Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction by Aishwarya Raj, Roon Banerjee, Vikram Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Indrani Datta

“…This study underscores the criticality of integrating astrocytes into treatment paradigms in synucleinopathies.…”
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Exploring affordable and effective pandemic containment measures in lower-income countries with a spatial SEIR model: a case study in South Africa by Lingyu Fan, Wenzhong Shi, Qing Pei, Anshu Zhang

“…Additionally, the spatial variation of containment measure effectiveness suggests that timely implementation of these measures before the infection rate escalates is critical for ensuring their effectiveness. …”
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Physical activity and eating habits of students of the University of Belgrade: An epidemiological study by Obradović Miloš, Nešić Goran, Popović Aleksandra, Božić Predrag, Savić Zoran, Kojić Filip, Đurić Saša

“…Methods. The survey method was used. Data were collected in the 2016/2017 school year during the spring semester. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

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A Systematic Review Uncovering Modifiable Influences on Statin Adherence by Rosenberg J, Lampridou S, Moores A, Garfield S, Wingfield D, Judah G

“…Existing reviews have methodological limitations, often failing to integrate qualitative and quantitative data or consider specific barriers to statin adherence. …”
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Predicting bearing capacity of gently inclined bauxite pillar based on numerical simulation and machine learning by Deyu WANG, Defu ZHU, Biaobiao YU, Chen WANG

“…To address this, a pillar strength prediction model is established by integrating parametric modelling's flexible interactivity, the scalability of numerical simulation sample data and the data-driven advantages of machine learning methods. …”
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IM4Equity: an implementation science meta-framework for community-engaged partnerships to advance health equity by Lilian G. Perez, James L. Merle, Justin D. Smith, Alex R. Dopp, Amy G. Huebschmann

“…For health equity initiatives, variations in which frameworks are used make synthesis and identification of shared determinants difficult, including equity constructs. …”
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Asymmetric white matter degeneration in amyotrophic lateral sclerosis: a diffusion kurtosis imaging study of motor and extra-motor pathways by Juan Carlos Quizhpilema, Ane Legarda, José Manuel Hidalgo, Pablo Lecumberri, Ivonne Jerico, Ivonne Jerico, Teresa Cabada, Teresa Cabada

“…Using whole-brain TBSS analysis and tractography with DIPY, we identified an asymmetric pattern of degeneration and involvement of integrative neural networks, providing new insights into ALS pathophysiology. …”
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Automatic Endoscopic Navigation for Monocular Depth and Ego-Motion Estimation in Wireless Capsule Endoscopy Through Transformer Network by Junjun Huang, Tianran He, Juan Xu, Weiting Wu, Wei Wu

“…Traditional Structure from Motion (SfM) and SLAM methods are often inadequate for GI scenes due to these inherent complexities. …”
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Effect of Elevated Temperature on Physical Activity and Falls in Low-Income Older Adults Using Zero-Inflated Poisson and Graphical Models by Tho Nguyen, Dahee Kim, Yingru Li, Christopher T. Emrich, Jennifer Crook, Ladda Thiamwong, Rui Xie

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Validation of Nova Stat Profile Prime Plus point-of-care testing for dialysis in South Africa by Kagiso M. Masemola, Ngalulawa Kone, Chemedzai Chikomba, Siyabonga Khoza

“…Results: In phase one, SPP+ showed acceptable precision (coefficients of variation 0% – 2.7%), linearity, and correlation (r  0.90). …”
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Unleashing the power of AI in predicting the technological and phenolic maturity of pomegranates cultivated in Lebanon by Rim Ghannoum, Nourhan Taha, David D. Gaviria, Hiba N. Rajha, Nada El Darra, Shadi Albarqouni

“…However, traditional methods often fail to consider the intricate interactions between environmental conditions and fruit maturity. …”
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Exploring nurse and patient perspectives on WeChat-based prenatal education in Chinese public hospitals: a qualitative inquiry by Yushi He, Guangmei Fan, Guangrui Fan, Dandan Liu

“…Pregnant women similarly recognized WeChat’s convenience for quick clarifications and access to nurse-vetted information, yet wide variations in digital health literacy led to uneven engagement. …”
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Insect conservation in agricultural landscapes needs both high crop heterogeneity and semi-natural habitats by Sara Tassoni, David Becker, Marit Kinga Kasten, Jérôme Morinière, Ingo Grass

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From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody by Shuyuan Cao, Bo Sun, Feng Gao, Feng Gao, Feng Gao

“…By enhancing nanobody efficacy, our method provides a viable framework for developing targeted countermeasures against evolving SARS-CoV-2 variants and other pathogens.…”
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Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities by Jiaqi Zhou, Miao Li, Yu Chen, Shangzi Wang, Danke Wang, Chen Suo, Xingdong Chen

“…Through covariance analysis, we demonstrated that sex differences in cancer are predominantly driven by variations in the magnitude of shared DNAm signals, referred to as “amplification.” …”
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Serum creatinine as a risk factor for endometriosis: insights from cross-sectional study, mendelian randomization analysis, and diagnostic model study by Yanan Duan, Yiqing Peng, Aiping Chen

“…Bidirectional MR analysis, utilizing genetic variation data from Large Genome Association Studies (GWAS), was performed to evaluate causal relationships using the inverse variance weighted (IVW) method, complemented by sensitivity analysis. …”
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Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma by Shangyi Luo, Li Liu, Yang Sun, Jian Shi, Yajing Zhang, Yajing Zhang, Yajing Zhang

“…The HCC evolutionary signature (HCCEvoSig) was developed and assessed across six cross-platform HCC cohorts.ResultsGenes exhibiting high intra- and inter-tumor expression variation were significantly enriched in a gene set associated with HCC prognosis, from which we developed and validated a reproducible and robust transcriptomic signature, HCCEvoSig. …”
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Indirect sliding mode adaptive fractional order nonlinear observer based controller with fractional order single-ended primary inductor converter by Sena Alemu Wondimu, Desalegn Tsega Dagne, Kinde Anlay Fante

“…The Mittag-Leffler function, along with Lyapunov methods, are used to analyze the system’s dynamic stability. …”
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Delivering a national de-adoption programme: a documentary analysis of local commissioning policy compliance with England's Evidence-based Interventions programme (EBI) by Carmel Conefrey, Nicola Farrar, Maeve Coyle, Mike Bell, Jane Blazeby, Christopher Burton, Jenny Donovan, Andy Gibson, Joel Glynn, Tim Jones, Angus McNair, Josie Morley, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, William Hollingworth, Leila Rooshenas

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