Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

“…Methods: We retrospectively collected clinical and genomic data from 275 patients with treatment-naïve advanced NSCLC who had undergone plasma-based NGS at diagnosis in our institution. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…To this end, whole blood genome-wide transcriptome of three trypanotolerant taurine breeds (N’Dama, Lagune and Baoulé), one susceptible zebu (Zebu Fulani) and one African taurine x zebu admixed breed (Borgou) were profiled by RNA sequencing at four time points, one before and three during infection. …”
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Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…Among 299 high-quality ARG-carrying metagenome-assembled genomes (MAGs), we further revealed that the soil warming enhances the abundance of “supercarriers” including human pathogens with multiple ARGs and virulence factors. …”
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Características de empresas que influenciam o seu disclosure voluntário de indicadores de desempenho by Roberto Carlos Klann, Ilse Maria Beuren

“…Pesquisa descritiva com abordagem quantitativa foi realizada por meio das Demonstrações Financeiras Padronizadas (DFPs) do ano de 2008 de 90 empresas listadas no segmento do Novo Mercado de Governança Corporativa da BM&FBovespa. Tendo como referência a pesquisa de Watson, Shrives e Marston (2002), com base nestas demonstrações foram calculados indicadores de desempenho relacionados com as Teorias da Agência e da Sinalização e o disclosure voluntário. …”
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Integrating microplastic research in sustainable agriculture: Challenges and future directions for food production by Marcelo Illanes, María-Trinidad Toro, Mauricio Schoebitz, Nelson Zapata, Diego A. Moreno, María Dolores López-Belchí

“…Currently, the application of omics technologies, including genomics, transcriptomics, and metabolomics, offers novel insights into molecular mechanisms that enable the identification of specific biomarkers associated with MP exposure. …”
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Writers, readers, and erasers of N6-Methyladenosine (m6A) methylomes in oilseed rape: identification, molecular evolution, and expression profiling by Chaofan Shan, Kui Dong, Dongyu Wen, Ziyi Ye, Fei Hu, Meryem Zekraoui, Jun Cao

“…During the course of evolution, whole genome duplication (WGD) and segmental duplication were the primary drivers of the expansion of m6A-related gene families. …”
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O VOTO DO ACIONISTA-CREDOR NO PLANO ALTERNATIVO: UMA ABORDAGEM EMPÍRICA by Ivana Harter

“… O presente trabalho analisa a possibilidade de exercício de direito de voto pelo acionista/sócio e credor da sociedade em recuperação judicial, tendo em vista as alterações promovidas pela Lei nº 14.112/2020 à Lei nº 11.101/2005 (“Lei de Falência e Recuperação Judicial” ou “LRF”), que previu a legitimidade residual dos credores para apresentação de proposta alternativa de reestruturação. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Geotrichum candidum is a fungus used for cheese making and is also found in other environments such as soil and plants. By analyzing whole-genome data from 98 strains, we found that all strains isolated from cheese formed a monophyletic clade. …”
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Eucalyptus grandis WRKY genes provide insight into the role of arbuscular mycorrhizal symbiosis in defense against Ralstonia solanacearum by Jianlang Zhang, Xinzhu Yang, Chunyu Huo, Xinyi Fan, Qiutong Liu, Zhihong Liu, Yu Su, Zujing Chen, Zujing Chen

“…IntroductionWRKY transcription factors are essential for plant growth, health, and responses to biotic and abiotic stress.MethodsIn this study, we performed a deep in silico characterization of the WRKY gene family in the genome of Eucalyptus grandis. We also analyzed the expression profiles of these genes upon colonization by the arbuscular mycorrhizal fungus (AMF) Rhizophagus irregularis (Ri) and infection with the bacterial pathogen Ralstonia solanacearum (Rs).ResultsA total of 117 EgWRKYs were identified. …”
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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. by Anton W Roodnat, Chelsey Doyle, Breedge Callaghan, Karen Lester, Megan Henry, Carl Sheridan, Declan J McKenna, Colin E Willoughby, Sarah D Atkinson

“…This is the first study to present a genome-wide microRNA-mRNA regulatory network for human trabecular meshwork cells treated with TGF-β1 and may serve to generate unbiased hypotheses about regulatory functions and mRNA targets of miRNAs in pseudoexfoliation glaucoma and may help to develop miRNA-based therapeutics.…”
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Efecto de diferentes fuentes de nitrógeno en la emisión de óxido nitroso en plantaciones de café en Costa Rica by Johnny Montenegro

“…[Resultados]: El patrón de emisión mostró que, en Naranjo, los mayores eventos se determinaron luego de fertilizar en junio, razón por la cual la emisión fue mayor (P<0.0005) que la determinada en San Marcos de Tarrazú. …”
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The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The average age of patients and healthy individuals was 48.9 ± 13.1 and 47.89 ± 12.1 years, respectively. Genomic DNA was isolated by a standard phenol-chloroform extraction method. …”
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Implementación del dispositivo de atención a las urgencias subjetivas en la emergencia de un hospital de Guayaquil by Rodolfo Francisco Rojas Betancourt, Mariana de Lourdes Estacio Campoverde, Juan Andrés Cando Zapata, Mario Luis Burgos Calle

“…En respuesta a esta problemática, la presente investigación evaluó la efectividad del Dispositivo Analítico para el Tratamiento de Urgencias Subjetivas (DATUS) como una alternativa psicoterapéutica para abordar el sufrimiento psíquico derivado de eventos catastróficos. La metodología incluyó un enfoque mixto, combinando análisis cuantitativos para determinar la prevalencia de síntomas y la percepción de los pacientes sobre el tratamiento, y un enfoque cualitativo para documentar casos clínicos que ilustran la experiencia subjetiva de los afectados.  …”
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Competencias sociales y tecnologías de la información y la comunicación como factores asociados al desempeño en estudiantes de básica primaria con experiencia de desplazamiento... by Inírida Avendaño-Villa, Omar Fernando Cortés-Peña, Hilda Guerrero-Cuentas

“…Los resultados reflejan una actitud positiva frente al uso de las TIC en los estudiantes y docentes, el empleo de estrategias de solución de conflictos ante la prevalencia de expo - sición a eventos de agresión escolar, un mayor nivel de reconocimiento de conductas Prosociales en comparación con el reporte de conductas agresivas por parte de los docentes y el establecimiento de asociaciones estadísticamente significativas en - tre las competencias sociales de conducta prosocial y solución de conflictos de forma directamente proporcional, a diferencia de la relación inversa entre la conducta agresiva y la conducta prosocial; así como una relación directamente proporcional entre las conductas Prosociales y el desempeño académico y una asociación estadísticamente significativa entre el uso de TIC y el desempeño académico.…”
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Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk by Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang, Jianguo Zhang

“…The research incorporated UK Biobank genomic data to examine associations between genetic variants and lipid metabolism parameters. …”
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A MODIS based tool to assess inundation patterns: an example for the Paraná Delta River by M. Durante, C.M. Di Bella

“…Un valor umbral de NDWI1 = -0,2 permitió separar píxeles con menos de 60% de cobertura de agua de aquellos con más del 60% con una precisión del 91%. …”
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Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR by Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim, Andreas Dengel

“…This groundbreaking technology holds immense potential for the development of targeted therapies for a wide range of diseases, including cancers, genetic disorders, and hereditary diseases. CRISPR-Cas9 based genome editing is a multi-step process such as designing a precise gRNA, selecting the appropriate Cas protein, and thoroughly evaluating both on-target and off-target activity of the Cas9-gRNA complex. …”
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Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis by Ding X, Bai Z, Wang W, Gu Y, Li Z, Fan Y

“…In this study, a Mendelian randomization (MR) analysis was utilized to discover the causal associations between FI and AGA.Methods: Genome-wide association study (GWAS) data for FI and AGA were retrieved, and bidirectional MR analysis was conducted. …”
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Degradation and ultrastructural changes of resin-based pit and fissure sealants under simulated chewing conditions by Pimduean Sivavong, Ekamon Mahapoka, Anucharte Srijunbarl, Thawanrat Singthong, Thanchanok Suriyapongprapai, Soranun Chantarangsu, Murali Srinivasan, Thantrira Porntaveetus, Dusit Nantanapiboon

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A Bidirectional Mendelian Randomization Study Investigating the Causal Relationship Between Ankylosing Spondylitis and Chronic Obstructive Pulmonary Disease by Pan D, Dai X, Li P, Xue L

“…The analysis utilized publicly available statistics on AS and COPD from the Genome-wide Association Study (GWAS). The primary MR method employed was Inverse-Variance Weighting (IVW), supplemented by additional MR methods such as weighted median, MR-Egger, simple mode, and weighted mode. …”
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