The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…Carbon disequilibrium chemistry strongly shapes the mid-infrared spectra of these sources, as a complex function of the metallicity and surface gravity. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
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Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep by Xindong Cheng, Yanping Liang, Kaixi Ji, Mengyu Feng, Xia Du, Dan Jiao, Xiukun Wu, Chongyue Zhong, Haitao Cong, Guo Yang

“…Correlation analysis indicated that butyrate holds a central position in both networks, with Hulunbuir sheep exhibiting a more complex and tightly regulated network involving SCFAs, microbiota, microbial functions, and transcriptomes. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…Today, countries are achieving significant progress in the field of innovation in a tight competition. Tourism is one of the most important sectors that has been recently noticed in the discussion of innovation. …”
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Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate by Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang, Yuxin Yin

“…Abstract Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance. …”
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Non-canonical internalization mechanisms of mGlu receptors by Marta Cimadevila, Junke Liu, Damien Maurel, Isabelle Brabet, Marine Hoscar, Julia Drube, Carsten Hoffmann, Asuka Inoue, Philippe Rondard, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin

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Measuring communities’ efficiencies within the global tourism network by He Zhu

“…Abstract Tourist flows between countries shape the global tourism network, with tightly interconnected nations forming distinct communities. …”
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Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells by Akiko Sugimoto-Ishige, Aya Jodo, Takashi Tanaka

“…Activation of transcription factor NF-κB is tightly regulated by negative regulatory systems that prevent excessive inflammation leading to autoimmune diseases. …”
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Endoscopic Debridement, Ostectomy, Release, and Radiofrequency: A Fully Endoscopic Technique for Treating Recalcitrant Plantar Fasciitis by Walter-Soon-Yaw Wong, M.B.Ch.B., M.R.C.S., Dhivakaran Gengatharan, M.B.B.S., Inderjeet Singh Rikhraj, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Keen Wai Chong, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Wen Xian Png, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Eric Wei Liang Cher, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth)

“…This comprehensive approach aims to improve patient satisfaction and functional outcomes.…”
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Regulators and Effectors of Arf GTPases in Neutrophils by Jouda Gamara, François Chouinard, Lynn Davis, Fawzi Aoudjit, Sylvain G. Bourgoin

“…G protein-dependent signalling pathways tightly control PMN functions. In this review, we will focus on the small monomeric GTPases of the Arf family and their guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) as components of signalling cascades regulating PMN responses. …”
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A controllable photoresponsive potassium transporter by Zhongyan Li, Lin Yuan, Wenju Chang, Junqiu Liu, Jie Shen, Huaqiang Zeng

“…We report here a controllable, photoresponsive, ion-transporting carrier, achieving controllability through a photoregulated β-cyclodextrin (β-CD)-azobenzene host-guest complex. In this complex, a lipid-anchored β-CD serves as the launch base, tightly immobilizing through host-guest interactions the otherwise freely moving trans-transporter derived from a crown ether-modified trans-azobenzene motif, but rapidly releasing most of it upon 365 nm UV irradiation that converts transporter to its cis-configuration. …”
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Glucose deprivation and identification of TXNIP as an immunometabolic modulator of T cell activation in cancer by Agathe Dubuisson, Adèle Mangelinck, Samantha Knockaert, Adrien Zichi, Etienne Becht, Wendy Philippon, Sandra Dromaint-Catesson, Manon Fasquel, Fabien Melchiore, Nicolas Provost, Dawid Walas, Dawid Walas, Hélène Darville, Jean-Pierre Galizzi, Céline Lefebvre, Véronique Blanc, Vincent Lombardi

“…BackgroundThe ability of immune cells to rapidly respond to pathogens or malignant cells is tightly linked to metabolic pathways. In cancer, the tumor microenvironment (TME) represents a complex system with a strong metabolism stress, in part due to glucose shortage, which limits proper T cell activation, differentiation and functions preventing anti-tumor immunity.MethodsIn this study, we evaluated T cell immune reactivity in glucose-restricted mixed lymphocyte reaction (MLR), using a comprehensive profiling of soluble factors, multiparametric flow cytometry and single cell RNA sequencing (scRNA-seq).ResultsWe determined that glucose restriction potentiates anti-PD-1 immune responses and identified thioredoxin-interacting protein (TXNIP), a negative regulator of glucose uptake, as a potential immunometabolic modulator of T cell activation. …”
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PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease by Purin Charoensuksai, Wei Xu

“…The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. …”
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Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections by Kayle Brenna Dickson, Juan Zhou, Christian Lehmann

“…Iron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. …”
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Proteoglycans in normal physiology and carcinogenesis by A. V. Suhovskih, E. V. Grigorieva

“…An important role in this process belongs to the complex protein-carbohydrate molecules – proteoglycans (PG), which are one of the main component of ECM and cell surface of any tissue and are tightly involved in cell-cell and cell-matrix interactions and signaling. …”
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A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment by Mengting Xu, Qi Zhang, Yuan Li, Wei Zhou, Lingyun Lei, Fucheng Lin, Yanjun Kou, Zeng Tao

“…RSC1 is indispensable for establishing open chromatin architecture, and its activity is tightly correlated with altered nucleosome occupancy. …”
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Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis by Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei

“…Mechanistically, NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional RUNX2 (exon 6 exclusive) to reinforce osteoblast differentiation. …”
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Plants Drive Microbial Biomass and Composition but Not Diversity to Promote Ecosystem Multifunctionality in Karst Vegetation Restoration by Yunlong Sun, Shu Zhang, Yueming Liang, Xuan Yu, Fujing Pan

“…The structure of plant, bacterial, and fungal communities varied across different stages of vegetation restoration, exhibiting the highest microbial diversity indices in the SH stage. Additionally, the tightness and complexity of co-occurrence networks of bacteria and fungi increased with advancing vegetation restoration, and higher positive links were observed in fungi than bacteria. …”
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Quantitative determination of iron (III) in polymaltose haematinic formulations on the Ghanaian market. by Rita Okwampah, Kofi Dzorgbenyuie Bedzra, Oti Kwasi Gyamfi, James Ataki, Foster Kyei, Martin Adarkwah-Yiadom, Edem Sosu, Emmanuel Boateng

“…Iron is an essential element needed by living organisms to enable their bodies to perform a variety of cellular functions and it is tightly regulated in the body systems of living organisms. …”
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Transmission interference microscopy of anterior human eye by Samer Alhaddad, Wajdene Ghouali, Christophe Baudouin, Albert Claude Boccara, Viacheslav Mazlin

“…Specifically, we show that the tightly localized illumination spot at the sclera functions analogously to a closed condenser aperture in conventional microscopy, significantly enhancing interference contrast. …”
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