Breast cancer scoring based on a multiplexed profiling of soluble and cell-associated (immune) markers facilitates the prediction of pembrolizumab therapy by Verena Schweihofer, Christina Bruss, Stephan Seitz, Gunther Glehr, Madeleine Hetterich, Florian Weber, Maria Hatzipanagiotou, Miriam Fernández-Pacheco Álvarez, Olaf Ortmann, Gero Brockhoff, Richard J. Bauer, Anja Kathrin Wege

“…Abstract Background The immune checkpoint targeting is nowadays an integral part of cancer therapies. However, only a minority of patients experience long-term benefits. …”
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A Systematic Review on the Occurrence of <i>Babesia</i> spp. and <i>Anaplasma</i> spp. in Ticks and Wild Boar from Europe—A 15-Year Retrospective Study by Ioan Cristian Dreghiciu, Diana Hoffman, Tiana Florea, Ion Oprescu, Simona Dumitru, Mirela Imre, Vlad Iorgoni, Anamaria Plesko, Sorin Morariu, Marius Stelian Ilie

“…Molecular detection methods, primarily PCR and sequencing, were the most used diagnostic tools. …”
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MentalAId: an improved DenseNet model to assist scalable psychosis assessment by Muxi Li, Farong Liu, Fei Du, Guolin Hong, Qing Hu, Zhi-Liang Ji, Pan You

“…Regretfully, traditional symptom-based, one-to-one assessment face inherent limitations in large-scale and longitudinal screening, likely delaying early intervention. Methods We developed MentalAId, an improved densely connected convolutional network (DenseNet) model, to assist automated psychosis recognition, leveraging accessible routine laboratory data without requiring additional specialized tests. …”
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Dental biofilm serves as an ecological reservoir of acidogenic pathobionts in head and neck cancer patients with radiotherapy-related caries by Julia S. Bruno, Vitor Heidrich, Felipe C. F. Restini, Tatiana M. M. T. Alves, Wanessa Miranda-Silva, Franciele H. Knebel, Elisangela M. Cóser, Lilian T. Inoue, Paula F. Asprino, Anamaria A. Camargo, Eduardo R. Fregnani

“…Leveraging shotgun metagenomics, we characterize the unique microbial variations in in vivo irradiated dental biofilms, unveiling novel insights into the microbial ecology of radiotherapy-treated patients. …”
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A Comparative Analysis of Genetic and Epigenetic Factors in METH Addiction: A Focus on SLC (SLC6A4) and COMT Genes by Haider K. Hussain, Yolanda Loarce Tejada, Anna Barbaro

“…The reviewed evidence highlights the need for more comprehensive, regionally diverse studies and integrative approaches that combine genetics, neurobiology, and psychosocial factors. …”
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Community readiness and acceptance for the implementation of the malaria vaccine among caretakers of at-risk children in sub-Saharan Africa: a systematic review and meta-analysis by Eustes Kigongo, Sean Steven Puleh, Amir Kabunga, Stella Immaculate Akech, Francis Ocen, Marc Sam Opollo, Moses Ebong

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Clinical features and hematological and biochemical blood parameters of dogs with hepatobiliary disorders by Nguyen Vu Thuy Hong Loan, Nguyen Van Chao, Tran Thi Nhung

“…This study aimed to characterize the clinical manifestations and hematobiochemical profiles of dogs diagnosed with hepatobiliary disorders in Ho Chi Minh City, Vietnam. Materials and Methods: Eighty client-owned dogs diagnosed with hepatobiliary disorders through histopathological confirmation were retrospectively evaluated. …”
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MSFA-YOLO: A Multi-Scale SAR Ship Detection Algorithm Based on Fused Attention by Zhao Liangjun, Ning Feng, Xi Yubin, Liang Gang, He Zhongliang, Zhang Yuanyang

“…Leveraging the excellent feature representation capabilities of neural networks, deep learning methods have been widely adopted for object detection in synthetic aperture radar (SAR) images. …”
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Spatial, temporal and demographic distribution characteristics of adenomyosis symptom clusters from the perspective of traditional Chinese medicine: a multicenter cross-sectional s... by Xin Wang, Yu Tao, YuDan Fu, XinChun Yang, RuiHua Zhao

“…ObjectiveThis study aimed to explore the differences in symptom clusters of adenomyosis (AM) patients across spatial, temporal, and age-stratified dimensions based on the theory of “Treatment in Accordance with Three Categories of Etiologic Factors”.MethodsA cross-sectional study was conducted in China from 2020 to 2022, involving 1,816 AM patients. …”
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Differential gene expression in patients with anal fistula reveals high levels of prolactin recepetor by Song Yi-Huan, Qiu Jian-Ming, Yang Guan-Gen, Wang Dong, Lin A-Li, Xu Kan

“…There are limited data examining variations in the local expression of inflammatory mediators in anal fistulas where it is anticipated that an improved understanding of the inflammatory milieu might lead to the potential therapeutic option of instillation therapy in complicated cases. …”
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Systematic review on the cost of seasonal malaria chemoprevention (SMC) by Anika Ruisch, Miranda Iodice, Ishani Mathur, Sara Harris, Damian G. Walker, Richmond Owusu, Justice Nonvignon, Colin Gilmartin

“…Costs incurred by households and costs of the integrated delivery of SMC with other health interventions were often overlooked. …”
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Major medical events in patients with acute coronary syndrome during helicopter emergency medical service operations by Julian Ganter, Hans-Jörg Busch, Alina Henis, Florian Reifferscheid, Jörg Braun, Sebastian Heinrich

“…The objective of this study is to evaluate the incidence of medical events and to assess risk stratification using scoring systems. Methods This retrospective observational cohort study analyzed prehospital records from 38,473 HEMS operations with “ACS” coding conducted between 2012 and 2024 in Germany. …”
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Chilean National Sports Talent Detection System: Influence of Biological Age, Sex, and Geographic Area by Ariel Guevara-Araya, Samuel Curripan-Henríquez, Juan Aguilera-Julio, Ana Antinao-Soto, Oscar F. Araneda

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The impact of digital literacy on farmland scale operations:exploring the mediating and moderation roles of land transfer and land dependence by Lulu Yang, Song Yu, Song Yu, Bin Liu

“…It is important to note that agricultural scale operation underscores not only the expansion of land acreage but also the contiguous and integrated management of land parcels.MethodsThis study utilizes data from the 2020 Chinese Academy of Social Sciences rural revitalization research to assess farmers' digital literacy levels through factor analysis and principal component analysis. …”
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Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction by Aishwarya Raj, Roon Banerjee, Vikram Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Indrani Datta

“…This study underscores the criticality of integrating astrocytes into treatment paradigms in synucleinopathies.…”
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Exploring affordable and effective pandemic containment measures in lower-income countries with a spatial SEIR model: a case study in South Africa by Lingyu Fan, Wenzhong Shi, Qing Pei, Anshu Zhang

“…Studies on targeted containment measures for Omicron have dramatically declined even in higher-income regions, and their findings could be much less applicable in lower-income regions due to substantial socioeconomic disparities. Methods This study addresses this gap by focusing on South Africa. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

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A Systematic Review Uncovering Modifiable Influences on Statin Adherence by Rosenberg J, Lampridou S, Moores A, Garfield S, Wingfield D, Judah G

“…Existing reviews have methodological limitations, often failing to integrate qualitative and quantitative data or consider specific barriers to statin adherence. …”
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IM4Equity: an implementation science meta-framework for community-engaged partnerships to advance health equity by Lilian G. Perez, James L. Merle, Justin D. Smith, Alex R. Dopp, Amy G. Huebschmann

“…For health equity initiatives, variations in which frameworks are used make synthesis and identification of shared determinants difficult, including equity constructs. …”
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Asymmetric white matter degeneration in amyotrophic lateral sclerosis: a diffusion kurtosis imaging study of motor and extra-motor pathways by Juan Carlos Quizhpilema, Ane Legarda, José Manuel Hidalgo, Pablo Lecumberri, Ivonne Jerico, Ivonne Jerico, Teresa Cabada, Teresa Cabada

“…Using whole-brain TBSS analysis and tractography with DIPY, we identified an asymmetric pattern of degeneration and involvement of integrative neural networks, providing new insights into ALS pathophysiology. …”
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