Outcomes of complex decongestive therapy in managing upper limb lymphedema in female breast cancer patients at a palliative care unit of a tertiary care hospital in Bangladesh. by Rifat Jahan, A K M Motiur Rahman Bhuiyan, Afroja Alam, Mostofa Kamal Chowdhury, Romena Hassan, Nisha Mortuja Aktar

“…<h4>Background</h4>Lymphedema is a chronic condition that significantly affects both physical function and quality of life of breast cancer patients. …”
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p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases by Madison E. Gamble, Sruthi Sureshkumar, Maria Janina Carrera Espinoza, Natalie L. Hakim, Claudia M. Espitia, Fangchao Bi, Kevin R. Kelly, Wei Wang, Steffan T. Nawrocki, Jennifer S. Carew

“…Within NOX2, the essential scaffold protein p47phox plays a pivotal role in orchestrating enzyme activation and facilitating the assembly and membrane translocation of cytosolic components of the complex. Tight regulation of p47phox activity is crucial, and its disruption is linked to a number of pathological conditions. …”
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Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. by Tale Sliedrecht, Chao Zhang, Kevan M Shokat, Geert J P L Kops

“…<h4>Background</h4>Proper execution of chromosome segregation relies on tight control of attachment of chromosomes to spindle microtubules. …”
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The Ideal City by Federico M. Butera

“…The cause lies in human activities, which are the product of the current economic and cultural model. The complex environmental system, with its tight interconnections between various planetary boundaries, is closely linked to another complex system: human society. …”
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Protein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis by Qin Meng, Zhikang Li, Qiguan Qiu, Shuyu Chen, Haiyan Gong, Xiaoruo Tan, Xiaoheng Liu, Zhaoguo Chen, Wei Liu

“…The annotated phosphoproteins were associated with various biological processes, including cytoskeletal remodeling, supramolecular complex assembly, and developmental regulation. The phosphopeptide functional enrichment revealed that B. procyonis phosphoproteins were mostly involved in the cytoskeleton cellular compartment, protein binding molecular function, and multiple biological processes, including regulating supramolecular fiber and cytoskeleton organization and assembling cellular protein-containing complexes and organelles. …”
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Unique Function of the Bacterial Chromosome Segregation Machinery in Apically Growing Streptomyces - Targeting the Chromosome to New Hyphal Tubes and its Anchorage at the Tips. by Agnieszka Kois-Ostrowska, Agnieszka Strzałka, Natalia Lipietta, Emma Tilley, Jolanta Zakrzewska-Czerwińska, Paul Herron, Dagmara Jakimowicz

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Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429 by Yuxuan Wang, Bilan Chen, Tingzhou Xuan, Kun Ouyang, Jingshen Chen, Hailong Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yongliang Zhang, Ting Chen

“…We systematically identified the circRNAs involved in this process and analyzed the miRNAs through which PM-sEV deliver circRNAs to regulate intestinal barrier function. Our findings revealed that PM-sEV promote the expression of the intestinal tight junction proteins ZO-1 and Occludin, both in vivo (mice) and in vitro (IPEC-J2). …”
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Comprehensive identification of cotton EPF/EPFL receptors and functional characterization of the GhEPFL1-1-GhER1 module in drought tolerance by Shichang He, Huijian Sun, Qing Chen, Yanlong Yang, Zixin Zhou, Saiwen Chang, Shuaiqi Lu, Zhencai Liang, Julan Yang, Xiao fei

“…Abstract The development of stomatal lineage cells in terrestrial plants is tightly regulated by epidermal patterning factors (EPFs/EPFLs) and their downstream receptors, including ERECTA, TOO MANY MOUTHS (TMM), and SOMATIC EMBRYOGENESIS RECEPTOR KINASEs (SERKs). …”
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SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair by Sofiya Kandelis-Shalev, Manish Goyal, Tal Elam, Shany Assaraf, Noa Dahan, Omer Farchi, Eduard Berenshtein, Ron Dzikowski

“…However, while the nuclear periphery of P. falciparum was implicated in several important functions, the role of the LINC complex in Plasmodium biology is unknown. …”
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Engeletin Targets Mitochondrial Dysfunction to Attenuate Oxidative Stress and Experimental Colitis in Intestinal Epithelial Cells Through AMPK/SIRT1/PGC-1α Signaling by Jing Li, Zhijun Geng, Lixia Yin, Ju Huang, Minzhu Niu, Keni Zhang, Xue Song, Yueyue Wang, Lugen Zuo, Jianguo Hu

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Perfect Roman Domination: Aspects of Enumeration and Parameterization by Kevin Mann, Henning Fernau

“…We also consider the enumeration of minimal Perfect Roman Dominating Functions and show a tight relation to minimal Roman Dominating Functions. …”
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Advances in ERECTA Family Regulation of Female Gametophyte Development in <i>Arabidopsis thaliana</i> by Han Su, Xiaohu Jiang, Yanfen Liu, Zhuangyuan Cao, Ziqi Liu, Yuan Qin, Qing He, Hanyang Cai

“…The female gametophyte is central to the reproductive success of flowering plants, with its development being tightly controlled by an intricate network of genes and signaling pathways. …”
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Stochastic Block-Coordinate Gradient Projection Algorithms for Submodular Maximization by Zhigang Li, Mingchuan Zhang, Junlong Zhu, Ruijuan Zheng, Qikun Zhang, Qingtao Wu

“…Moreover, we show that the proposed algorithm achieves the tight (pmin/2F⁎-ϵ) approximation guarantee after O(1/ϵ2) iterations for DR-submodular functions by choosing appropriate step sizes. …”
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Evolution Characteristics and Regional Roles’ Influencing Factors of Interprovincial Population Mobility Network in China by Wei Fang, Pengli An, Siyao Liu

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Tad pili with adaptable tips mediate contact-dependent killing during bacterial predation by Julien Herrou, Laetitia My, Caroline L. Monteil, Marine Bergot, Rikesh Jain, Emmanuelle Martinez, Tâm Mignot

“…Remarkably, the activity of these Tips also depends on the T3SS*, revealing a tight functional connection between the Kil system and the T3SS*. …”
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PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. by Federica Lo Sardo, Chiara Lanzuolo, Federico Comoglio, Marco De Bardi, Renato Paro, Valerio Orlando

“…However, the interconnection between replication timing control and PcG functions remains unknown. Using Drosophila embryonic cell lines, we find that, while presence of specific PcG complexes and underlying transcription state are not the sole determinants of cellular replication timing, PcG-mediated higher-order structures appear to dictate the timing of replication and maintenance of the silenced state. …”
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The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. by Krasimir Slanchev, Thomas J Carney, Marc P Stemmler, Birgit Koschorz, Adam Amsterdam, Heinz Schwarz, Matthias Hammerschmidt

“…On the molecular level, EVL cells of epcam mutant embryos display reduced levels of membranous Ecad, accompanied by an enrichment of tight junction proteins and a basal extension of apical junction complexes (AJCs). …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. …”
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A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. by Satoko Nishimoto, Carolina Minguillon, Sophie Wood, Malcolm P O Logan

“…Forelimb-restricted expression of Tbx5 and ultimately forelimb formation is therefore achieved through co-option of two characteristics of Hox genes; their colinear expression along the body axis and the functional specificity of different paralogs. Active complexes can be formed by Hox PG proteins present throughout the rostral-caudal LPM while restriction of Tbx5 expression is achieved by superimposing a dominant repressive (Hoxc9) complex that determines the caudal boundary of Tbx5 expression. …”
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CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid—Maintaining Health and Preventing Thyroid Dysfunction in Aging by Jennifer Nhieu, Fatimah Najjar, Li-Na Wei

“…The CRABP1 sequence is highly conserved, likely due to its functional constraint in forming various signalosomes; its tight regulation ensures proper expression of CRABP1 required for the forming of various signalosomes critical to the health and functions of multiple cell types/organ systems. …”
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