Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile by Claudia Carrera-Bravo, Claudia Carrera-Bravo, Tianchi Zhou, Tianchi Zhou, Trang Chu, Jing Wen Hang, Harshvardhan Modh, Chenyuan Huang, Chenyuan Huang, Sitong Zhang, Sitong Zhang, Haining Hao, Haining Hao, Haining Hao, María José Cabada-García, Benoit Malleret, Benoit Malleret, Matthias G. Wacker, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Laurent Rénia, Kevin S. W. Tan

“…IntroductionMalaria is a vector-borne parasitic disease that affects millions worldwide. …”
Get full text

The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging by Enzhao Shen, Yuecheng Wu, Weijian Ye, Sihang Li, Junjie Zhu, Meifan Jiang, Zhicheng Hu, Gaoyong Cao, Xiaojing Yi, Fan Li, Zhouhao Tang, Xiaokun Li, Kwang Youl Lee, Litai Jin, Xu Wang, Weitao Cong

“…FGF13 (Fibroblast growth factor 13) has been implicated in various pathophysiological processes. However, its role in premature myocardial aging and cardiomyocyte senescence remains unknown. …”
Get full text

Laser-induced Breakdown Spectroscopy Based on Pre-classification Strategy for Quantitative Analysis of Rock Samples by Weiheng KONG, Lingwei ZENG, Yu RAO, Sha CHEN, Xu WANG, Yanting YANG, Yixiang DUAN, Qingwen FAN

“…Therefore, in order to improve the accuracy and stability of quantitative analysis, different methods are used to pre-process the data. For different pre-processing methods, the R2 values of four elements in six types of rock samples are mostly greater than 0.90, as shown in Table 2. …”
Get full text

Therapeutic effects and mechanisms of Xinmaitong formula for type 2 diabetes mellitus via GLP-1R signaling by Weidong Pu, Weidong Pu, Weidong Pu, Yang Pan, Yang Pan, Yang Pan, Kang Yang, Kang Yang, Kang Yang, Jian Gao, Jian Gao, Jian Gao, Fen Tian, Fen Tian, Fen Tian, Jingrui Song, Jingrui Song, Yubing Huang, Yubing Huang, Yanmei Li, Yanmei Li, Yanmei Li

“…This study aimed to investigate the therapeutic effects and potential mechanisms of XMT in the treatment of T2DM, focusing on the glucagon-like peptide-1 receptor (GLP-1R) signaling pathway.MethodsA TCM formula that promotes GLP-1R expression was screened using a GLP-1R promoter-dependent luciferase reporter gene vector (PGL3-GLP-1R-luc). The T2DM mouse model was established using a high-fat diet and streptozotocin (STZ). …”
Get full text

Research Status of Agricultural Nanotechnology and Its Application in Horticultural Crops by Xiaobin Wen, Zhihao Lin, Bin Sheng, Xueling Ye, Yiming Zhao, Guangyang Liu, Ge Chen, Lin Qin, Xinyan Liu, Donghui Xu

“…In terms of the research status, certain progress has been made in the research of nano-fertilizers, nano-pesticides, nano-sensors, nano-preservation materials, and nano-gene delivery vectors. However, it also faces problems such as complex processes and incomplete safety evaluations. …”
Get full text

Genetic diversity of Lecanicillium lecanii and its pathogenicity against Diaphorina citri by Lu Lianming, Cheng Baoping, Du Danchao, Hu Xiurong, Pu Zhanxu, Chen Guoqing

“…Diaphorina citri may be the most serious pest of citrus worldwide, primarily because it is the vector of huanglongbing (HLB), one of the most destructive citrus diseases, and can damage citrus directly by feeding fresh shoots and cause citrus sooty mold disease. …”
Get full text

Screening the Unidentified Noncommunicable Disease Prevalence in Orthopedic Outpatient Department in a Tertiary Care Teaching Institute in India by Vetrivel C Sengodan, Kalidas Ponnusami, Vijay KA Subramaniyan, Venkatesh Venkatachalam, Sreehari Vikram

“…With the burden of NCDs rising faster than that of communicable diseases like human immunodeficiency virus (HIV), tuberculosis (TB), and other vector- or waterborne illnesses, India is going through a rapid health shift. …”
Get full text

DENV2 and ZIKV modulate the feeding behavior of Aedes aegypti by altering the tyrosine-dopamine pathway by Dongmin Gao, Ruixu Jiang, Zhaoyang Wang, Jichen Niu, Gang Wang, Yicheng Wang, Yan Liang, Yibin Zhu, Gong Cheng

“…This research could help in developing strategies to target these processes, ultimately aiding efforts to control the spread of dengue and Zika viruses and reducing the risk of outbreaks.…”
Get full text

Wireless Authentication Method Based on Near-Field Feature Fusion Network by QIU Jiefan, ZHOU Kezhong, ZHU Dongfu, ZHANG Jinhong, CHI Kaikai

“…This fused feature vector was then processed by a linear classifier to perform probabilistic prediction, completing the identity recognition process. …”
Get full text

Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model. by Rocío Vega, Manuel Carretero, Rui D M Travasso, Luis L Bonilla

“…During angiogenesis, new blood vessels sprout and grow from existing ones. This process plays a crucial role in organ development and repair, in wound healing and in numerous pathological processes such as cancer progression or diabetes. …”
Get full text

Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma by Xiyuan Zhang, Xiyuan Zhang, Tiange Lu, Chunlei Shi, Mengfei Ding, Ling Wang, Xinting Hu, Xin Wang, Xin Wang

“…To evaluate the role of RGC32 in DLBCL, lentivirus vectors either encoding shRGC32 or shControl were transfected into DLBCL cell lines. …”
Get full text

Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Mario Romeo, Marcello Dallio, Fiammetta Di Nardo, Giuseppina Martinelli, Claudio Basile, Alessia Silvestrin, Giusy Senese, Annachiara Coppola, Carmine Napolitano, Angela Amoresano, Carlo Altucci, Alessandro Federico

“…Plastics can also serve as vectors for different potentially toxic additives, with specific MNPs constituting a persistent source of release of bisphenol A (BPA), a well-recognized exogenous etiological factor contributing to MASLD genesis and worsening. …”
Get full text

Analysis of the phenotypic traits of 20 crabapple varieties (Malus spp.) by ZHAO Dandan, ZHANG Yanwen, HU Yifei, WU Xiaojun, LIU Weichao, ZHANG Kaiming, LI Fei

“…The index with large absolute values of the feature vector was the length of the stem and the thickness of the stem. …”
Get full text

ACO-NM hybrid optimization calculation method for transit time of oxygen activation logging in CO2 injection profile by WANG Zhengyan, CHEN Meng, YANG Guofeng, LIU Guoquan, PEI Yang, CHEN Qiang

“…This approach reduced the dimension of the solution vector and enhanced operational efficiency. Despite the NM algorithm’s advantages of requiring no prior guidance and exhibiting rapid convergence, as a direct optimization algorithm, its results were greatly affected by the initial solution. …”
Get full text

Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi. by Maria Albertina Romaniuk, Alberto Carlos Frasch, Alejandro Cassola

“…Trypanosomes, protozoan parasites of medical importance, essentially rely on post-transcriptional mechanisms to regulate gene expression in insect vectors and vertebrate hosts. RNA binding proteins (RBPs) that associate to the 3'-UTR of mature mRNAs are thought to orchestrate master developmental programs for these processes to happen. …”
Get full text

Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis by Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan, Xinhua Liu

“…In vivo, adeno-associated virus (AAV) vectors carrying SMYD5 short-hairpin RNA (AAV-shSMYD5) were injected into the knee joints to knock down SMYD5 in a collagen-induced arthritis (CIA) mouse model to evaluate its role in joint damage. …”
Get full text

Muscle‐specific gene editing improves molecular and phenotypic defects in a mouse model of myotonic dystrophy type 1 by Mariapaola Izzo, Jonathan Battistini, Elisabetta Golini, Christine Voellenkle, Claudia Provenzano, Tiziana Orsini, Georgios Strimpakos, Ferdinando Scavizzi, Marcello Raspa, Denisa Baci, Svetlana Frolova, Spyros Tastsoglou, Germana Zaccagnini, Jose Manuel Garcia‐Manteiga, Genevieve Gourdon, Silvia Mandillo, Beatrice Cardinali, Fabio Martelli, Germana Falcone

“…Results and Conclusion Systemic delivery of CRISPR/Cas9 components in DM1 mice, through myotropic adeno‐associated viral vectors, led to significant improvement of molecular alterations in the heart and skeletal muscle. …”
Get full text

Bayesian Tapered Narrowband Least Squares for Fractional Cointegration Testing in Panel Data by Oyebayo Ridwan Olaniran, Saidat Fehintola Olaniran, Ali Rashash R. Alzahrani, Nada MohammedSaeed Alharbi, Asma Ahmad Alzahrani

“…We propose the Bayesian Tapered Narrowband Least Squares (BTNBLS) estimator, which addresses three critical challenges: (1) spectral leakage in long-memory processes, mitigated via tapered periodograms; (2) precision loss in fractional parameter estimation, resolved through narrowband least squares; and (3) unobserved heterogeneity in cointegrating vectors (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>θ</mi><mi>i</mi></msub></semantics></math></inline-formula>) and memory parameters (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>ν</mi><mo>,</mo><mi>δ</mi></mrow></semantics></math></inline-formula>), modeled via hierarchical Bayesian priors. …”
Get full text

A Detailed Single-pulse Study of Four-component Pulsar PSR J1239+0326 Discovered by FAST by R. Rejep, W. W. Zhu, N. Wang, W. M. Yan, J. P. Yuan, M. Kramer, L. Q. Meng, E. Gügercinoğlu, M. Yuan, W. Y. Wang, Z. W. Wu, Q. D. Wu, D. Zhao, S. Q. Wang, H. M. Tedila, S. J. Dang, M. Y. Xue, P. Wang, The FAST Collaboration

Get full text

KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Using CRISPR/Cas9 technology, this study generated cells with KEAP1 and STK11 knockouts, and utilized lentiviral vectors to overexpress PD-L1. Cellular sensitivity to KRAS-G12C inhibitors—AMG510, MRTX849, and JAB-21822—was evaluated through CCK-8 assays. …”
Get full text