Insights into high-altitude adaptation and meat quality regulation by gastrointestinal metabolites in Tibetan and black pigs by Xue Bai, Xue Bai, Zhiying Huang, Helin Tan, Yiren Gu, Xun Wang, Long Jin, Peng Shang, Keren Long, Diyan Li, Mingzhou Li

“…Our goal was to correlate omic variations with meat quality traits and identify potential biomarkers predictive of superior meat quality, elucidate the regulatory effects of digestive tract microbial metabolites on Tibetan pig muscle characteristics, and reveal the genetic and nutritional mechanisms that promote adaptation to extreme environmental conditions.MethodsThis analysis encompassed metabolomic profiling of the entire digestive tract-including the stomach, jejunum, cecum, colon, and rectum-as well as histological, amino acid, fatty acid composition, and transcriptomic assessments of the longissimus dorsi muscle tissues to investigate how digestive tract microbial metabolites influence muscle adaptation to high altitudes.ResultsAnalyses revealed that Tibetan pig muscles contain smaller, more oxidative fibers enriched with flavor-enhancing amino acids. …”
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Evaluating the long-term impact of a distance learning course on attitudes, skills, practices, and knowledge in gender-affirming healthcare among healthcare professionals in Italy by Matteo Marconi, Ughetta Maria Favazzi, Pietro Carbone, Debora Guerrera, Angela Ruocco, Martina Manoli, Martina Manoli, Cristiana Barbati, Francesca Molinaro, Federica Maria Regini, Andrea Vittozzi, Alfonso Mazzaccara, Marina Pierdominici

“…The findings underscore the need for structural support and integrated reinforcement to embed gender-affirming care into routine practice.…”
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Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse c... by Farah Al-Marzooq, Akela Ghazawi, Maitha Alshamsi, Abdulrahman Alzaabi, Omar Aleissaee, Hamad Almansoori, Abdullah Alsaadi, Rauda Aldhaheri, Hafsa Ahli, Lana Daoud, Amna Ahmad, Timothy Collyns, Seema Oommen

“…We aimed to correlate their antibacterial efficacy with the genomic characteristics of the strains. Methods: This study investigated 73 E. coli strains and tested them for susceptibility to different antibiotics, including DBOs. …”
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Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
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Examining the social distributions in neighbourhood black carbon and ultrafine particles in Montreal and Toronto, Canada by Emmanuelle Batisse, Marshall Lloyd, Alicia Cavanaugh, Arman Ganji, Junshi Xu, Marianne Hatzopoulou, Jill Baumgartner, Scott Weichenthal

“…Final exposure surfaces were generated by integrating predictions from land-use regression models and deep convolutional neural network models. …”
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Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort by Tahzeeb Fatima, Yuan Zhang, Georgios K. Vasileiadis, Araz Rawshani, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Cristina Maglio

“…Metabolomics may help to identify such biomarkers as it allows for a comprehensive exploration of disease-related variations that extends beyond the genome and proteome. …”
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Spatial Analysis of the Relationship between Ecological Factors and Housing Prices in Tehran by Atefeh Kolyaei, Tahir Prizadi, Habibollah Fasihi

“…This research aimed to explore the extent to which spatial variations in residential property prices in Tehran were affected by ecological factors. …”
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Association of <i>OPRM1</i> and <i>OPRD1</i> Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer by Carolina Gutiérrez-Cáceres, Nikolas Ávila, Leslie C. Cerpa, Matías F. Martínez, Carlos E. Irarrazabal, Benjamín Torres, Olga Barajas, Nelson M. Varela, Luis A. Quiñones

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Syndemic geographic patterns of cancer risk in a health-deprived area of England by Catherine Jones, Thomas Keegan, Andy Knox, Alison Birtle, Jessica A. Mendes, Kelly Heys, Peter M. Atkinson, Luigi Sedda

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Analysis of costs in implementing the HEARTS hypertension program in Nigerian primary care by Emmanuel Ndenor Sambo, Muhammad Jami Husain, Soumava Basu, Malau Mangai Toma, Sunday Victor Eze, Kufor Osi, Nanlop Ogbureke, Okeoma Erojikwe, Bolanle Banigbe, Andrew E. Moran, Deliana Kostova

“…Abstract Background The Nigeria Hypertension Control Initiative (NHCI) program, launched in 2020, integrates hypertension care into primary healthcare using the HEARTS technical package, which includes screening, health counselling, and standardized hypertension treatment protocols. …”
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Incorporating gene expression and environment for genomic prediction in wheat by Jia Liu, Jia Liu, Andrew Gock, Kerrie Ramm, Sandra Stops, Tanya Phongkham, Adam Norman, Russell Eastwood, Eric Stone, Shannon Dillon

“…Here we explored the role transcriptome data could play in enhancing GS in wheat.MethodsAcross 286 wheat lines, we integrated phenotype and multi-omic data from controlled environment and field experiments including ca. 40K single nucleotide polymorphisms (SNP), abundance data for ca. 50K transcripts as well as meta-data (e.g. categorical environments) to predict individual genetic merit for two agronomic traits, flowering time and height. …”
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Neuroprotective effects of creatine supplementation in mild TBI management among contact sport athletes: A scoping review by John E. Giraldo, Diego A. Bonilla, Luis F. Bedoya, Katherine F. Hoyos, Santiago G. Velasquéz, Mayra M. Márquez, Jorge L. Petro

“…In studies involving contact sport athletes, creatine was integrated into nutritional protocols to aid concussion recovery, with observed variations in the N-acetylaspartate/creatine ratio highlighting a potential role in restoring cerebral metabolism.Conclusion Although the evidence is limited, findings from animal models and contact sports athletes suggest that creatine supplementation may help mitigate the metabolic disturbances associated with concussions. …”
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Public attitudes and values regarding a semi‐urban feral ungulate by Danhe Yang, Debottam Bhattacharjee, Kate J. Flay, Yifu Wang, Hannah S. Mumby, Alan G. McElligott

“…Studying public attitudes and values, such as appreciation and preservation for semi‐urban feral buffalo, points to methods for successful strategies using buffalo as ‘agents’ of conservation. …”
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Understanding Gender-Specific Daily Care Preferences: Topic Modeling Study by Kyungmi Woo, Se Hee Min, Aeri Kim, Subin Choi, Gregory L Alexander, Terrence O’Malley, Maria D Moen, Maxim Topaz

“…ObjectiveThis study aims to identify and analyze the key themes and daily care preferences from unstructured adult text narratives with a focus on uncovering gender-specific variations. MethodsThis study used 4350 deidentified, unstructured textual data from MyDirectives (MyDirectives, Inc), an interactive online platform. …”
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Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA by Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky, Wei-Chiao Chang

“…Understanding these interactions is crucial for elucidating differences in immune responses and disease severity among diverse populations. Methods We updated the T-CoV portal to incorporate and analyze EG.5 and XBB.1.16 variants. …”
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Defining Reablement in the Dutch Context: A Modified Delphi Study by Buma LE, Mouchaers I, Zwakhalen SM, Vluggen S, Satink T, Metzelthin SF

“…This study extends the original conceptual definition by integrating these elements, offering clearer, more practical guidance for real-world application.Materials and methods: A modified Delphi study was performed to develop a definition of reablement that fits the Dutch health and social care system, extending beyond conceptual understanding. …”
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Empowering excellence: transforming GIRFT accessibility through a centralised Trust intranet portal: Northern Care Alliance Experience by Ayesha Lala, Robert Nipah, Alistair Craig, Molly Gollop, Shirley Naylor, William Keith Gray, Janet Cox, Katrein Savage, Paul Mcmullen, Alshymaa Eltahan

“…Background: The Getting It Right First Time (GIRFT) programme is a national initiative focused on enhancing clinical quality and efficiency by minimising unwarranted variations in care.1 Within the Northern Care Alliance (NCA) Trust, we identified that streamlined access to GIRFT-related resources is essential for successful implementation. …”
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Adaptation and validation of the Washington group/unicef child functioning module in a nationally representative sample of Canadian children and youth by Emma Nolan, Katherine Cost, Ryan Miller, Li Wang, Chen Yun-Ju, Jordan Edwards, Eric Duku, Stelios Georgiades, Peter Szatmari, Harriet MacMillian, Charlotte Waddell, Katholiki Georgiades

“…Findings highlight the value of a dimensional approach to functional difficulties, offering a more comprehensive understanding of population-level variations in functioning. Integrating this measure into large-scale surveys can facilitate trend monitoring, improve data-driven policy interventions, and support strategic planning for education, healthcare, and social services. …”
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Unraveling Cefiderocol Resistance Strategies in Klebsiella pneumoniae Strains from the United Arab Emirates by Dr. Farah Al Marzooq, Ms Lana Daoud

“…MLST analysis revealed variations in the sequence types (STs) among the strains. …”
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Neoadjuvant chemoradiotherapy with or without PD-1/PD-L1 inhibitors in locally advanced rectal cancer: a systematic review and meta-analysis by Muhammad Ansab, Sepideh Razi, Farwa Nisa, Eiman Araib, Shree Rath, Iqra Khan, Noor Ul Huda Ramzan, Esha Dilawar, Anwaar Saeed

“…Methods A systematic search of PubMed, Embase, ClinicalTrials.gov, and Cochrane Central Library was conducted up to October 11, 2024. …”
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