Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism by Ronghua Ling, Ronghua Ling, Xingxing Cen, Shaoyou Wu, Min Wang, Ying Zhang, Juanjuan Jiang, Jiaying Lu, Yingqian Liu, Chuantao Zuo, Jiehui Jiang, Yinghui Yang, Zhuangzhi Yan, Zhuangzhi Yan

“…BackgroundAccurate differentiation of parkinsonian syndromes remains challenging due to overlapping clinical manifestations and subtle neuroimaging variations. This study introduces an explainable graph neural network (GNN) framework integrating a Regional Radiomics Similarity Network (R2SN) and Transformer-based attention mechanisms to address this diagnostic dilemma.MethodsOur study prospectively enrolled 1,495 participants, including 220 healthy controls and 1,275 patients diagnosed with idiopathic Parkinson’s disease (IPD), multiple system atrophy (MSA), or progressive supranuclear palsy (PSP), all undergoing standardized 18F-fluorodeoxyglucose positron emission tomography imaging. …”
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Estimated inpatient malnutrition prevalence, screening tool utilization, and dietitian referral rates across hospitals during extension of phase 2 of More-2-Eat by Yingying Xu, Rachel A. Warren, Shirley M. Peters, Sonya Boudreau, Tina N. Strickland, Mari Somerville, Brenda L. MacDonald, Heather Keller, Leah E. Cahill

“…This study aims to understand (1) the prevalence of inpatient nutrition screening completion, (2) the proportion of at-risk inpatients referred to dietitians, and (3) the malnutrition prevalence among a sample of hospital inpatients. Methods: In 2021, INPAC was implemented in five hospital wards across Nova Scotia (NS) as an extension of More-2-Eat NS Study. …”
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MLK-TR: a Multi-branch Large Kernel TRansformer for UAV-based images by Xun Li, Yuzhen Zhao, Yang Zhao, Zhun Guo, Jianjing Gao, Baoxi Yuan

“…However, due to the small size of targets captured by UAV, along with challenges such as scale variation and blurred edges, existing methods struggle to maintain high detection accuracy while ensuring efficient inference speed. …”
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Defining Nephritic Factors as Diverse Drivers of Systemic Complement Dysregulation in C3 Glomerulopathy by Jill J. Hauer, Yuzhou Zhang, Renee Goodfellow, Amanda Taylor, Nicole C. Meyer, Sarah Roberts, Dingwu Shao, Lauren Fergus, Nicolo Ghiringhelli Borsa, Monica Hall, Carla M. Nester, Richard J.H. Smith

“…However, disease heterogeneity and rarity make accurately defining characteristics of the C3G population difficult. Methods: Here, we present a retrospective analysis of the Molecular Otolaryngology and Renal Research Laboratories C3G cohort. …”
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Sexually Transmitted Infections among Human Immunodeficiency Virus Patients in a Tertiary Hospital in Surabaya, Indonesia by Jose Suryanegara, Nissa Avina Pilar, Cintya Dipta Riswanto, Regitta Indira Agusni, Maylita Sari, Astindari, Septiana Widyantari, Afif Nurul Hidayati, Dwi Murtiastutik

“…The findings highlight the variations in STI prevalence based on sex and age distribution among HIV patients. …”
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Overview of RING gene family in maize (Zea mays L.): ZmRING-93 enhances drought tolerance in transgenic Arabidopsis by Xiaotian Zhang, Huili Chen, Wei Tian, Zihui Gao, Hewei Du, Shuangcheng Ding, Hongwei Wang

“…Results We employed three distinct methods and identified a total of 590 proteins. Phylogenetic analysis revealed that these proteins could be grouped into 11 separate clusters. …”
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Physiochemical and functional properties of gelatin obtained from frigate mackerel (Auxis thazard), skipjack tuna (Katsuwonus pelamis), Longtail tuna (Thunnus tonggol) and yellowfi... by Qinghe Yin, Haohao Shi, Yongqiang Zhao, Gang Yu, Haohao Wu, Guanghua Xia, Tao Yang

“…Comparative analyses revealed notable species-specific variations in gelatin yield, amino acid composition, molecular weight distribution, and functional performance. …”
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A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI by Charlems Alvarez-Jimenez, Jacob T. Antunes, Thomas DeSilvio, Zhouping Wei, Marwa Ismail, Joseph E. Willis, Emily Steinhagen, Andrei Purysko, David Liska, Smitha Krishnamurthi, Marka Crittenden, Michael Gough, Kristina Young, Anant Madabhushi, Eduardo Romero, Pallavi Tiwari, Satish E. Viswanath

“…Combined with traditional radiomic texture features, StODeO showed superior performance in distinguishing pathologic response groups of rectal cancer patients post-chemoradiation (hold-out validation AUC 0.77) as well as segregating composite response groups in a clinical trial of immune checkpoint inhibitors (external validation accuracy 0.71; NCT02688712). The integrated StODeO-texture signature demonstrated robustness across annotation sources and imaging variations, intuitive modeling of therapy-associated structural changes, and statistical associations with tumor-immune biology, including macrophages and CD8+ T-cells from multiplexed biopsy analysis. …”
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Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients by Tingze Feng, Pengfei Li, Siyi Li, Yuhan Wang, Jing Lv, Tian Xia, Hoy-Jong Lee, Hai-Long Piao, Di Chen, Yegang Ma

“…Methods First, we characterized the metabolic states of cells in ESCC using single-cell transcriptome profiles of key metabolite-interacting proteins. …”
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The Impact of Celiprolol in Vascular Ehlers–Danlos Syndrome: A Systematic Review of Current Evidence by Pandit Bagus Tri Saputra, Wynne Widiarti, Paulus Parholong Siahaan, Rendra Mahardhika Putra, Johanes Nugroho Eko Putranto, Raden Mohammad Budiarto, Nadya Luthfah, Chaq El Chaq Zamzam Multazam, Mario D’Oria, Firas Farisi Alkaff

“…Methods: A comprehensive literature search was conducted across scientific databases for studies comparing celiprolol with placebo or other treatments, focusing on relevant outcomes. …”
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Exploration of beta diversity across altitude gradients in an Alpine region in Trentino using FOSS4G and a historical floristic archive by F. Geri, F. Zottele, N. La Porta, C. Tattoni, P. Zatelli, M. Ciolli, M. Ciolli

“…Future research will compare historical and contemporary floristic data, apply alternative statistical methods, and incorporate remote sensing for enhanced biodiversity assessments.…”
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Determinants of Health and Performance in Wildland Firefighters: A Narrative Review by Fabio García-Heras, Jorge Gutiérrez-Arroyo, Juan Rodríguez-Medina, Belén Carballo-Leyenda, Pilar Sánchez-Collado, Gerardo Villa-Vicente, Jose A. Rodríguez-Marroyo

“…This narrative review seeks to analyze the main factors influencing the health and performance of WFFs, with a particular focus on physical, environmental, and psychological challenges. Methods: A narrative review was performed, synthesizing data from diverse sources. …”
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Global, Regional, and National Burden of Breast Cancer, 1990–2021, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 by Tong Deng, Hao Zi, Xing‐Pei Guo, Li‐Sha Luo, Ya‐Long Yang, Jin‐Xuan Hou, Rui Zhou, Qian‐Qian Yuan, Qing Liu, Qiao Huang, Gao‐Song Wu

“…ABSTRACT Background This study analyzes the global burden of breast cancer (BC) over the past 30 years, identifies key risk factors, and projects future incidence and mortality through 2050. Methods Data were sourced from the 2021 Global Burden of Disease (GBD) database. …”
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A deep learning-based detection model and illumination-adaptive behavioral analysis for soldier crabs in the intertidal zone by Liangjun Li, Zhihao Ren, Cheng Tang, Shengning Lu, Yong Liang

“…Their behavioral rhythms respond sensitively to environmental fluctuations, especially variations in sediment composition and illumination. …”
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Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy by Ibrahim Antoun, Georgia R. Layton, Ali Nizam, Joseph Barker, Ahmed Abdelrazik, Mahmoud Eldesouky, Abdulmalik Koya, Edward Y. M. Lau, Mustafa Zakkar, Riyaz Somani, Ghulam André Ng

“…<i>Conclusion:</i> This review highlights the urgent need for integrated strategies that combine BP control, AF screening, and lifestyle modifications to minimise the burden of AF and its complications. …”
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Spatio-temporal dynamics and drivers of cropland ecosystem services value during the past two decades in Yangtze river economic belt, China by Hanjun Xia, Pengbo Zhang, Qi Zhang, Baofa Peng, Chenxin Zhou, Qian Zhu, Songchao Chen, Bifeng Hu

“…Clarifying the spatio-temporal variation of the cropland ecosystem service value (Crop-ESV) and understanding its main drivers are critical for maintaining and regulating cropland ecosystem functions.MethodsThus, this study systematically assessed the Crop-ESV in the Yangtze River Economic Belt (YREB) in China and mapped it at 1 km spatial resolution from 2001 to 2020. …”
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Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry by Lisa K Micklesfield, Tinashe Chikowore, Julia H Goedecke, Michèle Ramsay, Bontle Masango, Karl-Heinz Storbeck

“…Introduction This study aimed to, first, determine the clusters of sex hormones, liver enzymes, and cardiometabolic factors associated with postprandial glucose (PPG) and, second to evaluate the variation these clusters account for jointly and independently with polygenic risk scores (PRSs) in South Africans of African ancestry men and women.Research design and methods PPG was calculated as the integrated area under the curve for glucose during the oral glucose tolerance test (OGTT) using the trapezoidal rule in 794 participants from the Middle-aged Soweto Cohort. …”
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Leveraging Promotional Strategies to Enhance Hospital Influence on Social Media: Cross-Sectional Study by Xinyun Zhong, Yiyuan Ma, Haiyue Yu

“…MethodsData were collected from 721 officially verified hospital Weibo accounts and integrated with multidimensional hospital characteristics from the DXY National Hospital Database. …”
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Short- and long-term weekly patient-reported outcomes prediction undergoing radiotherapy: single-patient time series model vs. transformer-based multi-patient time series model by Yang Yan, Zhong Chen, Xinglei Shen, Ronald C. Chen, Hao Gao

“…Results Key experimental results on prostate cancer patients demonstrate that (1) VAR-Inc demonstrated superior performance (lower MAE/RMSE) over VAR, highlighting the importance of incremental PRO updates. (2) TFT significantly outperformed both VAR models in long-term prediction, with statistical significance, by utilizing multi-patient data. (3) TFT effectively captured weekly PRO trends and variations, aligning closely with ground truth. (4) Unlike single-patient models, TFT built robust predictive frameworks by integrating cross-patient similarities and complementary patients’ PRO information. …”
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Sensitivity analysis of the INRA 2018 feeding system for ruminants by hybrid local and global approaches: Comparing the contribution of dietary input variables to multiple response... by Seoyoung Jeon, Tristan Senga Kiessé, Sophie Lemosquet, Pierre Nozière

“…Hence, hybridizing the SA methods can help to interpret the system and facilitate a more precise evaluation thereof, especially GSA, which is amenable to nonmonotonic models such as those characterizing complex feeding systems integrating multiple nutritional and animal factors.…”
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