Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The geometric mean ratios (GMRs) for the peak concentration in plasma (Cmax), area under the curve from zero to the time point (AUClast), and area under the curve from zero to infinite (AUCinf) postprandially versus fasted were 108.45% (98.51% – 119.40%), 105.23% (100.25% – 110.47%), and 104.14% (97.41% – 111.34%), respectively. …”
Get full text

Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction by Longxiang Su, Lin Feng, Qing Song, Hongjun Kang, Xingang Zhang, Zhixin Liang, Yanhong Jia, Dan Feng, Changting Liu, Lixin Xie

“…An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. …”
Get full text

Production of organic fertilizer using pleurotus sp. as a process accelerator by A. Medina-Buelvas, A. Garcia-Guan, B. Barraza-Amador, E. Espinosa-Fuente, M. Del Castillo-Cabrales, K. Mendez-Gutiérrez, N. Rosales-Hernández

“…Otherwise, in the composting process, the fungus significantly accelerates the process and at the same time shows an overgrowth.…”
Get full text

Laparoscopic suture repair for perforated peptic ulcer disease: a meta-review and trial sequential analysis by S. I. Panin, T. V. Nechay, I. V. Sazhin, K. Yu. Melnikov-Makarchuk, A. V. Sazhin, A. V. Puzikova, A. N. Akinchits, A. V. Bykov

“…The calculated DARIS for operative time and hospital stay were 40.1% and 14.6%, respectively, and the TSA showed neither significant benefit nor harm of laparoscopic surgery in the attained information size in the meta-analysis. …”
Get full text

CRISPR/Cas13a combined with reverse transcription and RPA for NoV GII.4 monitoring in water environments by Yiqiang Sun, Weiwei Zhang, Houyun Zhang, Feng Zhao, Laijin Su

“…The results of the two methods showed 100 % concordance with no significant difference in viral load. …”
Get full text

Association Between Patient-Reported Pain and Remission or Low Disease Activity in Patients with Rheumatoid Arthritis: Data from RA-BE-REAL Prospective Observational Study by Peter C. Taylor, Walid Fakhouri, Samuel Ogwu, Ewa Haladyj, Inmaculada de la Torre, Bruno Fautrel, Rieke Alten, Peter Nash, Eugen Feist

“…Pain was measured using the visual analogue scale (VAS) (0–100 mm) and clinically meaningful pain improvement thresholds of ≥ 30%, ≥ 50% and ≥ 70% from baseline to 3, 6, 12 and 24 M. …”
Get full text

Valorization of pinecone as a pyrolysis feedstock: identification of bio-oil and synthesis of activated biochar for Cr(VI) elimination from wastewater by Alfares, Amenah Adnan, Younis, Afyaa Muayed, Rasheed, Lana Abdalhameed, Fadhil, Abdelrahman Basil

“…The ABC exhibited an adsorptive elimination of 98.71% for 100 mL of solution containing 150 ppm of Cr(VI) from its aqueous phase using 0.20 g of ABC at 35 °C for 140 min and a pH = 2.0. …”
Get full text

Clinical validation of a biopsy‐based six‐gene signature prognostic for aggressive prostate cancer by Agnieszka Krzyzanowska, Debra F. Higgins, Stephen Barron, Tony Loughman, Amanda O'Neill, Katherine M. Sheehan, Chan‐Ju Angel Wang, Bozena Fender, Leah McGuire, Joanna Fay, Anthony O'Grady, Des O'Leary, R. William Watson, Anders Bjartell, William M. Gallagher

“…Methods MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason (≥G4) and high pathological T‐stage (≥T3) were assessed by likelihood ratio statistics and area under the receiver operating characteristic curves from logistic regression models; time to biochemical recurrence was assessed by likelihood ratio statistics and C‐indexes from Cox proportional hazard regression models. …”
Get full text

Students Perceptions, Satisfactions and Challenges on Problem-Based Learning (PBL): A Survey Study Among Final Year Pharmacy Students by Engku Nuraishah Huda E. Zainudin, Fakhira Damia Khaidir, May Khin Soe, Nurul Asyiqin Yusof, Khairool Azizul Mohammad

“…Although, most findings highlight positive aspects of PBL, this study also identified three major challenges in PBL implementation, namely 1) insufficient time for PBL preparation, 2) lack of teamwork, and 3) difficulty in finding adequate reading materials. …”
Get full text

ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study by Demis Zelelew, Milkyas Endale, Yadessa Melaku, Taye B. Demissie, Japheth O. Ombito, Rajalakshmanan Eswaramoorthy

“…In the present study, a new series of nine Thiazolo[3,2-α] pyrimidine analogs were synthesized in good to excellent yields (87.9–96.9%) and improved reaction time using a ZnO nanoparticle-assisted protocol. …”
Get full text

Heterogeneous long-term changes in larch forest and shrubland cover in the Kolyma lowland are not captured by coarser-scale greening trends by Heather Kropp, Michael M Loranty, Howard Epstein, Gerald V Frost, Adam Koplik, Logan T Berner

“…Increases in shrubland cover were highest in proximity to surface water (<100 m) and in close proximity to areas with stable shrubland cover. …”
Get full text

The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…Abstract Background Wound healing is a restoration process of tissue integrity and function targeting reducing the healing time and complications with priority of available, acceptable and affordable medication. …”
Get full text

Investigating the Effect of Coffee Husk Ash as Partial Replacement of Cement in Concrete C30. by Niwainamani, Laban

“…The initial and final setting time of OPC - CHA at 5% replacement was observed to be 79 minutes and 431 minutes respectively. …”
Get full text

Impact of Gender-Based Violence on Social Wellbeing in Rukiga District: A case Study of Muhanga Town Council Rukiga District. by Amanya, Grace

“…Based on the results from the study, 100% of the respondents agreed that there are various forms of domestic violence in Muhanga town council, Rukiga district. …”
Get full text

Infestation and damage status assessment of white mango scale (Aulacaspis tubercularis) insect at boloso sore and boloso bombe districts of Wolaita Zone South Ethiopia by Andualem Alemayehu, Zerhun Tomas

“…From the total study area, almost 31% of mango farms reduced 100% yield and the reduction of yield ranged from 50% to 100%. …”
Get full text

Field Deployment of a Mobile Biosafety Laboratory Reveals the Co-Circulation of Dengue Viruses Serotype 1 and Serotype 2 in Louga City, Senegal, 2017 by Idrissa Dieng, Maryam Diarra, Moussa Moïse Diagne, Martin Faye, Marie Henriette Dior Ndione, Yamar Ba, Mamadou Diop, El Hadji Ndiaye, Paolo Marinho de Andrade Zanotto, Boly Diop, Mamadou Ndiaye, Abdoulaye Bousso, Ndongo Dia, Mawlouth Diallo, Aliou Barry, Gamou Fall, Cheikh Loucoubar, Amadou Alpha Sall, Ousmane Faye, Oumar Faye

“…Serotyping revealed two serotypes, Dengue 1 (100/104; 96, 15%) and Dengue 2 (04/104; 3, 84%). …”
Get full text

Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…Incidence rates (IRs; patients with events/100 patient-years [PY]; 95% CIs) of first-time occurrences were obtained for adverse events (AEs) of interest.Results 7061 patients received tofacitinib (total exposure: 22 875 PY; median [range] exposure: 3.1 [0 to 9.6] years). …”
Get full text

Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…Results: Among 18,772 medical cause OHCA cases, the crude incidence rate was 17.4 per 100,000 population, with an age-standardised rate of 38.4. …”
Get full text

Chikungunya intra-vector dynamics in Aedes albopictus from Lyon (France) upon exposure to a human viremia-like dose range reveals vector barrier’s permissiveness and supports local... by Viginier, Barbara, Cappuccio, Lucie, Garnier, Céline, Martin, Edwige, Maisse, Carine, Valiente Moro, Claire, Minard, Guillaume, Fontaine, Albin, Lequime, Sébastian, Ratinier, Maxime, Arnaud, Frédérick, Raquin, Vincent

“…Vector competence is a complex, time-dependent, quantitative phenotype influenced by biotic and abiotic factors. …”
Get full text

Process evaluation of Project Daire: a food environment intervention that impacted food knowledge, wellbeing and dietary habits of primary school children by Naomi Anderson, Sarah F. Brennan, Fiona Lavelle, Sarah E. Moore, Dilara Olgacher, Amy Junkin, Moira Dean, Michelle C. McKinley, Patrick McCole, Ruth F. Hunter, Laura Dunne, Niamh E. O’Connell, Chris T. Elliott, Danielle McCarthy, Jayne V. Woodside

“…Findings also identified suggestions for improvement including provision of increased teacher training, support and planning time, content reduction to facilitate easy integration, and implementation across the full academic year. …”
Get full text