Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis by Pengjian Zhang, Weizhang Chen, Kai Chen, Yuanhang Ye, Weijun Wu

“…Abstract Background Laryngeal squamous cell carcinoma (LSCC) is a common head and neck tumor with an increasing incidence rate and limited therapeutic efficacy in advanced stages. Methods This study integrated multi-omics data from multiple databases to comprehensively analyze the role of pan-apoptosis-related genes (PANRGs) in the prognosis of LSCC. …”
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Disaster medicine in Swedish undergraduate medical education: analysing current programs and future integration in the six-year curriculum by Sofia Olsson, Lisa Kurland, Fabian Taube, Joakim Björås, Yohan Robinson

“…Since the introduction of a revised six-year medical curriculum in 2021, it is unclear how disaster medicine will be integrated into the new program. This study aimed to evaluate the status of undergraduate disaster medicine education in Swedish medical schools, the teaching methodologies employed, plans for future curriculum integration, and the extent of variation across universities. …”
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Local pathways of association by Jiao Hu, Rui Qu, Yongze Song, Peng Wu

“…However, in large-scale studies, path analysis methods are often affected by local effects, which can influence the accuracy and reliability of the results. …”
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Seasonal dynamics and molecular regulation of flavonoid biosynthesis in Cyclocarya paliurus (Batal.) Iljinsk by Duo Chen, Yixin Xiao, Xuehai Zheng, Huamiao Sun, Cifeng Zhang, Jinmao Zhu, Ting Xue

“…Understanding the seasonal dynamics and molecular regulation of flavonoid biosynthesis in this species is crucial for optimizing its production.MethodsWe conducted an integrated analysis of transcriptomic and metabolomic data to identify key genes involved in flavonoid biosynthesis and regulation. …”
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AD-Det: Boosting Object Detection in UAV Images with Focused Small Objects and Balanced Tail Classes by Zhenteng Li, Sheng Lian, Dengfeng Pan, Youlin Wang, Wei Liu

“…Object detection in unmanned aerial vehicle (UAV) images poses significant challenges due to complex scale variations and class imbalance among objects. Existing methods often address these challenges separately, overlooking the intricate nature of UAV images and the potential synergy between them. …”
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Integrating Multimodal Neuroimaging and Genetics: A Structurally-Linked Sparse Canonical Correlation Analysis Approach by Jiwon Chung, Sunghun Kim, Ji Hye Won, Hyunjin Park

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An Integrative Multi-Omics Analysis Based on Nomogram for Predicting Prostate Cancer Bone Metastasis Incidence by Jun Zhao, Rui Wang, Xiaoxin Sun, Kai Huang, Jiacheng Jin, Lan Lan, Yuli Jian, Zhongyang Xu, Haotian Wu, Shujing Wang, Jianbo Wang

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Testing of Saline–Alkali Tolerance in Oat Germplasm Through Integrated Germination and Field Performance Assessments by Biru Zhang, Junzhen Mi, Baoping Zhao, Zhongshan Xu, Xingyan Li, Jinghui Liu, Zhiqiang Yuan

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Integrated geophysical prospecting for deep ore detection in the Yongxin gold mining area, Heilongjiang, China by Yechang Yin, Jun Chen, Zhonghai Zhao, Yuanjiang Yang, Chenglu Li, Haina Li, Xiang Zhao

“…However, relying solely on individual methods often introduces uncertainties. This study presents a case study from the Yongxin gold deposit, where we integrated audio-frequency magnetotelluric (AMT) methods with gravimetric surveying and high-resolution magnetic profiling to overcome this challenge. …”
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Implementation of the Integrated Lean Six Sigma Philosophy in an Angolan Manufacturing Company – a Case Study by Afonso Mkaka, Anna Burduk

“…This paper aims to compare two very well-known philosophies in the manufacturing industry: Lean Manufacturing (LM) and Six Sigma (6S). The integration of these two philosophies solves the insufficiency that the absence of one of them causes, considering that Six Sigma is based on statistical tools that focus on measuring and reducing variations in processes and achieving goals set by the customers' requirements. …”
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Choose your shortcuts wisely: COVID-19 rapid reviews of traditional, complementary and integrative medicine by Jennifer Hunter, Susan Arentz, Joshua Goldenberg, Guoyan Yang, Jennifer Beardsley, Myeong Soo Lee, Stephen P. Myers

“…Results: Included studies were five RR protocols of TCIM and 16 RRs, of which five considered TCIM. Wide variations in RR methods were proposed or applied, as were the reporting standards. …”
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HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development by Lu Chen, Wenxuan Li, Wenjing Zai, Xiangyi Zheng, Xianlong Meng, Qunyan Yao, Wei Li, Ying Liang, Mu Ye, Kaicheng Zhou, Mengxing Liu, Zhicong Yang, Zhanrui Mao, Hongyan Wei, Shuai Yang, Guoming Shi, Zhenghong Yuan, Wenqiang Yu

“…Results We identified nine fragments of HBV Sequences Integrated To Enhancer, termed as “HBV-SITEs”. Particularly, a single nucleotide variation (T > G) was embedded at seed sequence of HBV-miR-2 in the highest integrated HBV-SITE-1 between genotypes B and H. …”
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An Integrated Approach for Multiarea Reliability Improvement With Risk-Based Contingency Analysis and Optimal Load Curtailment by Tanmay Jain, Kusum Verma

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Assessment of Eurygaster integriceps parameters to improve integrated pest management in Southeastern Türkiye wheat fields by Mehmet Duman, İsmail Alaserhat

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Assessing the RNA integrity in dry seeds collected from diverse endangered species native to the USA by Hannah M. Tetreault, Zoe Zingerman, Lisa Hill, Shaimaa Ibrahim, Joyce Maschinski, Katherine D. Heineman, Katherine D. Heineman, Christina Walters

“…Germination conditions are often unknown for seeds produced from wild species and are an important criterion for seed testing.MethodsUsing standardized methods (i.e., commercially available kits) we tested the feasibility of adapting a new seed quality assay that measures RNA integrity and is promising for cultivated species, to seeds from wild species. …”
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Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature by Keyuan Zhao, Gang Xu, Jing Jin, Chao Peng, Jiajun Chen, Yulei Li, Weihao Wang, Shouhua Pan

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Integrating metabolism gene clusters and tumor immune microenvironment in head and neck squamous cell carcinoma by Meina Lian, Xiaoxia Wang, Zixian Huang, Yudong Wang, Zhiquan Huang

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Community integration enhances migrants’ satisfaction with primary care across districts with varying economic levels: survey evidence from Guangzhou, China by Yao Xiao, Sisi Zhong, Lingshan Chen, Lingshan Chen, Diwen Xiao, Wenhao Huang, Shangjian Wu, Luwen Zhang, Luwen Zhang

“…This study aimed to provide empirical evidence and recommendations for improving primary care utilization and community integration among migrant populations.MethodsWe conducted a stratified random sampling of 1,996 migrant individuals from seven districts in Guangzhou. …”
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Effects of Induced Endotoxaemia on Global Cardiovascular, Oxygenation and Haematologic Variables and the Integrity of the Endothelial Glycocalyx in the Horse by Stephan Neudeck, Philipp K. Sauter, Annette P. N. Kutter, Barbara Steblaj, Franz J. Söbbeler, Julia Reiners, Fritjof Freise, Alvaro. J. Gutiérrez Bautitsta, Sabine B. R. Kästner

“…Study design In vivo experiments Methods In a prospective, randomised, controlled experimental trial, endotoxaemia was induced with E. coli B55:O5 LPS 30 ng kg−1 over 30 min IV in six healthy adult horses ventilated with oxygen supplemented with isoflurane. …”
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Multisensor Remote Sensing and Advanced Image Processing for Integrated Assessment of Geological Structure and Environmental Dynamics by Luo Bin, Rana Waqar Aslam, Iram Naz, Dmitry E. Kucher, Zohaib Afzal, Danish Raza, Rana Muhammad Zulqarnain, Yahia Said

“…This study presents a comprehensive methodological framework that integrates various remote sensing techniques with field investigations to examine the geological structure, environmental conditions, and land use patterns of the lake. …”
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