The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…The ORR was 45.5% (95% CI, 31.97-59.45). The median progression-free survival was 11.0 (95% CI, 8.21-15.24) months. …”
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Clinical profile and outcomes in patients with moderate to severe aortic stenosis with or without concomitant chronic kidney disease by Jinghao Nicholas Ngiam, Ching-Hui Sia, Nicholas Wen Sheng Chew, Tze Sian Liong, Zi Yun Chang, Chi Hang Lee, Wen Ruan, Edgar Lik-Wui Tay, William Kok-Fai Kong, Huay Cheem Tan, Tiong-Cheng Yeo, Kian Keong Poh

“…Results: There were 270 (37.1%) patients with concomitant CKD. The CKD group was older (78.0 ± 10.3 vs. 72.1 ± 12.9 years, P < 0.001), with a higher prevalence of hypertension, diabetes mellitus, hyperlipidaemia and ischaemic heart disease. …”
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Minute-cadence Observations of the LAMOST Fields with the TMTS. VI. Physical Parameters of Contact Binaries by Qiqi Xia, Xiaofeng Wang, Kai Li, Xiang Gao, Fangzhou Guo, Jie Lin, Cheng Liu, Jun Mo, Haowei Peng, Qichun Liu, Gaobo Xi, Shengyu Yan, Xiaojun Jiang, Jicheng Zhang, Cui-Ying Song, Jianrong Shi, Xiaoran Ma, Danfeng Xiang, Wenxiong Li

“…Spectral subtraction analysis revealed that the equivalent width of H α indicates strong magnetic activity in J0047, J0305, J0638, and J1402. …”
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Center-Related Variation in Hospitalization Cost for Patients Undergoing Percutaneous Left Atrial Appendage Occlusion by Shivaraj Patil, MD, Chaitanya Rojulpote, MD, Abhijit Bhattaru, BS, Avica Atri, MD, Krishna Vamsi Rojulpote, BS, Ola Khraisha, MD, Viha Atri, MD, William Frick, MD, Tarek Nafee, MD, Kishore Harjai, MD, Sumeet Mainigi, MD, Chien-Jung Lin, PhD, MD

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Accelerated photonic design of coolhouse film for photosynthesis via machine learning by Jinlei Li, Yi Jiang, Bo Li, Yihao Xu, Huanzhi Song, Ning Xu, Peng Wang, Dayang Zhao, Zhe Liu, Sheng Shu, Juyou Wu, Miao Zhong, Yongguang Zhang, Kefeng Zhang, Bin Zhu, Qiang Li, Wei Li, Yongmin Liu, Shanhui Fan, Jia Zhu

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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Methods: We searched the MEDLINE and Embase databases for SARS-CoV-2-related studies. Meta-analysis, observational studies, case series and case reports published in English or Chinese between 1 January 2020 and 1 May 2020 were included. …”
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Polybrominated Dibenzo-p-dioxins/Furans (PBDD/Fs) and Diphenyl Ethers (PBDEs) in the Indoor and Outdoor of Gymnasiums by Ching-Kai Su, Jian-He Lu, How-Ran Chao, Wei-Hsiang Chang, Ming-Hsien Tsai, Chih-Lung Wang, I-Cheng Lu, Yu-Ting Chang, Hsiao-Chi Chuang, Wan-Nurdiyana-Wan Mansor, Yi-Chyun Hsu, Ying-I Tsai, Shang-Ming Ma

“…To assess the risks, the non-dietary daily intakes of PBDEs and PBDD/Fs were estimated as 1.61–2.11 × 10–7 and 4.15–5.42 × 10–13 mg kg b.w.–1 day–1, respectively, in the employees and 5.04–6.58 × 10–8 and 1.29–1.69 × 10–13 mg kg b.w.–1 day–1, respectively, in the gym users. …”
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A NOVEL DATASET FOR VIETNAMESE NEW YEAR FOOD CLASSIFICATION by Duy Nguyen Vo, Van Tan Luu Ngo, Thi Phuong Vy Le, Nguyen Ngoc Huyen Van, Duc Anh Phuc Nguyen, Van Tuan Kiet Ngo, Thanh Thang Truong, Tan Tai Pham, Nhat Minh Dinh, Thai Ngoc Ho, Tan Tran Minh Khang Nguyen

“…Tạp chí Khoa học Đại học Đà Lạt…”
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FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma by Xuejuan Gao, Donglan Huang, Ying Liu, Gui Zhang, Xiaofen Zheng, Baiye Guan, Aiwen Chen, Jiayao Wu, Shi-Ming Luo, Zonghua Liu, Luxuan Chen, Xiaohui Liu, Jingjie Jin, Xingfeng Yin, Zhenghua Sun, Yunfang Zhang, Meizhi Lu, Gong Zhang, Wanting Liu, Langxia Liu

“…Specifically, FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression, leading to the inhibition of proliferation and migration of LUAD cells. …”
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Incident prescriptions for common cardiovascular medications: comparison of recent versus pre-2020 medication adherence and discontinuation in three universal health care systems by Candace D. McNaughton, Peter C. Austin, Cynthia A. Jackevicius, Anna Chu, Jessalyn K. Holodinsky, Michael D. Hill, Colleen M. Norris, Mukesh Kumar, Noreen Kamal, Douglas S. Lee, Nadia Khan, Manav V. Vyas, Raed A. Joundi, Moira K. Kapral, Amy Y. X. Yu

“…We compared the recent period (April 1, 2020 through most recently available follow-up: September 30, 2021 for Ontario; March 31, 2021 for Alberta; and March 31, 2022 for Nova Scotia) to the baseline, pre-pandemic period (April 1, 2014 through March 31, 2019). …”
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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in healthy volunteersResearch in context by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

Subjects: “…SARS-CoV-2…”
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Comparison of clinical metagenomics with 16S rDNA Sanger sequencing for the bacteriological diagnosis of culture-negative samples by Camille d’Humières, Skerdi Haviari, Marie Petitjean, Laurène Deconinck, Signara Gueye, Nathan Peiffer-Smadja, Lynda Chalal, Naima Beldjoudi, Geoffrey Rossi, Yann Nguyen, Charles Burdet, Ségolène Perrineau, Diane Le Pluart, Roza Rahli, Michael Thy, Piotr Szychowiak, Xavier Lescure, Véronique Leflon-Guibout, Victoire de Lastours, Etienne Ruppé

“…Bacteria were identified using MetaPhlAn4. Results: Among the 73 samples, 20 (27 %, 17 patients) had a clinically relevant 16S rDNA Sanger sequencing result (used for patient management) while 11 (15 %, 9 patients) were considered contaminants. …”
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Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Polygenic risk for obesity was nominally associated with EFNA4 and VWC2 expression. However, we did not find support for mediating mechanisms via these proteins. …”
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An impermeable copper surface monolayer with high-temperature oxidation resistance by Su Jae Kim, Young-Hoon Kim, Bipin Lamichhane, Binod Regmi, Yousil Lee, Sang-Hyeok Yang, Seon Je Kim, Min-Hyoung Jung, Jae Hyuck Jang, Hu Young Jeong, Miaofang Chi, Maeng-Je Seong, Hak Soo Choi, Seong-Gon Kim, Young-Min Kim, Se-Young Jeong

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Tungsten impurity reduction by ICRH in a high power injection and high performance H-mode discharge on EAST by Zhen Zhou, Shengyu Shi, Ling Zhang, Tao Zhang, Xiaohe Wu, Yunxin Cheng, Wenmin Zhang, Chaowei Mai, Shengyu Fu, Yifei Jin, Xiang Jian, Kaixuan Ye, Lin Yu, Ziqiang Zhou, Jiuyang Ma, Shuqi Yang, Kangning Geng, Gongshun Li, Jia Huang, Fei Wen, Yunfeng Liang, Xiang Gao

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Image-based anomaly detection in low-light industrial environments with feature enhancement by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Son-Anh Bui, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Viet-Anh Trinh, Quang-Huy Ha, Nguyen Dinh Bao Long, Duc-Thanh Tran, Xuan-Tung Dinh, Van-Hiep Duong, Tran Thi Thuy Trang

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ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3 by Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

“…This, in turn, prevents STK25-mediated LATS1/2 phosphorylation, leading to YAP activation and CRC progression. …”
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Compliance with face mask use during the COVID-19 pandemic: a community observational study in Singapore by Sean Wei Xiang Ong, Ying Wei Tang, Kyaw Zaw Linn, Xiao Wei Huan, Allie Lim, Chu Ying Poon, Danielle Hui Ru Tan, Nur Hafizah Binte Hamed, Sharifah Farhanah Binte Syed Husen, Clara Chong Hui Ong, Monica Chan, Shawn Vasoo, Yee-Sin Leo, Oon-Tek Ng, Kalisvar Marimuthu

“…Logistic regression analyses were used to determine variables associated with mask and hand hygiene compliance. Results: We made 3,821 observations — 2,149 (56.2%) females, 3,569 (93.4%) adults (≥21 years), 212 (5.5%) children (6–20 years) and 40 (1.0%) children (2–5 years). …”
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Three-dimensional mapping of the altermagnetic spin splitting in CrSb by Guowei Yang, Zhanghuan Li, Sai Yang, Jiyuan Li, Hao Zheng, Weifan Zhu, Ze Pan, Yifu Xu, Saizheng Cao, Wenxuan Zhao, Anupam Jana, Jiawen Zhang, Mao Ye, Yu Song, Lun-Hui Hu, Lexian Yang, Jun Fujii, Ivana Vobornik, Ming Shi, Huiqiu Yuan, Yongjun Zhang, Yuanfeng Xu, Yang Liu

“…Here, using synchrotron-based angle-resolved photoemission spectroscopy (ARPES), spin-resolved ARPES and model calculations, we uncover a large altermagnetic splitting, up to  ~1.0 eV, near the Fermi level in CrSb. We verify its bulk-type g-wave altermagnetism through systematic three-dimensional k-space mapping, which unambiguously reveals the altermagnetic symmetry and associated nodal planes. …”
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