Effect of seed priming and foliar application of organic liquid manure on germination, growth, yield and quality of late-sown wheat by Okram Ricky Devi, Omvati Verma, Bibek Laishram, S. Anbarasan, Abhijit Debnath, Narinder Panotra, Priyanka Elumle, Sunita T. Pandey, R. Ajaykumar, Samreen

“…Treatments consisted of T1 :No seed priming + 100% RDN, T2: Hydropriming + 100% RDN, T3: 10% HK priming + 100% RDN+ foliar application of 10% HK, T4: 10% HK priming + 75% RDN+ foliar application of 10% HK, T5: 10% HK priming + 50% RDN+ foliar application of 10% HK, T6: 10% HK priming + no Fertilizer+ foliar application of 10% HK, T7: 25% HK priming + 100% RDN+ foliar application of 10% HK, T8: 25% HK priming + 75% RDN+ foliar application of 10% HK, T9: 25% HK priming + 50% RDN+ foliar application of 10% HK, T10: 25% HK priming + no fertilizer+ foliar application of 10% HK, T11:50% HK priming + 100% RDN+ foliar application of 10% HK, T12: 50% HK priming + 75% RDN+ foliar application of 10% HK, T13: 50% HK priming + 50% RDN+ foliar application of 10% HK, T14: 50% HK priming + no fertilizer+ foliar application of 10% HK. …”
Get full text

Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study by Manami Nomura, Takahiko Sugihara, Hiroyuki Baba, Tadashi Hosoya, Mari Kamiya, Tatsuro Ishizaki, Takumi Matsumoto, Kanae Kubo, Fumio Hirano, Masayo Kojima, Nobuyuki Miyasaka, Shinsuke Yasuda, Masayoshi Harigai

“…Infections requiring hospitalization, deterioration of extra-articular manifestations and fractures were more frequently reported as SAEs in patients with CLD, and multivariable analysis showed that patients with CLD had a higher risk of developing these SAEs (adjusted hazard ratio:2.53, 95% CI 1.60–4.00, p < 0.001). Conclusion For LORA patients with CLD, the T2T strategy is effective, but comorbidities and SAEs make the implementation of the T2T more difficult.…”
Get full text

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The extracts reduced the DPPH and ABTS radicals, showing a range of IC50 values of 7.35 ± 0.43 - 12.02 ± 0.21 µg/mL. However, the extracts were less toxic to the cells as they showed IC50 values > 20 µg/mL. …”
Get full text

Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Expression of tight junction gene and protein expression was decreased maximally 4 h after administration, along with inhibition of efflux transporter, ABCB1, activity. …”
Get full text

Comprehensive evaluation of physico-chemical, antioxidant, and antimicrobial properties in commercial soaps: A study on bar soaps and liquid hand wash by Jannatul Ferdous Nova, Susmita Zaman Smrity, Mahadi Hasan, Md. Tariquzzaman, Md Al Amin Hossain, Md. Tanvirul Islam, Md. Raysul Islam, Selina Akter, Md. Sifat Rahi, Md. Tuhinur R. Joy, Zannatul Kowser

“…Besides, SN-21 among liquid hand wash soaps possesses overall excellence as it moisturizes skin well (MC-83.75 ± 0.05 %), is almost safe for skin (pH-7.73 ± 0.02, TAC-0.98 ± 0.01 %), has TFM (11.35 %), has good cleansing capacity (FH-22.66 ± 0.58 cm) and bacteria growth inhibiting activity (29.27 ± 0.25 mm/100 % conc.), destroys selected bacteria (MIC – 1.2 × 107 CFU at 1 min and 5.5 × 107 CFU at 10 seconds), and wash away free radicals from skin (420.64 ± 3.62 μg/mL).…”
Get full text

Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases by Wei Guo, Bolun Zhou, Lizhou Dou, Lei Guo, Yong Li, Jianjun Qin, Zhen Wang, Qilin Huai, Xuemin Xue, Yin Li, Jianming Ying, Qi Xue, Shugeng Gao, Jie He

“…The analysis of 161,333 cells revealed specific subclusters of epithelial cells that were significantly enriched in metastatic lymph nodes, suggesting pro-metastatic characteristics. …”
Get full text

Temporal and Spatial Patterns of Wind Erosion Climate Indices and Their Responses to Atmospheric and Oceanic Circulation Patterns in the Chinese Mollisol Region over the Past 61 Years by HU Wentao, ZHENG Fenli, GAO Xiaoyu, ZHENG Runhe, FU Jinxia, LI Zhi, ZHANG Jiaqiong

“…[Results] The occurrence frequency of ≥ 5 m/s threshold wind speed of transporting sand varied from 5 to 30 times per season, daily maximum wind velocity varied from 6.1 to 8.7 m/s, daily extreme wind velocity varied from 9.8 to 12.2 m/s, and wind erosion climatic erosivity varied from 19.5 to 101.1 in the Chinese Mollisol region form 1960 to 2020. …”
Get full text

Психоэмоциональное состояние среднего медицинского персонала отделений реанимации и интенсивной терапии при работе с пациентами, инфицированными COVID-19: сравнительное поперечное... by А. Д. Каштанов, Е. В. Карташова, А. А. Галата, В. А. Алиев, Андрей Георгиевич Яворовский, Б. А. Волель, Ю. Л. Васильев, С. С. Ибрахим

“…РЕЗУЛЬТАТЫ: Медсестры в ОРИТ с пациентами, инфицированными COVID-19 (ОРИТ COVID+), более склонны к деперсонализации, снижению личных достижений и чаще проявляют вербальную и косвенную агрессию (14,82/12,76 и 38/31, 19/16 баллов по методиками соответственно между группами сравнения). …”
Get full text

Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Study results will be disseminated via research conference presentations and peer-reviewed publications.Trial registration number NCT02941809.…”
Get full text

ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway by Qikang Yan, Quan Sun, Yan Feng, Qingyun Hu, Jinling Zhu

Subjects: Get full text

چالش‌های مطالعه ازدیاد برداشت در مخازن شکاف‌دار با کلاهک گازی حجیم اولیه و ارائه راهکارها با رویکرد غربالگری پیشرفته... by محمد پروازدوانی, شیما ابراهیم زاده رجائی, شهاب گرامی

Get full text

Insulin resistance surrogates are associated with all-cause mortality and cardiovascular mortality in population with metabolic syndrome: a retrospective cohort study of NHANES by Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

“…As IGR gradually approached inflection points, the two types of mortality risks descended by 15%[HR 0.85(0.80,0.91)] and 19%[HR 0.81(0.71,0.92)], respectively. …”
Get full text

Age-related changes in brain signal variability in autism spectrum disorder by Priyanka Sigar, Nicholas Kathrein, Elijah Gragas, Lauren Kupis, Lucina Q. Uddin, Jason S. Nomi

“…Methods We conducted a cross-sectional examination of resting-state BSV and its relationship with age and RRBs in a cohort of individuals with Autism Brain Imaging Data Exchange (n = 351) and typically developing (TD) individuals (n = 402) aged 5–50 years obtained from the Autism Brain Imaging Data Exchange. …”
Get full text

Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX) by Elisabetta Pupillo, Elisa Bianchi, Ettore Beghi, Francesco Andrea Pedrazzini, Angela Giglio, Edoardo Dalmato Schilke, Marco Percetti, Carlo Morotti Colleoni, Gabriele Mainini, Paolo Calabresi, Guido Primiano, Giovanni Frisullo, Alessandro Padovani, Viviana Cristillo, Andrea Pilotto, Davide Arici, Stefano Gipponi, Gioacchino Tedeschi, Alessandro d’Ambrosio, Rosario Domenico Melisi, Antonio Gallo, Alvino Bisecco, Andrea Salmaggi, Paola Basilico, Chiara Scaccabarozzi, Lorenzo Kiferle, Raffaella Valenti, Gianluca Avino, Annamaria Borghi, Sara Contardi, Andrea Zini, Carlo Ferrarese, Simone Beretta

“…The most frequent neurological diagnosis in cases were stroke (60.4%), multiple sclerosis (11.3%) and seizures (6.4%). The proportion of vaccinated participants was 72.1% among cases and 79.6% among controls. …”
Get full text

In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…Systemic delivery of mRNA in mice resulted in a dose-dependent expression of 3N39v4 in plasma (20–261 μg/mL at 1–10 mg/kg) with sufficient tolerability. …”
Get full text

Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…The average level of distress decreased from 14.9 ± 10.0 to 7.5 ± 6.2 (14th day) and to 4.4 ± 5.8 scores (28th day). The number of patients reporting no distress symptoms increased by 49.4 %, reaching 91.1 % (n = 51) on the 28th day of treatment. …”
Get full text

Investigating knowledge and attitudes toward genetic testing and counseling among palestinians by Mustafa Ghanim, Maha Rabayaa, Malik Alqub, Ahmad Hanani, Mohammad Abuawad, Belal Rahhal, Shurouq Qadous, Myassar Barahmeh, Sameeha Atout, Saad Al-Lahham, Aseel Aref, Majdi Dwikat, Samar Alkhaldi, Ahmad Makhamreh

“…Other reasons for undergoing genetic testing were diagnosis (22.1%), followed by carrier testing (17.9%), and predictive and pre-symptomatic testing (10.5%). …”
Get full text