein, we identified the neuronal chemokine CCL21 as a major cause of microglial cell imbalance through the CCR7 receptor pathway with therapeutic implications for PD. In humans, we found that CCL21 transcript expression was increased in dopaminergic neurons (DANs) of the substantia nigra in PD patients. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Furthermore, THB exhibited significant inhibition of sPLA2 activity in human serum from dengue patients (n = 31, p < 0.0001) than that exhibited by CAY 10590. …”
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Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort stud... by Xin Liu, Kaihua Zhao, Ziyan Zhang, Meiyan Liu, Hongwu Chu, Xiao Zou

“…Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. …”
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A systematic review of neurological symptoms and brain abnormalities in SARS-CoV-2 infections by Daniel Montoya, Jacobo Albert, Sarah Lopez-Martin

“… The aim of this systematic review is to show some clear evidence of COVID-19 infections in the human brain and draw attention to the neurological symptoms that were described during the early stages of the pandemic. …”
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Primordial Cause of Armament, Disarmament, Weaponry and Weapons of Mass Destruction by Effiong Ekpo

“… The entirety of humanity has been confronted with a serious threat to security, especially since after the cold war. …”
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Bacterial community assembly of specific pathogen-free neonatal mice by Elizabeth A. Kennedy, James S. Weagley, Andrew H. Kim, Avan Antia, Anna L. DeVeaux, Megan T. Baldridge

“…Abstract Background Neonatal mice are frequently used to model diseases that affect human infants. Microbial community composition has been shown to impact disease progression in these models. …”
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Efficacy of unified protocol for transdiagnostic treatment of emotional disorders in adolescents (UP-A) in China: protocol for a randomised controlled trial by Xue Gao, Lu Liu, Mei-Rong Pan, Hai-Mei Li, Yu-Feng Wang, Xue-Ying Liu, Zhong-Fang Fu, Qiujin Qian

“…The findings may contribute to providing an effective and feasible transdiagnostic intervention in Chinese clinical settings.Ethics and dissemination This trial has been approved by the Ethics and Clinical Research Committees of Peking University Sixth Hospital and will be performed under the Declaration of Helsinki with the Medical Research Involving Human Subjects Act (WMO). The results will be disseminated in a peer-reviewed journal and a conference presentation.Trial registration number ChiCTR2300069354.…”
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