Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phox N-Terminus: An Elusive Target by Gábor Csányi, Patrick J. Pagano

“…Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known. …”
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Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation by Wenhan Ju, Shuai Zhao, Danping Li, Jinfu Zhang, Jinfu Zhang, Shan Xiang, Fang Lian

“…The cyclic recruitment of primordial follicles and the preservation of oocyte quality involve complex and tightly regulated biological processes. …”
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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy by Muhan Wang, Zhijie Zhang, YouYou Yang, Xiaoyi Peng, Hongping Yin

“…TRIAS-expressing tumor cells exhibited enhanced antitumor activity, likely due to increased cytokine release and upregulated major histocompatibility complex (MHC) expression, enabling tumor cells to function as antigen-presenting cells. …”
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The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. by David S Guttery, Jon K Pittman, Karine Frénal, Benoit Poulin, Leon R McFarlane, Ksenija Slavic, Sally P Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry M Staines

“…Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms are therefore of interest as putative drug targets. …”
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Successful management of severe anaerobic infection inducing mediastinal and subcutaneous emphysema, septic shock, and ARDS: a case report highlighting VV-ECMO and NGS-guided thera... by Haohao Wu, Pin Lan, Kechun Zhou, Xingzhen Wu, Lutao Xie

“…After 7 days of ECMO support and anti-infective treatment, the patient’s oxygenation improved significantly, inflammatory markers decreased, and ECMO was successfully weaned.ConclusionVV-ECMO is of critical value in managing septic shock and ARDS caused by severe anaerobic infections, effectively improving oxygenation and supporting organ function. This case highlights the pivotal role of airway management, VV-ECMO support, and comprehensive therapeutic strategies in the management of complex infectious ARDS, providing valuable insights for similar clinical scenarios.…”
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Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Such multifaceted roles can be fulfilled thanks to the vast variety of vimentin proteoforms, which in turn arise from the combinations of a myriad of tightly regulated posttranslational modifications. …”
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Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions by Dipak Maskey, Dipak Maskey, Jessica Granados Pineda, Jessica Granados Pineda, Pablo A. Ortiz, Pablo A. Ortiz

“…Here, we update the latest molecular mechanisms and players that control NKCC2 function, which gives an increasingly complex picture of NKKC2 regulation in the apical membrane of the TAL.Recent FindingsProtein-protein interactions are required as a regulatory mechanism in many cellular processes. …”
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Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development by Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

“…The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…Abstract Macrophage polarization is a dynamic process driven by a complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated by pathogens. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. …”
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Hydrogen-bonded supramolecular polymer networks for effective removal of perchlorate in water via clustered hydrogen-bonding by Jintao Tian, Xing Han, Hao-Ran Yang, Juan Liu, Jin-Fa Chen, Tai-Bao Wei, Hong Yao, Wen-Juan Qu, Bingbing Shi, Qi Lin

“…Here, we demonstrate a hydrogen-bonded supramolecular polymer network crystal (HBPC) for efficient complexation of ClO4 −. The HBPC network is constructed by an A,A’-bis-pyridyl-hydrazone-phenyl conjugate-functionalized pillar[5]arene (PYP5), which self-assembles via the formation of clustered hydrogen-bonds. …”
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Cleavage site heterogeneity at the pre-mRNA 3′-untranslated region regulates gene expression in oxidative stress response by Feba Shaji, Jamshaid Ali, Rakesh S. Laishram

“…The endonucleolytic cleavage step of the eukaryotic mRNA 3′-end processing is considered imprecise, which leads to heterogeneity of cleavage site (CS) with hitherto unknown function. Contrary to popular belief, we show that this imprecision in the cleavage is tightly regulated, resulting in the CS heterogeneity (CSH) that controls gene expression in antioxidant response. …”
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Niemann - Pick C2 regulates steroid hormone secretion and lipid deposition in chicken follicular granulosa cells by Ruihao Yu, Shuo Wei, Felix Kwame Amevor, Liuting Wu, Dan Xu, Zheliang Liu, Kunlong Qi, Yingjie Wang, Gang Shu, Xiaoling Zhao

“…Follicular development is tightly regulated by the coordinated action of multiple hormones and complex gene regulatory networks in granulosa cells, which play a crucial role in egg production and fertility in hens. …”
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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
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Case Report: Giant pheochromocytoma complicated by takotsubo syndrome: a case of emergency robot-assisted left adrenalectomy and multidisciplinary management by Jia Miao, Jia Miao, Xuanhan Hu, Xuanhan Hu, Ting Wang, Feng Liu, Dahong Zhang, Haibin Wei

“…Postoperatively, cardiac function normalized within three months, and catecholamine levels returned to baseline. …”
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An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. …”
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Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches by Cristina Uța, Alexandru Tîrziu, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Marius Georgescu, Laura Haidar, Carmen Panaitescu

“…Recurrent pregnancy loss (RPL) is a complex early pregnancy complication affecting 1–2% of couples and is often linked to immune dysfunction. …”
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Effects of Pueraria montana and Melastoma dodecandrum Intercropping on Soil and Tea Plant Growth in Terraced Tea Gardens: A Sustainable Agricultural Practice by Lingshan Shi, Dongliang Li, Shuaibo Shao, Fajie Feng, Qisong Li, Fanfan Zeng, Lingyuan Shi, Jianming Zhang, Yongcong Hong, Pumo Cai

“…However, HWT has a greater impact on functional microorganisms related to C and N cycles, especially N cycling. …”
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Robust Symbol Detection in Large-Scale Overloaded NOMA Systems by Hiroki Iimori, Giuseppe Thadeu Freitas De Abreu, Takanori Hara, Koji Ishibashi, Razvan-Andrei Stoica, David Gonzalez G., Osvaldo Gonsa

“…</italic>, 2020), the method is not relaxed into the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm, but rather approximated with a continuous and asymptotically exact expression without resorting to parallel interference cancellation (PIC). The objective function of the resulting formulation is thus a sum of concave-over-convex ratios, which is then tightly convexified via the quadratic transform (QT), such that its solution can be obtained via the iteration of a simple closed-form expression that closely resembles that of the classic zero-forcing (ZF) receiver, making the method particularly suitable to large-scale set-ups. …”
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CCR3 deficiency shifts adaptive to innate-driven immunity in asthma by Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD

“…Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. …”
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