KLF5 promotes esophageal squamous cell carcinoma radioresistance by targeting the Keap1-Nrf2 pathway by Yang Wang, Yue-ying Yang, Abulajiang Kamili, Dilimulati Aishanjiang, Yi Liu

“…The enrichment of KLF5 at the Keap1 promoter was analyzed by ChIP-base, and the binding of KLF5 to Keap1 was analyzed by ChIP and dual-luciferase. They then injected ESCC cells into mice and used radiation to monitor tumor progression. …”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…In vitro studies with bone marrow-derived macrophage (BMDM), RAW264.7, and THP-1 cells further demonstrated Blimp-1 promotes M2 polarization and modulates key metabolic pathways. Metabolomics and dual-luciferase assays revealed Blimp-1 significantly influences purine biosynthesis and the downstream Ornithine cycle, which are essential for M2 macrophage polarization. …”
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Mechanisms of corporate digital transformation on asymmetric capital structure adjustment—the mediating role of information asymmetry and financial stability by Jin Li, Zijian Li

“…In the context of the digital economy, enterprises face dual challenges in optimizing their capital structure and achieving sustainable development. …”
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Exploring short-term memory and listening effort in two-talker conversations: The influence of soft and moderate background noise. by Chinthusa Mohanathasan, Cosima A Ermert, Janina Fels, Torsten W Kuhlen, Sabine J Schlittmeier

“…Previous research has mainly focused on short-term memory using simple cognitive tasks with unrelated words or digits. …”
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An explainable deep learning model for diabetic foot ulcer classification using swin transformer and efficient multi-scale attention-driven network by R. Karthik, Armaano Ajay, Anshika Jhalani, Kruthik Ballari, Suganthi K

“…The proposed work also incorporates Grad-CAM-based Explainable Artificial Intelligence (XAI) to visualize and interpret the decision making of the network. …”
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Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…Among different bivalve species, clams and scallops are the most efficient producers of EPA + DHA and EAAs, while oysters produce the least. …”
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Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta by Jennifer Walsh, Catriona Keerie, Stuart H Ralston, Christopher J Weir, Muhammad K Javaid, WAYNE LAM, Bente L Langdahl, Jannie D Hald, Patricia Osborne

“…At baseline, participants will undergo a spine X-ray, and have bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) at the spine and hip. …”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…Mechanistically, YAP/TAZ regulates apoptosis induced by ER stress in tumor cells by controlling the activation of the TRAIL-R2/DR5-mediated extrinsic apoptotic pathway through a dual mechanism. …”
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Sustentabilidade econômico-financeira dos serviços de manejo de resíduos sólidos urbanos (RSU): aspectos legais e desafios para consecução by Yuri Mariano Carvalho, Rodrigo Loth Machado, Samuel Rodrigues Castro, Júlia Righi de Almeida

“…Em sequência, discute-se a sustentabilidade econômico-financeira dos serviços de manejo de RSU, apresentando as atuais conjunturas de cobranças no país, suas validações legais e seus problemas. …”
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Tocar, interpretar, escutar: praticar a música ou fazê-la agir? by Antoine Hennion

“…Socorrendo-se das particularidades da música, defende que esta fornece um modelo de abordagem das obras de arte que funciona numa dupla entrada: de um lado, a música é objeto de uma performance necessária da obra; mas do outro, a música assume-se como uma performance ativa de quem a aprecia (amador) no amplo sentido. …”
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Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study by Jing Qian, Jiahao Zhu, Yifan Wang, Ruoqi Dai, Jingyou Miao, Ye Yang, Wenxia Zhao, Jing Wang, Lilu Ding, Dan Zhou, Min Yu, Yingjun Li

“…Additionally, using genome-wide association statistics, we examined the potential causal associations between air pollution-related DNA methylation (DNAm) and OA risk. Gene-environment interaction analyses were conducted to explore the potential modification effect of DNA methylation-related genetic variants on the impact of air pollution on OA risk. …”
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Designing multi-function rapid right angle set slurry compositions for a high pressure-high temperature well by Pooria Kianoush, Mostafa Gomar, Nasser Keshavarz Faraj Khah, Seyednooroldin Hosseini, Ali Kadkhodaie, Shahaab Varkouhi

“…A blend of additives—including 3 % boric acid as a dual-functioning dispersant and 1 % latex materials—enhanced dispersing properties, compressive strength, and gas migration resistance. …”
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U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults by Chuanwei Zhao, Xiaochun Zhang, Xu Zhang, Bo Zhao, Yane Yang, Mu Lin, Wenli Qiao, Zeyao Hu, Haijie Yang

“…Osteoporosis was defined by self-reported physician diagnosis or dual-energy x-ray absorptiometry (DXA) measurements. …”
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Design of strategies for the process of digitalisation and technological modernisation in social services organisations. by Aleix Morilla-Luchena, Teresa Gómez-Rasco, Rocío Muñoz Moreno, Octavio Vázquez-Aguado

“…El análisis produjo 248 códigos y 2543 citas, de las cuales se consolidaron 57 códigos a partir del código central "Uso de medios tecnológicos". …”
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THE IMPACT OF CORPORATE SOCIAL RESPONSIBILITY ON BANK PERFORMANCE IN NIGERIA by Ibrahim Yinka Agbeyinka

“…The study concluded that the dual-edged nature of corporate social responsibility engagement, where the benefits to profitability and long-term value must be balanced against the potential short-term financial drawbacks. …”
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Impact of Human Capital Development on Economic Growth in Uganda. by Nuwagaba, Christopher

“…To address this issue, Uganda must adopt a dual-priority strategy focusing on expanding access to education from pre-primary through lower secondary levels, as well as improving the quality of education at all levels. …”
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Health system governance for injury care in low- and middle-income countries: a survey of policymakers and policy implementors by Alice Sitch, Justine Davies, Kathryn Chu, Stephen Tabiri, Junaid Razzak, Lucia D’Ambruoso, Alemayehu Amberbir, Abebe Bekele, Agnieszka Ignatowicz, Mohammed Bukari, Derbew Fikadu Berhe, Barnabas Alayande, Pascal Nzasabimana, Jean Claude Byiringiro, Huba Atiq, Komal Abdul Rahim, Jane Acquaye, Anita Eseenam Agbeko, Napoleon Bellua Sam, Leila Ghalichi, Denys Ndangurura, Irene Bagahirwa, Dominic Konadu-Yeboah, Frederick Sarfo-Antwi, Lambert Nzungize, Ntombekhaya Tshabalala, Richard Osei, Tamlyn MacQuene, Zaheer Babar Chand, Zabin Wajidali, Adams Dramani, Ebenezer Kwame Amofa, Eric Twizeyimana, Fazila Sahibjan, Ghislaine Umwali, Mehreen Mustafa, Nadine Mugisha, Tariq Jakhro

“…Median scores were higher for policymakers (33, 27–48) than for policy implementers (27, 17–42), but the difference was not statistically significant.Conclusion The four studied countries have developed some of the foundations of good injury care governance, although many governance domains require more attention. …”
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HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

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A Organização do Conhecimento e da Informação: aspectos conceituais e sua aplicação nas funções arquivísticas by Camila Schwinden Lehmkuhl, Eva Cristina Leite da Silva

“…Esta pesquisa busca analisar as definições relativas aos conceitos de Organização do conhecimento e Organização da informação e suas aplicações na prática arquivística, a partir das funções arquivísticas de Classificação, Avaliação e Descrição/Indexação. …”
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Sexología basada en la evidencia: historia y actualización by Mirta Granero

“…Posteriormente, se publican las investigaciones de Kinsey, con las cuales empieza la sexología en sentido moderno.  Masters y Johnson fueron pioneros en trabajos experimentales de la sexología.  …”
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