Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…At a mechanistic level, accumulating preclinical and clinical data indicate dual mechanisms for αCTLA-4; ICB and regulatory T cell (Treg) depletion are both thought to contribute efficacy and toxicity in available, systemic, αCTLA-4 regimens. …”
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O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Furthermore, both the chromatin immunoprecipitation (ChIP) assay and the dual-luciferase reporter assay indicated that Nrf2 could bind with translation start site (TSS) of glucose-6-phosphate dehydrogenase (G6PDH) and promote its transcriptional activity. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Pegmolesatide showed significant PK-PD dual prolongation effects and was well tolerated. …”
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The hidden crisis: double burden of malnutrition among refugee children in South Asia – a systematic review and meta-analysis from observational studies by Pooja Panchal, Mohd Usman, Tajung Longkumer, Reshma Susan Babu, Mahalaqua Nazil Khatib, Shariza Abdul Razak, Kavitha Menon

“…We searched JSTOR, Scopus, PubMed, Web of Science, and MEDLINE databases for studies on the prevalence of malnutrition in refugee children from 1984 to August 2024 with restricted English language. …”
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Correlación entre eosinófilos y aminotransferasas en pacientes diabéticos y no diabéticos de un policlínico ubicado en el distrito de Villa El Salvador, Lima, Perú by Alberto Guevara Tirado

“…Materiales y métodos: Estudio observacional, analítico y correlacional que evaluó a 767 personas, de las cuales 500 fueron pacientes no diabéticos y 267 diagnosticados con diabetes mellitus en tratamiento, con tiempo de enfermedad igual o mayor a seis meses. …”
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Pengamanan Citra Digital Menggunakan Kriptografi DnaDan Modified LSB by Sabrina Adela Br Sibarani, Andreas Munthe, Ronsen Purba, Ali Akbar Lubis

“…Proses enkripsi terdiri dari dua lapisan. Lapisan pertama, sistem chaos seperti Arnold's Cat Map (ACM) digunakan untuk mengacak posisi piksel melalui beberapa iterasi, sementara Logistic Map (LM) membangkitkan keystream karena sensitivitasnya yang tinggi. …”
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Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

“…Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
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Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…In recent years, the Chinese government has proposed the “dual carbon” goal of achieving a carbon peak by 2030 and carbon neutrality by 2060. …”
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Reinfección por sífilis gestacional: reporte de caso y revisión sistemática de la literatura by Harold Villamizar, Natalia Vergara, Daniela Martínez-Barreto, Jaime Moreno-Chaparro, Hernando Gaitán-Duarte

“…Resultados: se identificaron 208 títulos potencialmente relevantes, de los cuales 12 fueron evaluados en texto completo. Finalmente, se incluyeron seis artículos. …”
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Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Lung cancer cells co-cultured with Jurkat T cells were xenografted into nude mice to evaluate tumor growth and metastatic potential. Next, RNA-seq, COIP, Dual-luciferase reporter experiment, and CHIP-seq were used to explore the potential underlying mechanism. …”
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Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

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Ice-nucleating particles active below −24 °C in a Finnish boreal forest and their relationship to bioaerosols by F. Vogel, F. Vogel, M. P. Adams, L. Lacher, P. B. Foster, G. C. E. Porter, G. C. E. Porter, B. Bertozzi, B. Bertozzi, K. Höhler, J. Schneider, T. Schorr, N. S. Umo, J. Nadolny, Z. Brasseur, P. Heikkilä, E. S. Thomson, N. Büttner, M. I. Daily, R. Fösig, A. D. Harrison, J. Keskinen, U. Proske, U. Proske, U. Proske, J. Duplissy, J. Duplissy, M. Kulmala, T. Petäjä, O. Möhler, B. J. Murray

“…Using the 6 <span class="inline-formula">min</span> time resolution PINE data, we present several lines of evidence that INPs below <span class="inline-formula">−</span>24 <span class="inline-formula">°C</span> in this location are also from biological sources: (i) an INP parameterization developed for a pine forest site in Colorado, where many INPs were shown to be biological, produced a good fit to our measurements; a moderate correlation of INPs with aerosol concentration larger than 0.5 <span class="inline-formula">µm</span> and the fluorescent bioaerosol concentration; (ii) a negative correlation with relative humidity that may relate to enhanced release of bioaerosol at low humidity from local sources such as the prolific lichen population in boreal forests; and (iii) the absence of correlation with ultra-fine particles (3.5 to 50 <span class="inline-formula">nm</span>), indicating that new particle formation events are not sources of INPs. …”
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El INBio: su labor innovadora en el conocimiento y el uso sostenible de la biodiversidad en Costa Rica by Rodrigo Gámez, Vilma Obando, Natalia Zamora

“…Se describen los principales resultados de su labor y los reconocimientos nacionales e internacionales que el INBio recibió por sus novedosos enfoques y aportes, al igual que se resumen las razones de carácter financiero y político por las cuales el INBio descontinuó sus actividades en el período 2015-2016. …”
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Evolution, Characteristics and Inspirations of Management Zoning for National Parks in the United States by Zhenwei ZHANG, Hanyue XIAO, Yankang MAO

“…In addition, this research analyzes the nine characteristics of the management zoning for national parks in the United States: 1) Functional attribute of zoning — transform from functional zoning to comprehensive control zoning; 2) functional characteristics of zoning — most zones are similar to China’s main functional zone, rather than the restricted red line zone; 3) functional goal of zoning — strive to achieve the dual balance of “protection − utilization”; 4) zoning policies are of flexibility and complete; 5) zoning is based on the dynamic adaptive management theory; 6) zoning should be supported by a more comprehensive and systematic policy system; 7) zoning must be based on a scientific and rigorous policy system; 8) different designation areas and autonomous zoning composed its rigid and flexible frame; 9) zoning may be deduced through the comparison of multiple scenaro.ConclusionChina’s national park zoning should be regarded as a technical method relying on management rules, for which the system development should be strengthened. …”
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Editorial by Lindsay B. Flynn

“…The first, a global financial crisis, was triggered by the 2008 US housing market crash. The second now asks them to shelter in homes they struggle to afford. …”
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