Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…A clinical trial evaluating intratumoral VVGM-αhCTLA-4 (BT-001) alone and in combination with αPD-1 in metastatic or advanced solid tumors has commenced.…”
Get full text

Impacts of Sandstorms on Chemistries of Ambient PAHs in a Small City in North China by Zhiyong Li, Zhen Zhai, Jixiang Liu, Lan Chen, Zhuangzhuang Ren, Chen Liu, Ziyi Zhan, Ziyuan Yue, Wenjia Zhu, Jihong Wei, Huiying Gao, Songtao Guo

“…ILCRs for adults and children increased from 3.90 × 10−7 to 4.74 × 10−7 and from 2.41 × 10−7 to 2.93 × 10−7, respectively, in the SSP, which should be more concerned.…”
Get full text

Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion by Meng Lin, Yutong Wang, Xiaoye Wang, Lailai Yan, Linlin Wang, Chan Tian

“…In terms of the individual effect, high concentration group of barium (Ba) increased the risk of spontaneous abortion by 150 % (95 % CI: 1.38–4.51), whereas rubidium (Rb), cesium (Cs) and Magnesium (Mg) all clearly demonstrated dose dependency in reducing the incidence of spontaneous abortion. …”
Get full text

بررسی دیاژنز، ژئوشیمی و کیفیت مخزنی سازند فهلیان در یکی از میادین نفتی جنوب غرب ایران by امیر کاظمی, محمدعلی صالحی, جواد سبحانی, جواد هنرمند, نواب خدائی

“…تخلخل و تراوایی مغزه در بخش مخزنی سازند فهلیان در توالی مورد مطالعه به ترتیب دارای تغییراتی در محدوده 01/0 تا 5/27% و کمتر از 01/0 تا بیشتر از mD 630 می‌باشد. …”
Get full text

Effects of Digital Storytelling Package on Students’ Motivation and Attitude to Christian Religious Studies (CRS) in Junior Secondary Schools by Adetunmbi L. Akinyemi, Jonathan Iyanuoluwa Makinde

“…Additionally, there was a significant effect observed from the digital storytelling package on both the motivation and attitude of students (F (2; 61) = 29.67; p = 0.49 for motivation, and F (2; 61) = 32.49; p = 0.52 for attitude). …”
Get full text

Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…We compared patients at low risk of anticholinergic adverse effects (ACB < 3) versus patients at high risk (ACB ≥ 3). Chi-square test and Mann–Whitney test were used to compare the two groups. …”
Get full text

The prevalence of hand pathology in regional orthopaedic hospitals in KwaZulu-Natal: A cross-sectional study by S Thabit, M O'Connor, W Parker, T Mashishi, K Moodley, A Peer, K Matanzima, A J de Villiers, O Adewusi, R Aboobaker, A Rocher

“…During the investigation, 2 335 patients presented to orthopaedic services. HP represented 21% of these cases. The majority (17%, 406/2 335) were related to trauma and represented 23% of all the traumatic orthopaedic presentations. …”
Get full text

Removal and adsorption kinetics of copper(II) ions from aqueous media on activated carbon in dynamic adsorption on a fixed-bed column by Mve Mfoumou, Charly, Tonda-Mikiéla, Pradel, Ngoye, Francis, Bouassa Mougnala, Spenseur, Mbouiti, Berthy Lionel, Feuya Tchouya, Guy Raymond

“…The best Qsat and E (52.52 mg/g and 55.02%, respectively) were obtained with 0.01 < x < 0.04 mm, D = 2 mL/min, and h = 3 cm, with Cu2+ concentration and pH constant at 250 mg/L and 6.5, respectively. …”
Get full text

The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…A total of 200 juvenile bullfrogs (initial weight 6.85 ± 0.71 g) were randomly assigned into six groups, each receiving diets supplemented with citral at 0, 1, 2, 4, 8, and 16 mL/kg feed for 8 weeks. …”
Get full text

Supervised Injecting Room Cohort Study (SIRX): study protocol by Lisa Maher, Thomas Kerr, Matthew Hickman, Alexander Thompson, Peter Higgs, Paul Dietze, Paul A Agius, Nick Scott, Daniel O’Keefe, Mark A Stoové, Jack Stone, Dylan Vella-Horne, Ashleigh C Stewart, Amanda Roxburgh, Sione Crawford, Josephine Norman, Zachary Lloyd, Nico Clark

“…Local-level reports and outputs will be distributed to key study stakeholders and policymakers. Summary findings via accessible outputs (eg, short infographic summaries) for participants will be displayed in relevant services including the Melbourne MSIR and the study van, and distributed via Harm Reduction Victoria.…”
Get full text

Structure of Patients with Hepatocellular Cancer (Data Analysis from Two Specialised Centres) by M. V. Mayevskaya, M. S. Novruzbekov, I. M. Borovkov, D. G. Trofimova, M. S. Zharkova, V. D. Lunkov, K. N. Lutsyk, O. D. Olisov

“…A retrospective analysis of the medical records of hepatological patients who sought medical treatment at to the V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the Sechenov University in 2013, 2014 and 2017 (total 2459 patients) was carried out. …”
Get full text

Collagen turnover biomarkers to predict outcome of patients with biliary cancer by Leonard Kaps, Muhammed A. Genc, Markus Moehler, Stephan Grabbe, Jörn M. Schattenberg, Detlef Schuppan, Rasmus Sund Pedersen, Morten A. Karsdal, Philipp Mildenberger, Annett Maderer, Nicholas Willumsen

“…Patients with high levels (cohort separated by median split) of PRO-C8 (HR 2.85, 95% CI 1.42; 5.73) followed by C3M (HR 2.33, 95% CI 1.2; 4.5), PRO-C3 (HR 3.09, 95% CI 1.5; 6.36) and CA 19–9 (HR 2.52, 95% CI 1.37; 4.64) as reference biomarker had a shorter OS. …”
Get full text

Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report by Hebatullah Abdulazeem, Israel Júnior Borges do Nascimento, Ishanka Weerasekara, Amin Sharifan, Victor Grandi Bianco, Ciara Cunningham, Indunil Kularathne, Genevieve Deeken, Jerome de Barros, Brijesh Sathian, Lasse Østengaard, Frederique Lamontagne-Godwin, Joost van Hoof, Ledia Lazeri, Cassie Redlich, Hannah R Marston, Ryan Alistair Dos Santos, Natasha Azzopardi-Muscat, Yongjie Yon, David Novillo-Ortiz

“…Trial RegistrationPROSPERO CRD42024511241; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=511241…”
Get full text

Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis by Chao Zhu, Guofan Peng, Jincan Li, Yalong Deng, Tianqi Jin, Qimin Liu, Heran Cao, Zifang Wu, Yuxuan Ma, Zhenpeng Li, Yang Wang, Lijuan Zheng, Xiangtong Yuan, Lijun Zhang, Fangxia Yang, Hong Ji, Wuzi Dong

“…Interestingly, we found supplementing 0.9 mg/kg biogenic SeNPs decreased MDA, iron content, and enhanced T-AOC levels in the liver of O. macrolepis fry after a challenged by Aeromonas hydrophila (P˂0.01). Especially, the diet with 0.9 mg/kg biogenic SeNPs could significantly increase the expression level of Glutathione peroxidase-4 (GPX4), nuclear factor erythroid2-related factor 2 (Nrf2), and Ferroportin 1 (FPN1) in the liver of O. macrolepis after infection with A. hydrophila. …”
Get full text

Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production by Alessandro Guerrini, Roberta Salaroli, Augusta Zannoni, Giancarlo Avallone, Francesca Leone, Valentina Serra, Giulia Quaglia, Francesca del Zozzo, Thibaut Chabrillat, Claire Carlu, Caterina Lupini, Doriana Eurosia Angela Tedesco

“…The treatment was supplied in drinking water, as follows: 26th to 27th wk (T1, 14 d) first treatment administration at a dose of 1 mL/L (0.5 mL/L only the first d of the treatment); 28th to the 31st wk (T2, 4 wk of withdrawal period); 32nd to 33rd wk (T3, 14 d) second treatment at a dose of 1 mL/L, until the end of the trial (T4). …”
Get full text

Effect of seed priming and foliar application of organic liquid manure on germination, growth, yield and quality of late-sown wheat by Okram Ricky Devi, Omvati Verma, Bibek Laishram, S. Anbarasan, Abhijit Debnath, Narinder Panotra, Priyanka Elumle, Sunita T. Pandey, R. Ajaykumar, Samreen

“…Treatments consisted of T1 :No seed priming + 100% RDN, T2: Hydropriming + 100% RDN, T3: 10% HK priming + 100% RDN+ foliar application of 10% HK, T4: 10% HK priming + 75% RDN+ foliar application of 10% HK, T5: 10% HK priming + 50% RDN+ foliar application of 10% HK, T6: 10% HK priming + no Fertilizer+ foliar application of 10% HK, T7: 25% HK priming + 100% RDN+ foliar application of 10% HK, T8: 25% HK priming + 75% RDN+ foliar application of 10% HK, T9: 25% HK priming + 50% RDN+ foliar application of 10% HK, T10: 25% HK priming + no fertilizer+ foliar application of 10% HK, T11:50% HK priming + 100% RDN+ foliar application of 10% HK, T12: 50% HK priming + 75% RDN+ foliar application of 10% HK, T13: 50% HK priming + 50% RDN+ foliar application of 10% HK, T14: 50% HK priming + no fertilizer+ foliar application of 10% HK. …”
Get full text

Influence of volatiles (H$_{2}$O and CO$_{2}$) on shoshonite phase equilibria by Vetere, Francesco, Namur, Olivier, Holtz, Francois, Almeev, Renat, Donato, Paola, Frondini, Francesco, Cassetta, Michele, Pisello, Alessandro, Perugini, Diego

Subjects: Get full text

Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study by Manami Nomura, Takahiko Sugihara, Hiroyuki Baba, Tadashi Hosoya, Mari Kamiya, Tatsuro Ishizaki, Takumi Matsumoto, Kanae Kubo, Fumio Hirano, Masayo Kojima, Nobuyuki Miyasaka, Shinsuke Yasuda, Masayoshi Harigai

“…Infections requiring hospitalization, deterioration of extra-articular manifestations and fractures were more frequently reported as SAEs in patients with CLD, and multivariable analysis showed that patients with CLD had a higher risk of developing these SAEs (adjusted hazard ratio:2.53, 95% CI 1.60–4.00, p < 0.001). Conclusion For LORA patients with CLD, the T2T strategy is effective, but comorbidities and SAEs make the implementation of the T2T more difficult.…”
Get full text

Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity by Andrew Overholser, Eric Czech, Linda Speer, Joel Wilson, Alex Overholser

Subjects: “…GLP-1RAs…”
Get full text

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The extracts reduced the DPPH and ABTS radicals, showing a range of IC50 values of 7.35 ± 0.43 - 12.02 ± 0.21 µg/mL. However, the extracts were less toxic to the cells as they showed IC50 values > 20 µg/mL. …”
Get full text