Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review by Yoshiaki Suzuki, Wayne R. Giles, Gerald W. Zamponi, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura

“…This allows Ca2+ signaling to be tightly controlled in localized areas within the cell, resulting in a balanced vascular tone. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

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Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability by Alexandra Berroyer, Albino Bacolla, John A. Tainer, Nayun Kim

“…Interestingly, Top1 binds tightly to G4 struc-tures, and its inhibition or depletion can cause elevated instability at these ge-nomic loci. …”
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Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

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Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Ulcerative colitis (UC) is an incurable and highly complex digestive disease affecting millions of people worldwide. …”
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Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…IntroductionPlant roots, nematodes, and soil microorganisms have a complex interaction in the rhizosphere by exchanging or communicating through biomolecules or chemicals or signals. …”
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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

“…The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…Summary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. …”
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The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severit... by Elizabeth M. Ortega Rocha, Paul Hernández-Herrera, Sofia V. de los Santos- Carmona, Saraí G De León-Rodríguez, Ángel Juárez-Flores, Vadim Pérez-Koldenkova, Octavio Castro-Escamilla, Samira Muñoz-Cruz, Alicia Lemini-López, Laura C. Bonifaz

“…Our findings emphasize the complex interplay between epidermal barrier distribution, SEB localization, and functional CD4 TCRvβ17 cells in psoriatic skin, highlighting their potential in patient stratification in association with the severity of the disease.…”
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Alternative Splicing in Tumorigenesis and Cancer Therapy by Huiping Chen, Jingqun Tang, Juanjuan Xiang

“…Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms. …”
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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans by Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao

“…Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. …”
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Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies by Shu-Yun Li, Francesco John DeMayo

“…Implantation is a complex and tightly regulated process essential for the establishment of pregnancy. …”
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Identifying the effectiveness of face mask in a large population with a network-based fluid model. by Akshay Anand, Kourosh Shoele

“…The study also elucidates the complex role of nose clips in improving sealing efficacy for tightly fitted masks and redirecting leaked flow in typical imperfect facemasks. …”
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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Conclusions: These findings highlight the complex regulatory mechanisms underlying retinal responses to bTOI, involving neuroinflammation, oxidative stress, and disruptions in melatonin synthesis and photoreceptor cell functions. …”
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Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions by Ana Castañeda-Sampedro, Esther Alcorta, Carolina Gomez-Diaz

“…Additionally, similarities between the molecular signatures of peripheral glia in Drosophila and vertebrates highlight the utility of model organisms in elucidating glial cell functions in complex systems.…”
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RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

“…Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. …”
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ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report by Bin Wu, Yinliang Sheng, Zhenyang Geng, Yiming Xu, Xueyuan Fan, Ping Yuan, Feng Li, Yu Qi

“…The patient’s postoperative course was uneventful, and she was discharged on postoperative day 4 with satisfactory respiratory function and no major complications. Conclusions This case demonstrates the feasibility and potential benefits of combining ECMO support with uniportal VATS for complex carinal surgeries. …”
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The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells by Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques

“…Centrosome numbers are tightly regulated, typically duplicating once per cell cycle, during the S phase. …”
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Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. by Luke Boldock, Amanda Inzoli, Silvia Bonardelli, Sarah Hsiao, Alberto Marzo, Andrew Narracott, Julian Gunn, Gabriele Dubini, Claudio Chiastra, Ian Halliday, Paul D Morris, Paul C Evans, Perrault C M

“…Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. …”
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