Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation by Donghyun Kang, Jeeyeon Lee, Geunho Yook, Sehan Jeong, Jungkwon Shin, Mi-Sung Kim, Yi-Jun Kim, Hyeryeon Jung, Jinsung Ahn, Tae Woo Kim, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Won Ho Yang, Yong-ho Lee, Jin Won Cho, Eugene C. Yi, Chanhee Kang, Jin-Hong Kim

“…Abstract UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage proteoglycans and simultaneously acts as a substrate for O-GlcNAcylation. Here, we show that transporters for UDP-GlcNAc to the endoplasmic reticulum (ER) and Golgi are significantly downregulated in osteoarthritic cartilage, leading to increased cytosolic UDP-GlcNAc and O-GlcNAcylation in chondrocytes. …”
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Large-scale prospective serum metabolomic profiling reveals candidate predictive biomarkers for suspected preeclampsia patients by Yan Cao, Lanlan Meng, Yifei Wang, Shenglong Zhao, Yuanyuan Zheng, Rui Ran, Jie Du, Hongqiang Wu, Jiaqi Han, Zhengwen Xu, Yifan Lu, Lin Liu, Lu Chen, Jing Wang, Youran Li, Yanhong Zhai, Zhi Sun, Zheng Cao

“…In order to explore the global changes of serum metabolites in PE patients and identify potential predictive biomarkers for suspected PE patients (pregnant women who had already shown PE-related symptoms in the middle to late stages of pregnancy, but were not yet confirmatively diagnosed as PE.), a large-scale serum metabolomic analysis was conducted in this study with a prospective cohort of 328 suspected PE patients in the middle or late pregnancy stages, as well as a retrospective cohort of 30 healthy pregnant women and 30 PE patients. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…The inclusion of supply codes for mechanical valve replacements enhanced accuracy but led to fewer eligible patients being included in the sample. This study provides a potentially optimal framework for future research on valve diseases and surgeries using claims databases.…”
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Metabolite profile and antioxidant activities of Trikatu, black pepper, Javanese long pepper, and red ginger essential oils by Dewa Ayu Ika Pramitha, Tati Herlina, Iman Permana Maksum, Ari Hardianto, Abd. Wahid Rizaldi Akili, Jalifah Latip

“…Methods: The essential oils from BP, JLP, and RG were extracted using the stahl hydro-distillation method. …”
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An App-Based Intervention With Behavioral Support to Promote Brisk Walking in People Diagnosed With Breast, Prostate, or Colorectal Cancer (APPROACH): Process Evaluation Study by Fiona Kennedy, Susan Smith, Rebecca J Beeken, Caroline Buck, Sarah Williams, Charlene Martin, Phillippa Lally, Abi Fisher

“…MethodsAdults (aged ≥18 y) with breast, prostate, or colorectal cancer who reported not meeting the UK guidelines for moderate-to-vigorous physical activity (≥150 min/wk) were recruited from a single hospital site in Yorkshire, United Kingdom. …”
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Isolated central nervous system relapse in blast crisis of chronic myeloid leukemia: a case report by Hari Priya Raghvan, Caroline Ho Siew Ling, Wee Shiang Yui, Boo Yang Liang, Ehram Jamian, Indhira Subbiah

“…Central nervous system (CNS) involvement is an uncommon manifestation of CML, particularly as an isolated CNS relapse. Here, we present a rare case of CML in lymphoid blast crisis with an isolated CNS relapse. …”
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Convolutional Attention Based Mechanism for Facial Microexpression Recognition by Hafiz Khizer Bin Talib, Kaiwei Xu, Yanlong Cao, Yuan-Ping Xu, Zhijie Xu, Muhammad Zaman, Adnan Akhunzada

“…Using the ConvMixer architecture, we Proposed a novel technique for facial microexpression identification based on convolutional attention mechanism. …”
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Heme-Iron OptiFer® in the Treatment of Iron Deficiency Anemia During Pregnancy by Ibrahim A. Abdelazim, Mohannad AbuFaza, Soud M. Al-Ajmi, Osama O. Amer, Svetlana Shikanova, Bakyt Karimova

“… OBJECTIVES: This study designed to compare the efficacy, and tolerability of heme-iron OptiFer® to ferrous fumarate in the treatment of iron deficiency anemia during pregnancy. STUDY DESIGN: Two hundred and thirty-four (234) women with iron deficiency anemia during pregnancy were included in this study; 121 women in the heme-iron OptiFer® group, and 113 women in the ferrous fumarate group. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…Matériels et méthodes- L’étude a été réalisée durant la pandémie du 01 Janvier 2022 au 31 Mars 2022 au moyen d’un questionnaire distribué aux pharmaciens d’officines exer­çant à Tiaret, Sidi Bel-Abbès et El-Bayadh. Le critère de jugement principal était l’éva­luation des pratiques d’automédication. …”
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A comprehensive environmental index for monitoring ecological quality of typical alpine wetlands in Central Asia by Jiudan Zhang, Junli Li, Changming Zhu, Anming Bao, Amaury Frankl, Philippe De Maeyer, Tim Van de Voorde

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Automated on-site broiler live weight estimation through YOLO-based segmentation by Mahmoud Y. Shams, Wael M. Elmessery, Awad Ali Tayoush Oraiath, Ahmed Elbeltagi, Ali Salem, Pankaj Kumar, Tamer M. El-Messery, Tarek Abd El-Hafeez, Mohamed F. Abdelshafie, Gomaa G. Abd El-Wahhab, Ibrahim S. El-Soaly, Abdallah Elshawadfy Elwakeel

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Evaluating the impacts of microplastics on agricultural soil physical, chemical properties, and toxic metal availability: An emerging concern for sustainable agriculture. by Tapos Kumar Chakraborty, Md Simoon Nice, Md Sozibur Rahman, Baytune Nahar Netema, Khandakar Rashedul Islam, Samina Zaman, Gopal Chandra Ghosh, Md Ripon Hossain, Asadullah Munna, Mst Shamima Akter, Md Abu Rayhan, Sk Mahmudul Hasan Asif, Abu Shamim Khan

“…PLoS ONE…”
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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…UPLC-QE-Orbitrap-MS was applied to analyze the serum compositions of HVO. Network pharmacology and molecular docking were employed to uncover the complex mechanisms of HVO in treating SRA and predict potential effective compounds in HVO. …”
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Efficacy of TIPS plus extrahepatic collateral embolisation in real-world data: a validation study by Chao Chen, Feng Zhang, Hao Wu, Wei Wu, Hui Xue, Yuzheng Zhuge, Chunqing Zhang, Guangchuan Wang, Zhengjie Li, Qiong Wu, Bo Wei, Jun Tie, Xiubin Sun, Lianhui Zhao, Yifu Xia, Jiao Xu, Peijie Li

“…This study aims to confirm the effectiveness of TIPS+E using real-world data.Methods The multicentre retrospective cohort included 2077 patients with cirrhosis who underwent TIPS±E (TIPS: 631, TIPS+E: 1446) between January 2010 and December 2022. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Mammography of patients with pathologically proven breast cancer was obtained from two centers. A deep learning-based model (CBAM ResNet-18) for predicting HER2, ER, and PR expressions was trained and validated using five-fold cross-validation on a training dataset. …”
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Silicon photonic modulators with a 2 × 1 Fabry–Perot cavity by Cao Hengzhen, Xie Jin, Sun Weichao, Zhu Mingyu, Xiang Yuluan, Zhang Gong, Guo Jingshu, Shi Yaocheng, Dai Daoxin

“…Silicon photonics modulators based on a 2 × 1 Fabry–Perot (FP) cavity, which is circulator-free, are proposed and demonstrated by introducing two asymmetric multimode-waveguide grating (AMWG) reflectors and a short straight modulation section with interleaved PN junctions. …”
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Pregnancy Loss Was Associated With the Increased Risk of Cardiovascular Diseases in Middle-Aged Women: Evidence From the China Health and Retirement Longitudinal Study by Xiaoyan Yang, Qingling Fan, Can Shen, Ruirui Hou, Ruoling Chen, Jiaqian Yin, Huifeng Xiang, Yunxia Cao, Xiaoqing Peng

“…Therefore, this study aimed to investigate the associations of pregnancy loss, number of pregnancy losses, subtype of pregnancy loss (i.e. induced abortion, miscarriage and stillbirth) and age at the first pregnancy loss with CVD risk in Chinese population. Methods: We examined data of 7,486 middle-aged women (mean age 58.1 years) from the China Health and Retirement Longitudinal Study. …”
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