RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation by Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo

“…Here, we map the genome‐wide occupancy of RNAPII and Polycomb from pluripotent ESCs to non‐dividing functional dopaminergic neurons. We find that poised RNAPII complexes are ubiquitously present at Polycomb‐repressed genes at all stages of neuronal differentiation. …”
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Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling by Liang Hu, Zi Yang, Zi Yang, Ying Zhang, Conglin Du, Yang Yang, Yang Yang, Zhichao Chang, Xiangchun Li, Zhaochen Shan

“…IntroductionInflammatory bowel disease (IBD) is a complex disease that is characterized by tight junction loss and dysregulation of immune homeostasis. …”
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Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells. by Adam G Grieve, Rachel D Daniels, Elena Sanchez-Heras, Matthew J Hayes, Stephen E Moss, Karl Matter, Martin Lowe, Timothy P Levine

“…We show that a proportion of OCRL1 targets intercellular junctions at the early stages of their formation, co-localizing both with adherens junctional components and with tight junctional components. Correlating with this distribution, OCRL1 forms complexes with junctional components α-catenin and zonula occludens (ZO)-1/2/3. …”
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Data-driven prediction and design of bZIP coiled-coil interactions. by Vladimir Potapov, Jenifer B Kaplan, Amy E Keating

“…Testing more than 132 candidate protein complexes using a fluorescence resonance energy transfer assay confirmed the formation of tight and selective heterodimers between the designed peptides and their targets. …”
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SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. by Cristina González-Estévez, Daniel A Felix, Matthew D Smith, Jordi Paps, Simon J Morley, Victoria James, Tyson V Sharp, A Aziz Aboobaker

“…Here we show that the planarian homolog of the phosphoinositide 3-kinase-related kinase (PIKK) family member SMG-1 and mTOR complex 1 components are required for this tight control. …”
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A $C^\ast$-algebraic view on the interaction of real- and reciprocal space topology in skyrmion crystals by Pascal Prass, Fabian R. Lux, Emil Prodan, Duco van Straten, Yuriy Mokrousov

“…We approach it from the viewpoint of $C^\ast$-algebras and calculate all admissible Chern numbers of a strongly coupled tight-binding skyrmion system on a triangular lattice as a function of Fermi energy and texture parameters. …”
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Porcine intestinal organoids cultured in an organ-on-a-chip microphysiological system by James Bacon, Halie Kitchel, John Stutz, Jack Jia Hua Chen, Aaron Smith, Robert D. Van Horn, Christopher Moreland, Trent Abraham, Thomas Baker, Eitaro Aihara, Kathleen Hillgren

“…These cultures formed villi-like structures and established a tight barrier replete with F-actin and tight junctions. …”
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A New Method for Constructing Integral-Resistance Matrix for 5-Round AES by Fanyang Zeng, Tian Tian

“…Since it is well known that there is a 4-round integral distinguisher for AES, our result is tight for AES. As far as we know, this is the first proof for the integral-resistance property of 5-round AES.…”
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Berry curvature-induced transport signature for altermagnetic order by T. Farajollahpour, R. Ganesh, K. V. Samokhin

“…This quantity can be easily measured as a function of temperature, without any spin-selective apparatus. …”
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Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes by Ana Filipa Sobral, Inês Costa, Vanessa Teixeira, Renata Silva, Daniel José Barbosa

“…In particular, astrocytes are essential for BBB function, as they maintain BBB integrity through their end-feet, which form a physical and biochemical interface that enhances endothelial cell function and barrier selectivity. …”
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Modern View on the Role of Epidermal Barrier in Atopic Phenotype Development in Children by Nikolay N. Murashkin, Alena A. Savelova, Roman A. Ivanov, Dmitri V. Fedorov, Leonid A. Opryatin, Wasel Ahmad

“…Filaggrin and tight junctions (TJs) proteins are important structural components of the epidermal barrier. …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Additionally, the influence of calcium and magnesium ions on the resulting complexes of these indole derivatives with ct-DNA has been evaluated. …”
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Preparation and Characterization of Rosa roxburghii Tratt Polyphenol-Sodium Alginate-Soy Protein Isolate Nanocomposites and Their Antioxidant Activity by Han LIU, Xiaoyan LIU, Yinping GUO, Xingyan MU, Zihui SHI

“…To investigate the stability and functional properties of binary (SPI-SA, SPI-RRTP) and ternary (SPI-SA-RRTP) complexes of soy protein isolates (SPI) with sodium alginate (SA) and Rosa roxburghii Tratt polyphenols (RRTP). …”
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Stability and Finite-Time Synchronization Analysis for Recurrent Neural Networks with Improved Integral-Type Time-Varying Delays by Meng Li, Gulijiamali Maimaitiaili

“…Firstly, a sufficient criterion for universal asymptotic stability of RNNs with integral time-varying delays is obtained by estimating a tight upper bound of augmented Lyapunov-Krasovskii functional (LKF) derivative with inequality scaling technique and mutually convex combined inequality. …”
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In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction by Shafaat Hossain, Omar Hamza Bin Manjur, Mst Sharmin Sultana Shimu, Tamanna Sultana, Mustafizur Rahman Naim, Shahariar Siddique, Abdullah Al Mamun, Md Miftaur Rahman, Md Abu Saleh, Md Rakibul Hasan, Tania Rahman

“…Cystatin A (CSTA) functions as a cysteine protease inhibitor by forming tight complexes with the cathepsins. …”
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Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia. by Jon Paulin Zumthor, Lenka Cernikova, Samuel Rout, Andres Kaech, Carmen Faso, Adrian B Hehl

“…Here, we investigated the molecular consequences of these adaptations on the Giardia endocytic machinery and membrane coat complexes. Despite the absence of canonical clathrin coated vesicles in electron microscopy, Giardia possesses conserved PV-associated clathrin heavy chain (GlCHC), dynamin-related protein (GlDRP), and assembly polypeptide complex 2 (AP2) subunits, suggesting a novel function for GlCHC and its adaptors. …”
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A Novel Multi-Agent-Based Approach for Train Rescheduling in Large-Scale Railway Networks by Jin Liu, Lei Chen, Zhongbei Tian, Ning Zhao, Clive Roberts

“…While recent research has introduced intelligent solutions to railway traffic management, the tight interdependence of train timetables and the intrinsic complexity of railway networks have hindered the scalability of these approaches to large-scale systems. …”
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Elucidating Key Motifs Required for Arp2/3-Dependent and Independent Actin Nucleation by Las17/WASP. by Ellen G Allwood, Joe J Tyler, Agnieszka N Urbanek, Iwona I Smaczynska-de Rooij, Kathryn R Ayscough

“…Actin nucleation is the key rate limiting step in the process of actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific times and at defined regions of the cell. …”
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Examining Stromal Cell Interactions in an In Vitro Blood–Brain Barrier Model with Human Umbilical Vein Endothelial Cells by Andrea Margari, Simon Konig, Vignesh Jayarajan, Silvia Rizzato, Giuseppe Maruccio, Emad Moeendarbary

“…Understanding the function of the blood–brain barrier (BBB) in health and disease, as well as improving drug delivery across the BBB, remains a critical priority in neuroscience research. …”
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RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. by Kelly E Coller, Kristi L Berger, Nicholas S Heaton, Jacob D Cooper, Rosa Yoon, Glenn Randall

“…Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions, culminating in internalization via clathrin-mediated endocytosis. …”
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