Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) by Yayu Fang, Wei Liu, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Siqian Gong, Xiangqing Wang, Chu Lin, Rui Zhang, Sai Yin, Juan Li, Yongran Huo, Xiaodan Hu, Xiaoqi Xie, Linong Ji

Subjects: “…Type 1 diabetes…”
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Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…Objective This study aimed to develop and validate robust predictive models for patients with oesophageal cancer who achieved a pathological complete response (pCR) and those who did not (non-pCR) after neoadjuvant therapy and oesophagectomy.Design Clinicopathological data of 6517 primary oesophageal cancer patients who underwent neoadjuvant therapy and oesophagectomy were obtained from the National Cancer Database for the training cohort. …”
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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…To mimic the feature of T-cell receptor (TCR) that recognizes the complex of major histocompatibility class I and peptide on the cell surface derived from the processed intracellular antigen, we used NY-ESO-1, a cancer-testis antigen, to develop a TCR-like fully human IgG1 antibody and its derivative, CAR-T cells, for cancer immunotherapy.Methods Human single-chain variable antibody fragment (scFv) phage library (~10∧11) was screened against HLA-A2/NY-ESO-1 (peptide 157–165) complex to obtain target-specific antibodies. …”
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Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment by Jingwen Yang, Chenquan Qiu, Renhai Tang, Wenbin Dong, Enlong Yao, Huyunzhao Wang, Shuwen Lin, Minyang Xiao, Zuyang Zhang, Jin Niu, Liru Fu, Lijun Song, Xuehua Li, Yuhua Shi, Xiaowen Wang

“…We also observed that having support services was preferable (β = 0.50, p < 0.01) to support services not being available. Free HIV testing was the most preferred cost attribute (β = 1.61, p < 0.001). …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…Besides, we discovered that caffeic acid directly binds to aconitate decarboxylase 1 and influenced its enzymatic activity. Moreover, we indicated that caffeic acid exhibits anti-neuroinflammation effect through aconitate decarboxylase 1 mediated PERK-NF-κB pathway in vitro. …”
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Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex. by Shun Hao, Man Xue, Qi-Yu Chen, Jinjin Wan, Yu-Jie Ma, Wantong Shi, Xuanying Chen, Xu-Hui Li, Jing-Shan Lu, Fang Xu, Guo-Qiang Bi, Wucheng Tao, Min Zhuo

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…We tracked allele frequency changes as a function of viability across different age bins and prioritized 34 variants with an immediate implication on lipid metabolism, body mass index (BMI), and cognitive performance, among other traits, revealed by PheWAS analysis in the UK Biobank. Given the highly complex and non-linear interactions between the genetic determinants of longevity, we reasoned that a composite polygenic score would approximate a substantial portion of the variance in lifespan and developed the integrated longevity genetic scores (iLGSs) for distinguishing exceptional survival. …”
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A Comprehensive Study of Type I (Thermonuclear) Bursts in the New Transient SRGA J144459.2–604207 by Tao Fu, Zhaosheng Li, Yuanyue Pan, Long Ji, Yupeng Chen, Lucien Kuiper, Duncan K. Galloway, Maurizio Falanga, Renxin Xu, Xiaobo Li, Mingyu Ge, L. M. Song, Shu Zhang, Shuang-Nan Zhang

“…We found that 14 out of 60 X-ray bursts exhibited photospheric expansion, and thus we estimated the distance to the source as 10.03 ± 0.71 kpc. Combined with IXPE observations, the burst recurrence time increased from 1.55 to 8 hr as the local mass accretion rate decreased, which can be described as ${\rm{\Delta }}{T}_{{\rm{rec}}}\sim {\dot{m}}^{-0.91\pm 0.02}$ .…”
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New hope for the world cancer day by Gerry Melino, Julia Bischof, Wen-Lian Chen, Wei Jia, Harmut Juhl, Gelina S Kopeina, Alessandro Mauriello, Flavia Novelli, Manuel Scimeca, Yufang Shi, Brunella Maria Pirozzi, Giuseppe Sica, Alexey V. Zamaraev, Boris Zhivotovsky

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Outpatient Versus Inpatient Total Joint Arthroplasty: Do Medically and Socially Complex Patients Require More Resources but Achieve Similar Outcomes? by Justin Leal, BS, Christine J. Wu, MD, Niall H. Cochrane, MD, Thorsten M. Seyler, MD, PhD, William A. Jiranek, MD, Samuel S. Wellman, MD, Michael P. Bolognesi, MD, Sean P. Ryan, MD

“…Results: Patients in the inpatient total knee arthroplasty group had a higher proportion of patients requiring an emergency department visit (11.4% vs 4.5%; P = .008) and admission (6.7% vs 2.7%; P = .025) within the first 90 days after surgery than the outpatient group; however, 2-year revision-free (97.9% vs 97.9%; P = .75) survival was similar between groups. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

Subjects: “…CD274 (PD-L1)…”
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Assessment of the essential oil extracted from Citrus aurantifolia leaves using solvent-free microwave extraction technique by G.M. Masud Rana, Md. Jasim Uddin, Jaytirmoy Barmon, Bijoy Chandra Ghos, Tahmina Akter Chowdhury, Amit Kumar Dey, Bijoy Maitra, Ismat Moin Tamanna, AHM Mahbubur Rahman, Barun Kanti Saha, Mst. Sarmina Yeasmin

“…The zone of inhibition of EO varied from 6.52 to 18.1 mm. The potency of EO against S. choleraesuis, E. coli, L. monocytogenes, and P. aeruginosa was demonstrated by the reaction orders of 0.5588, 0.163, 0.2663, and 0.0871, respectively. …”
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Gestational diabetes induces autistic-like behaviors in offspring by disrupting the GABAergic system by Xuan-Qi Liu, Tian-li Huang, Shu-Yu Zhang, Yu-Tong Huang, Jia-Ying Mo, Yi-Shang Yan, Yi-Ning Cao, Yue-Ran Cai, Jian-Zhong Sheng, Hong Zhu, He Feng Huang

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Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022. by Jiaqing Xu, Xiaohua Tan, Yi Quan, Dexin Gong, Hui Deng, Jianguo Zhao, Xing Huang, Yingtao Zhang, Zhoupeng Ren, Zuhua Rong, Weilin Zeng, Xing Li, Wenyuan Zheng, Shu Xiao, Jianpeng Xiao, Meng Zhang

“…According to BSTS model estimates, 6557 local dengue cases may have been reduced in Guangdong Province from 2020 to 2022, with a relative reduction of 99.91% (95%CI: 98.85-99.99%).<h4>Conclusion</h4>The incidence of dengue in Guangdong notably declined from 2020 to 2022, which may be related to the co-benefits of COVID-19 intervention measures and the intensified interventions against dengue during that period. …”
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Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning by Jindou Shi, Alexander Ho, Corey E. Snyder, Eric J. Chaney, Janet E. Sorrells, Aneesh Alex, Remben Talaban, Darold R. Spillman, Marina Marjanovic, Minh Doan, Gary Finka, Steve R. Hood, Stephen A. Boppart

“…Employing simultaneous label-free autofluorescence multiharmonic (SLAM) microscopy with fluorescence lifetime imaging microscopy (FLIM), we characterized Chinese hamster ovary (CHO) cell lines at early passages (0–2). A machine learning (ML)-assisted analysis pipeline leveraged high-dimensional information to classify single cells into their respective lines. …”
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Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis by Fang-fang Yu, Juan Zuo, Miao Wang, Shui-yuan Yu, Kang-ting Luo, Tong-tong Sha, Qian Li, Zai-chao Dong, Guo-yu Zhou, Feng Zhang, Xiong Guo, Yue Ba, Yan-jie Wang

“…In addition, the mitochondria of chondrocytes shrunk and the mitochondrial crest decreased or disappeared. However, Fer-1 (Ferrostatin-1) inhibited ferroptosis induced by T-2 toxin in chondrocytes. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…Positive predictive values (PPVs) were calculated as the number of true positives divided by the total claims data.Results The PPVs (95% CI) for aortic valve (AV) surgery aetiologies were as follows: infectious endocarditis (IE), 94.1% (87.6%–97.7%); rheumatic heart disease (RHD), 88.2% (67.3%–97.5%); bicuspid AV, 93.3% (83.3%–98.1%); and degeneration, 91.7% (85.3%–95.8%). …”
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Aircraft Measurements of Physicochemical Evolution of Atmospheric Aerosols in Air Pollution Plumes over a Megacity and Suburban Areas by Taehyun Park, Yongjoo Choi, Jinsoo Choi, Junyoung Ahn, Jinsoo Park, Yonghwan Lee, Jihee Ban, Gyutae Park, Seokwon Kang, Kyunghoon Kim, Beom-Keun Seo, Jongho Kim, Soobog Park, Hyunjae Kim, HaEun Jeon, Taehyoung Lee

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Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats. by Nelly S C Mak, Jingyan Liu, Dan Zhang, Jordan Taylor, Xiaomeng Li, Kazi Rahman, Feiyu Chen, Siddhartha A K Datta, Kin Kui Lai, Zhengli Shi, Nigel Temperton, Aaron T Irving, Alex A Compton, Richard D Sloan

“…These bat IFITMs have conserved structures in vitro as demonstrated by circular dichroism spectroscopy, yet they exhibit distinct antiviral specificities against influenza A virus, Nipah virus and coronaviruses including SARS-CoV, SARS-CoV-2 and MERS-CoV. In parallel with human IFITM1-3, bat IFITM isoforms localize to distinct sites of virus entry which influences their antiviral potency. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…VSIG4 deficiency recovered the antigen presentation (B2m, H2-k1, H2-d1) of TAMs and activated antigen-specific CD8+ T cells by promoting their in vivo proliferation and intratumoral infiltration. …”
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