Comparative analysis of the multi-element and pharmacological composition of Gastrodia elata blume from different geographic origins by Yujie Shang, Shunqiang Yang, Qinxiang Chang, Kaize Shen, Shaoning Chen, Zongsuo Liang

“…Our results showed significant variations in both the chemical and mineral composition of the samples. …”
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Genetic and codon usage analyses reveal the evolution of the seoul virus by Yamei Wei, Yamei Wei, Yanan Cai, Yanan Cai, Xu Han, Zhanying Han, Yanbo Zhang, Yonggang Xu, Caixiao Jiang, Qi Li, Qi Li

“…However, its molecular evolutionary dynamics and codon usage patterns remain poorly understood.MethodsThis study integrated coding sequences from GenBank and previously acquired SEOV strains to systematically analyze genetic evolution and codon usage bias.ResultsIt revealed that SEOV evolved seven clades (A-G) with distinct amino acid variation sites and geographic clustering. …”
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Purine Nucleoside Phosphorylase (PNP) as a Biomarker and Therapeutic Target in Muscle-Invasive Bladder Cancer by Yanfei Chen, Peiyi Xian, Jianming Lu, Le Zhang, Chao Cai, Weide Zhong

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A study on the impact of neoadjuvant therapy on molecular subtype conversion in breast cancer by Run-Ze Zhang, Dong Liu, Yuan Ke, Wen-Qi Cai, Lin-Hui Zheng, Chao-Yan Wu, Hai-Jun Yu

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Explaining the Mechanism of Multiscale Groundwater Drought Events: A New Perspective From Interpretable Deep Learning Model by Hejiang Cai, Haiyun Shi, Zhaoqiang Zhou, Suning Liu, Vladan Babovic

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Infertility trends in China: analyzing temporal changes, public demand, and demographic differences based on Baidu index by Xun Li, Mengmeng Wei, Jingrui Zou, Jin Wei, Xin Lai, Xun Gong, Hong Hu, Xuanxuan Wang

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Precision computerised cognitive behavioural therapy (cCBT) intervention for adolescents with depression (SPARX-UK): protocol for the process evaluation of a pilot randomised contr... by Charlotte Lucy Hall, Chris Hollis, Kareem Khan, Peter Fonagy, Kirsty Sprange, Cathy Creswell, Yi Yang, Vibhore Prasad, Kapil Sayal, Nitish Jawahar, Ellen Townsend, Dorothee Auer, Praveetha Patalay, Aja Murray, Yvonne Kelly, Boliang Guo, Christopher R Tench, Paul Stallard, Louise Arseneault, Sieun Lee, Sally Merry, Charlotte Hall, Jo Gregory, Rory O’Connor, Emma Nielsen, Edmund Sonuga-Barke, Hannah Wright, Petr Slovak, Emily Lloyd, Josimar De Alcantara Mendes, Carolyn Ten Holter, Marina Jirotka, Aaron Kandola, Sonia Livingstone, Kasia Kostryka-Allchorne, Jake Bourgaize, Mariya Stoilova, Marianne Etherson, Chris Greenhalgh, Jim Warren, Vajisha Wanniarachchi, Kevin Glover, Mathijs Lucassen, Karolina Stasiak, Camilla Babbage, Adam Parker, Joanna Lockwood, Elvira Perez Vallejos, Rebecca Woodcock, Sarah Doherty, Lucy-Paige Willingham, Camilla May Babbage, Matthew Jeffery, Peiyao Tang, Holly Griffiths, Lily Roberts, A. Jess Williams, Lucy Hitcham

“…This protocol paper describes the rationale, aims and methodology of the SPARX-UK trial process evaluation.Methods and analysis The process evaluation will use a mixed-methods design following the UK Medical Research Council’s 2015 guidelines, comprising quantitative and qualitative data collection. …”
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Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer by Teng Wang, Zhaoming Chen, Wang Wang, Wang Wang, Heng Wang, Shenglong Li

“…BackgroundColorectal cancer (CRC) is a highly heterogeneous tumor, with significant variation in malignant cells, posing challenges for treatment and prognosis. …”
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Agenda-setting Policy Analysis on Iranian Physical Activity Promotion Policies: An application of Kingdon’s Multiple Streams Framework by Behrouz Fathi, Rahim Khodayari-Zarnaq, Sara Pourazavi, Haidar Nadrian, Ahmad Kousha

“…Purposeful sampling with a maximum variation was used to identify the key informants. …”
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A preliminary attempt to harmonize using physics-constrained deep neural networks for multisite and multiscanner MRI datasets (PhyCHarm) by Gawon Lee, Dong Hye Ye, Se-Hong Oh

“…The proposed physics constraints could be integrated with unsupervised methods, paving the way for more sophisticated harmonization qualities.…”
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Diversity and Distribution Patterns of Amphibians in the Huangshan Mountain Region: The Roles of Climate and Human Activities by Fei Hong, Dapeng Pang, Xiaojia Lin, Weixin Huang, Jie Fang, Wenbo Li

“…In this study, we applied field survey methods, the MaxEnt model, and integrated climate and human activity data to predict potential changes in the diversity and distribution of amphibian species in Huangshan Mountain, China. …”
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Nutrigenomics and personalized diets - Tailoring nutrition for optimal health by Divya Chaudhary, Diksha Guleria, Himanshi Aggarwal, Vaibhav Mishra, Abhishek Chauhan, Laurent Dufossé, Naveen Chandra Joshi

“…In addition, systems biology tools like proteomics, transcriptomics, and metabolomics work alongside statistical methods to analyse genetic variation and gut microflora differences that influence metabolic health through food bioactives. …”
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Identification, Geographical Traceability, and Thermal Oxidation and Photodegradation Studies of Camellia Oil Based on Raman Spectroscopy by Boxue Chang, Jingyue Huang, Qingli Xie, Yinlan Ruan, Rukuan Liu

“…However, its high market value and regional variations have led to frequent adulteration, highlighting the need for rapid, non-destructive methods for authentication, geographical traceability, and quality assessment. …”
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Detection of Pear Quality Using Hyperspectral Imaging Technology and Machine Learning Analysis by Zishen Zhang, Hong Cheng, Meiyu Chen, Lixin Zhang, Yudou Cheng, Wenjuan Geng, Junfeng Guan

“…Spectral data within the 398~1004 nm wavelength range were analyzed to compare the predictive performance of the Least Squares Support Vector Machine (LS-SVM) models on various quality parameters, using different preprocessing methods and the selected feature wavelengths. The results indicated that the combination of Fast Detrend-Standard Normal Variate (FD-SNV) preprocessing and Competitive Adaptive Reweighted Sampling (CARS)-selected feature wavelengths yielded the best improvement in model predictive ability for forecasting key quality parameters such as firmness, soluble solids content (SSC), pH, color, and maturity degree. …”
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Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer by Chen Zhang, Hubin Yin, Tinghao Li, Junrui Chen, Weiyang He, Ke Ren, Bo Li, Xudong Liu

“…Gene Set Variation Analysis and Gene Set Enrichment Analysis unveiled SDCBP exerted cancer-promoting biological processes, such as angiogenesis, EMT, metastasis and proliferation. …”
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Three-dimensional visualization and navigation for micro-noninvasive uterine fibroid surgery based on MRI and ultrasound image fusion by Ting Wang, Yingang Wen, Zhibiao Wang, Zhibiao Wang, Xi Li

“…ObjectiveTo address the challenges of low surgical precision and poor consistency in focused ultrasound ablation surgery (FUAS) for uterine fibroids, which are often caused by variations in clinical experience and operator fatigue, this study aims to develop an intelligent three-dimensional (3D) visualization and navigation system by integrating magnetic resonance imaging (MRI) with real-time ultrasound (US) imaging, thereby improving the accuracy and efficiency of uterine fibroid surgery.MethodsMRI and US images from 638 patients were annotated by experienced clinicians. …”
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Anaerobic Soccer Training Model: Enhancing Soccer Players’ Performance through a Combination of Repeated Sprints and 4 vs 4 Games by I Dewa Made Aryananda Wijaya Kusuma, Nining Widyah Kusnanik, Bayu Agung Pramono, Adi Pranoto, Yanyong Phanpheng, Indra Himawan Susanto, Dewa Ayu Praba Amustikarani, Waristra Tyo Nirwansyah, Muhammad Bagus Firzam Bharlaman

“…This study aimed to evaluate the effectiveness of the training model in improving soccer players’ anaerobic abilities. Materials and methods. The research method used was the ADDIE model consisting of five integrated phases: Analysis, Design, Development, Implementation, and Evaluation. …”
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Timing Matters: An Observational Study on Circadian Effects of Spinal Anesthesia in Cesarean Delivery by Evangelia Nikouli, Nikoleta Koutlaki, Kostas Anagnostopoulos, Soultania Anna Toubalidou, Christina Tsigalou, Pelagia Chloropoulou

“…Understanding these variations is important for optimizing anesthetic care. …”
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Research trends and frontiers of groundwater-lake interaction by Zesen YANG, Jingjing LIN, Qixin CHANG, Aiguo ZHOU, Xiaolong HUANG

“…The primary research methods are stable isotopes, radioisotopes, temperature tracing, remote sensing, and numerical modelling. …”
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‘Feeling Hot’: Exploring the feasibility of nocturnal erection detection through penile temperature measurements by Hille J. Torenvlied, Evelien Trip, Wouter Olthuis, Loes I. Segerink, Rob C. M. Pelger, Jack J. H. Beck

“…Subjects/Patients and Methods In this proof‐of‐concept study, 10 healthy men aged 20–25 were recruited, following the methodology outlined in the ‘Staying Hot’ study by Torenvlied et al. …”
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