Secondary Prevention Using Cholesterol-Lowering Medications in Patients with Prior Atherosclerotic Cardiovascular Disease Events: A Retrospective Cohort Analysis by Xue Han, Steven Fox, Michelle Chu, Jeff McCombs

“…Eligible patients were categorized by treatment group: (1) patients who initiated treatment before an ASCVD-related hospitalization and (2) patients who either did not initiate treatment until after an ASCVD hospitalization or never initiated treatment. …”
Get full text

KLF4: a multifunctional nexus connecting tumor progression and immune regulation by Yunjie Ju, Wen Xiao, Bryan James Mathis, Ying Shi

Get full text

Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

Get full text

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…Finally, we established that the suppression of NET formation by S100A8/A9 inhibition is primarily mediated through the AMPK/Nrf2/HO-1 signaling pathway. These findings underscore the critical pathological role of S100A8/A9 in TBI and emphasize the need for further exploration of S100A8/A9 inhibitor Paquinimod as a potential therapeutic strategy for TBI.…”
Get full text

Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

“…M/M risk was higher in placebo patients < 35 versus 35–64 years (SERAPHIN: hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.10–2.72, p = 0.02; GRIPHON: HR 1.81, 95% CI 1.28–2.56, p < 0.001). …”
Get full text

Assessing the impact of educational methods on influenza vaccine uptake and patient knowledge and attitudes: a randomised controlled trial by Pei Lin Hu, Eileen Yi Ling Koh, Jolene Shi Han Tay, Valerie Xin-Bei Chan, Shermin Shi Min Goh, Sinead Zhen Wang

“…Factors positively associated with vaccine uptake were willingness to receive vaccination immediately after intervention (adjusted odds ratio [OR] 12.15, 95% confidence interval [CI] 4.42–33.38), and male gender (adjusted OR 2.96, 95% CI 1.23–7.12). Individualised counselling was more effective in improving knowledge (P < 0.01). …”
Get full text

Identification of maize kernel varieties based on interpretable ensemble algorithms by Chunguang Bi, Chunguang Bi, Xinhua Bi, Jinjing Liu, Hao Xie, Shuo Zhang, He Chen, Mohan Wang, Lei Shi, Lei Shi, Shaozhong Song

Get full text

Ortner's syndrome resulting from aortic pseudoaneurysm owing to intimal sarcoma of the aorta by Akio Shimoji, MD, Naoto Fukunaga, MD, PhD, Tatsuto Wakami, MD, Otohime Mori, MD, Kosuke Yoshizawa, MD, Nobushige Tamura, MD, PhD

Get full text

Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion by Wenbo Mu, MD, PhD, Boyong Xu, MD, Fei Wang, MD, Wentao Guo, MD, PhD, Xiaogang Zhang, MD, Li Cao, MD

“…Methods: A retrospective review of 151 patient records from May 1, 2010 to December 30, 2022 was conducted at a single academic hospital. …”
Get full text

National Institutes of Health Stroke Scale: comparison of original and modified versions for Singapore culture by Shu Han Lim, Tai Yan Guek, Fung Peng Woon, Deirdre Danyi Tay, Shu Swen Ho, Szu Chyi Ng, Deidre Anne De Silva

“…Results: The error rates were high for four original dysphasia objects (Hammock: 62.9%, Cactus: 38.6%, Feather: 23.6%, Glove: 20.7%) and significantly lower for alternative items (Snail: 5%, Horse: 1.4%, Hanger: 1.4%, Car: 0%) (P < 0.001). For dysphasia phrases and dysarthria words, the error rates were low and there were no differences in error rates between the original and alternative items. …”
Get full text

Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Design This study is a multicenter, non-inferiority, randomized (1:1), open-label, controlled trial. Methods & analysis The patients assigned to the control group will undergo curative surgery within two weeks after successful SEMS placement. …”
Get full text

Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

“…Exon 19 deletion was observed in 50.3% of patients, while the L858R mutation in exon 21 was observed in 46.4% of patients. 45.1% of patients had brain metastasis. …”
Get full text

Joint effects of temperature and humidity with PM2.5 on COPD by Huan Minh Tran, Feng-Jen Tsai, Yuan-Hung Wang, Kang-Yun Lee, Jer-Hwa Chang, Chi-Li Chung, Chien-Hua Tseng, Chien-Ling Su, Yuan-Chien Lin, Tzu-Tao Chen, Kuan-Yuan Chen, Shu-Chuan Ho, Feng-Ming Yang, Sheng-Ming Wu, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Hsiao-Chi Chuang

“…For temperature and RH, we observed U-shaped effects on OR for COPD with optimal temperatures identified as 21.2 °C, 23.8 °C, and 23.8 °C for 1-day, 7-day, and 1-month mean temperature, respectively, and optimal RH levels identified as 73.8%, 76.7%, and 75.4% for 1-day, 7-day, and 1-month mean RH, respectively (p < 0.05). …”
Get full text

Resveratrol-derived carbon dots integrated into gelatin/chitosan multifunctional films for intelligent packaging by Tianxin Fu, Yuchao Feng, Shu Zhang, Yanan Sheng, Changyuan Wang

“…As well as excellent mechanical properties, the prepared films exhibited smooth surfaces, thermal stability, and good antioxidant, ultraviolet-shielding, antibacterial, and pH-responsive properties. Furthermore, cell viability measurements showed that the films were safe. …”
Get full text

Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults by SUN Yuxin, GUO Xiaoyuan, CHEN Shi, PAN Hui, ZHU Huijuan

“…The literature was screened by 2 researchers according to inclusion and exclusion criteria and relevant data were extracted.Meta-analysis of included literature was performed using RevMan 5.3 software, and publication bias was assessed using funnel plots.ResultsA total of 17 papers and 700 study subjects were included, with 351 cases in the test group, and 349 cases in the control group.Meta-analysis results showed that compared with the control group, the glycosylated hemoglobin of the test group with resistance exercise[SMD (95% CI) =-0.30(-0.53--0.07), P=0.010], fasting blood glucose[SMD (95% CI)=-0.58(-0.90--0.26), P < 0.001], insulin resistance index[SMD (95% CI) =-0.90 (-1.42--0.38), P < 0.001], and low-density lipoprotein cholesterol (LDL-C)[SMD (95% CI) =-0.28 (-0.53--0.04), P=0.020] levels were reduced.Subgroup analysis showed that the glucose metabolism levels of the test group with only resistance exercise and a combination of resistance-anaerobic exercise were significantly lower than those of the control group(both P < 0.05).The heterogeneity of the effect of resistance exercise on glucose metabolism in Asian populations(I2=57%) was smaller than that in Caucasion(I2=76%) and other populations(I2=94%), and the level of decrease in glucose metabolism indexes was significant[SMD(95% CI)=-1.15(-1.73--0.57), P < 0.001].ConclusionResistance exercise can significantly reduce the level of glycolipid metabolism indexes in overweight or obese people.…”
Get full text

Research progress on Haemophilus parasuis vaccines by Yu Duan, Yue Hao, Huapeng Feng, Jianhong Shu, Yulong He

Get full text

An engineered Yarrowia lipolytica with rapid growth and efficient lipid utilization by Tianyu Dong, Yujie Shu, Ying Wang, Mingdong Yao, Wenhai Xiao

“…Herein, an integrated strategy was implemented to enhance lipid uptake, accumulation and metabolism and systematically promote the growth and lipid utilization of the commonly used Y. lipolytica Po1f strain. The engineered strain had a specific growth rate of 0.32 h−1 and a lipid content of 67.66 % (g/g DCW), which were 54 % and 26 % greater than those of the original strain. β-Carotene was used to verify the production of lipophilic natural compounds, and the highest yield was obtained 48 h earlier using the engineered strain compared to the original strain when consuming same carbon source. …”
Get full text

Improving compliance and evaluating physician–patient concerns in glaucoma: a pilot study by Mohannad Albdour, Aaron Shi, Chuhan Wang, Ibrahim Saleh, Karanjit S Kooner

“… Purpose: To improve glaucoma treatment compliance via education, medication reminders, and understanding of patient and physician concerns. …”
Get full text

NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity by Yixuan Liu, Baoyue Liu, Mingzhu Shi, Tianxiang Ye, Huifang Li

Get full text