Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…BackgroundAlthough the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. …”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…A vaccination assay on a humanized mouse model (HLA-A2/DR1) was used to validate the immunogenicity and the presentation of these peptides. …”
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Modelling the air quality impacts of a zero emission zone scenario in the city of Milan by Andrea Piccoli, Valentina Agresti, Marco Bedogni, Giovanni Lonati, Guido Pirovano

“…The assessment of possible benefit of ZEZ on emissions, air quality and human health can be performed with a dedicated modelling chain. …”
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Cyanidin and Cyanidin-3-Glucoside Alleviate Peptic Ulcer Disease: Insights from in vitro, and in vivo Studies by Prayoga DK, Aulifa DL, Budiman A, Levita J, Jiranusornkul S

“…These compounds have proven effective in managing other health problems, including peptic ulcers, but more in-depth exploration in clinical settings is required to confirm therapeutic potential in humans. It is necessary to validate the therapeutic efficacy and safety in human populations. …”
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Vertical and horizontal bone loss following alveolar socket preservation using bone grafts and autologous platelet concentrates vs bone grafts alone: a systematic review and meta-a... by Shivang Davda, Rawand Shado, Ines Novo Pereira, David Madruga, Haidar Hassan

“…The inclusion criteria involved comparative human studies ranging from evidence levels II to III (Oxford Centre for Evidence-Based Medicine Levels of Evidence). …”
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Distribution and Antifungal Susceptibility Profile of Oropharyngeal Candida Species Isolated from People Living with HIV in the Era of Universal Test and Treat Policy in Uganda. by Musinguzi, Benson, Turyamuhika, Laban, Mwesigwa, Alex, Nalumaga, Pauline Petra, Kabajulizi, Immaculate, Njovu, Israel Kiiza, Mwebesa, Edson, Luggya, Tonny, Ocheng, Francis, Kateete, David Patrick, Itabangi, Herbert, Mboowa, Gerald, Obondo, James Sande, Achan, Beatrice

“…Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and the emergence of antifungal resistance (AFR). …”
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An Update on African Trypanocide Pharmaceutics and Resistance. by Keneth Iceland, Kasozi, MacLeod, Ewan Thomas, Ntulume, Ibrahim, Welburn, Susan Christina

“…African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T. b rhodesiense are responsible for chronic and acute human African trypanosomiasis (HAT), respectively. …”
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Jere COVID-19 : Pi bon Pratik pou Agribiznis by Tom Maddox, Laurel Dunn, Michelle Danyluk, Emmanuel Duvalsaint

“…This new 2-page publication of the UF/IFAS Food Science and Human Nutrition Department is the Haitian Creole translation of FSHN20-27/FS369: Handling COVID-19: Best Practices for Agribusiness. …”
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Planificación de menú para adultos con diabetes by Nancy Gal, Wendy J. Dahl, Daniela Rivero Mendoza

“…Dahl, translated by Daniela Rivero Mendoza, and published by the UF/IFAS Food Science and Human Nutrition Department. …”
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Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis by Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun

“…It is worth emphasizing that such pathological thickness of growth plates was evident in adolescent humans with enthesitis-related arthritis, which could progress to AS in adulthood. …”
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Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2 by Yun-Ya Yang, Gurpal S. Toor

“…This series is intended to give state and local government officials, soil scientists, consulting engineers, extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects, and source of various contaminants in the environment and (2) guidance on ways to protect human and environmental health. This 9-page fact sheet discusses the sources and impacts of PPCPs and offers common-sense ways we can protect our environment from PPCPs. …”
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Florida's Bats: Florida Bonneted Bat by Holly K. Ober, Terry J. Doonan, Emily H. Evans

“…The Florida bonneted bat was listed as federally endangered in 2013 because of concerns over habitat loss, degradation, and modification caused by humans. Additional concerns include the species’ small population size and restricted range, the small number of known colonies, their slow reproduction, and the relative isolation of separate populations of bonneted bats. …”
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Safe Handling of Food and Water in a Hurricane or Related Disaster by Ronald H. Schmidt, Keith L. Schneider, Renée M. Goodrich, Amarat Simonne, Douglas L. Archer

“…This document is FSHN0520, one of a series of the Food Science and Human Nutrition Department, UF/IFAS Extension. Original publication date October 2005. …”
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Barriers to health equity in the United States of America: can they be overcome? by Allen M. Chen

“…In 1948, the inaugural Constitution of the newly founded World Health Organization clearly stated that “the enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic or social condition.” …”
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3D convolutional deep learning for nonlinear estimation of body composition from whole body morphology by Isaac Y. Tian, Jason Liu, Michael C. Wong, Nisa N. Kelly, Yong E. Liu, Andrea K. Garber, Steven B. Heymsfield, Brian Curless, John A. Shepherd

“…In this study, we present a novel application of deep 3D convolutional graph networks and nonlinear Gaussian process regression for human body shape parameterization and body composition estimation. …”
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Mechanism study on the enhancement of bile acid-binding capacity in corn by-product juice via Lactiplantibacillus plantarum HY127 fermentation by Huanyong Lv, Xiaohui Tang, Jian Zhang, Menghan Ma, Xinyi Li, Zhenjie Zheng, Yunhe Xu, Lili Zhang

“…Hyperlipidemia is a common endocrine metabolic disease in humans. Long-term medications often have adverse effects, making the search for safer and more effective treatments crucial. …”
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Feminist spiritualities, gender equality and sustainable development: The possibilities of a countermovement by N. Swanepoel, T. van Wyk

“…Feminist spirituality became a countermovement – countering perceptions and ingrained convictions that a woman could not be a mediator between God and humanity. …”
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Biomimic models for in vitro glycemic index: Scope of sensor integration and artificial intelligence by Mohammed Salman C K, Muskan Beura, Archana Singh, Anil Dahuja, Vinayak B. Kamble, Rajendra P. Shukla, Sijo Joseph Thandapilly, Veda Krishnan

“…In vitro digestion models face challenges in replicating the dynamic conditions of the human gastrointestinal tract, such as enzyme variability and multi-time point analysis, leading to suboptimal predictive accuracy. …”
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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

“…While resistance and persistence have been described, whether drug-induced tolerance exists in cancer cells remains largely unknown. Here, we show that human cancer cells elicit a tolerant response when exposed to commonly used chemotherapy regimens, propelled by the pervasive activation of autophagy, leading to the comprehensive activation of DNA damage repair pathways. …”
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COMPARATIVE ANALYSIS OF TRADITIONAL AFRICAN AND WESTERN PEACE BUILDING by TANKO SHAWULU PAUL PAUL, KINGSLEY PHILIPS NOYE, EMMANUEL ACHUS JAH

“… Conflict is a two edge phenomenon that can instigate human creativity toward innovation with the aim of providing stability and peace; on the other side is the distractive role it provides to the society. …”
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